198 results about "Macromolecular drug" patented technology

The invention discloses a group of polypeptides having a percutaneous and transmembrane penetration promoting effect, and applications thereof, and is suitable for the fields of transdermal and transmembrane drug delivery systems and cosmetics. Each of the polypeptides has eleven amino acid residues, and has an annular structure formed by nine amino acid residues and a disulfide bond, and the structure of each of the polypeptides is characterized in that the N-5 and N-6 positions of the N-terminal of each of the polypeptides are alkaline amino acids or the C-terminal is amidated. The polypeptides synthesized through substituting the N-5 or N-6 position of the N-terminal by an alkaline amino acid and C-terminal amidated polypeptides have substantially higher insulin transdermal and transmembrane penetration capabilities than reported polypeptides having penetration promoting activities. The transdermal and transmembrane penetration promoting capabilities of the polypeptides obtained after the simultaneous substitution of the N-5 and N-6 positions of the N-terminal by the alkaline amino acids are further enhanced, the blood sugar reducing effects of diabetic rats are substantially improved through insulin common transdermal drug delivery, the in-vivo blood sugar level of the diabetic rats within 8h after the transdermal drug delivery is reduced to 20-30% of the original level, and the group of the polypeptides disclosed in the invention can be used in solutions, gels and ointments to promote the percutaneous and transmembrane absorption of biological macromolecular drugs comprising insulin, vaccines and the like.