Painless synergistic amoxicillin powder injection for animals and preparation method thereof

Abstract

The invention belongs to the field of the medicines for animals and discloses a painless synergistic amoxicillin powder injection for animals and a preparation method thereof. The powder injection comprises the following components in parts by weight: 48-52 parts of amoxicillin or amoxicillin sodium (active ingredient), 10-30 parts of a cosolvent, 1-3 parts of an analgetic, 5-8 parts of probenecid sodium and 1-2 parts of an antifebrile anti-inflammatory analgesic. The preparation method of the powder injection comprises the following steps of: in parts by weight, evenly mixing 1-3 parts of analgetic, 5-8 parts of probenecid sodium and 1-2 parts of antifebrile anti-inflammatory analgesic together, and then evenly mixing the mixture with 48-52 parts of amoxicillin or amoxicillin sodium (active ingredient) and 10-30 parts of cosolvent, thereby obtaining the painless synergistic amoxicillin powder injection. The amoxicillin powder injection prepared by the preparation method provided by the invention solves the problems of strong injection pricking stress, poor effects of anti-inflammation and analgesia, and heat elimination and defervescence, ingestion reduction after the administration of the drug, and the like; and the product is highly required in clinical application, and is wide in market prospect and huge in social benefit.

Description

technical field [0001] The invention belongs to the field of veterinary drugs, and relates to a painless and synergistic penicillin powder injection and a preparation method thereof, in particular to a veterinary painless and synergistic amoxicillin powder injection and a preparation method thereof. technical background [0002] Amoxicillin and other penicillins are bactericidal β-lactam broad-spectrum antibiotics, which can kill a variety of Gram-positive and Gram-negative bacteria, and are one of the most widely used antibiotics in clinical practice. In human medicine, it is widely used in the form of tablets, powder injections, granules, powders, and capsules; in veterinary medicine, it is also used in powder injections, powders, tablets, and oily suspension injections. Amoxicillin is one of the antibiotics currently shared by humans and animals. [0003] At present, amoxicillin and other penicillins have relatively good application effects in veterinary medicine, and th...

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Problems solved by technology

[0004] In fact, the penicillin powder injections such as amoxicillin currently used in veterinary medicine are generally single powder injections made of penicillin such as amoxicillin or amoxicillin sodium or penicillin sodium (potassium) salt, and are commonly injected into pigs and other livestock. There is stinging stress, pain during injection and diffusion of the drug solution after injection, these pains will cause some adverse stress reactions, some of which are very strong

Many farms have reported that when and after injection with this single penicillin powder such as amoxicillin, livestock, especially young animals, are found to have strong stinging stress, irritability, head hitting the barn, jumping and trembling, screaming One or more stress symptoms such as strange screams, decreased feed intake, lying on the ground, reduced lactation of female animals, abortion of pregnant animals, premature birth, etc., have brought considerable economic losses to farmers; in addition, due to the amoxicillin The half-life is short. After this kind of single powder injection is used, the action time is not long and cannot last long. The medicine is taken 2 to 3 times a day, which increases the work frequency and labor intensity of veterinarians. The antipyretic and antipyretic effect is not ideal, and there are still quite a few livestock that eat less food or are in a fasting state for a period of time after taking the drug

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