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Hydrochloric acid boningmycin solid preparation and preparation method thereof

A technology of boningmycin hydrochloride and solid preparations, applied in the field of medicine, can solve problems such as poor stability, achieve good stability, simple preparation process, simple production conditions and equipment

Active Publication Date: 2012-05-23
MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is to provide a solid preparation for external use containing bonomycin hydrochloride, which solves the problem of poor stability of bonomycin hydrochloride liquid or semi-solid preparations

Method used

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  • Hydrochloric acid boningmycin solid preparation and preparation method thereof
  • Hydrochloric acid boningmycin solid preparation and preparation method thereof
  • Hydrochloric acid boningmycin solid preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Calculated by preparing 1000 tablets, the weight of raw and auxiliary materials consists of: boningmycin hydrochloride 15g, lactose 251g as filler, polyethylene glycol 4000 3g as lubricant, polyvinylpyrrolidone K30 6g as binder, 25g of sodium carboxymethyl starch as a disintegrant. Mix the raw materials and auxiliary materials of the above-mentioned prescription amount evenly, and directly compress into tablets to obtain the bonomycin hydrochloride soluble tablet of the present invention, each tablet contains 15 mg of bonomycin hydrochloride, and the theoretical tablet weighs 300 mg.

[0027] Preparation of special solvent for soluble tablets (dispersible tablets): Take 20g of hypromellose 2910, 1g of benzalkonium chloride, add an appropriate amount (about 300ml) of hot water at 80-90°C, stir well to hydrate, then place it at room temperature to completely After dissolving, add water to 1000ml, shake well, that is.

Embodiment 2

[0029]Calculated by preparing 1000 tablets, the weight of raw and auxiliary materials consists of: boningmycin hydrochloride 1.5g, glucose 270.5g as filler, sodium stearyl fumarate 4g as lubricant, methyl cellulose as binder Su 4g, low-substituted hydroxypropyl cellulose 20g as a disintegrant. Mix the raw materials and auxiliary materials of the above-mentioned prescription amount evenly, and directly compress into tablets to obtain the bonomycin hydrochloride soluble tablet of the present invention, each tablet contains 1.5 mg of bonomycin hydrochloride, and the theoretical tablet weighs 300 mg.

[0030] Preparation of special solvent for soluble tablets (dispersible tablets): Take 20g of sodium alginate, 10g of methylparaben, add appropriate amount of water (about 300ml), stir well to disperse evenly, place at room temperature to dissolve completely, add water to 1000ml, shake Uniform, that is.

Embodiment 3

[0032] Calculated by preparing 1000 tablets, the weight of raw and auxiliary materials consists of: boningmycin hydrochloride 150g, lactose 45g as filler, boric acid 15g as lubricant, maltodextrin 30g as binder, Sodium carboxymethyl starch 60g. Mix the raw materials and auxiliary materials of the above-mentioned prescription amount evenly, and directly compress into tablets to obtain the bonomycin hydrochloride soluble tablet of the present invention, each tablet contains 150 mg of bonomycin hydrochloride, and the theoretical tablet weighs 300 mg.

[0033] Preparation of special solvent for soluble tablets (dispersible tablets): Take 50g of sodium carboxymethylcellulose, 50g of benzyl alcohol, add an appropriate amount of water (about 300ml), stir well to disperse evenly, place at room temperature to dissolve completely, add water to 1000ml, shake Uniform, that is.

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Abstract

The invention provides a hydrochloric acid boningmycin solid preparation, which is a soluble tablet or a dispersible tablet. The compositions and weight percentages of the hydrochloric acid boningmycin solid preparation are as follows: 0.5 to 50wt% of hydrochloric acid boningmycin, 15 to 99.4wt% of fillers achieving a filling effect, 0 to 20wt% of disintegrants achieving a disintegration effect, 0 to 10 wt% of adhesives achieving an adhesion effect and 0.1 to 5wt% of lubricants achieving a lubrication effect. The invention also provides a preparation method of the soluble tablet and the dispersible tablet. By adopting the hydrochloric acid boningmycin tablet provided by the invention, on the one hand, the deficiency that preparations such as ointment, gel, and the like have poor stabilityafter being placed for a long time under a room temperature condition is overcome, and the storage and the carrying are facilitated; and on the other hand, before being used, the tablet is added to aspecial solvent so as to be dissolved or dispersed to form a water solution or an injectable suspension with certain viscosity, and thereby the tablet also has the advantage of a semi-solid or liquidexternal preparation on the aspects of the use and the pharmaceutical effect.

Description

technical field [0001] The invention relates to the technical field of medicine, more specifically, a skin and mucous membrane external solid preparation containing the active ingredient of boningmycin hydrochloride, including soluble tablets and dispersible tablets, and also relates to a preparation method of the preparation. Background technique [0002] Boningmycin hydrochloride is a new antibiotic, its chemical structure is glycopeptides, belonging to the Bleomycin (Bleomycin) family of drugs. Boningmycin hydrochloride is a new compound obtained by microbial fermentation and extraction originally created by the Institute of Pharmaceutical Biotechnology, Chinese Academy of Medical Sciences. There are no reports of listing or clinical use at home and abroad. Therefore, boningmycin hydrochloride and its related preparations belong to the first class of chemical drugs. For the research of its preparation, all do not see any research report both at home and abroad. Studies ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K38/14A61P35/00A61P31/20A61P17/06A61P17/00
Inventor 李桂玲李眉陈汝贤许鸿章
Owner MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
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