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35 results about "N-trimethyl chitosan" patented technology
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Facial cleanser for effectively preventing haze hazards
InactiveCN104606071ABacteriostaticFunctionalCosmetic preparationsToilet preparationsWater soluble chitosanBeta-Cyclodextrins
The invention relates to the field of daily use chemicals and in particular relates to a facial cleanser for effectively preventing haze hazards. The facial cleanser comprises the following raw materials in parts by weight: 0.1-10 parts of chitosan and derivatives thereof, 5-25 parts of an amino acid-based surfactant and 0.2-3 parts of a thickening agent, wherein the chitosan and derivatives thereof are selected from one or more in chitosan, water-soluble chitosan, N-trimethyl chitosan, N-malely chitosan, carboxymethyl chitosan, hydroxypropyl chitosan or beta-cyclodextrin grafted chitosan; and the deacetylation degree of the chitosan and derivatives thereof is 60-99 percent. The chitosan and derivatives thereof are added into the amino acid-based facial cleanser, and the slightly acidic facial cleanser disclosed by the invention is rich in foam, high in stability, mild and non-irritating, has the effects of inhibiting bacteria and chelating heavy metals and is applied to skin care in hazy weather.
Owner:SHENZHEN AESTHETIC BIOLOGICAL TECH +1
Method for synthesizing N,N,N-trimethyl chitosan sulfate methyl ammonium
InactiveCN101157735AHave physical and chemical propertiesWith physiological functionsSolubilityOrganic synthesis
A synthesis method of N, N, N-trimethyl chitosan ammonium methosulfate (TMCS) pertains to the field of organic synthesis technology. The present invention takes the chitosan with the deacetylation of more than 90 percent as the raw materials and uses a two-step reaction to synthesize a target product. The first step is that the chitosan, formic acid and aldehyde reacts by taking the water as the solvent, so as to get an intermediate N, N-dimethyl chitosan; the second step is that the N, N-dimethyl chitosan reacts with dimethyl sulfate in the organic solvent to prepare the target product. Compared with the raw materials of chitosan, TMCS not only has the similar physical and chemical properties and physiological functions with chitosan, but also has the good water solubility and strong antibacterial capability, so the application field is much broader; as the formic acid, formaldehyde, trioxymethylene or paraformaldehyde and dimethyl sulfate have rich sources and low price, the present invention is the method which is more environmental -friendly and economic for the industrial production.
Owner:JIANGNAN UNIV
Preparation method of trinary composite stent of plasmid DNA / fibrin gel / polymer
The invention discloses a preparation method of a trinary composite stent of plasmid DNA / fibrin gel / polymer. The preparation method comprises the following steps of: geometrically and uniformly mixing an N-trimethyl chitosan solution and a plasmid DNA solution to prepare plasmid DNA composite particles; dissolving fibrinogen in physiological saline to prepare a fibrinogen solution; dissolving thrombin in a calcium chloride solution to prepare a thrombin calcium chloride solution; sterilizing a polymer porous stent with ethanol; simultaneously filling the plasmid DNA composite particles, the fibrinogen solution and the thrombin calcium chloride solution with the same volumes in the polymer porous stent by utilizing negative pressure; and arranging the stent filled with the plasmid DNA composite particles, the fibrinogen solution and the thrombin calcium chloride solution in a constant-temperature oven to fully gelatinize the fiber protein. The preparation method is simple and convenient, uses materials with wide resources and can simulate the composition and the structure of the cartilage of a human body. The composite stent of the invention has favorable mechanical property and biological activity, can accelerate the restoration of the cartilage and the osseous tissue and have strong application values of cartilage and bone restoration.
Owner:ZHEJIANG UNIV
Preparation method of chitosan quaternary ammonium salt
ActiveCN106167532AGood choiceOvercoming Situations That Require PressurizationMethyl carbonateIonic liquid
The invention relates to a preparation method of a chitosan quaternary ammonium salt, and belongs to the technical field of high molecule modification. The preparation method comprises following steps: firstly, chitosan is subjected to Eschweiler-Clarke reaction so as to obtain N, N-dimethyl chitosan; at an ionic liquid environment, quaternization reagent dimethyl carbonate is added for quaternization of N, N-dimethyl chitosan; and at last, an obtained reaction product solution is washed with an organic solvent and is dried so as to obtain N, N, N-trimethyl chitosan. According to the preparation method, the quaternization reagent dimethyl carbonate is nontoxic, the reaction products are carbon dioxide and methyl alcohol, and methyl alcohol can be recycled to prepare dimethyl carbonate, so that the preparation method is green, and is friendly to the environment. In addition, compared with dimethyl sulfate, selectivity of methylation reaction of dimethyl carbonate with amines is higher.
