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A preparing method for slow release hydrogel carrier material and an application thereof

A carrier material and hydrogel technology, applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulations, can solve the problems of poor solubility of IDM, obvious gastrointestinal damage, and bioavailability. Low-level problems, to achieve the effect of simple method, good sustained-release effect, and mild preparation conditions

Active Publication Date: 2018-08-10
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, IDM has obvious damage to the gastrointestinal tract, and the incidence rate of adverse reactions (ADRs) after long-term use is higher, and its side effects on the gastrointestinal tract and central nervous system can reach 35%-50%. associated with high blood levels
And the solubility of IDM is poor, and the bioavailability of common preparations such as tablets and capsules is low

Method used

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  • A preparing method for slow release hydrogel carrier material and an application thereof
  • A preparing method for slow release hydrogel carrier material and an application thereof
  • A preparing method for slow release hydrogel carrier material and an application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1: A kind of preparation method of the hydrogel carrier material of sustained release

[0047] Weigh 0.4g HPMC in a round bottom flask filled with 20mL deionized water, stir and dissolve, and prepare 2% HPMC solution. Weigh 0.2 g of SA into a round bottom flask filled with 20 mL of deionized water to prepare a 1% SA solution. Mix the HPMC and SA solutions, stir evenly, and drop the mixed solution into 400mL 2% CaCl 2 In the solution, after the dropwise addition, cross-link for 40 minutes, and wash the residual CaCl on the surface of the hydrogel with deionized water. 2 , after absorbing the moisture on the surface of the hydrogel, put the hydrogel in 400mL 2% CS solution, after cross-linking for 40min, wash the remaining CS on the surface of the hydrogel with deionized water, and finally let it dry naturally at room temperature to obtain HPMC-SA-CS composite hydrogels dried at room temperature.

Embodiment 2

[0048] Embodiment 2: A kind of preparation method of the hydrogel carrier material of sustained release

[0049] Weigh 0.4g HPMC in a round bottom flask filled with 20mL deionized water, stir and dissolve, and prepare 2% HPMC solution. Weigh 0.2 g of SA into a round bottom flask filled with 20 mL of deionized water to prepare a 1% SA solution. Mix the HPMC and SA solutions, stir evenly, and drop the mixed solution into 400mL 2% CaCl 2 In the solution, after the dropwise addition, cross-link for 40 minutes, and wash the residual CaCl on the surface of the hydrogel with deionized water. 2 , after absorbing the moisture on the surface of the hydrogel, place the hydrogel in 400mL 2% CS solution, and after cross-linking for 40min, wash the remaining CS on the surface of the hydrogel with deionized water, and place the gel in a -80°C Pre-freeze in the refrigerator for 12 hours, and then freeze-dry in a freeze dryer at -80°C to obtain a freeze-dried HPMC-SA-CS composite hydrogel. ...

Embodiment 3

[0050] Example 3: A preparation method of a slow-release drug-loaded HPMC-SA-CS composite hydrogel

[0051] Weigh 0.4g of BSA in a round-bottomed flask filled with 20mL of deionized water. After it is completely dissolved, add 0.4g of HPMC powder to prepare a mixed solution of HPMC and medicine. Weigh 0.2g SA into a round bottom flask filled with 20mL deionized water, stir and dissolve, and prepare 1% SA solution. Mix the drug, HPMC and SA solution and stir evenly.

[0052] Weigh 0.02g of IDM in a round-bottomed flask equipped with 20mL ethanol aqueous solution (the volume ratio of absolute ethanol: water is 1:1). After it is completely dissolved, add 0.4g of HPMC powder to prepare a mixed solution of HPMC and medicine. Weigh 0.2g SA into a round-bottom flask filled with 20mL deionized water, stir and dissolve, and prepare a 1% SA solution. Mix the drug, HPMC and SA solution and stir evenly.

[0053] Using the drop method, the above two mixed solutions were dropped into 400...

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Abstract

The invention belongs to the field of a medicine slow release carrier material and specifically discloses a preparing method for slow release hydrogel carrier material with a semi-interpenetrating structure modified by a polyelectrolyte membrane and an application thereof. The slow release hydrogel material is comprised of HPMC and SA as raw materials, firstly an HPMC-SA semi-interpenetrating composite gel is prepared by a Ca2+ physical crosslinking method and polyelectrolyte membrane modification is performed on the HPMC-SA hydrogel with low molecular weight CS so as to increase the stabilityof the HPMA-SA hydrogel, so that the HPMA-SA-CS hydrogel is obtained. The hydrogel has advantages of mild preparing condition, simple method, less reagent and no violent reactions. BSA and micromolecule indissolvable IDM are regarded as model medicine and the slow release effect of the HMPC-SA-CS composite hydrogel material on macro-molecule medicine and micromolecule medicine is investigated. The result shows that the gel system continuously swell for 50 hours, the swellability reaches above 52 times and the slow release effect of the protein medicine and IDM is increased.

Description

technical field [0001] The invention relates to the field of drug sustained-release carrier materials, in particular to a preparation method and application of a sustained-release hydrogel carrier material. Background technique [0002] Hydrogel is a three-dimensional network or interpenetrating network between liquid and solid. It is a hydrophilic polymer gel that can significantly swell in water but cannot be dissolved in water. It has been widely used in drug delivery, switch materials and so on. Since hydrogel is very beneficial to the dispersion of drugs in the hydrogel matrix, and by selecting polymer networks with different physicochemical properties, the purpose of highly controlled release of drugs can be well achieved, making hydrogels in various Small molecule drugs, as well as various biotechnology preparations, such as protein, polypeptide and nucleotide drugs, have great application prospects in the field of controlled and sustained release. [0003] Sodium a...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08J3/24C08L5/08C08L1/28C08L5/04
CPCA61K9/0002A61K9/06A61K31/405A61K38/385A61K47/36A61K47/38C08J3/075C08J3/246C08J2301/28C08J2305/08C08J2401/28C08J2405/04C08J2405/08
Inventor 胡燕张尚文肖新才
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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