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66 results about "Trimethyl chitosan" patented technology
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Curcumin coated liposome preparation and preparation method thereof
InactiveCN102008439AEasy to makeEvenly dispersedSenses disorderAntipyreticCurcumin LiposomeOral medication
The invention relates to a curcumin coated liposome preparation and a preparation method thereof. The curcumin coated liposome preparation consists of curcumin, phospholipids, cholesterol, water-soluble vitamin E and trimethyl chitosan, and can be prepared into freeze-dried powder applied to oral administration. The gastrointestinal absorption efficiency of the curcumin coated liposome is significantly higher than that of the traditional curcumin liposome preparation, so the curcumin coated liposome further improves the oral absorption of the curcumin and improve the oral bioavailability.
Owner:SHANDONG UNIV
Trimethyl chitosan-graft-polyethylene glycol/nucleic acid brain-targeting micellar and preparation method thereof
The invention belongs to the technical field of medicine, and relates to an acetylcholine-receptor-mediated trimethyl chitosan-graft-polyethylene glycol / nucleic acid brain-targeting micellar and a preparation method thereof. According to the invention, trimethyl chitosan-graft-polyethylene glycol-brain-targeting functional peptide is obtained through the steps that: chitosan is sequentially subjected to quaternary ammonium modification such that trimethyl chitosan is obtained; the amino group of trimethyl chitosan is subjected to a reaction with an active group of two-end-activated polyethylene glycol, such that trimethyl chitosan-graft-polyethylene glycol is obtained; and another active group of polyethylene glycol is subjected to a reaction with brain-targeting functional peptide RVG. According to the invention, ion composite micellar is adopted as a carrier, and brain-targeting functional peptide RVG is adopted as a targeting molecule, such that nucleic acid medicine can actively target and position through blood-brain barrier and brain. The ion composite micellar provided by the invention is formed through static composition of positively charged trimethyl chitosan-graft-polyethylene glycol-brain-targeting functional peptide and negatively charged nucleic acid. With the invention, nucleic acid medicine defects such as easy in-vivo degradation, poor stability, and low transfection efficiency are solved.
Owner:SHENYANG PHARMA UNIVERSITY
Preparation method and application of fatty acid-trimethyl chitosan polymer modified by lactobionic acid
InactiveCN102863557AGood biocompatibilityPromote degradationPowder deliveryPharmaceutical non-active ingredientsSolubilityPolymer modified
The invention discloses a fatty acid-trimethyl chitosan polymer modified by a lactobionic acid, a preparation method and an application. The fatty acid-trimethyl chitosan polymer modified by the lactobionic acid is an active targeting nano micelle carrier material. A trimethyl chitosan with a good water-solubility is used as a carrier material, the hydrophobic modification is performed by a fatty acid, and then the surface modification is performed by the lactobionic acid to obtain a polymer micelle with the lactobionic acid which mediates tumor tissue target. Harmine is used as a model drug to prepare a drug-loaded nano-micelle in a rubbing and self-assembly mode. A test confirms that the drug loading capacity and encapsulated ratio of the drug-loaded nano-micelle are high, the slow-release property is achieved, cells are effectively taken in through a lactobionic acid receptor pathway, and distribution of drugs on the tumor tissue is increased, so that the curative effect is improved, the toxic and side effect is reduced, and targeted therapy is achieved. The fatty acid-trimethyl chitosan polymer modified by the lactobionic acid, the preparation method and the application provide an ideal novel drug carrier and a preparation form for antitumor drugs with slightly solubility.
Owner:SUZHOU UNIV
Facial cleanser for effectively preventing haze hazards
InactiveCN104606071ABacteriostaticFunctionalCosmetic preparationsToilet preparationsWater soluble chitosanBeta-Cyclodextrins
The invention relates to the field of daily use chemicals and in particular relates to a facial cleanser for effectively preventing haze hazards. The facial cleanser comprises the following raw materials in parts by weight: 0.1-10 parts of chitosan and derivatives thereof, 5-25 parts of an amino acid-based surfactant and 0.2-3 parts of a thickening agent, wherein the chitosan and derivatives thereof are selected from one or more in chitosan, water-soluble chitosan, N-trimethyl chitosan, N-malely chitosan, carboxymethyl chitosan, hydroxypropyl chitosan or beta-cyclodextrin grafted chitosan; and the deacetylation degree of the chitosan and derivatives thereof is 60-99 percent. The chitosan and derivatives thereof are added into the amino acid-based facial cleanser, and the slightly acidic facial cleanser disclosed by the invention is rich in foam, high in stability, mild and non-irritating, has the effects of inhibiting bacteria and chelating heavy metals and is applied to skin care in hazy weather.
