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Berberine hydrochloride pellet and preparation method thereof

Inactive Publication Date: 2021-04-02
CHENGDU JINHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides a kind of berberine hydrochloride pellets and a preparation method thereof, in order to solve the problem that both sugar-coated tablets and film-coated tablets have long disintegration time, cannot quickly achieve dissolution and release, and cannot play the role of rapid onset of action question

Method used

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  • Berberine hydrochloride pellet and preparation method thereof
  • Berberine hydrochloride pellet and preparation method thereof
  • Berberine hydrochloride pellet and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0035] A kind of berberine hydrochloride pellets, after berberine hydrochloride is prepared into quick-release pellets according to prescription, after adopting gelatin hollow capsules to fill, obtain promptly; Said prescription composition is as follows:

[0036] 54.47% of berberine hydrochloride, 10.89% of corn starch or microcrystalline cellulose, 8.50% of pregelatinized starch, 3.81% of carboxymethyl starch sodium or carmellose calcium, and the balance is water or aqueous solution. Water is purified water.

[0037] A preparation method for berberine hydrochloride pellets, for preparing berberine hydrochloride pellets, such as figure 1 shown, including the following steps:

[0038] Step S1. Get the berberine hydrochloride, cornstarch or microcrystalline cellulose, pregelatinized starch, carboxymethyl starch sodium or carmellose calcium of prescription quantity and place in the granulating pot, set stirring speed 120rpm, shearing speed 600rpm, premix for 5 minutes;

[003...

Embodiment 2

[0055] Embodiment 2 is a further application of Embodiment 1.

[0056] 1) Take 100g of berberine hydrochloride, 20g of cornstarch, 15.6g of pregelatinized starch, and 7g of carboxymethyl starch sodium and place them in the granulation pot, set the stirring speed at 120rpm, the shearing speed at 600rpm, and pre-mix for 5 minutes; 2) keep The above parameters remain unchanged, weigh 41g of purified water into the slurry tank, set the atomization pressure of slurry addition to 0.2-0.25Mpa, and perform slurry addition, and the slurry addition time is controlled at 30-60 seconds; 3) After the slurry addition is completed, set the stirring The rotation speed is 120rpm, the shear rotation speed is 1200rpm, and the granulation is 1min. After the granulation is completed, the material is discharged; 4) The prepared intermediate is extruded by a screw, and the screen is 40 mesh; 5) The extruded soft material is placed in a spheronizing pot, and the speed is set at 500-1000rpm for sphero...

Embodiment 3

[0058] Embodiment 3 is a further application of Embodiment 1.

[0059] 1) Take 100g of berberine hydrochloride, 20g of microcrystalline cellulose, 15.6g of pregelatinized starch, and 7g of carboxymethyl starch sodium in a granulation pot, set the stirring speed at 120rpm, the shearing speed at 600rpm, and pre-mix for 5 minutes; 2 ) Keep the above parameters unchanged, weigh 41g of purified water into the slurry tank, set the atomization pressure of slurry addition to 0.2-0.25Mpa, and add slurry, and the slurry addition time is controlled at 30-60 seconds; 3) After the slurry addition is completed, Set the stirring speed at 120rpm, the shearing speed at 1200rpm, and granulate for 1min. After the granulation is completed, the material is discharged; 4) The prepared intermediate is extruded by a screw, and the screen is 40 mesh; 5) The extruded soft material is placed in a spheronizing pot, and the speed is set at 500-1000rpm for spheronization, that is Obtain pellets with a dia...

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PUM

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Abstract

The invention provides a berberine hydrochloride pellet and a preparation method thereof. The preparation method comprises the following steps: S1, putting a prescription quantity of raw materials into a granulating pot, and performing premixing for 5 minutes at a stirring speed of 120rpm and a shearing speed of 600rpm; S2, weighing purified water, adding the weighed purified water into a slurry adding tank, setting the slurry adding atomization pressure to be 0.2-0.25 Mpa, adding slurry, and controlling the slurry adding time to be 30-60 seconds; S3, after the slurry is added, setting the stirring rotating speed to be 120rpm and the shearing rotating speed to be 1200rpm, performing granulating for 1 minute and performing discharging after the granulation is finished; S4, extruding a prepared intermediate by adopting a screw rod, wherein the size of a screen is 40 meshes; S5, placing the extruded soft material in a rounding pot, setting the rotating speed to be 500-1000 rpm, and performing rounding so as to obtain the pellet with the diameter ranging from 1.5 mm to 2.7 mm; S6, laying the pellet on a baking tray, and drying the pellet at the temperature of 55-65 DEG C until the moisture content is 13-16%; and S7, performing stuffing into gelatin hollow capsules through a capsule stuffing machine. The berberine hydrochloride pellet solves the problems that existing sugar-coated tablets and film-coated tablets have long disintegration time, cannot dissolve and release quickly, and cannot take effect quickly.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine pellets, in particular to a berberine hydrochloride pellet and a preparation method thereof. Background technique [0002] Berberine hydrochloride, also known as berberine, is an alkaloid extracted from plants such as Cortex Phellodendron, Coptidis Rhizoma, and Three Needles, and can also be synthesized artificially. Its molecular formula is C20H18CLNO4·2H2O. [0003] Berberine hydrochloride has a broad antibacterial spectrum, and has antibacterial effects on a variety of Gram-positive and negative bacteria in vitro, including hemolytic streptococci, Staphylococcus aureus, and Vibrio cholerae. Meningococcus, Shigella dysenteriae, typhoid bacillus, diphtheria bacillus, etc. have a strong inhibitory effect, inhibiting bacteria at low concentrations and sterilizing at high concentrations. It also has a certain inhibitory effect on influenza virus, amoeba, leptospira, and some sk...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/38A61K47/36A61K47/42A61K31/4375A61P31/04
CPCA61K9/1652A61K9/4825A61K31/4375A61P31/04
Inventor 江敏唐金容张波练心结罗洪罗丹胡晶杨鑫嵎严冬郭敏
Owner CHENGDU JINHUA PHARMA
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