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Chloro-N-trimethyl chitin hyamine

A technology of trimethyl chitosan and quaternary ammonium salt, which is applied in the field of chloride-N-trimethyl chitosan quaternary ammonium salt, can solve problems such as limitation, and achieves low cost, simple operation and good water solubility. Effect

Inactive Publication Date: 2005-07-27
OCEAN UNIV OF CHINA
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0002] At present, there are few reports on the development of chitosan quaternary ammonium salt derivatives, and its application is limited to flocculants and antibacterial agents
However, it has a good effect of promoting the absorption of water-soluble macromolecular drugs such as peptides and protein drugs through the monolayer of intestinal epithelial cells, and it has not been reported that it can be used as a macromolecular drug absorption enhancer.

Method used

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  • Chloro-N-trimethyl chitin hyamine
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Examples

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Embodiment Construction

[0009] The present invention is illustrated by examples below.

[0010] 1. Swell 40.0 g (0.24 mol) of chitosan pulverized and passed through a 120-mesh sieve into 1-methyl-2-pyrrolidone of 120 mL, add 96.0 g (0.64 mol) of sodium iodide solid, Heat to 60°C, add 220mL of 30% (weight percent concentration, the same below) sodium hydroxide aqueous solution and 120mL (1.93mol) of iodomethane liquid under stirring, stir and react at 60°C for 2 hours; then add 30% sodium hydroxide aqueous solution 80mL and methyl iodide 80mL (1.29mol), stirred at 60°C for 1h, then continued to add 40mL of 30% sodium hydroxide aqueous solution and 40mL (0.64mol) of methyl iodide, continued to stir at 60°C for 1h, chitosan, iodine The total molar ratio of sodium chloride and methyl iodide is 1: 2.7: 16.1. After the reaction is completed, cool the reaction solution to room temperature and add it to industrial acetone for precipitation. The precipitate is collected by suction filtration and washed with ...

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Abstract

A chloride-n-trimethide chitose quaternary ammonium salt is characterized by the molecular formula is (C8H13NO5)n (C8H17NO4)m-x (C9H20NO4Cl)x, n=0.07-0.19, x=0.39-0.75, n+m+x=1. The production is carried out by expanding dissolving chitose into 1-methyl-2- pyrrolidone, adding sodium iodide, adding iodomethane, keeping temperature 50-65deg.C, agitating reacting, reacting liquid cooling, precipitating settling, washing deposit matter with acetone methyl - water solution, dissolving the deposit matter into water, dripping chlorhydric acid - alcohol solution and ion exchanging, adding acetone methyl into reacting liquid, washing the deposit matter, dissolving into water, adding into acetone methyl and settling, washing with acetone methyl - water solution, washing with acetone methyl, and drying. It achieves low cost, simple operation, and good water soluble performance.

Description

technical field [0001] The invention relates to a water-soluble chitosan quaternary ammonium salt derivative, in particular to a chloride-N-trimethyl chitosan quaternary ammonium salt. Background technique [0002] At present, there are few reports on the development of chitosan quaternary ammonium derivatives, and their applications are limited to flocculants and antibacterial agents. However, there is no report that has a good effect of promoting the absorption of water-soluble macromolecular drugs such as polypeptides and protein drugs through the monolayer of intestinal epithelial cells, and can be used as a macromolecular drug absorption enhancer. Contents of the invention [0003] The purpose of this invention is to provide a kind of chloride-N-trimethyl chitosan quaternary ammonium salt, it can make up the above-mentioned deficiency of prior art. [0004] A kind of chloride-N-trimethyl chitosan quaternary ammonium salt is characterized in that its molecular formula...

Claims

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Application Information

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IPC IPC(8): C08B37/08
Inventor 李英霞玉坤宇宋妮
Owner OCEAN UNIV OF CHINA
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