Owner:SHENZHEN AESTHETIC BIOLOGICAL TECH +1
Chloro-N-trimethyl chitin hyamine
A chloride-n-trimethide chitose quaternary ammonium salt is characterized by the molecular formula is (C8H13NO5)n (C8H17NO4)m-x (C9H20NO4Cl)x, n=0.07-0.19, x=0.39-0.75, n+m+x=1. The production is carried out by expanding dissolving chitose into 1-methyl-2- pyrrolidone, adding sodium iodide, adding iodomethane, keeping temperature 50-65deg.C, agitating reacting, reacting liquid cooling, precipitating settling, washing deposit matter with acetone methyl - water solution, dissolving the deposit matter into water, dripping chlorhydric acid - alcohol solution and ion exchanging, adding acetone methyl into reacting liquid, washing the deposit matter, dissolving into water, adding into acetone methyl and settling, washing with acetone methyl - water solution, washing with acetone methyl, and drying. It achieves low cost, simple operation, and good water soluble performance.
Owner:OCEAN UNIV OF CHINA
Method for synthesizing N,N,N-trimethyl chitosan sulfate methyl ammonium
InactiveCN101157735AHave physical and chemical propertiesWith physiological functionsSolubilityOrganic synthesis
A synthesis method of N, N, N-trimethyl chitosan ammonium methosulfate (TMCS) pertains to the field of organic synthesis technology. The present invention takes the chitosan with the deacetylation of more than 90 percent as the raw materials and uses a two-step reaction to synthesize a target product. The first step is that the chitosan, formic acid and aldehyde reacts by taking the water as the solvent, so as to get an intermediate N, N-dimethyl chitosan; the second step is that the N, N-dimethyl chitosan reacts with dimethyl sulfate in the organic solvent to prepare the target product. Compared with the raw materials of chitosan, TMCS not only has the similar physical and chemical properties and physiological functions with chitosan, but also has the good water solubility and strong antibacterial capability, so the application field is much broader; as the formic acid, formaldehyde, trioxymethylene or paraformaldehyde and dimethyl sulfate have rich sources and low price, the present invention is the method which is more environmental -friendly and economic for the industrial production.
Owner:JIANGNAN UNIV
Method for improving anti-pollution performance of hydrophobic separation membrane by grafting hyperbranched PEG (polyethylene glycol) to surface of hydrophobic separation membrane
ActiveCN103962011AEffective chemical graftingImprove anti-pollution performanceSemi-permeable membranesPolyethylene glycolPolyvinylidene difluoride
The invention provides a method for improving the anti-pollution performance of a hydrophobic separation membrane by grafting hyperbranched PEG (polyethylene glycol) to the surface of the hydrophobic separation membrane. The method is characterized by comprising specific steps as follows: step 1, the hydrophobic separation membrane is placed in a plasma processing device for plasma electro discharge treatment; and step 2, the hyperbranched PEG is grafted to the surface of the hydrophobic separation membrane after electro discharge treatment by adopting a Grafting from or a Grafting to manner. According to the method, active group sites such as hydroxyl and the like are generated on the membrane surface through the plasma electro discharge treatment, and effective chemical grafting of the membrane surface is achieved by using orientation response of PEG and TMC (trimethyl chitosan) high-activity functional groups. The surface contact angle of a modified PVDF (polyvinylidene fluoride) membrane is reduced to lower than 70 degrees, and the anti-pollution performance of the hydrophobic separation membrane is improved remarkably.