Owner:JIANGNAN UNIV
Polysialic acid-based n-trimethyl chitosan gel nanoparticles for systemic drug delivery
ActiveUS20120294904A1Safely and effectively deliverReduce sizeMaterial nanotechnologyBiocideDrug compoundMethotrexate
Gel nanoparticles for encapsulating and delivering a pharmaceutical compound to a patient. The nanoparticles are formed from N-trimethyl chitosan and polysialic acid, preferably in the presence of sodium tripolyphosphate. A ratio of polysialic acid to N-trimethyl chitosan of about 0.5 to 1 produces nanoparticles having diameter of about 100 nm (plus or minus 25 nm) and a zero potential above 30 milivolts that can stability contain a pharmaceutical compound, such as methotrexate, for delivery to a patient.
Owner:SYRACUSE UNIVERSITY
O-alpha-methyl mandelate-N-trimethyl chitosan quaternary ammonium salt as well as preparation method and application thereof
InactiveCN106380526AGood water solubilityGood antibacterial effectAntibacterial agentsOrganic active ingredientsSolubilityMethyl iodide
The invention belongs to the field of high molecular compound materials and discloses a chitosan-chemically modified functional derivative, namely O-alpha-methyl mandelate-N-trimethyl chitosan quaternary ammonium salt as well as a preparation method and application thereof. The preparation method of the O-alpha-methyl mandelate-N-trimethyl chitosan quaternary ammonium salt comprises the following steps: taking chitosan, formaldehyde and formic acid as starting materials, carrying out microwave reaction to obtain chitosan schiff base, and then carrying out reaction with iodomethane to obtain N,N,N-trimethyl chitosan; and dissolving N,N,N-trimethyl chitosan with methane sulfonic acid, and then adding O-alpha-formyl mandelate acyl chloride into the mixed solution for reacting so as to obtain the O-alpha-methyl mandelate-N-trimethyl chitosan quaternary ammonium salt. The O-alpha-methyl mandelate-N-trimethyl chitosan quaternary ammonium salt has good water solubility, has greatly increased antibacterial properties compared with the chitosan raw material and N,N,N-trimethyl chitosan, and can be applied to many application fields of antibacterial medical materials, chemical products for daily use, food packages and the like.
Owner:HUNAN UNIV OF TECH
Air-permeable moisturizing dressing with bacteriostasis and drug percutaneous absorption promotion functions and preparation method of air-permeable moisturizing dressing
ActiveCN105079860AGuaranteed moisturizingGuaranteed breathabilityAbsorbent padsBandagesFiberPolyvinyl alcohol
The invention discloses an air-permeable moisturizing dressing with bacteriostasis and drug percutaneous absorption promotion functions and a preparation method of the air-permeable moisturizing dressing. The air-permeable moisturizing dressing comprises the following raw materials in parts by weight: 12-14 parts of N-trimethyl chitosan, 8-12 parts of menthanol, 5-7 parts of isopropyl myristate, 20-30 parts of chitosan, 25-35 parts of loofah sponge fibers, 8-14 parts of isomalto-oligosaccharide, 5-9 parts of polyvinyl alcohol, 6-10 parts of carboxymethyl cellulose sodium, 10-12 parts of glycerol, 8-10 parts of mannitol, 12-20 parts of medicinal powder, 3-7 parts of weak-acid calcium chloride and a proper amount of deionized water. As chitosan and loofah sponge fibers are combined together, the moisturizing property of the dressing is guaranteed by adsorbability of chitosan, and the air permeability of the dressing is guaranteed by the hollow tube bundle structures of the loofah sponge fibers; meanwhile, chitosan derivatives are used together to effectively promote percutaneous absorption and wound healing, so that a favorable effect is achieved.
