83 results about "Amoxicillin Sodium" patented technology

The invention discloses a preparation method of amoxicillin sodium and sulbactam sodium for injection and a freeze-dried powder injection thereof as well as a separating and purifying method of the amoxicillin sodium and sulbactam sodium for injection. By adopting high speed countercurrent chromatography, the invention prepares trichloromethane, ethyl acetate, methanol and water to form a solvent system with an immobile phase and a mobile phase and separates and purifies amoxicillin sodium and sulbactam sodium to obtain the amoxicillin sodium and sulbactam sodium for injection; the purity of the obtained product can reach more than 98% and the prepared injection has improved stability.

The invention provides liposome injection of an amoxicillin sodium sulbactam sodium medicinal composition. The liposome injection consists of amoxicillin sodium, sulbactam sodium, liposome carriers, freeze-drying supporting agents and optional antioxidant, wherein the liposome carriers are dipalmitoyl phosphatidyl choline and deoxysodium cholate. The liposome injection has high stability; in the freeze-drying process, a phenomenon of breaking liposome caused by dehydration, fusion, ice crystal generation and the like does not occur; and the liposome can remain good encapsulation ratio after being hydrated and redissolved.

The invention relates to suspensoid powder injection of an amoxicillin sodium sulbactam sodium medicine composition and a preparation method thereof. The suspensoid powder injection contains Tween 80, cholesterol, deoxysodium cholate, a freeze-drying support agent and active components. The invention also relates to a novel application of the suspensoid powder injection in preparing a medicine treating prostatitis further.

The invention provides a novel high-efficiency liquid chromatography (HPLC) method capable of synchronously detecting the contents of two single ingredients and relevant impurities in injection use compound amoxicillin sodium and clavulanate potassium. Compared with the existing detection method, the invention has higher precision on the 7/1 compound preparation with relatively low clavulanic acid content, and has better separation degree on the injection preparation with higher purity requirement, in addition, the two ingredients of the amoxicillin and the clavulanic acid can not be mutually interfered or influenced in the detection process. The method has the advantages of simple operation, easy implementation, strong specificity, high sensitivity, large linear range, good stability and good repetitiveness, and can be used for detecting compound sterile injection preparations and raw materials.

The present invention relates to a compound injection preparation formed from probenecid sodium and benzylpenicillin antibiotics, belonging to the field of chemical pharmaceutical technology. The benzylpenicillin antibiotics include amoxicillin sodium and piperacillin sodium. The amoxicillin sodium and piperacillin sodium are mixed according to ratio of 1:3 and 1:5 through a conventional preparation process.

The invention belongs to the technical field of medical technology, and particularly relates to an amoxicillin and clavulanate potassium injection and a preparation method of the amoxicillin and clavulanate potassium injection. The amoxicillin and clavulanate potassium injection includes amoxicillin sodium, potassium clavulanate and a pH regulator. The preparation method comprises the steps of crushing and mixing the amoxicillin sodium, the potassium clavulanate and the pH regulator uniformly through air flows according to certain proportion, then respectively packaging the mixture into penicillin bottles, controlling the water content to be 0.5%, filling nitrogen for protection, plugging, rolling a cover and finally packaging. According to the invention, the obtained product is stable in quality, the problems of the color changing and the deterioration caused by the easy oxidization of the similar products can be solved, the product quality is improved, and high economical benefits are obtained.

The present invention relates to a method for preparing medicine mixture containing amoxicillin sodium and potassium clavulunate. Said method includes the following processes: (a), dissolving two medicine active components in solvent according to a certain ratio so as to form a solution; (b), mixing said solution with supercritical fluid; and (c), separating out medicine micropowder from supercritical fluid. Said medicine granules have good fluidity.

The invention discloses an amoxicillin sodium/sulbactam sodium composition microsphere injection, which is characterized by comprising 2 parts of amoxicillin sodium, 1 part of sulbactam sodium, 1.5-6 parts of PLGA, 1.5-3 parts of tween 80, 1.5-3 parts of propylene glycol and 0.5-1.0 part of trehalose by weight. Compared with the prior art, the microsphere injection has good stability, high encapsulation efficiency, good preparation process repeatability, uniform particle distribution, less solvent residues, good injectability and excellent slow-release characteristic and is suitable for industrial production.

The preparation method of amoxicillin sodium includes the following steps: firstly, making amoxicillin trihydric acid react with triethylamine, and making purification, then making obtained product react with purified sodium isocaprylate, crystallizing, filtering, washing and drying to obtain the invented product with high quality.

The invention provides an amoxicillin sodium flucloxacillin sodium medicine compound liposome injection which comprises amoxicillin sodium, flucloxacillin sodium, liposome carrier, lyoprotectant and optionally existing preservative, wherein the liposome carrier is soy lecithin and cholesterol. The liposome injection has good preparation stability, the liposome during freeze drying process does not crack caused by dehydration, fusion, ice crystal formation and the like; and likewise, the liposome keeps good encapsulation efficiency after hydration redissolution.