Owner:DONGHUA UNIV
High-efficiency stabilizing agent for hard-soluble medicine nanometer system
InactiveCN102451469APharmaceutical non-active ingredientsPill deliverySystem stabilityPharmaceutical formulation
The invention belongs to the technical field of medicinal preparations and specifically relates to a cationic polymer stabilizing agent capable of substantially reducing the particle size of nanoparticles of a hard-soluble medicine and improving stability of a system. A cationic polymer used as the stabilizing agent comprises chitosan of different molecular weight and different deacetylation degrees, trimethyl chitosan of different molecular weight and different substitution degrees, polyethyleneimine of different molecular weight, polylysine, etc. When a nanometer suspended system of a hard-soluble medicine is being prepared by using different methods, 0.1 to 0.5% of the cationic polymer is added as a stabilizing agent; through electrostatic repulsion, steric hindrance and increased kinetic stability, aggregation and coalescence of particles are effectively prevented and a particle size is inhibited from increasing, thereby preparing nanometer crystals or nanoparticles with a small particle size and good stability. The nanometer crystals or nanoparticles can be further solidified as needed so as to obtain solid dosage forms, e.g., tablets, capsules, etc.
Owner:SHENYANG PHARMA UNIVERSITY
Preparation method of chitosan quaternary ammonium salt
ActiveCN106167532AGood choiceOvercoming Situations That Require PressurizationMethyl carbonateIonic liquid
The invention relates to a preparation method of a chitosan quaternary ammonium salt, and belongs to the technical field of high molecule modification. The preparation method comprises following steps: firstly, chitosan is subjected to Eschweiler-Clarke reaction so as to obtain N, N-dimethyl chitosan; at an ionic liquid environment, quaternization reagent dimethyl carbonate is added for quaternization of N, N-dimethyl chitosan; and at last, an obtained reaction product solution is washed with an organic solvent and is dried so as to obtain N, N, N-trimethyl chitosan. According to the preparation method, the quaternization reagent dimethyl carbonate is nontoxic, the reaction products are carbon dioxide and methyl alcohol, and methyl alcohol can be recycled to prepare dimethyl carbonate, so that the preparation method is green, and is friendly to the environment. In addition, compared with dimethyl sulfate, selectivity of methylation reaction of dimethyl carbonate with amines is higher.
Owner:JIANGNAN UNIV
Polysialic acid-based n-trimethyl chitosan gel nanoparticles for systemic drug delivery
ActiveUS20120294904A1Safely and effectively deliverReduce sizeMaterial nanotechnologyBiocideDrug compoundMethotrexate
Gel nanoparticles for encapsulating and delivering a pharmaceutical compound to a patient. The nanoparticles are formed from N-trimethyl chitosan and polysialic acid, preferably in the presence of sodium tripolyphosphate. A ratio of polysialic acid to N-trimethyl chitosan of about 0.5 to 1 produces nanoparticles having diameter of about 100 nm (plus or minus 25 nm) and a zero potential above 30 milivolts that can stability contain a pharmaceutical compound, such as methotrexate, for delivery to a patient.
Owner:SYRACUSE UNIVERSITY
Transmucosal cannabinoid formulation including a chitosan excipeint
InactiveUS20190000794A1Improve transmucosal deliveryReduce deliveryOrganic active ingredientsPharmaceutical delivery mechanismPalmitic acidExcipient
A cannabinoid formulation for transmucosal delivery includes a first excipient comprising shea butter containing at least 40% oleic acid, at least 20% steraic acid, at least 3% linoleic acid, and at least 2% palmitic acid, a second excipient comprising soy lecithin and a third excipient that is a glycolipid precursor. In one embodiment, the glycolipids precursor is a bioadhesive polysaccharide composed of randomly distributed β-(1→4)-linked D-glucosamine and N-acetyl-D-glucosamine to improve mucosal and cellular permeability. Preferably the polysaccharide is derived from naturally occurring chitosan. In one embodiment, the polysaccharide is naturally occurring chitosan having a concentration of between 1-20 mg / ml in the formulation. In an alternate embodiment, the polysaccharide is trimethylchitosan having a concentration of between 1-20 mg / ml in the formulation.
