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Child soluble amantadine hydrochloride soluble tablet

A technology of amantadine hydrochloride and children's amantadine hydrochloride, which is applied in the field of children's amantadine hydrochloride soluble tablets, can solve the problems of inconvenient dose division operation and inability to realize personalized drug administration requirements, and achieve the effect of rapid onset of action and high bioavailability

Inactive Publication Date: 2010-09-01
何德义
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0004] At present, the "Usage and Dosage" item in the instructions for use of amantadine hydrochloride tablets in China stipulates that "children aged 1 to 9 years old should take 1.5-3 mg / kg once every 8 hours, or 2.2-4.4 mg / kg once every 12 hours. ;” However, the drug specification is 100mg per tablet, which cannot be conveniently and accurately divided into doses, and in fact cannot achieve the prescribed individualized drug administration requirements

Method used

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Embodiment Construction

[0031] The focus of the present invention is to enable each child who needs to take amantadine hydrochloride preparations to obtain the most suitable dosage for them simply and easily through innovative specifications and styles of products, so as to achieve the purpose of safe, effective and convenient treatment . Relatively, the types and dosages of excipients under specific specifications, and even whether they are soluble tablets, effervescent tablets, or buccal tablets, are not the most important.

[0032] (1) Take 1.5g to 3.0g of amantadine hydrochloride, feed certain excipients in an appropriate proportion, carry out wet or dry granulation in a certain way, and then press into 1000 tablets, or mix all the main ingredients and The dry powder of the auxiliary material is directly mixed and pressed into 1000 tablets. The tablets made according to this plan are taken 3 times a day, 1 tablet per 1 kg of body weight each time.

[0033] (2) Take 3.0 g to 6.0 g of amantadine ...

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Abstract

The invention relates to an amantadine hydrochloride soluble tablet exclusively used for children, which is made up of an effective dose of hydrochloric acid admantadine and a water soluble medical excipient that can rapidly disintegrate and release drugs. Patients determine the dose of the tablet according to weight, thus realizing personalized medicine administration and ensuring the medicine intake dose more appropriate with higher security. Once in solution, the medicine instantly becomes a sweet and sour beverage, which is more easily to be accepted by children; meanwhile the medicine solution is easily to be absorbed fully and the bioavailability is high.

Description

1. Technical field [0001] The invention belongs to the field of pharmaceutical preparations. Specifically, it relates to an oral formulation of amantadine hydrochloride specially designed for children, specifically a soluble amantadine hydrochloride tablet for children. 2. Background technology [0002] Amantadine hydrochloride is an antiviral drug, and its chemical name is tricyclo[3.3.1.13,7]decane-1-amine hydrochloride. Amantadine was the first antiviral drug approved in the United States. Earlier studies suggested that it works by preventing the influenza virus from penetrating and / or shedding its outer membrane. Recent studies have found that low concentrations of drugs interact with viral hemagglutinin to inhibit virus assembly; high concentrations inhibit early infection, including inhibition of viral envelope fusion with secondary lysosomal membranes. There are many opinions about the mechanism of action, such as closing the virus channel on the cell membrane; inh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/13A61K9/20A61K47/12A61P31/12A61P31/16
Inventor 何德义
Owner 何德义
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