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Composition of vitamin C and preparation method thereof

A composition and vitamin technology, which is applied in the directions of drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems affecting the clinical use of vitamin C, inconvenient to carry and use, complex production processes, etc., and achieve improved bioavailability. Accurate dosage, accurate dosage and good taste

Active Publication Date: 2014-05-28
PHARMA CHANGZHOU PHARMA FACTORY NO 4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are defects such as easy discoloration, easy degradation, poor stability, inconvenience to carry and use, and complex production processes (chewable tablets, effervescent tablets, dispersible tablets, injections) to varying degrees.
In addition, the sour and astringent taste of vitamin C, when in contact with the taste buds, will transmit the information of the bad stimulus to the cerebral cortex center, resulting in bad taste, resulting in poor compliance of taking, which affects the clinical use of vitamin C

Method used

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  • Composition of vitamin C and preparation method thereof
  • Composition of vitamin C and preparation method thereof
  • Composition of vitamin C and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044]

[0045] Preparation:

[0046] 1) Thoroughly mix vitamin C, vitamin C-Na, and calcium stearate evenly, and grind to a particle size of 25-50um to obtain core granules.

[0047]2) Put the core particles of 1) in a fluidized bed coating machine (equipment model SFP-01), prepare an 8% ethanol solution as a slurry with acrylic resin L100 and absolute ethanol 316.25 g, and spray coating continuously; Fixed spray volume 10g / min, spray pressure 0.5MPa, air intake volume 1m 3 / min, the air inlet temperature is 80°C; after coating, it is dried at 50°C for 15 minutes.

[0048] 3) passing 2) the coated granules through an 80-mesh sieve to obtain taste-masked granules;

[0049] 4) Mix 3) granules with microcrystalline cellulose, microcrystalline cellulose-carboxymethyl cellulose sodium and place them in a fluidized bed (equipment model MP-01), and dissolve HPC-L with water (specific amount? 447.5g) , PEG6000, sodium saccharin, essence and tartrazine, prepared into 5% HPC solu...

Embodiment 2

[0052]

[0053] Preparation:

[0054] According to the preparation process described in Example 1, the packaging specification is 2g / bag in an aluminum-plastic composite bag.

Embodiment 3

[0056]

[0057] Preparation:

[0058] According to the preparation process described in Example 1, the packaging specification is 3g / bag in an aluminum-plastic composite bag.

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PUM

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Abstract

The invention provides a composition of vitamin C. The composition consists of the following active components and pharmaceutic adjuvants in percentage by weight: active components: 5-30% of vitamin C, 3.25-19.25% of vitamin C sodium and 0.2-0.8% of calcium pantothenate; and pharmaceutic adjuvants: 0.05-0.45% of lubricant, 1-9% of suspension, 30-80% of filler, 0.5-4.5% of binder, 0.05-2.45% of plasticizer, 0.2-0.8% of flavoring agent, 0.2-0.8% of spice, 0.2-0.8% of food colorant and 0.05-5.45% of coating material. The composition of vitamin C provided by the invention has good mouthfeel, is taken without water or with little water and is convenient to carry and use; and moreover, the composition has high stability, is quickly absorbed and takes effect quickly, improves the taking compliance, realizes dual functions of treatment and healthcare, and is particularly suitable for the children or old people and some patients with difficulty in swallowing. The composition of vitamin C provided by the invention is superior to the sugar coated tablet of vitamin C in both appearance and content. The stability of the composition of vitamin C provided by the invention is greatly improved. The preparation technology provided the invention is reasonable, easy to operate and suitable for industrial production. The composition of vitamin C has relatively good clinical effect and relatively high application values.

Description

technical field [0001] The present invention relates to pharmaceutical preparations. Specifically relates to a vitamin C composition and a preparation method. Background technique [0002] Vitamin C and dehydrovitamin C form a reversible redox system in the body, which plays an important role in biological oxidation and reduction and cellular respiration. Vitamin C participates in the metabolism of amino acids, the synthesis of neurotransmitters, and the synthesis of collagen and tissue interstitium, which is very important to human health. The main physiological functions of vitamin C: promote the biosynthesis of collagen, facilitate the faster healing of tissue wounds, promote the metabolism of tyrosine and tryptophan in amino acids, prolong the life of the body, improve the utilization of iron, calcium and folic acid, Improve the metabolism of fats and lipids, especially cholesterol, prevent cardiovascular diseases, promote the growth of teeth and bones, prevent gum ble...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/375A61P3/02A61K31/197
Inventor 范新华屠永锐贺赟傅益清黄建荣张明洁周岳宇杨京华
Owner PHARMA CHANGZHOU PHARMA FACTORY NO 4
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