Owner:TANAKA DANIEL S
O-alpha-methyl mandelate-N-trimethyl chitosan quaternary ammonium salt as well as preparation method and application thereof
InactiveCN106380526AGood water solubilityGood antibacterial effectAntibacterial agentsOrganic active ingredientsSolubilityMethyl iodide
The invention belongs to the field of high molecular compound materials and discloses a chitosan-chemically modified functional derivative, namely O-alpha-methyl mandelate-N-trimethyl chitosan quaternary ammonium salt as well as a preparation method and application thereof. The preparation method of the O-alpha-methyl mandelate-N-trimethyl chitosan quaternary ammonium salt comprises the following steps: taking chitosan, formaldehyde and formic acid as starting materials, carrying out microwave reaction to obtain chitosan schiff base, and then carrying out reaction with iodomethane to obtain N,N,N-trimethyl chitosan; and dissolving N,N,N-trimethyl chitosan with methane sulfonic acid, and then adding O-alpha-formyl mandelate acyl chloride into the mixed solution for reacting so as to obtain the O-alpha-methyl mandelate-N-trimethyl chitosan quaternary ammonium salt. The O-alpha-methyl mandelate-N-trimethyl chitosan quaternary ammonium salt has good water solubility, has greatly increased antibacterial properties compared with the chitosan raw material and N,N,N-trimethyl chitosan, and can be applied to many application fields of antibacterial medical materials, chemical products for daily use, food packages and the like.
Owner:HUNAN UNIV OF TECH
Air-permeable moisturizing dressing with bacteriostasis and drug percutaneous absorption promotion functions and preparation method of air-permeable moisturizing dressing
ActiveCN105079860AGuaranteed moisturizingGuaranteed breathabilityAbsorbent padsBandagesFiberPolyvinyl alcohol
The invention discloses an air-permeable moisturizing dressing with bacteriostasis and drug percutaneous absorption promotion functions and a preparation method of the air-permeable moisturizing dressing. The air-permeable moisturizing dressing comprises the following raw materials in parts by weight: 12-14 parts of N-trimethyl chitosan, 8-12 parts of menthanol, 5-7 parts of isopropyl myristate, 20-30 parts of chitosan, 25-35 parts of loofah sponge fibers, 8-14 parts of isomalto-oligosaccharide, 5-9 parts of polyvinyl alcohol, 6-10 parts of carboxymethyl cellulose sodium, 10-12 parts of glycerol, 8-10 parts of mannitol, 12-20 parts of medicinal powder, 3-7 parts of weak-acid calcium chloride and a proper amount of deionized water. As chitosan and loofah sponge fibers are combined together, the moisturizing property of the dressing is guaranteed by adsorbability of chitosan, and the air permeability of the dressing is guaranteed by the hollow tube bundle structures of the loofah sponge fibers; meanwhile, chitosan derivatives are used together to effectively promote percutaneous absorption and wound healing, so that a favorable effect is achieved.
Owner:扬州市旅游日用品制造总厂
Curcumin coated liposome preparation and preparation method thereof
InactiveCN102008439BEasy to makeEvenly dispersedSenses disorderAntipyreticCurcumin LiposomeOral medication
Owner:SHANDONG UNIV
Cadmium reducing agent for rape
InactiveCN108719322ADoes not affect normal production capacitySimple production processBiocidePlant growth regulatorsAdhesiveNormal growth
The invention relates to a cadmium reducing agent for rape. The cadmium reducing agent is prepared from cadmium reducing components, an adhesive, pigment and an aid through crushing and mixing. The cadmium reducing components are calcium acetate and magnesium sulfate, the adhesive is N-trimethyl chitosan, the pigment is brilliant blue and the aid is bentonite. The cadmium reducing agent is applicable to foliage spray of rape planted in cadmium contaminated soil and can reduce the cadmium content of rapeseeds. The cadmium reducing agent for the rape is mixed with water in the mass ratio being 1:(120-140) to be prepared into a suspension, foliage spray is performed once in the bolting period, the later blooming period and the middle silique development period of rape respectively, and the cadmium content of the rapeseeds is reduced by 40.6%-58.2%. The cadmium reducing agent has no adverse effects on normal growth of the rape and the soil environment quality. The cadmium reducing agent isconvenient to produce and use, low in cost and capable of reducing the cadmium content of the rapeseeds effectively and has significant economic, social and ecological benefits.