The invention discloses a preparation process of amoxicillin sodium crystal, which specifically comprises the following steps of: adding distilled water and amoxicillin in proportion to 3-neck flask in turn, heating in water bath, stirring, adding sodium salt powder slowly in proportion until the solution is clear after the suspension is formed fully, then extracting to remove the solid impurities, putting the filtrate in a crystallizer, adding entrainer in proportion, conducting vacuum azeotropic distillation, adding entrainer again in proportion after a certain amount of entrainer is distilled, conducting temperature-controlled cooling crystallization after a certain amount of water is distilled, then filtering and drying to obtain an amoxicillin sodium crystal product. The amoxicillin sodium crystal obtained by the preparation process provided by the invention has the advantages of uniform particle size distribution, high purity, good fluidity, good stability, low production cost, easiness of operation and small environmental pollution.

The invention discloses a process for recovering isooctanoic acid from pharmaceutical waste liquor and transforming isooctanoic acid into sodium isooctoate. The process comprises the following steps of: removing water and residual organic solvents which are contained in the waste liquor through preliminary distillation, then adding acid for acidification to transform isooctoate contained in a waste material into isooctanoic acid, adding an extracting agent to split the phase of the acidified waste material, and repeatedly washing an oil phase rich in the isooctanoic acid by using distilled water to obtain a crude isooctanoic acid product; then carrying out reduced pressure distillation to obtain a finished isooctanoic acid product; finally reacting the obtained finished isooctanoic acid product with sodium alkali to generate sodium isooctoate. The process disclosed by the invention can be used for effectively recovering isooctanoic acid contained in antibiotic production waste liquor, namely ampicillin sodium, amoxicillin sodium, cephalosporin sodium salt and the like which are obtained through a solvent crystallization method, and transforming isooctanoic acid into salt-forming agent sodium isooctoate capable of being recycled.

The invention provides a sustained-release drug intercalation magnetic houghite which has the fluorescence lighting performance, and a preparation method. A salt liquid is prepared by the mixture of a magnetic stroma, bivalent metal salt and trivalent metal salt; a lye prepared by NaOH and Na2CO3 is prepared into CO3-LDH/Fe3O4; the dried CO3-LDH/Fe3O4 is baked for 2h at the temperature of 450 DEG C to form a double-metal oxide; under the protection of N2, the double-metal oxide obtained by baking is put in a container filled with an amoxicillin sodium lye; finally the mixture is put into a constant temperature oscillator to be oscillated for 24h at the speed of 180r/min, then filtered, washed and dried to obtain the sustained-release drug intercalation magnetic houghite which has the fluorescence lighting performance and has a chemical formula: [M(II)<1-x>M(III)(1-Beta)xM'(III)Betax(OH)2]<x+>(AMX<->)a(A<n->)b question mark mH2O/Fe3O4. The invention has the advantages of removing the inorganic anions of the metal salt which completes the intercalation with the organic anions and being suitable for being inserted with a medical molecule with larger size.

The present invention provides an acid type amoxicillin and a production method thereof. The purpose of the present invention is to solve a poor dissolution rate of amoxicillin in the prior art. The acid type amoxicillin comprises amoxicillin and citric acid. The production method for the acid type amoxicillin comprises the following steps: uniformly mixing the amoxicillin and the citric acid; carrying out ultrafine grinding on the resulting mixture to obtain fine powder with a particle size of 700-900 meshes; and carrying out sub-packaging in a sterile room. The acid type amoxicillin of the present invention provides the same dissolution rate as amoxicillin sodium, and meets the solubility standard in the national pharmacopoeia. In addition, with the present invention, no three-waste pollution is generated, and the production cost is low, wherein the production cost of the acid type amoxicillin of the present invention is 2/3 of the production cost of the amoxicillin sodium.

The invention discloses a filling machine for amoxicillin sodium and sulbactam sodium medicine powder used for injection. The filling machine comprises an operating platform, a rotating device and a medicine bottle fixing tray, wherein the rotating device is fixed on the operating platform, and the medicine bottle fixing tray is fixed on the rotating device. Grooves are formed in the periphery of the medicine bottle fixing tray. A circle of bound plate is arranged outside the medicine bottle fixing tray, and a base plate is arranged at the bottom of the medicine bottle fixing tray. A medicine feeding device and a medicine bottle discharging device are arranged on the base plate. Discharging ports and feeding ports are formed in the bound plate and the base plate. The discharging ports and the feeding ports correspond to the medicine bottle discharging device and the medicine bottle feeding device respectively in terms of positions, and a medicine powder filling device is further arranged above the medicine bottle fixing tray and fixedly connected to the operating platform through a supporting rod. The filling machine for the amoxicillin sodium and sulbactam sodium medicine powder used for the injection has the advantages of being simple in structure, automatically filling the medicine powder and reducing the tedious degree of operation processes.