Owner:扬州市旅游日用品制造总厂
Cadmium reducing agent for rape
InactiveCN108719322ADoes not affect normal production capacitySimple production processBiocidePlant growth regulatorsAdhesiveNormal growth
The invention relates to a cadmium reducing agent for rape. The cadmium reducing agent is prepared from cadmium reducing components, an adhesive, pigment and an aid through crushing and mixing. The cadmium reducing components are calcium acetate and magnesium sulfate, the adhesive is N-trimethyl chitosan, the pigment is brilliant blue and the aid is bentonite. The cadmium reducing agent is applicable to foliage spray of rape planted in cadmium contaminated soil and can reduce the cadmium content of rapeseeds. The cadmium reducing agent for the rape is mixed with water in the mass ratio being 1:(120-140) to be prepared into a suspension, foliage spray is performed once in the bolting period, the later blooming period and the middle silique development period of rape respectively, and the cadmium content of the rapeseeds is reduced by 40.6%-58.2%. The cadmium reducing agent has no adverse effects on normal growth of the rape and the soil environment quality. The cadmium reducing agent isconvenient to produce and use, low in cost and capable of reducing the cadmium content of the rapeseeds effectively and has significant economic, social and ecological benefits.
Owner:HUNAN AGRICULTURAL UNIV
Bactericide for clinical laboratory
InactiveCN104798823ABroad spectrum antibacterialNon-irritatingBiocideCosmetic preparationsAutoimmune responsesPolyhexamethylene guanidine
The invention discloses a bactericide for a clinical laboratory. The bactericide comprises the following components in percentage by weight: 3.0% to 8.0% of goldthread essence, 2.0% to 6.0% of lctuc tiwnin mxim root essence, 2.0% to 8.0% of N-trimethyl chitosan, 6.0% to 15.0% of polyhexamethylene guanidine, 5.0% to 10.0% of double-chain quaternary ammonium salt, 5.0-10.0% of DNA desmolase and the balance of distilled water. The bactericide provided by the invention has the advantages of being wide in antibacterial spectrum, effective in both gram positive and negative bacteria and mold and nonirritant to skin, various amino acids essential to human bodies are contained in a pure traditional Chinese medicine essence extracted from goldthread and lctuc tiwnin mxim root in the raw materials, the bactericide has the effect of improving the autoimmunity after the breathing of the human bodies, and the bactericide can serve as a spray or a hand soap for use.
Owner:SHANDONG UNIV QILU HOSPITAL
Compound air disinfectant and preparation method thereof
InactiveCN104886165AEfficient killingImprove the bactericidal effectBiocideFungicidesDisinfectantPolyhexamethylene guanidine
The invention relates to a compound air disinfectant and a preparation method thereof. The materials for the preparation of the compound air disinfectant and the parts by weight thereof are as follows: 3 to 4 parts of tachyplesin antibacterial peptide, 3 to 4 parts of marine indole alkaloid, 3 to 3.5 parts of Chinese mosla herb extract, 3 to 3.5 parts of giant knotweed extract, 2 to 2.5 parts of cyrtomium rhizome extract, 2 to 2.5 parts of houttuynia cordata extract, 6 to 7 parts of N-trimethyl chitosan, 8 to 10 parts of polyhexamethylene guanidine and 63 to 70 parts of deionized water. Compared with the prior art, the compound air disinfectant has the following advantages: (1) the disinfection and sterilization effect is remarkable, and the effect of killing common pathogenic bacteria in hospitals is particularly remarkable; (2) the application range is wide, and the compound air disinfectant is applicable to disinfection and sterilization in various environmental places and air environments around various groups of people; (3) the compound air disinfectant is non-toxic, non-irritant, non-corrosive and harmless to the human body.
Owner:荆永正
Efficient disinfectant and preparation method thereof
InactiveCN104904753AEfficient killingImprove the bactericidal effectBiocideFungicidesDisinfectantDesmolases
The invention relates to an efficient disinfectant and a preparation method thereof. The efficient disinfectant is composed of the following materials in parts by weight: 6.0-7.0 parts of N-trimethyl chitosan, 3.0-4.0 parts of marine probiotics DNA desmolase, 3.0-3.5 parts of Chinese goldthread extracting solution, 3.0-3.5 parts of honeysuckle extracting solution, 2.0-2.5 parts of fructus forsythiae extracting solution, 2.0-2.5 parts of isatis root extracting solution and 3.0-3.5 parts of formosan lattuce herb extracting solution. Compared with the prior art, the efficient disinfectant has the following advantages of being significant in disinfection and sterilization effect, particularly significant in killing common pathogenic bacterium in hospitals; being wide in application range, and applicable to disinfecting and sterilizing various fields, various environments and skin of all kinds of people; being free of toxicity, stimulation, corrosivity and harm to human bodies; being stable in chemical property, and strong in continuous sterilization; being an biological agent, green and environment-friendly.