Owner:HUNAN AGRICULTURAL UNIV
Bactericide for clinical laboratory
InactiveCN104798823ABroad spectrum antibacterialNon-irritatingBiocideCosmetic preparationsAutoimmune responsesPolyhexamethylene guanidine
The invention discloses a bactericide for a clinical laboratory. The bactericide comprises the following components in percentage by weight: 3.0% to 8.0% of goldthread essence, 2.0% to 6.0% of lctuc tiwnin mxim root essence, 2.0% to 8.0% of N-trimethyl chitosan, 6.0% to 15.0% of polyhexamethylene guanidine, 5.0% to 10.0% of double-chain quaternary ammonium salt, 5.0-10.0% of DNA desmolase and the balance of distilled water. The bactericide provided by the invention has the advantages of being wide in antibacterial spectrum, effective in both gram positive and negative bacteria and mold and nonirritant to skin, various amino acids essential to human bodies are contained in a pure traditional Chinese medicine essence extracted from goldthread and lctuc tiwnin mxim root in the raw materials, the bactericide has the effect of improving the autoimmunity after the breathing of the human bodies, and the bactericide can serve as a spray or a hand soap for use.
Owner:SHANDONG UNIV QILU HOSPITAL
Compound air disinfectant and preparation method thereof
InactiveCN104886165AEfficient killingImprove the bactericidal effectBiocideFungicidesDisinfectantPolyhexamethylene guanidine
The invention relates to a compound air disinfectant and a preparation method thereof. The materials for the preparation of the compound air disinfectant and the parts by weight thereof are as follows: 3 to 4 parts of tachyplesin antibacterial peptide, 3 to 4 parts of marine indole alkaloid, 3 to 3.5 parts of Chinese mosla herb extract, 3 to 3.5 parts of giant knotweed extract, 2 to 2.5 parts of cyrtomium rhizome extract, 2 to 2.5 parts of houttuynia cordata extract, 6 to 7 parts of N-trimethyl chitosan, 8 to 10 parts of polyhexamethylene guanidine and 63 to 70 parts of deionized water. Compared with the prior art, the compound air disinfectant has the following advantages: (1) the disinfection and sterilization effect is remarkable, and the effect of killing common pathogenic bacteria in hospitals is particularly remarkable; (2) the application range is wide, and the compound air disinfectant is applicable to disinfection and sterilization in various environmental places and air environments around various groups of people; (3) the compound air disinfectant is non-toxic, non-irritant, non-corrosive and harmless to the human body.
Owner:荆永正
Preparation method of supermolecule globular micelle based on antidepressant medicament chlorpromazine
InactiveCN103550156AReduce dosageHigh load rateOrganic active ingredientsNervous disorderDrug carrierTrimethyl chitosan
The invention discloses a preparation method of a supermolecule globular micelle based on an antidepressant medicament chlorpromazine. The method comprises the following steps: constructing a medicament carrier through the supermolecule interaction of amphiphilic sulfonated calix [4] arene and an antidepressant medicament chlorpromazine hydrochloride, dissolving the amphiphilic sulfonated calix [4] arene and the antidepressant medicament chlorpromazine hydrochloride in water, and uniformly mixing to obtain a nano supermolecule globular micelle solution; and non-covalently modifying a targeting agent trimethyl chitosan through a bonding site of the calix arene on the surface of the micelle to obtain the supermolecule micelle loaded with trimethyl chitosan on the surface. The preparation method has the advantages that the preparation method is simple and convenient, and fewer subjective and objective raw materials are used; the medicament load rate is high since the medicament molecules are the constructing units of the medicament carrier and the medicament molecules are immobilized; the micelle can be used for non-covalently modifying the targeting agent trimethyl chitosan through the bonding site of the surface calix arene so that the micelle has a wide application prospect in the field of targeted medicament delivery.
