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Method for preparing valnemulin hydrochloride coating granule

A technology of varnemulin hydrochloride and coated granules, which is applied in the field of preparation of varnemulin hydrochloride coated granules, and can solve the problems of strong powder irritation, instability to light, and easy decomposition on contact

Inactive Publication Date: 2009-12-16
河北远征药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the raw material of warnimulin hydrochloride has the disadvantages of hygroscopicity, strong irritant powder, unstable to light, easy to decompose when contacting with feed, etc.

Method used

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Examples

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Embodiment Construction

[0032] The present invention will be further described below in conjunction with the examples, but not as a limitation of the present invention.

[0033] The technological process of the present embodiment is as follows:

[0034] Step A, pre-granulation of warnemulin hydrochloride

[0035] Pre-granulation of warnemulin hydrochloride raw materials by using a fluidized bed device, so that the particle size of more than 80% of the warnemulin hydrochloride granules is between 125 μm and 250 μm, and the particles with a particle size of less than 125 μm do not exceed 10%. The quality of each raw material in the process is:

[0036] Warnemulin Hydrochloride 100g

[0037] Lactose 15g

[0038] Hydroxypropyl Methyl Cellulose 3g

[0039] Talc powder 5g;

[0040] Step B, the preparation of coating solution

[0041] The quality of each component in the coating liquid is:

[0042] 6mPa·s hydroxypropyl methylcellulose 25g

[0043] PEG6000 1g

[0044] Titanium dioxide 1g

[0045] T...

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PUM

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Abstract

The invention belongs to a process for preparing a valnemulin hydrochloride premix of pleuromutilin antibiotics specially used for animals, and in particular relates to a method for preparing a valnemulin hydrochloride coating granule. The method comprises the following process steps of pre-granulation of the valnemulin hydrochloride, preparation of coating solution, coating of the valnemulin hydrochloride and the like. The method has the advantages of solving the problems existing in the prior art that the valnemulin hydrochloride materials are hygroscopic, sensitive to light and strong in powder irritation, and are easily decomposed when being mixed with feed and the like, effectively achieving the aim of odor masking and the like; moreover, after coating, the coating granule is stable under conditions of a light accelerating experiment.

Description

Technical field [0001] The invention belongs to a preparation process of a special pleuromutilin antibiotic warnemulin hydrochloride premix for animals. Specifically, it relates to a preparation method of warnemulin hydrochloride coated granules. Background technique [0002] my country's animal husbandry industry mainly focuses on breeding edible animals, so drug residues and cross-resistance with human drugs must be considered when using drugs. Therefore, the Ministry of Agriculture is very strict in the approval of veterinary antibacterial drugs, and actively promotes the special use of veterinary drugs. Valnemulin Hydrochloride is a pleuromutilin semi-synthetic antibiotic approved by the European Union in 1999 for the prevention and treatment of swine dysentery caused by Brachyspira hyodysenteriae infection and porcine enzootic pneumonia caused by Mycoplasma pneumoniae infection , it is the first drug premix approved in Europe. At present, there is no warnemulin hydroc...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/22A61K47/38A61K47/32A61P31/04
Inventor 刘海亮杨芳岳永波
Owner 河北远征药业有限公司
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