Owner:荆永正
Preparation and application of O-3, 4-methylenedioxy phenylacetate-N-trimethylchitosan quaternary ammonium salt
ActiveCN106432542AGood water solubilityGood antibacterial effectBiocideFungicidesSolubilityPhenylacetic acid
Owner:贺强
Method for modifying real silk fibers by using methylated chitosan
InactiveCN102330340AReduce hydrogen bondingImprove approachAnimal fibresMegasonic cleaningDistilled water
The invention relates to a method for modifying real silk fibers by using methylated chitosan. The method is characterized by comprising the following steps of: (1) dissolving N-trimethyl chitosan: weighing a formula amount of N-trimethyl chitosan, dissolving the N-trimethyl chitosan into distilled water, stirring uniformly, and forming a 0.5 to 2.5 percent solution; and (2) treating mulberry silks by using the N-trimethyl chitosan: performing primary rolling after the mulberry silks are soaked into the solution prepared in the step 1 for 5 to 10 minutes, performing secondary rolling after the mulberry silks are soaked for 5 to 10 minutes, drying the mulberry silks for 5 to 10 minutes at the temperature of between 80 and 100 DEG C, drying the mulberry silks for 2 to 5 minutes at the temperature of between 100 and 150 DEG C, balancing the mulberry silks for 2 to 5 hours in a dryer, performing ultrasonic cleaning, dehydrating, drying and weighing. The process is simple, and additional cross-linker is not needed.
Owner:WUJIANG RUIFENG WEAVING
Base fertilizer for water chestnut planting field
InactiveCN106588509ALarge specific surface areaImprove adsorption capacityExcrement fertilisersBioloigcal waste fertilisersWater ChestnutsSodium hydroxide
The invention discloses base fertilizer for a water chestnut planting field. The base fertilizer is characterized by being prepared from the following raw materials in percentage by mass: 28 percent to 32 percent of composted cattle pen manure, 8 percent to 12 percent of phosphorus fertilizer, 2 percent to 4 percent of zinc-boron fertilizer, 28 percent to 32 percent of plant ash, 20 percent to 24 percent of oilseed cake and 4 percent to 6 percent of an auxiliary material. The auxiliary material comprises the following components in parts by weight: 14 to 20 parts of modified bamboo powder, 4 to 8 parts of vermiculite powder, 5 to 9 parts of sepiolite powder, 2 to 4 parts of sodium humate, 2 to 4 parts of straw powder and 3 to 5 parts of turf. The modified bamboo powder is prepared by adopting the following process: stirring N,N,N-trimethyl chitosan, glacial acetic acid and water; dropwise adding a silver nitrate solution under a stirring state; then dropwise adding a sodium borohydride solution and stirring to obtain a prefabricated material; stirring gelatin and the water; adding sodium hydroxide and stirring; adjusting the pH (Potential of Hydrogen) value to be 7.1 to 7.5; adding succinic anhydride and stirring; drying and crushing; adding a silane coupling agent, the bamboo powder, the prefabricated material and toluene; raising the temperature, stirring, washing, drying and crushing to obtain the modified bamboo powder.
