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Veterinary chlortetracycline premix and preparation method thereof

A technology of premix and chlortetracycline, applied in the field of feed additives, can solve problems such as increasing costs and risks, antibiotic resistance, etc., and achieve the effects of improving bioavailability, promoting absorption, and prolonging the time of absorption

Active Publication Date: 2016-10-12
GUANGZHOU CARDLO BIOCHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional aureomycin premix is ​​prepared by direct spray drying of the fermentation broth. In order to ensure that the aureomycin content obtained by fermentation meets the usage requirements, in addition to the strains with the best performance, strict production management is also required, which increases the Production costs and risks
In addition, the product formed by spray drying is a powder, and users are easy to inhale the dust of chlortetracycline when using chlortetracycline premix, resulting in antibiotic resistance

Method used

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  • Veterinary chlortetracycline premix and preparation method thereof
  • Veterinary chlortetracycline premix and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0028] Preparation of experimental example 1 chitosan-EDTA complex

[0029]

[0030]

[0031] Preparation method: Take chitosan, add 1% glacial acetic acid solution 6 times the weight of chitosan and stir until completely dissolved, then add EDTA-2Na and stir evenly, use sodium hydroxide solution to adjust pH to 5, add condensing agent 1-B Base-(3-dimethylaminopropyl) carbodiimide hydrochloride, the concentration of the condensing agent in the reaction system is 30mmol / L, after stirring at room temperature for 4h, carry out deionized water dialysis to obtain the product, freeze the product Just do it.

[0032] The chitosan-EDTA complex freeze-dried powder prepared by A-E group was carried out to measure the degree of substitution, and the results are shown in the following table:

[0033] group

[0034] It can be seen from the above table that chitosan: EDTA-2Na undergoes amidation condensation reaction at a weight ratio of 1:2, and the resulting chitosan-EDTA...

Embodiment 2

[0036] Embodiment 2 of the present invention veterinary chlortetracycline premix comprises the following raw materials in parts by weight: 25 parts of chlortetracycline hydrochloride, 35 parts of N-trimethyl chitosan, 30 parts of starch, 4 parts of povidone K30, Chitosan-EDTA complex 2 parts and water 14 parts

[0037] Preparation:

[0038] (1) Get povidone K30, add water and stir evenly to obtain povidone K30 solution for subsequent use;

[0039] (2) get aureomycin hydrochloride, N-trimethyl chitosan, starch, chitosan-EDTA compound and mix uniformly, add the povidone K30 solution of step (1) gained, stir and make soft material;

[0040] (3) Extrude the soft material obtained in step (2) through a 30-mesh sieve twice, and then through a 50-mesh sieve once to prepare granules, and dry at 45°C until the water content is <3% to obtain the premix .

Embodiment 3

[0042] Embodiment 3 of the present invention veterinary chlortetracycline premix comprises the following raw materials in parts by weight: 20 parts of chlortetracycline hydrochloride, 30 parts of N-trimethyl chitosan, 20 parts of starch, 2 parts of povidone K30, Chitosan-EDTA complex 1 part and water 10 parts.

[0043] The preparation method is the same as in Example 2.

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Abstract

The invention belongs to the field of feed additives and in particular relates to a veterinary chlortetracycline premix and a preparation method thereof. The premix is prepared from the following raw materials in parts by weight: 20 to 30 parts of chlortetracycline hydrochloride, 30 to 40 parts of N-trimethyl chitosan, 20 to 40 parts of starch, 2 to 6 parts of polyvinylpyrrolidone K30, 1 to 3 parts of a chitosan-EDTA (Ethylene Diamine Tetraacetic Acid) complex and 10 to 18 parts of water, and further comprises 4 to 8 parts of a sweetener; the sweetener is one of sucrose, lactose, sorbitol and mannitol. The premix is prepared into grains by adopting a wet-process granulation process and the prepared premix grains are uniform and have high granulation rate and stable quality. Furthermore, the premix can be used for effectively reducing complex compounds formed by the chlortetracycline hydrochloride and metal ions in gastrointestinal tracts; the chlortetracycline hydrochloride can be incompletely released in gastric juice and the bioavailability of the chlortetracycline hydrochloride is improved. The preparation process of the premix provided by the invention is simple and industrial application is easy to realize.

Description

technical field [0001] The invention belongs to the field of feed additives, and in particular relates to a veterinary aureomycin premix and a preparation method thereof. Background technique [0002] Chlortetracycline (Chlortetracycline), also known as chlortetracycline, referred to as CTC, is the first tetracycline antibiotic discovered. Chlortetracycline has a broad antibacterial spectrum, and has inhibitory effects on Gram-positive and negative bacteria, mycoplasma, chlamydia, spirochetes, rickettsia, amoeba, etc. The excellent antibacterial properties of aureomycin have attracted much attention in feed additives. Feed grade chlortetracycline is chlortetracycline calcium salt, which is prepared from the whole fermentation broth and appropriate amount of calcium carbonate. It is brown or tan powder or granules, no agglomeration, mildew, and odorless. Low, no cross-resistance between humans and animals, and few incompatibility with other antibiotics and chemical drugs, my...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/36A61K47/32A61K47/18A61K31/65A61P31/04
CPCA61K9/1617A61K9/1635A61K9/1652A61K9/1682A61K31/65
Inventor 徐怀义
Owner GUANGZHOU CARDLO BIOCHEM TECH
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