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Ergothioneine-lipid complex gel and preparation method therefor

The technology of lipid complex and ergothioneine is applied in the directions of pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., and can solve the problems of damage of antioxidant properties, decreased activity and the like, and achieves simple preparation process, resistance to damage, and preparation of The effect of easy operation

Active Publication Date: 2021-03-23
LINYI UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And ergothioneine also has inherent defect at the same time, promptly its anti-oxidant property is very easily subjected to the destruction of skin acidic environment, causes its activity to decline, and this is also one of technical problems to be solved in the present invention

Method used

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  • Ergothioneine-lipid complex gel and preparation method therefor
  • Ergothioneine-lipid complex gel and preparation method therefor
  • Ergothioneine-lipid complex gel and preparation method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] An ergothioneine lipid complex gel, prepared from the following raw materials in parts by weight: 1 part of ergothioneine, 8 parts of phospholipids, 0.2 parts of polyol esters, 10 parts of carbomer, 60 parts of glycerin, propylene glycol 10 parts, 5 parts of N-trimethyl chitosan, 0.1 part of Kathon.

[0026] The phospholipid is lecithin.

[0027] The polyol esters are mixed with 0.1 part of stearyl alcohol and 0.1 part of polyethylene glycol-12-hydroxystearate.

[0028] A preparation method for ergothioneine lipoplex gel, comprising the following steps:

[0029] 1) Weigh 1 part of ergothioneine, 8 parts of phospholipids, and 0.2 parts of polyol esters, add anhydrous ethanol to dissolve, heat and reflux at 50°C for 1 hour, leave at room temperature for 24h, use a rotary evaporator to evaporate in a 55°C water bath under reduced pressure Ethanol, vacuum drying at room temperature for 24 hours to obtain ergothioneine lipid complex;

[0030] 2) Take step (1) obtained erg...

Embodiment 2

[0033] An ergothioneine lipid complex gel, which is prepared from the following raw materials in parts by weight: 1 part of ergothioneine, 15 parts of phospholipids, 1 part of polyol esters, 15 parts of carbomer, 110 parts of glycerin, propylene glycol 30 parts, 12 parts of N-trimethyl chitosan, 0.15 parts of Kathon.

[0034] The phospholipid is soybean phospholipid.

[0035] The polyol esters are mixed with 0.5 part of stearyl alcohol and 0.5 part of polyethylene glycol-12-hydroxystearate.

[0036] A preparation method for ergothioneine lipoplex gel, comprising the following steps:

[0037] 1) Weigh 1 part of ergothioneine, 15 parts of phospholipids, and 1 part of polyol ester, add absolute ethanol to dissolve, heat and reflux at 50°C for 1 hour, leave at room temperature for 24h, use a rotary evaporator to evaporate in a water bath at 55°C under reduced pressure Ethanol, vacuum drying at room temperature for 24 hours to obtain ergothioneine lipid complex;

[0038] 2) Take...

Embodiment 3

[0041] An ergothioneine lipid complex gel, prepared from the following raw materials in parts by weight: 1 part of ergothioneine, 20 parts of phospholipids, 1.5 parts of polyol esters, 20 parts of carbomer, 150 parts of glycerin, propylene glycol 50 parts, 20 parts of N-trimethyl chitosan, 0.2 part of Kasong.

[0042] The phospholipid is hydrogenated soybean lecithin.

[0043] The polyol esters are mixed with 1 part of stearyl alcohol and 0.5 part of polyethylene glycol-12-hydroxystearate.

[0044] A preparation method for ergothioneine lipoplex gel, comprising the following steps:

[0045] 1) Weigh 1 part of ergothioneine, 20 parts of phospholipids, and 1.5 parts of polyol esters, add absolute ethanol to dissolve, heat and reflux at 50°C for 1 hour, leave at room temperature for 24h, use a rotary evaporator to evaporate in a 55°C water bath under reduced pressure Ethanol, vacuum drying at room temperature for 24 hours to obtain ergothioneine lipid complex;

[0046]2) Take ...

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Abstract

The invention discloses ergothioneine-lipid complex gel and a preparation method therefor and belongs to the technical field of macromolecular materials. The complex gel disclosed by the invention isprepared from the following raw materials in parts by weight: 1 part of ergothioneine, 8-20 parts of phospholipid, 0.2-1.5 parts of polyol ester, 10-20 parts of carbomer, 60-150 parts of glycerine, 10-50 parts of propylene glycol, 5-20 parts of N-trimethyl chitosan and 0.1-0.2 part of Kathon. According to the ergothioneine-lipid complex gel and the preparation method therefor, through adding the polyol ester and carrying out heated refluxing, the polyol ester promotes the phospholipid to coat the active substance ergothioneine, and the stable ergothioneine-lipid complex is formed through interaction among the polyol ester, the phospholipid and the ergothioneine; the ergothioneine is stably coated, so that the obtained end product can be used for effectively resisting destruction to oxidation resistance of the ergothioneine caused by an acidic environment of skin, and the skin retention level in 24 hours can reach 389micrograms / cm<2>; and the preparation process is simple and easy in operation, so that the ergothioneine-lipid complex gel has a broad market application prospect.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to an ergothioneine lipid complex gel and a preparation method thereof. Background technique [0002] Ergothioneine is a natural small molecular amino acid with a chemical name of 2-mercapto-L-histidine trimethyl inner salt, which has significant antioxidant, anti-ultraviolet (UV) and gamma-ray-induced damage, cell protection, etc. A variety of functions, it is a natural antioxidant. Ergothioneine is abundant in certain mushroom species, red beans, black beans, red meat, liver, kidney, and various grains, but is present in very small amounts in most organisms. It can only be produced by edible fungi, blue-green algae Microorganisms such as bacteria, mycobacteria, and non-yeast fungi synthesize ergothioneine, and humans and other mammals consume ergothioneine only through the diet. Compared with common oxidants (such as glutathione, ascorbic acid, etc.), ergot...

Claims

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Application Information

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IPC IPC(8): A61K8/49A61K8/34A61K8/86A61K8/55A61K8/04A61Q19/08
CPCA61K8/4946A61K8/342A61K8/86A61K8/553A61K8/042A61Q19/08A61K2800/592A61K2800/56
Inventor 李海刚张淳张增涛姜亮
Owner LINYI UNIVERSITY
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