Owner:无为县年香马蹄种植专业合作社
Rapeseed gel oil having slimming effect and preparation method thereof
The invention discloses rapeseed gel oil having a slimming effect. The rapeseed gel oil comprises the following components in parts by weight: 102-103 parts of rapeseed oil, 4-5 parts of yeast glucan, 2-3 parts of yeast vitamins B, 8-9 parts of monostearin stearic acid, 0.35-0.4 part of erucic acid sucrose ester, 2-3 parts of folium cortex eucommiae n-butyl alcohol abstracts, 2.5-3 parts of maltitol, 3-4 parts of N-trimethyl chitosan, 2.2-2.3 parts of gamma-oryzanol, 1.9-2 parts of beta-sitosterol and a proper amount of water. According to the invention, the constructed functional dispersoid, rapeseed oil, folium cortex eucommiae n-butyl alcohol abstracts, maltitol, gelator gamma-oryzanol and beta-sitosterol are prepared into the rapeseed gel oil; the rapeseed gel oil has special slimming effect and has excellent resistance to oxidation; the nutrition of the rapeseed gel oil is enriched; the yeast glucan orally taken together with yeast vitamins B has the slimming effect; the folium cortex eucommiae n-butyl alcohol abstracts have excellent resistance to oxidation for the rapeseed gel oil.
Owner:安徽国香粮油有限公司
O-thiazolidine methyl ester-N-trimethyl chitosan quaternary ammonium salt as well as preparation method and application thereof
InactiveCN103936886AGood water solubilityGood antibacterial effectDisinfectantsChemical productsIndustrial wastewater treatment
The invention belongs to the field of the high polymer compound materials and discloses an O-thiazolidine methyl ester-N-trimethyl chitosan quaternary ammonium salt as well as a preparation method and application thereof. The preparation method of the O-thiazolidine methyl ester-N-trimethyl chitosan quaternary ammonium salt comprises the following steps: carrying out a microwave reaction on starting raw materials (including chitosan, formaldehyde and formic acid) to obtain a chitosan Schiff base and then reacting the chitosan Schiff base with methyl iodide to obtain N-trimethyl chitosan; preparing thiazolidine formyl chloride by using L-thiazolidine-4-formic acid and thionyl chloride, adding the thiazolidine formyl chloride to N-trimethyl chitosan to obtain the O-thiazolidine methyl ester-N-trimethyl chitosan quaternary ammonium salt. The O-thiazolidine methyl ester-N-trimethyl chitosan quaternary ammonium salt is greatly improved in term of antibacterial property in contrast with the chitosan, and thus can be applied to various fields such as antibacterial materials, chemical products of daily use and industrial wastewater treatment.
Owner:SOUTH CHINA UNIV OF TECH
N-trimethyl chitosan microsphere, and preparation method and application thereof in reducing dielectric loss of mineral oil
InactiveCN107876024AStable structureLarge specific surface areaOther chemical processesHydrocarbon oils refiningFreeze-dryingSodium iodide
The invention provides an N-trimethyl chitosan microsphere, and a preparation method and an application thereof in reducing dielectric loss of mineral oil, and belongs to the field of modified chitosan. The preparation method comprises the following steps: mixing chitosan, sodium iodide, and N-methyl-2-pyrrolidone to carry out reactions, then adding sodium hydroxide and methyl iodide to carry outreactions; adding ethanol to carry out precipitation, performing separation and freeze-drying to obtain N-trimethyl chitosan with a quaternization substitution degree of 10-20%; preparing a N-trimethyl chitosan solution, spraying the N-trimethyl chitosan solution into sodium polyphosphate to carry out crosslinking reactions; washing the reaction product by water, filtering, adding the reaction product into a sodium hydroxide solution, stirring, adding epoxy chloropropane to carry out reactions to obtain microspheres; washing the microspheres by water, then washing microspheres by organic solvents with volume percentages of 10-20%, 30-40%, 70-80%, and 90-95%, and carrying out freeze-drying. The prepared modified chitosan can reduce the dielectric loss of mineral oil.
Owner:HUBEI ENG UNIV
N-trimethyl chitosan microsphere, preparation method thereof and application of microsphere in reduction of dielectric loss of vegetable oil
ActiveCN107778379AStable structureLarge specific surface areaOther chemical processesFatty-oils/fats refiningVegetable oilMicrosphere
The invention provides an N-trimethyl chitosan microsphere, a preparation method thereof and application of the microsphere in reduction of dielectric loss of vegetable oil, belonging to the field ofmodified chitosan. The preparation method of the N-trimethyl chitosan microsphere comprises the following steps: carrying out hybrid reaction on chitosan with the visocisty of 0.25-0.65Pa.s, sodium iodide and N-methyl-2-pyrrolidone, then adding sodium hydroxide and methyl iodide, reacting, then carrying out ethanol precipitation, separating, and carrying out freeze drying, thereby obtaining N-trimethyl chitosan with the quaternization substitution degree of 10-20%; preparing N-trimethyl chitosan into solution, spraying into sodium polyphosphate, reacting, washing with water, adding into sodiumhydroxide solution, stirring, adding glutaraldehyde, and reacting, thereby obtaining the microsphere; and washing the microsphere with water, then sequentially eluting with organic solvents with thevolume fractions of 21-29%, 41-49%, 61-69% and 85-89%, and carrying out freeze drying. The modified chitosan prepared by adopting the method can reduce the dielectric loss of the vegetable oil.
