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Compound amoxicillin sodium liposome drug and preparation method thereof

A technology of amoxicillin sodium lipid and amoxicillin sodium, which is applied in the field of compound amoxicillin sodium liposome medicine and its preparation, can solve the problems of complex antigenic determinants, inaccurate immune effects, and differences in immune mechanisms, and achieve Improve drug efficacy, good inhibitory effect, reduce the effect of dosage

Active Publication Date: 2015-02-18
CHONGQING TAITONG ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, vaccine immunization, due to the complexity of intestinal microbial antigens and epitopes, the immune mechanism is slightly different, and the immune effect is not exact
With the clinical abuse of antibacterial drugs, bacterial resistance is very common, such as gentamicin, oxytetracycline, norfloxacin and other drugs commonly used in clinical efficacy are reduced

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A kind of compound recipe amoxicillin sodium liposome medicine, its raw material component is as follows:

[0020] 1 part of amoxicillin sodium, 5 parts of berberine hydrochloride, 5 parts of lecithin, 1 part of cholesterol, 20 parts of ethyl acetate, 10 parts of propylene glycol, 0.0.1 part of laurocapram, 60 parts of water for injection.

[0021] The preparation method of above-mentioned compound recipe amoxicillin sodium liposome medicine, the steps are as follows:

[0022] (1) Lecithin and cholesterol are dissolved in an organic solvent, and amoxicillin sodium is added to obtain a suspension;

[0023] (2) Evaporate the suspension prepared in step (1) under reduced pressure for 10-20min at 35-50°C, pressure 0.02-0.06Mpa, speed ≥ 70r / min, a film forms on the container wall, stop evaporation , Nitrogen 10-20min.

[0024] (3) Wash the liposome film prepared in step (2) with phosphate buffer at a rotation speed of ≥90r / min and 35-50°C for 1h, then let it stand for 1h t...

Embodiment 2

[0029] Compound amoxicillin sodium liposome medicine as described in embodiment 1, difference is that raw material component is as follows:

[0030] 1.5 parts of amoxicillin sodium, 7.5 parts of berberine hydrochloride, 10 parts of lecithin, 2 parts of cholesterol, 30 parts of PEG600, 10 parts of propylene glycol, 0.25 parts of laurocaprine, and 38 parts of water for injection.

[0031] The preparation steps are as described in Example 1, the difference is that the obtained compound amoxicillin sodium liposome drug is mixed with glucose, and stirred evenly to obtain the compound amoxicillin sodium liposome powder.

Embodiment 3

[0033] Compound amoxicillin sodium liposome medicine as described in embodiment 1, difference is that raw material component is as follows:

[0034] 0.5 parts of amoxicillin sodium, 5.5 parts of berberine hydrochloride, 15 parts of lecithin, 5 parts of cholesterol, 30 parts of PEG400, 10 parts of propylene glycol, 0.25 parts of laurocaprolactone, and 45 parts of water for injection.

[0035] The preparation steps are as described in Example 1, except that the obtained compound amoxicillin sodium liposome drug is dissolved in purified water to obtain the compound amoxicillin sodium liposome oral liquid.

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PUM

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Abstract

The invention relates to compound amoxicillin sodium and a preparation method thereof, and particularly relates to a compound amoxicillin sodium liposome drug prepared by using a packaging technology and a preparation method thereof. The drug comprises the following components in parts by weight: 0.5-1.5 parts of amoxicillin sodium, 1-10 parts of berberine hydrochloride, 5-20 parts of lecithin, 1-10 parts of cholesterol, 10-40 parts of an organic solvent, 10-20 parts of propylene glycol, 0.1-1.0 part of laurocapram, and 30-60 parts of water for injection. The compound amoxicillin sodium liposome drug disclosed by the invention has targeting and long-term efficacy, reduces the toxicity and improves the stability of packaged drugs; and according to the invention, amoxicillin sodium and berberine hydrochloride are innovatively compounded, so that the curative effect of the drug is increased, and the toxicity of the drug is reduced. The compound amoxicillin sodium liposome drug has a broad market prospect.

Description

technical field [0001] The invention relates to a compound amoxicillin sodium liposome medicine and a preparation method thereof. Background technique [0002] Bacterial infection is an acute systemic infection caused by pathogenic bacteria or opportunistic pathogenic bacteria invading the blood circulation to grow and reproduce, producing toxins and other metabolites. Clinically, it is characterized by chills, high fever, rash, arthralgia, and hepatosplenomegaly. Some may have septic shock and migratory lesions. Acute systemic infection caused by pathogenic microorganisms invading the blood from wounds or infected lesions in the body. Clinically, some patients may also experience irritability, cold extremities and cyanosis, thin and rapid pulse, rapid breathing, and decreased blood pressure. Especially those with chronic diseases or low immune function, those who are not treated in time and have complications may develop sepsis or sepsis. [0003] At present, for the tre...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61K9/127A61K47/34A61P31/04A61K31/43
CPCA61K9/127A61K9/1277A61K31/43A61K31/4375A61K47/34A61K2300/00
Inventor 李良洪
Owner CHONGQING TAITONG ANIMAL PHARMA
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