Traditional Chinese medicine superfine crushing and orally disintegrating granule composition and preparation method thereof

A technology of ultrafine pulverization and composition, which is applied in the direction of drug delivery, pharmaceutical formulations, active ingredients of hydroxyl compounds, etc. It can solve the problems of complicated operations and achieve rapid disintegration, high bioavailability, and convenient use.

Inactive Publication Date: 2017-08-18
洛阳泽达慧康医药科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Patent CN 104523791 A "A Fresh Ginseng Active Extract Orally Disintegrating Tablet and Its Preparation Method", wherein the preparation method of the fresh ginseng active extract requires purification, coarse powder, countercurrent ultrasonic extraction, and concentration of the extract by a reverse osmosis concentrator , freeze-drying and other steps, the operation is complicated, and the product may not fully reflect the ingredients of the medicinal materials

Method used

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  • Traditional Chinese medicine superfine crushing and orally disintegrating granule composition and preparation method thereof
  • Traditional Chinese medicine superfine crushing and orally disintegrating granule composition and preparation method thereof
  • Traditional Chinese medicine superfine crushing and orally disintegrating granule composition and preparation method thereof

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preparation example Construction

[0017] The preparation method of the described traditional Chinese medicine ultrafine grinding orally disintegrating granule composition comprises the following steps:

[0018] Step 1. Superfinely pulverize the raw material of traditional Chinese medicine, pass through a 400-mesh-1000-mesh sieve to obtain the main drug, and set aside;

[0019] Step 2. Take 5-20% of the main drug, 70-90% of the filler, 1-5% of the binder, 1-5% of the disintegrant, 0.1-5% of the flavoring agent and 0.5% of the glidant according to the above weight percentage. ~3%, mixed evenly, made into soft material, set aside;

[0020] Step 3. Extrude and granulate the soft material in step 2, pass through a 5-15 mesh sieve, then dry at 30-70°C until the water content is lower than 10%, granulate with a 12-40 mesh sieve, and pack, that is The preparation of the traditional Chinese medicine ultrafinely pulverized orally disintegrating granule composition is completed.

[0021] The filler is one or more of ma...

Embodiment 1

[0028] The traditional Chinese medicine superfine powder oral disintegration granule for eliminating phlegm and relieving sore throat. The production method is:

[0029] Weigh the materials according to the following formula and mix them evenly. Extrude and granulate, pass through a 10-mesh sieve, dry at 50°C, take out after 1 hour and granulate with a 24-mesh sieve. Ready to serve.

[0030]

Embodiment 2

[0032] The traditional Chinese medicine superfine powder oral collapse granule for promoting blood circulation and removing blood stasis. The production method is:

[0033] Weigh the materials according to the following formula and mix them evenly. Extrude and granulate, pass through a 10-mesh sieve, dry at 50°C, take out after 1 hour and granulate with a 24-mesh sieve. Ready to serve.

[0034]

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Abstract

The invention discloses a traditional Chinese medicine superfine crushing and orally disintegrating granule composition. The traditional Chinese medicine superfine crushing and orally disintegrating granule composition is prepared from a main medicine and a substrate, wherein the main medicine is superfine crushed traditional Chinese medicine powder with granularity of 400 to 1000 meshes; the substrate is prepared from a filling agent, an adhesive, a disintegrating agent, a flavoring agent and a flowing aid; the composition is prepared from the following raw materials in percentage by weight according to the content of components: 5 to 20% of main medicine, 70 to 90% of filling agent, 1 to 5% of adhesive, 1 to 5% of disintegrating agent, 0.1 to 5% of flavoring agent and 0.5 to 3% of flowing aid, and the sum of weight percentages of the components is 100%. The traditional Chinese medicine superfine crushing and orally disintegrating granule composition has the advantages that by combining a traditional Chinese medicine superfine crushing technique and an orally integrating preparation technique, the quick-release advantages of the traditional Chinese medicine superfine crushing technique and the orally integrating preparation technique are realized, the composition can be quickly disintegrated and released in an oral cavity, and the composition is especially suitable for medicines for respiratory tract and first-aid medicines for sublingual; compared with the preparations, the disintegrating is quick, the effect is quick, the bioavailability is high, the effect of taking without water is realized, and the convenience in use is realized.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine ultrafinely pulverized orally disintegrating granule composition and a preparation method thereof. Background technique [0002] Orally disintegrating preparations refer to solid preparations that can be dissolved in the oral cavity without water or with only a small amount of water. Compared with ordinary preparations, orally disintegrating preparations have the characteristics of fast onset of action and high bioavailability, are used for local or systemic treatment, are convenient to take, and are suitable for a wide range of people. It is a new type of solid immediate release formulation. In the field of traditional Chinese medicine, orally disintegrating preparations can not only increase the dissolution and absorption of insoluble active ingredients, but also improve the hygroscopicity, stability, irritatio...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/38A61K36/484A61K36/537A61K36/888A61K31/045
CPCA61K9/0056A61K9/1652A61K31/045A61K36/126A61K36/232A61K36/258A61K36/346A61K36/484A61K36/537A61K36/888A61K2300/00
Inventor 刘雪松栾连军刘永孙彤荆海英
Owner 洛阳泽达慧康医药科技有限公司
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