Owner:HUBEI ENG UNIV +1
Veterinary chlortetracycline premix and preparation method thereof
ActiveCN105997894AReduce releaseExtended absorption timeAntibacterial agentsTetracycline active ingredientsSucroseChlortetracycline Hydrochloride
The invention belongs to the field of feed additives and in particular relates to a veterinary chlortetracycline premix and a preparation method thereof. The premix is prepared from the following raw materials in parts by weight: 20 to 30 parts of chlortetracycline hydrochloride, 30 to 40 parts of N-trimethyl chitosan, 20 to 40 parts of starch, 2 to 6 parts of polyvinylpyrrolidone K30, 1 to 3 parts of a chitosan-EDTA (Ethylene Diamine Tetraacetic Acid) complex and 10 to 18 parts of water, and further comprises 4 to 8 parts of a sweetener; the sweetener is one of sucrose, lactose, sorbitol and mannitol. The premix is prepared into grains by adopting a wet-process granulation process and the prepared premix grains are uniform and have high granulation rate and stable quality. Furthermore, the premix can be used for effectively reducing complex compounds formed by the chlortetracycline hydrochloride and metal ions in gastrointestinal tracts; the chlortetracycline hydrochloride can be incompletely released in gastric juice and the bioavailability of the chlortetracycline hydrochloride is improved. The preparation process of the premix provided by the invention is simple and industrial application is easy to realize.
Owner:GUANGZHOU CARDLO BIOCHEM TECH
Modified triadimefon-containing fungicide specially used for rice breeding
InactiveCN107950528AImprove immunityIncrease productionBiocidePlant growth regulatorsChelerythrineBenzyl chloride
The invention discloses a modified triadimefon-containing fungicide specially used for rice breeding. The fungicide is prepared from the following raw materials in parts by weight: 3-8 parts of modified triadimefon, 2-10 parts of quaternized zirconium phosphate, 1-3 parts of thymol, 2-5 parts of epoxiconazole, 1-5 parts of plant polysaccharides, 0.1-1 part of benzyl chloride, 0.1-0.8 part of diethylene triamine, 0.3-2 parts of O-carboxymethyl-N-trimethyl chitosan quaternary ammonium salt, 0.1-1.3 parts of chelerythrine, 1.2-2.5 parts of baicalin, 0.5-1.7 parts of an ethanol extract from cynanchum komarovii, 0.5-2 parts of amino acids, 2-20 parts of additives, 20-50 parts of montmorillonite and 30-50 parts of talcum powder. The modified triadimefon-containing fungicide, provided by the invention, specially used for rice breeding is good in fungicidal effect, and has little damage to rice; when being used for rice breeding, the modified triadimefon-containing fungicide can increase the survival rate of rice seedlings and the seed production yield.
Owner:安徽正丰农业科技有限公司
Polysialic acid-based N-trimethyl chitosan gel nanoparticles for systemic drug delivery
ActiveUS9241913B2Safely and effectively deliverReduce sizeOrganic active ingredientsBiocideZeta potentialDrug compound
Gel nanoparticles for encapsulating and delivering a pharmaceutical compound to a patient. The nanoparticles are formed from N-trimethyl chitosan and polysialic acid, preferably in the presence of sodium tripolyphosphate. A ratio of polysialic acid to N-trimethyl chitosan of about 0.5 to 1 produces nanoparticles having diameter of about 100 nm (plus or minus 25 nm) and a zeta potential above 30 milivolts that can stability contain a pharmaceutical compound, such as methotrexate, for delivery to a patient.