Owner:NANKAI UNIV
Sustained release drug delivery system
The invention discloses a controlled release dosage form comprising a therapeutically effective amount of a pharmaceutically active agent, illustrated by Acyclovir, that would release in about 12 hours not more than about 90% of the said active agent in a simulated gastric juice in a first order rate of release in a USP type 1 dissolution test, and not containing a solubilizer or a swelling enhancer or both, comprising (a) a tablet made from polymer matrix of at least two biocompatible polymers, illustrated by Carbopol 974P and polyethylene oxide, the said pharmaceutically active agent and pharmaceutically permitted excipients; the said tablet capable of rapid swelling without disintegration in the said simulated gastric juice to a size that shall result in its gastric retention in the stomach and start controlled release of the said active agent by starting controlled erosion as well as diffusion immediately after coming into contact with the said gastric juice, or (b) microspheres of ungrafted chitosan or a chitosan derivative illustrated by thiolated chitosan and trimethyl chitosan, or Carbopol incorporating the said active agent, wherein the said pharmaceutically active agent is not a polymeric molecule and after administration in stomach, the said microspheres adhare to the gastric mucosa for a long time releasing the active agent in a controlled way.
Owner:BIOPLUS LIFE SCI PVT
Moxifloxacin hydrochloride external preparation and preparation method thereof
ActiveCN104224691ASmooth appearanceEasy to carry and useAntibacterial agentsOrganic active ingredientsFenamic acidIrritation
The invention belongs to the field of pharmaceutical preparations and particularly relates to a moxifloxacin hydrochloride external preparation and a preparation method thereof. The external preparation specifically refers to a cream and comprises a combination of a skin penetration enhancer comprising N-trimethyl chitosan, menthol and isopropyl myristate, the external preparation can be directly acted on an infection part, the gastric and intestinal irritation caused by oral administration is avoided, and the skin is not irritated either. The cream further greatly improves the skin penetration rate of a medicine, so that the local absorption is fast, and the treatment effect is remarkable. To further enhance the anti-inflammatory and anti-allergic effects, a non-steroidal anti-inflammatory drug, namely butyl flufenamate, is further added in the cream. The preparation process of the cream is simple and feasible, is high in reproducibility, and is suitable for industrial production.
Owner:NANJING YOUKE BIOLOGICAL MEDICAL RES +2
Ergothioneine-lipid complex gel and preparation method therefor
ActiveCN112535644AResist damageEasy to wrapCosmetic preparationsToilet preparationsPolymer sciencePolyol
The invention discloses ergothioneine-lipid complex gel and a preparation method therefor and belongs to the technical field of macromolecular materials. The complex gel disclosed by the invention isprepared from the following raw materials in parts by weight: 1 part of ergothioneine, 8-20 parts of phospholipid, 0.2-1.5 parts of polyol ester, 10-20 parts of carbomer, 60-150 parts of glycerine, 10-50 parts of propylene glycol, 5-20 parts of N-trimethyl chitosan and 0.1-0.2 part of Kathon. According to the ergothioneine-lipid complex gel and the preparation method therefor, through adding the polyol ester and carrying out heated refluxing, the polyol ester promotes the phospholipid to coat the active substance ergothioneine, and the stable ergothioneine-lipid complex is formed through interaction among the polyol ester, the phospholipid and the ergothioneine; the ergothioneine is stably coated, so that the obtained end product can be used for effectively resisting destruction to oxidation resistance of the ergothioneine caused by an acidic environment of skin, and the skin retention level in 24 hours can reach 389micrograms / cm<2>; and the preparation process is simple and easy in operation, so that the ergothioneine-lipid complex gel has a broad market application prospect.
Owner:LINYI UNIVERSITY +1
Multifunctional cancer targeting nanoparticles
Multifunctional cancer targeting nanoparticles include a magnetic central core including gold coated iron oxide, an outer layer including trimethyl chitosan microspheres and folic acid and a linker between the central core and the outer layer, the linker including cysteamine. An anti-cancer drug can be supported by the outer layer. The multifunctional cancer targeting nanoparticle can provide simultaneous cancer cell diagnosis and therapy. An amount of heat and an amount of the anti-cancer drug released by the nanoparticle can be controlled by application of a magnetic field.
