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A kind of Qianxi tablet and preparation method thereof

A technology for Qianxi tablets and prescriptions, which is applied in the field of Qianxi sugar-coated tablets and film-coated tablets and their preparation. It can solve the problems of slow disintegration, cracks, loose tablets, etc., and achieve fast drying speed, short heating time, and favorable molding. Effect

Active Publication Date: 2015-10-07
江西欧氏药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The technical solution of the present invention is to conduct prescription research on the important process of granulation in the tablet preparation process, and solve the problems of splits, loose tablets, sticky impact, slow disintegration, etc. by selecting and using appropriate disintegrants and lubricants , the medicinal materials are made by crushing, percolating, acid precipitation, spray drying, granulating, drying, mixing, tableting, coating, aluminum-plastic packaging and other processes, and Qianxi film-coated tablets and sugar-coated tablets are made

Method used

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  • A kind of Qianxi tablet and preparation method thereof
  • A kind of Qianxi tablet and preparation method thereof
  • A kind of Qianxi tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 A kind of preparation method of Qianxi sugar-coated tablet

[0027] Take 40g of Andrographis paniculata and crush it into fine powder, sieve; 1960 grams of Andrographis paniculata and 2000 grams of Senecio are crushed into coarse powder, soak with 1.2% sodium hydroxide solution in an appropriate amount overnight, add water for percolation, and the percolation flow rate is 3ml / min per kilogram of medicinal materials , collect about 1000ml of the percolation liquid, add 1 / 7 amount of saturated saline, then adjust the pH to about 2-3 with hydrochloric acid, stir well, let stand for 12 hours, discard the supernatant, collect the precipitate, and spray dry; add The above-mentioned andrographis paniculata fine powder, 30 grams of starch, 7.5 grams of gelatin, mixed evenly, granulated, dried, granulated, then added 3 grams of magnesium stearate and 15 grams of low-substituted hydroxypropyl cellulose, mixed evenly, pressed into 1000 plain tablets , sugar-coated, al...

Embodiment 2

[0028] Embodiment 2 A kind of preparation method of Qianxi film-coated tablet

[0029] Take 40g of Andrographis paniculata and crush it into fine powder, sieve; the remaining 1960g of Andrographis paniculata and 2000g of Senecio are crushed into coarse powder, impregnated with an appropriate amount of 1.3% sodium hydroxide solution overnight, add water for percolation, and the percolation flow rate is 5ml / min per kilogram of medicinal materials , collect about 1000ml of the percolation liquid, add 1 / 7 amount of saturated saline, then adjust the pH to about 2-3 with hydrochloric acid, stir well, let it stand for 12 hours, discard the supernatant, collect the precipitate, and spray dry; add The above-mentioned Andrographis paniculata fine powder, 30 grams of starch, 7.5 grams of gelatin, mixed evenly, granulated, dried, granulated, then added 3 grams of magnesium stearate and 15 grams of low-substituted hydroxypropyl cellulose, mixed evenly, pressed into 1000 plain tablets , fil...

Embodiment 3

[0030] Embodiment 3: in vitro antibacterial test

[0031] 3.1 Materials

[0032] Bacteria: Staphylococcus aureus (26003), Escherichia coli (44103), typhoid bacillus (0602-10), Yersinia (52301-5), Shigella dysenteriae (1507-2), Shigella baumannii (51583), Shigella flexneri (51571) (the above strains were all obtained from the China Institute for the Control of Pharmaceutical and Biological Products, Ministry of Health), and Streptococcus B (from the Baozhi strains of the Department of Microbiology, Jiangxi University of Traditional Chinese Medicine).

[0033] Test substance: Qianxi tablets

[0034] 3.2 Method

[0035] Suspend Qianxi Tablets in 100ml broth, dilute the drug according to the double dilution method, and use the other tube as a control without adding the drug. -4 , each tube was inoculated with 0.1ml, incubated for 24 hours, then inoculated in a flat container, incubated at 37°C for 24 hours, determined whether there were colonies, and measured the minimum bacteric...

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Abstract

The invention discloses a qianxi sugar-coated and film-coated tablet and a preparation method thereof. The qianxi sugar-coated and film-coated tablet is prepared from common andrographis herbs and climbing groundsel herbs according to a certain proportion. The preparation method comprises the following steps of: grinding part of the common andrographis herbs into fine powders and screening; grinding the residual common andrographis herbs and climbing groundsel herbs into coarse powders, percolating, treating a percolate, collecting sediments, carrying out spray drying, adding a proper amount of fine powders of the common andrographis herbs, starch and gelatin, mixing uniformly, pelletizing, drying, then, adding a proper amount of magnesium stearate and partially substituted cellulose accessories to prepare a tablet, coating and packing by using aluminum plastics to obtain the qianxi sugar-coated and film-coated tablet. The qianxi tablet is safe and efficient and clinically used for treating enteritis, colitis, bacillary dysentery, nasosinusitis and the like; and proved by pharmacodynamic and clinical research, the qianxi tablet has the effects of clearing away heat and toxic materials, diminishing inflammation and stopping pain as well as stopping diarrhea and dysentery.

Description

technical field [0001] The invention relates to a Qianxi sugar-coated tablet, a film-coated tablet and a preparation method thereof, belonging to the technical field of medicine. technical background [0002] Enteritis is caused by irritation of the intestinal mucosa and can be divided into acute and chronic. In my country, acute enteritis occurs mostly in summer and autumn, most of which are caused by bacterial infection, and there is no gender difference. Chronic enteritis increases the permeability of the intestinal mucosa, and if it is not cured for a long time, it will lead to intestinal perforation, which is very harmful. [0003] Bacillary dysentery is mostly caused by exogenous damp-heat, epidemic poisonous gas, internal injury to diet, and damage to the spleen, stomach and intestines. Damp-heat poison stagnates in the intestines, qi movement is not smooth, conduction is abnormal, so abdominal pain, tenesmus; damp-heat burns the intestines, the meridian is injured,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61K9/20A61K9/42A61K47/38A61P1/00A61P31/04
CPCY02A50/30
Inventor 赵凯李新黄建丽熊丹美王菊月
Owner 江西欧氏药业有限责任公司
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