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Multiple-response polymer microsphere drug carrier material and a preparation method thereof

A multi-response, polymer technology, used in pharmaceutical formulations, wave energy or particle radiation treatment materials, inactive components of polymer compounds, etc., can solve the problems of single response factors and inability to meet

Inactive Publication Date: 2015-05-06
QUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, one of the main shortcomings of the current responsive non-covalent polymer microspheres is that the response factors are relatively single, such as the hollow microsphere system that is sensitive to oxidants, glucose sensitive, and electric field.
Especially in medical applications, it is often required that the microsphere system can respond to various changes in the body and release drugs, but most of the current multi-response non-covalent bond microspheres only have dual responsiveness to temperature and pH , cannot meet the needs of practical applications

Method used

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  • Multiple-response polymer microsphere drug carrier material and a preparation method thereof

Examples

Experimental program
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Effect test

Embodiment example 1

[0022] As shown in Figure 1, weigh 100 mg of sodium alginate grafted β-cyclodextrin (Alg-β-CD, β-CD grafting rate of 18.1%) to prepare a 0.6% solution, and add a corresponding amount of monomethyl Ether polyethylene glycol single-end modified ferrocene (PEG-Fc, conversion rate 95.4%), the concentration is 0.5%. Alg-β-CD and PEG-Fc were mixed (β-CD:Fc=1:1). Stir at room temperature for 3h, so that β-CD and Fc fully inclusion. Subsequently, excess α-CD was added with a concentration of 6%, and the stirring was continued for 12 hours. The system gradually changed from clear to turbid, and polymer microspheres were formed. This system can respond to oxidizing agents, and the microspheres disintegrate. Among them, when 0.1ml of hydrogen peroxide is added to the microsphere system, it can be found that the visible light transmittance of the system increases from 5% to 98.1% within 5 minutes, indicating that most of the microspheres have disintegrated. At the same time, when the s...

Embodiment example 2

[0024] Weigh 80 mg of hydroxymethyl konjac glucomannan grafted β-cyclodextrin (CKGM-β-CD, β-CD grafting rate is 20.4%) to prepare a 0.5% solution, add a corresponding amount of poly P65 single The end-modified ferrocene (P65-Fc, the conversion rate is 96.6%), its concentration is 0.55%. CKGM-β-CD and P65-Fc were mixed (β-CD:Fc=1.5:1). Stir at room temperature for 4 h, so that β-CD and Fc fully inclusion. Subsequently, excess α-CD was added with a concentration of 7%, and the stirring was continued for 12 hours. The system gradually changed from clear to turbid, and polymer microspheres were formed. Add 0.05ml of sodium hypochlorite to the system, and after stirring for 10 minutes, the light transmittance of the system rises from 5% to 96.3%, indicating that most of the microspheres have disintegrated. If the electrode is inserted into the microsphere system and a direct current of 6V is applied, the visible light transmittance of the system can reach 95.9% after 3 hours, ind...

Embodiment example 3

[0026]Weigh 150 mg of polyacrylic acid-polymethacrylic acid copolymerized grafted β-cyclodextrin (PAA-co-PMAA-β-CD, β-CD graft rate 17.2%) to prepare a 0.8% solution, add the corresponding amount The polyether P123 single-end modified ferrocene (P123-Fc, the conversion rate is 97.1%), its concentration is 0.65%. PAA-co-PMAA-β-CD and P123-Fc were mixed (β-CD:Fc=2:1). Stir at room temperature for 6h, so that β-CD and Fc fully inclusion. Subsequently, excess α-CD (concentration: 9%) and 10 mg / ml glucose oxidase GOD were added, and the stirring was continued for 6 hours. The system gradually changed from clear to turbid, and polymer microspheres were formed. Add 0.05ml oxidant cerium ammonium nitrate to this system, and after stirring for 10 minutes, it can be found that the visible light transmittance of the system rises from 5% to 94.7%, indicating that most of the microspheres have collapsed. If 0.5ml of saturated glucose solution is added to the microsphere system, it can be...

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Abstract

The invention discloses a preparation method of a polymer microsphere drug slow-release carrier with three responses to an oxidant, glucose and an electric field. The microsphere material consists of a polymer with beta-cyclodextrin, ferrocene-modified polyether and alpha-cyclodextrin. The preparation method of the polymer microsphere drug carrier comprises the following steps: firstly, synchronously dissolving the polymer with beta-cyclodextrin and the ferrocene-modified polyether in an aqueous solution, and stirring uniformly to ensure that the beta-cyclodextrin and ferrocene are fully compounded; and then adding alpha-cyclodextrin, and further stirring for a certain period of time to ensure that alpha-cyclodextrin and polyether are fully compounded. Along with the progress of compounding, a system gradually becomes cloudy, and polymer microspheres are formed. The polymer microspheres have good performance of wrapping macromolecular drugs and performance of effectively disintegrating the oxidant, glucose and electric field stimulation, so that gradual disintegration and slow release of a drug are realized. The polymer microsphere drug slow-release carrier disclosed by the invention is simple in preparation method and good in response effect, is environment-friendly and economical, and has a relatively great application value in the field of drug controllable slow-release.

Description

technical field [0001] The invention belongs to the field of functional polymer materials, and relates to a multi-response polymer microsphere drug carrier material and a preparation method thereof. Background technique [0002] Polymer hollow microspheres are a kind of polymer spheres with a hollow structure, and the particle size is generally nano or micron. The hollow core region can embed a large number of molecules, and has the characteristics of low density and high specific surface area, and has broad application prospects as a new type of functional material. Such materials can be used as catalytic carriers, microreactors, and drug delivery (such as enzymes, proteins), etc., and can also be used as fillers for coatings, anti-ultraviolet additives in the cosmetics industry, and hand modifiers, etc., and have attracted much attention in the field of materials one of the research directions. [0003] The classic preparation method of polymer hollow microspheres is gen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/40A61K47/34A61K47/36A61K41/00
Inventor 董振强张红素蔡飞贾德友
Owner QUZHOU UNIV
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