Owner:KING SAUD UNIVERSITY
Efficient disinfectant and preparation method thereof
InactiveCN104904753AEfficient killingImprove the bactericidal effectBiocideFungicidesDisinfectantDesmolases
The invention relates to an efficient disinfectant and a preparation method thereof. The efficient disinfectant is composed of the following materials in parts by weight: 6.0-7.0 parts of N-trimethyl chitosan, 3.0-4.0 parts of marine probiotics DNA desmolase, 3.0-3.5 parts of Chinese goldthread extracting solution, 3.0-3.5 parts of honeysuckle extracting solution, 2.0-2.5 parts of fructus forsythiae extracting solution, 2.0-2.5 parts of isatis root extracting solution and 3.0-3.5 parts of formosan lattuce herb extracting solution. Compared with the prior art, the efficient disinfectant has the following advantages of being significant in disinfection and sterilization effect, particularly significant in killing common pathogenic bacterium in hospitals; being wide in application range, and applicable to disinfecting and sterilizing various fields, various environments and skin of all kinds of people; being free of toxicity, stimulation, corrosivity and harm to human bodies; being stable in chemical property, and strong in continuous sterilization; being an biological agent, green and environment-friendly.
Owner:荆永正
Preparation and application of O-3, 4-methylenedioxy phenylacetate-N-trimethylchitosan quaternary ammonium salt
ActiveCN106432542AGood water solubilityGood antibacterial effectBiocideFungicidesSolubilityPhenylacetic acid
Owner:贺强
Base fertilizer for water chestnut planting field
InactiveCN106588509ALarge specific surface areaImprove adsorption capacityExcrement fertilisersBioloigcal waste fertilisersWater ChestnutsSodium hydroxide
The invention discloses base fertilizer for a water chestnut planting field. The base fertilizer is characterized by being prepared from the following raw materials in percentage by mass: 28 percent to 32 percent of composted cattle pen manure, 8 percent to 12 percent of phosphorus fertilizer, 2 percent to 4 percent of zinc-boron fertilizer, 28 percent to 32 percent of plant ash, 20 percent to 24 percent of oilseed cake and 4 percent to 6 percent of an auxiliary material. The auxiliary material comprises the following components in parts by weight: 14 to 20 parts of modified bamboo powder, 4 to 8 parts of vermiculite powder, 5 to 9 parts of sepiolite powder, 2 to 4 parts of sodium humate, 2 to 4 parts of straw powder and 3 to 5 parts of turf. The modified bamboo powder is prepared by adopting the following process: stirring N,N,N-trimethyl chitosan, glacial acetic acid and water; dropwise adding a silver nitrate solution under a stirring state; then dropwise adding a sodium borohydride solution and stirring to obtain a prefabricated material; stirring gelatin and the water; adding sodium hydroxide and stirring; adjusting the pH (Potential of Hydrogen) value to be 7.1 to 7.5; adding succinic anhydride and stirring; drying and crushing; adding a silane coupling agent, the bamboo powder, the prefabricated material and toluene; raising the temperature, stirring, washing, drying and crushing to obtain the modified bamboo powder.
Owner:无为县年香马蹄种植专业合作社
O-thiazolidine methyl ester-N-trimethyl chitosan quaternary ammonium salt as well as preparation method and application thereof
InactiveCN103936886AGood water solubilityGood antibacterial effectDisinfectantsChemical productsIndustrial wastewater treatment
The invention belongs to the field of the high polymer compound materials and discloses an O-thiazolidine methyl ester-N-trimethyl chitosan quaternary ammonium salt as well as a preparation method and application thereof. The preparation method of the O-thiazolidine methyl ester-N-trimethyl chitosan quaternary ammonium salt comprises the following steps: carrying out a microwave reaction on starting raw materials (including chitosan, formaldehyde and formic acid) to obtain a chitosan Schiff base and then reacting the chitosan Schiff base with methyl iodide to obtain N-trimethyl chitosan; preparing thiazolidine formyl chloride by using L-thiazolidine-4-formic acid and thionyl chloride, adding the thiazolidine formyl chloride to N-trimethyl chitosan to obtain the O-thiazolidine methyl ester-N-trimethyl chitosan quaternary ammonium salt. The O-thiazolidine methyl ester-N-trimethyl chitosan quaternary ammonium salt is greatly improved in term of antibacterial property in contrast with the chitosan, and thus can be applied to various fields such as antibacterial materials, chemical products of daily use and industrial wastewater treatment.