Owner:SYRACUSE UNIVERSITY
O-imidazolate-n-trimethyl chitosan quaternary ammonium salt and its preparation method and application
InactiveCN103965374BGood water solubilityGood antibacterial effectDisinfectantsPolymer scienceIndustrial waste water
The invention belongs to the field of macromolecular compounds and discloses a functional derivative, O-imidazate-N-trimethyl chitosan quaternary ammonium salt, prepared through chemical modification of chitosan, as well as a preparation method and application of the O-imidazate-N-trimethyl chitosan quaternary ammonium salt. The preparation method comprises the following steps: taking chitosan, formaldehyde and formic acid as starting materials, obtaining chitosan Schiff base through microwave reaction of the starting materials; then, carrying out reaction of the chitosan Schiff base and methyl iodide to obtain N,N,N-trimethyl chitosan; utilizing imidazole dicarboxylic acid and sulfoxide chloride to obtain imidazole acid acyl chloride; adding the imidazole acid acyl chloride into the N,N,N-trimethyl chitosan to obtain the O-imidazate-N trimethyl chitosan quaternary ammonium salt. The O-imidazate-N trimethyl chitosan quaternary ammonium salt is not only good in water-solubility, but also greatly higher in an antibiotic property, and can be applied to numerous application fields such as antibacterial materials, daily chemical products and industrial wastewater treatment.
Owner:SOUTH CHINA UNIV OF TECH
O-thiazolidine methyl ester-n-trimethyl chitosan quaternary ammonium salt and its preparation method and application
InactiveCN103936886BGood water solubilityGood antibacterial effectDisinfectantsChemical productsAntibacterial property
The invention belongs to the field of the high polymer compound materials and discloses an O-thiazolidine methyl ester-N-trimethyl chitosan quaternary ammonium salt as well as a preparation method and application thereof. The preparation method of the O-thiazolidine methyl ester-N-trimethyl chitosan quaternary ammonium salt comprises the following steps: carrying out a microwave reaction on starting raw materials (including chitosan, formaldehyde and formic acid) to obtain a chitosan Schiff base and then reacting the chitosan Schiff base with methyl iodide to obtain N-trimethyl chitosan; preparing thiazolidine formyl chloride by using L-thiazolidine-4-formic acid and thionyl chloride, adding the thiazolidine formyl chloride to N-trimethyl chitosan to obtain the O-thiazolidine methyl ester-N-trimethyl chitosan quaternary ammonium salt. The O-thiazolidine methyl ester-N-trimethyl chitosan quaternary ammonium salt is greatly improved in term of antibacterial property in contrast with the chitosan, and thus can be applied to various fields such as antibacterial materials, chemical products of daily use and industrial wastewater treatment.
Owner:SOUTH CHINA UNIV OF TECH
N-trimethyl chitosan modified baicalein ophthalmic lipid nanoparticle preparation and preparation method thereof
InactiveCN110051654AHuge membrane surface areaImprove drug loading capacityOrganic active ingredientsSenses disorderWater bathsBiocompatibility Testing
The invention discloses an N-trimethyl chitosan modified baicalein ophthalmic lipid nanoparticle preparation and a preparation method thereof. The preparation method includes (1) taking a lipid material, a stabilizer and baicalein, adding anhydrous ethanol, placing the mixture in a water bath for melting and conducting ultrasonic treatment to make all dissolved; conducting decompression spinning steaming to remove ethanol to obtain an oil phase; (2) adding a permeation enhancer and N-trimethyl chitosan to 20mM of Tris-Hcl solution with the pH of 6.0, stirring till complete dissolution, heatingto obtain an aqueous phase; (3) adding the aqueous phase to the oil phase and conducting shearing dispersion; cooling to the room temperature and conducting ultrasonic dispersing to obtain the N-trimethyl chitosan modified baicalein ophthalmic lipid nanoparticle preparation. The preparation has large membrane surface area, strong drug-loading capacity, good biocompatibility, high bioadhesion andlow eye irritation.
