The invention provides a hydrochloric acid boningmycin solid preparation, which is a soluble tablet or a dispersible tablet. The compositions and weight percentages of the hydrochloric acid boningmycin solid preparation are as follows: 0.5 to 50wt% of hydrochloric acid boningmycin, 15 to 99.4wt% of fillers achieving a filling effect, 0 to 20wt% of disintegrants achieving a disintegration effect, 0 to 10 wt% of adhesives achieving an adhesion effect and 0.1 to 5wt% of lubricants achieving a lubrication effect. The invention also provides a preparation method of the soluble tablet and the dispersible tablet. By adopting the hydrochloric acid boningmycin tablet provided by the invention, on the one hand, the deficiency that preparations such as ointment, gel, and the like have poor stabilityafter being placed for a long time under a room temperature condition is overcome, and the storage and the carrying are facilitated; and on the other hand, before being used, the tablet is added to aspecial solvent so as to be dissolved or dispersed to form a water solution or an injectable suspension with certain viscosity, and thereby the tablet also has the advantage of a semi-solid or liquidexternal preparation on the aspects of the use and the pharmaceutical effect.