The invention discloses a qianxi sugar-coated and film-coated tablet and a preparation method thereof. The qianxi sugar-coated and film-coated tablet is prepared from common andrographis herbs and climbing groundsel herbs according to a certain proportion. The preparation method comprises the following steps of: grinding part of the common andrographis herbs into fine powders and screening; grinding the residual common andrographis herbs and climbing groundsel herbs into coarse powders, percolating, treating a percolate, collecting sediments, carrying out spray drying, adding a proper amount of fine powders of the common andrographis herbs, starch and gelatin, mixing uniformly, pelletizing, drying, then, adding a proper amount of magnesium stearate and partially substituted cellulose accessories to prepare a tablet, coating and packing by using aluminum plastics to obtain the qianxi sugar-coated and film-coated tablet. The qianxi tablet is safe and efficient and clinically used for treating enteritis, colitis, bacillary dysentery, nasosinusitis and the like; and proved by pharmacodynamic and clinical research, the qianxi tablet has the effects of clearing away heat and toxic materials, diminishing inflammation and stopping pain as well as stopping diarrhea and dysentery.