Southernwood oil and medicine uses of its preparations

A technology of artemisia annua oil and preparations, which is applied in the directions of medical preparations, pharmaceutical formulations, and pill delivery containing active ingredients, and can solve the problems of antibacterial, antiviral and antipyretic that have not yet been seen in artemisia annua oil.

Inactive Publication Date: 2008-12-03
薛永新
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the reports on Artemisia annua are about the antimalarial effect of artemisinin. So far, there have been no reports about the antibacterial, antiviral and antipyretic properties of Artemisia annua oil, especially retroviruses including anti-HIV.

Method used

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  • Southernwood oil and medicine uses of its preparations
  • Southernwood oil and medicine uses of its preparations
  • Southernwood oil and medicine uses of its preparations

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Preparation of artemisinin mother liquor

[0015] Add the crude drug of Artemisia annua to No. 6 gasoline for extraction, put the extract on a silica gel column, recover the solvent from the effluent to obtain mother liquor A; add an eluent (petroleum ether: ethyl acetate = 95:5) to the silica gel column to elute until the Artemisia annua The eluent is eluted completely, the eluent is concentrated and crystallized, the crystallization solution is filtered to obtain the filtrate and the artemisinin recrystallization product, the solvent is recovered from the filtrate to obtain the mother liquor B, and the mother liquor A and the mother liquor B are combined to obtain the artemisinin mother liquor.

Embodiment 2

[0017] The test of Artemisia annua oil killing HIV: Artemisia annua oil and HIV virus (TCID 50 =1.78×10 5 After co-incubating for 1 hour, the HIV-1 P24 kit of Biomerieux was used to measure the amount of antigen P24, thereby deducing the amount of HIV virus. Inhibition rate=100×(1-measured OD value / HIV virus liquid control).

[0018] Artemisia annua oil has activity of killing HIV in vitro

[0019] The test of Artemisia annua oil directly killing HIV in vitro shows that Artemisia annua oil has a certain direct killing effect on HIV virus. When the concentration is 0.10mg / ml, the direct killing rate of HIV virus has reached more than 73%. The inhibitory effect is more obvious, as shown in Table 1.

[0020] Table 1 HIV-1P24 antigen detection method to detect the killing effect of Artemisia annua oil on HIV

[0021]

[0022]

Embodiment 3

[0024] Artemisia annua oil inhibits HIV-1 reverse transcriptase activity in vitro: add reverse transcriptase standard solution to the drug solution, and then use the Retrosys reverse transcriptase activity test kit from Innovagen Company to measure. Inhibition rate = 100 × (1 - measured OD value / positive control).

[0025] The test of Artemisia annua oil inhibiting the reverse transcriptase activity of HIV-1 in vitro shows that Artemisia annua oil has an inhibitory effect on the reverse transcriptase of HIV-1. The inhibition of recording enzyme reached 75.05%, see Table 2.

[0026] Table 2 The test results of artemisia annua oil in vitro on the reverse transcriptase inhibitory effect of HIV-1

[0027]

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PUM

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Abstract

The invention relates to the Chinese traditional medicine technical field, in particular to artemisia oil and a medicinal application of a preparation thereof, namely artemisia oil and a medicinal application of a preparation thereof in treating and preventing AIDS, flue, herpes, hepatitis and inflammatory reactions caused by pathogenic microbes, wherein the artemisia oil preparation can be an oral formulation, an injection, an external-use formulation and various sustained-release and controlled-release formulations; the oral formulation comprises a capsule, a tablet, a pill, pills drops a tiny capsule, a film-coated tablet and a sugar-coated tablet; the extracting manner can be realized by preparing beta-cyclodextrin inclusion compounds through beta-cyclodextrin inclusion; and the preparation method can be a saturated water solution method, a grinding method, a freeze-drying method and an ultrasonic method, wherein the applied sustained-release coating technique comprises a pH dependent type sustained-release coating technique, a corrosion delay coating technique and a colon enzyme degradation sustained-release coating technique, etc.

Description

Technical field: [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to the medical application of artemisia annua oil and its preparations, that is, artemisia annua oil and its preparations are used to treat and prevent AIDS, influenza, herpes, hepatitis and inflammatory diseases caused by pathogenic microorganisms. Medicinal use in response to disease. Background technique: [0002] In the prior art, Artemisia annua is one of the commonly used traditional Chinese medicines, and its antimalarial effect is relatively strong, and it is also curative for chronic bronchitis. Most of the reports about Artemisia annua are about the antimalarial effect of artemisinin. Up to now, no report has been seen about the antibacterial, antiviral and antipyretic properties of Artemisia annua oil, especially retroviruses including anti-HIV. Invention content: [0003] The object of the present invention is to provide the medical a...

Claims

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Application Information

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IPC IPC(8): A61K36/282A61K9/20A61K9/28A61K9/48A61K9/50A61K47/40A61P31/14A61P31/16A61P31/18A61P31/20A61P31/00
Inventor 薛永新
Owner 薛永新
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