Compound amoxicillin sodium injection

A technology of amoxicillin sodium and injection, applied in the field of animal medicine, can solve the problems of inaccurate immune effect, complex antigenic determinants, and differences in immune mechanism, and achieve the effects of improving drug stability, good inhibitory effect, and high antibacterial activity

Inactive Publication Date: 2015-02-18
CHONGQING TAITONG ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, vaccine immunization, due to the complexity of intestinal microbial antigens and epitopes, the immune mechanism is slightly different, and the immune effect is not exact
With the clinical abuse of antibacterial drugs, bacterial resistance is very common, such as gentamicin, oxytetracycline, norfloxacin and other drugs commonly used in clinical efficacy are reduced

Method used

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  • Compound amoxicillin sodium injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Amoxicillin Sodium 100g

[0012] Berberine 100g

[0013] Tween 80 100g

[0014] Glycine 50g

[0015] Sodium sulfite 100g

[0016] PVP100g

[0017] A total of 500 sticks were prepared

[0018] Add amoxicillin sodium, glycine and PVP into 300ml of water for injection in turn; dissolve Tween and sodium sulfite in 400ml of water for injection, slowly add berberine under stirring until completely dissolved; combine the two solutions, and add water for injection To 1000ml, add activated carbon, stir, filter, sterilize, and fill.

Embodiment 2

[0020] Amoxicillin Sodium 150g

[0021] Berberine 100g

[0022] Tween 80 100g

[0023] Sodium sulfite 50g

[0024] Glycine 50g

[0025] PVP50g

[0026] A total of 500 sticks were prepared

[0027] Add amoxicillin sodium, glycine and PVP to 300ml of water for injection in sequence; dissolve Tween and sodium sulfite in 400ml of water for injection, slowly add berberine under stirring until completely dissolved; combine the two solutions, add water for injection to 1000ml, add activated carbon, stir, filter, sterilize, and fill.

Embodiment 3

[0029] Amoxicillin Sodium 200g

[0030] Berberine 100g

[0031] Tween 20100g

[0032] Sodium sulfite 55g

[0033] Glycine 55g

[0034] PVP100g

[0035] A total of 500 sticks were prepared

[0036] Add amoxicillin sodium, glycine and PVP to 300ml of water for injection in sequence; dissolve Tween and sodium sulfite in 400ml of water for injection, slowly add magnolol with stirring until completely dissolved; combine the two solutions, add water for injection to 1000ml, add activated carbon, stir, filter, sterilize, and fill.

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PUM

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Abstract

The invention provides a compound amoxicillin sodium injection with a synergistic antibacterial effect. The composition comprises the following components in parts by weight: 1-4 parts of amoxicillin sodium, 1-2 parts of berberine, 0.5-1 part of sodium sulfite, 0.5-1 part of glycine, 1-2 parts of Tween and 1-2 parts of PVP. The injection disclosed by the invention is high in stability, and simple in preparation process, has a good inhibiting effect on gram-negative bacillus, and a wide market prospect, and is capable of reducing the dosage of a single preparation and shortening the treatment cycle.

Description

technical field [0001] The present invention relates to a medicine for animals, in particular to a compound preparation of antibiotics, especially to an injection of amoxicillin sodium and berberine. Background technique [0002] Bacterial infection is an acute systemic infection caused by pathogenic bacteria or opportunistic pathogenic bacteria invading the blood circulation to grow and reproduce, producing toxins and other metabolites. Clinically, it is characterized by chills, high fever, rash, arthralgia, and hepatosplenomegaly. Some may have septic shock and migratory lesions. Acute systemic infection caused by pathogenic microorganisms invading the blood from wounds or infected lesions in the body. Clinically, some patients may also experience irritability, cold extremities and cyanosis, thin and rapid pulse, rapid breathing, and decreased blood pressure. Especially those with chronic diseases or low immune function, those who are not treated in time and have complic...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61K9/14A61P31/04A61K31/43
CPCA61K31/4375A61K9/0019A61K9/08A61K31/43A61K47/32A61K2300/00
Inventor 李良洪
Owner CHONGQING TAITONG ANIMAL PHARMA
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