Owner:TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
Preparation method and application of mannose grafted trimethyl chitosan
ActiveCN105754017BSolve the problem of easy hydrolysis during the reactionEasy to removePharmaceutical non-active ingredientsGranular deliveryOrganic solventEpidermal Dendritic Cells
Owner:ZHEJIANG PHARMA COLLEGE
A kind of external preparation of moxifloxacin hydrochloride and preparation method thereof
ActiveCN104224691BPromote absorptionQuick effectAntibacterial agentsOrganic active ingredientsIrritationSkin penetration
Owner:NANJING YOUKE BIOLOGICAL MEDICAL RES +2
Chlortetracycline premix
InactiveCN107714708AReduce releaseQuality improvementTetracycline active ingredientsDigestive systemChlortetracycline HydrochlorideN-trimethyl chitosan
The invention discloses a chlortetracycline premix, which consists of the following components in parts by weight: 15-25 parts of chlortetracycline hydrochloride, 10-20 parts of corn starch, 1-3 partsof N-trimethyl chitosan, 3-6 parts of a sweetening agent and 6-12 parts of a binding agent. The chlortetracycline premix, which is prepared in accordance with the prescription, is stable in quality and high in utilization rate; chlortetracycline, which is less released in gastric juice, can reach an intestinal tracts well so as to achieve good efficacy; and the chlortetracycline premix has a goodapplication prospect and is worthy of popularizing.
Owner:江苏昕宇药业有限公司
Immunopotentiator and its preparation method and application
ActiveCN105561293BEnhance immune responseImprove the level ofOrganic active ingredientsPeptide/protein ingredientsImmune effectsWindow period
The invention provides an immunopotentiator and a preparation method and an application thereof, wherein the immunopotentiator comprises at least one of chitosan, N,N,N-trimethyl chitosan quaternary ammonium salt and mannatide. The immunopotentiator can significantly improve immune response of immunized animals, increases the antibody level, thereby improving the immune effect of vaccines, shortening the immune window period and prolonging the protection period.
Owner:北京中联康生物科技股份有限公司
A kind of aureomycin premix for veterinary use and preparation method thereof
ActiveCN105997894BReduce releaseExtended absorption timeAntibacterial agentsTetracycline active ingredientsSucroseChlortetracycline Hydrochloride
The invention belongs to the field of feed additives and in particular relates to a veterinary chlortetracycline premix and a preparation method thereof. The premix is prepared from the following raw materials in parts by weight: 20 to 30 parts of chlortetracycline hydrochloride, 30 to 40 parts of N-trimethyl chitosan, 20 to 40 parts of starch, 2 to 6 parts of polyvinylpyrrolidone K30, 1 to 3 parts of a chitosan-EDTA (Ethylene Diamine Tetraacetic Acid) complex and 10 to 18 parts of water, and further comprises 4 to 8 parts of a sweetener; the sweetener is one of sucrose, lactose, sorbitol and mannitol. The premix is prepared into grains by adopting a wet-process granulation process and the prepared premix grains are uniform and have high granulation rate and stable quality. Furthermore, the premix can be used for effectively reducing complex compounds formed by the chlortetracycline hydrochloride and metal ions in gastrointestinal tracts; the chlortetracycline hydrochloride can be incompletely released in gastric juice and the bioavailability of the chlortetracycline hydrochloride is improved. The preparation process of the premix provided by the invention is simple and industrial application is easy to realize.
Owner:GUANGZHOU CARDLO BIOCHEM TECH
Preparation method of trinary composite stent of plasmid DNA / fibrin gel / polymer
The invention discloses a preparation method of a trinary composite stent of plasmid DNA / fibrin gel / polymer. The preparation method comprises the following steps of: geometrically and uniformly mixing an N-trimethyl chitosan solution and a plasmid DNA solution to prepare plasmid DNA composite particles; dissolving fibrinogen in physiological saline to prepare a fibrinogen solution; dissolving thrombin in a calcium chloride solution to prepare a thrombin calcium chloride solution; sterilizing a polymer porous stent with ethanol; simultaneously filling the plasmid DNA composite particles, the fibrinogen solution and the thrombin calcium chloride solution with the same volumes in the polymer porous stent by utilizing negative pressure; and arranging the stent filled with the plasmid DNA composite particles, the fibrinogen solution and the thrombin calcium chloride solution in a constant-temperature oven to fully gelatinize the fiber protein. The preparation method is simple and convenient, uses materials with wide resources and can simulate the composition and the structure of the cartilage of a human body. The composite stent of the invention has favorable mechanical property and biological activity, can accelerate the restoration of the cartilage and the osseous tissue and have strong application values of cartilage and bone restoration.
Owner:ZHEJIANG UNIV
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