Owner:SOUTH CHINA UNIV OF TECH
Bio-macromolecular film filled with light calcium carbonate in situ and application of bio-macromolecular film in oily food and medicine packaging
ActiveCN113003596AEffective regulationStable structureCalcium/strontium/barium carbonatesCelluloseCytotoxicity
Owner:QILU UNIV OF TECH
N-trimethyl chitosan microsphere, and preparation method and application thereof in reducing dielectric loss of mineral oil
InactiveCN107876024AStable structureLarge specific surface areaOther chemical processesHydrocarbon oils refiningFreeze-dryingSodium iodide
The invention provides an N-trimethyl chitosan microsphere, and a preparation method and an application thereof in reducing dielectric loss of mineral oil, and belongs to the field of modified chitosan. The preparation method comprises the following steps: mixing chitosan, sodium iodide, and N-methyl-2-pyrrolidone to carry out reactions, then adding sodium hydroxide and methyl iodide to carry outreactions; adding ethanol to carry out precipitation, performing separation and freeze-drying to obtain N-trimethyl chitosan with a quaternization substitution degree of 10-20%; preparing a N-trimethyl chitosan solution, spraying the N-trimethyl chitosan solution into sodium polyphosphate to carry out crosslinking reactions; washing the reaction product by water, filtering, adding the reaction product into a sodium hydroxide solution, stirring, adding epoxy chloropropane to carry out reactions to obtain microspheres; washing the microspheres by water, then washing microspheres by organic solvents with volume percentages of 10-20%, 30-40%, 70-80%, and 90-95%, and carrying out freeze-drying. The prepared modified chitosan can reduce the dielectric loss of mineral oil.
Owner:HUBEI ENG UNIV
trimethyl chitosan fiber
The invention relates to a trimethyl chitosan fiber, which is characterized in that the components contained in the stock solution and the mass ratio ranges of each component are as follows: trimethyl chitosan 2wt%-5wt%, urea 0.2wt%-1.0 wt%, isopropanol 0.1wt%-1.5wt%, dichloroacetic acid 1wt%-5wt%, glycerin 0.1wt%-1.0wt%, zinc acetate 1wt%-5wt%, and water are prepared by wet and dry method . The fiber is prepared by using trimethyl chitosan with good water solubility, which is easy to prepare and has high tensile strength.
Owner:WUJIANG RUIFENG WEAVING
N-trimethyl chitosan microsphere, preparation method thereof and application of microsphere in reduction of dielectric loss of vegetable oil
ActiveCN107778379AStable structureLarge specific surface areaOther chemical processesFatty-oils/fats refiningVegetable oilMicrosphere
The invention provides an N-trimethyl chitosan microsphere, a preparation method thereof and application of the microsphere in reduction of dielectric loss of vegetable oil, belonging to the field ofmodified chitosan. The preparation method of the N-trimethyl chitosan microsphere comprises the following steps: carrying out hybrid reaction on chitosan with the visocisty of 0.25-0.65Pa.s, sodium iodide and N-methyl-2-pyrrolidone, then adding sodium hydroxide and methyl iodide, reacting, then carrying out ethanol precipitation, separating, and carrying out freeze drying, thereby obtaining N-trimethyl chitosan with the quaternization substitution degree of 10-20%; preparing N-trimethyl chitosan into solution, spraying into sodium polyphosphate, reacting, washing with water, adding into sodiumhydroxide solution, stirring, adding glutaraldehyde, and reacting, thereby obtaining the microsphere; and washing the microsphere with water, then sequentially eluting with organic solvents with thevolume fractions of 21-29%, 41-49%, 61-69% and 85-89%, and carrying out freeze drying. The modified chitosan prepared by adopting the method can reduce the dielectric loss of the vegetable oil.
Owner:HUBEI ENG UNIV +1
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