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Gibberellic-acid soluble tablet and preparing method thereof

A gibberellic acid and soluble technology, which is applied in the field of gibberellic acid soluble tablets and its preparation, can solve the problems of crystallization, affecting drug efficacy, inconvenient use, etc., and achieve the effect of increasing storage time, improving shelf life, and not being easily permeable

Inactive Publication Date: 2019-08-09
PILARQUIM SHANGHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Because the original drug of gibberellic acid is difficult to dissolve in water, it must be dissolved in ethanol or high-grade liquor first when preparing, and then diluted with water to the required concentration, which is inconvenient to use, so it is often made into soluble tablets, gibberellic acid soluble tablets The agent not only maintains the effective components and biological activity of the original drug of gibberellic acid, but also can be directly formulated with water to the required concentration. However, in humid areas, the soluble tablets of gibberellic acid are prone to water absorption and crystallization, which makes the tablets unable to form ingredients. Dissolved and dispersed in water, the active ingredients are not well applied, thus affecting the efficacy

Method used

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  • Gibberellic-acid soluble tablet and preparing method thereof
  • Gibberellic-acid soluble tablet and preparing method thereof
  • Gibberellic-acid soluble tablet and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1: A gibberellic acid soluble tablet, each component and its corresponding parts by weight are shown in Table 1, and are prepared through the following steps:

[0045] Step 1, preparation of coating agent: put polyethylene glycol 6000, talc powder, titanium dioxide, and hypromellose into a high-speed mixer and mix for 30 minutes at a speed of 2500 r / min;

[0046] Step 2, the gibberellic acid GA 3 , sodium dinaphthylmethanedisulfonate, hydroxymethyl cellulose, cross-linked hydroxymethyl cellulose sodium, and butylated hydroxyanisole were put into a mixer and mixed for 30 minutes, and then put into a pulverizer for pulverization. Vacuum low-temperature drying and pressing into tablets by a tablet machine, wherein the low-temperature vacuum drying temperature is 40°C, and the vacuum degree is -0.08MPa;

[0047] Step 3, use an air suction pump to remove the fine powder outside the tablet prepared in step 2, and then put it into a tablet press that is pre-filled ...

Embodiment 2-6

[0048] Example 2-6: A gibberellic acid soluble tablet, the difference from Example 1 is that each component and its corresponding parts by weight are shown in Table 1.

[0049] Each component and parts by weight thereof in table 1 embodiment 1-6

[0050]

Embodiment 7

[0051] Embodiment 7: a kind of gibberellic acid soluble tablet, differs from embodiment 1 in that:

[0052] Step 1, preparation of coating agent: put 0.3 part of polyethylene glycol 6000, 0.15 part of talc, 0 part of titanium dioxide, 0.3 part of hypromellose and 0.03 part of pregelatinized corn starch into a high-speed mixer and mix for 30 minutes, Speed ​​2500r / min;

[0053] All the other are identical with embodiment 1.

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Abstract

The invention discloses a gibberellic-acid soluble tablet and a preparing method thereof, and relates to the technical field of pesticide preparing. The gibberellic-acid soluble tablet and the preparing method thereof are characterized in that the gibberellic-acid soluble tablet is prepared from, by weight, 20-25 parts of gibberellic acid GA3, 1-5 parts of a dispersing agent, 0.5-4 parts of a binding agent, 0.5-4 parts of a disintegrating agent, 0.05-0.2 part of an antioxidant and 3-5 parts of a coating agent, wherein the coating agent is prepared from, by percentage content, 10%-20% of polyethylene glycol, 5%-30% of talcum powder, 0%-20% of titanium dioxide and 10%-30% of hydroxypropyl methylcellulose. The tablet is packaged with a layer of coating, the humidity resistance of the gibberellic-acid soluble tablet is greatly improved, and the shelf life is prolonged.

Description

technical field [0001] The invention relates to the technical field of pesticide preparation, more specifically, it relates to a gibberellic acid soluble tablet and a preparation method thereof. Background technique [0002] Gibberellin is a mixture of various homologues, and their biological activities on plants are quite different, among which GA 3 、GA 4 、GA 7 、GA 14 The activity is stronger, gibberellic acid GA 3 is particularly prominent. [0003] The most obvious biological activity of gibberellic acid is to stimulate the growth of plant cells, make the plant grow taller and the leaves increase; it can break the dormancy of seeds, tubers and roots, and promote their germination; it can stimulate the growth of fruits, increase the seed setting rate or form seedless fruits ; Part of the role of long-day sunshine, so that some plants can also bolting and flowering under short-day conditions. [0004] Because the original drug of gibberellic acid is difficult to disso...

Claims

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Application Information

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IPC IPC(8): A01N25/34A01N45/00A01N43/12A01N25/22
CPCA01N25/22A01N25/34A01N43/12A01N45/00
Inventor 代全启
Owner PILARQUIM SHANGHAI
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