The invention relates to amoxicillin sodium sulbactam sodium for injection for livestock and a preparation method of the amoxicillin sodium sulbactam sodium. The invention aims at providing an amoxicillin sodium sulbactam sodium freeze-dried powder injection. The amoxicillin sodium sulbactam sodium freeze-dried powder injection comprises effective components of amoxicillin sodium and sulbactam sodium, and also contains an antioxygen, a pH(Potential Of Hydrogen) regulating agent and a dispersing agent, and thus the solubility of the amoxicillin sodium is greatly increased, and the pH of medicine liquid after being re-dissolved is within a range of 8.5-9.5. According to the amoxicillin sodium sulbactam sodium and the preparation method of the amoxicillin sodium sulbactam sodium, through research of the preparation of an amoxicillin sodium sulbactam sodium stock solution and determination of a freeze-drying process, the amoxicillin sodium sulbactam sodium freeze-dried powder injection which is stable in quality, better in appearance characteristics and safe and effective in use is obtained.

The invention relates to flucloxacillin sodium and amoxicillin sodium for injection, in particular to a stable flucloxacillin sodium and amoxicillin sodium pharmaceutical composition for injection. The composition comprises flucloxacillin sodium and amoxicillin sodium, wherein flucloxacillin sodium is counted as flucloxacillin, amoxicillin sodium is counted as amoxicillin; and the weight ratio of flucloxacillin to amoxicillin is 1:(0.5-1.5). The pharmaceutical composition has an excellent pharmaceutical performance.

The invention relates to a preparation method for controlling pH (Potential of Hydrogen) of amoxicillin sodium/sulbactam sodium. The method comprises the following steps of: processing sulbactam sodium and amoxicillin sodium with pH of 8.5 to 9.5 by physically mixing the powder in a multi-direction movement mixing way in a closed container under the protection of laminar flow based on the proportion of 2: 1; discharging the powder; weighing; barreling; sub-packaging and capping to obtain the amoxicillin sodium/sulbactam sodium. By adopting the preparation method, the pH of the prepared amoxicillin sodium/sulbactam sodium for injection can be controlled well to within the range smaller than the range specified in the pharmacopeia, various technological conditions are also controlled strictly while controlling the pH, and the moisture, relevant substances, polymers and other various important parameter indexes also can be controlled to within a great range, so that the stability of the amoxicillin sodium/sulbactam sodium for injection can be further improved, and as a result, the effect and safety on taking the amoxicillin sodium/sulbactam sodium for injection can be ensured.

The invention relates to compound amoxicillin sodium and a preparation method thereof, and particularly relates to a compound amoxicillin sodium liposome drug prepared by using a packaging technology and a preparation method thereof. The drug comprises the following components in parts by weight: 0.5-1.5 parts of amoxicillin sodium, 1-10 parts of berberine hydrochloride, 5-20 parts of lecithin, 1-10 parts of cholesterol, 10-40 parts of an organic solvent, 10-20 parts of propylene glycol, 0.1-1.0 part of laurocapram, and 30-60 parts of water for injection. The compound amoxicillin sodium liposome drug disclosed by the invention has targeting and long-term efficacy, reduces the toxicity and improves the stability of packaged drugs; and according to the invention, amoxicillin sodium and berberine hydrochloride are innovatively compounded, so that the curative effect of the drug is increased, and the toxicity of the drug is reduced. The compound amoxicillin sodium liposome drug has a broad market prospect.

The invention belongs to the field of the medicines for animals and discloses a painless synergistic amoxicillin powder injection for animals and a preparation method thereof. The powder injection comprises the following components in parts by weight: 48-52 parts of amoxicillin or amoxicillin sodium (active ingredient), 10-30 parts of a cosolvent, 1-3 parts of an analgetic, 5-8 parts of probenecid sodium and 1-2 parts of an antifebrile anti-inflammatory analgesic. The preparation method of the powder injection comprises the following steps of: in parts by weight, evenly mixing 1-3 parts of analgetic, 5-8 parts of probenecid sodium and 1-2 parts of antifebrile anti-inflammatory analgesic together, and then evenly mixing the mixture with 48-52 parts of amoxicillin or amoxicillin sodium (active ingredient) and 10-30 parts of cosolvent, thereby obtaining the painless synergistic amoxicillin powder injection. The amoxicillin powder injection prepared by the preparation method provided by the invention solves the problems of strong injection pricking stress, poor effects of anti-inflammation and analgesia, and heat elimination and defervescence, ingestion reduction after the administration of the drug, and the like; and the product is highly required in clinical application, and is wide in market prospect and huge in social benefit.

Disclosed is an antibacterial medicinal composition of cefsulodine sodium for injection, which comprises cefsulodine sodium and amoxicillin sodium by the weight ratio of 1-32 : 1. The composition can be used for treating various infection caused by sensitive bacteria.