Paediatrics amoxicillin Na dissolve sheet

Abstract

The invention relates to an amoxicillin sodium soluble tablet with special specification for children, comprising effective amount of amoxicillin sodium and water-soluble medicinal excipient which disintegrates fast to release efficacy in water. When the patient takes the tablet, the patient can determine the taken number of the tablets according to the body weight of the patient. Thus, personalized administration can be realized; the medicine intake can be more accurate; and the safety is higher. After the medicine is dissolved in the water, the water can become a sweet and sour beverage, so the taken method is more acceptable by children with good compliance. At the same time, the medicine solution is easy to be fully absorbed by the body , and the bioavailability is higher.

Description

1. Technical field [0001] The invention belongs to the field of pharmaceutical preparations. It specifically relates to an oral formulation of amoxicillin sodium specially designed for children, specifically a soluble tablet of amoxicillin sodium for children. 2. Background technology [0002] Amoxicillin sodium is the sodium salt of amoxicillin and is easily soluble in water. Amoxicillin, also known as amoxicillin, amoxicillin, and relin, is a penicillin antibiotic, which is effective against aerobic Gram bacteria such as Streptococcus pneumoniae, hemolytic streptococcus, non-penicillinase-producing Staphylococcus, and Enterococcus faecalis. Positive cocci, Escherichia coli, Proteus mirabilis, Salmonella, Haemophilus influenzae, Neisseria gonorrhoeae and other aerobic Gram-positive cocci that do not produce β-lactamase strains and Helicobacter pylori have good antibacterial activity. Amoxicillin exerts a bactericidal effect by inhibiting the synthesis of bacterial cell wa...

AI Technical Summary

Problems solved by technology

At present, there is a major problem in the use of amoxicillin oral preparations in the domestic market for children, that is, the divided doses are not accurate, and the dosage indicated in the instructions cannot be determined according to body weight.

[0003] The "Usage and Dosage" item in the instructions for use of amoxicillin tablets stipulates that "children should weigh 6.7-13.3mg / kg once every 8 hours or follow the doctor's advice", but in clinical practice, it cannot be conveniently and accurately Dosing operation, so that this regulation becomes empty talk, and other such as tablets cannot realize this kind of personalized drug delivery