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Atomoxetine tablet composition

A technology for atomoxetine tablets and compositions, applied in the field of pharmaceutical preparations, can solve the problems that highly bitter and highly water-soluble drugs are not very successful, affect normal use, loose tablets, etc., and achieve content uniformity that is difficult to control and improve. The effect of content uniformity and stability improvement

Inactive Publication Date: 2018-03-16
WEIHAI GUANBIAO INFORMATION TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has been reported in the literature that this method is not very successful for highly bitter and highly water soluble drugs
In addition, atomoxetine is easy to absorb moisture. When the tablet is stored at room temperature for about 1 year, the tablet will become loose, and the related substances will increase significantly, which will affect its normal use.

Method used

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  • Atomoxetine tablet composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1. Atomoxetine 5g, β-cyclodextrin 18g, calcium sulfate 30g, fumed silica 16g, lactose 30g, low-substituted hydroxypropyl methylcellulose 6g, sorbitol 2g, magnesium stearate 0.8 g, prepare 1000 tablets according to the preparation method described in the technical scheme.

Embodiment 2

[0023] Example 2, atomoxetine 30g, β-cyclodextrin 26g, calcium sulfate 46g, fumed silica 8g, lactose 50g, low-substituted hydroxypropyl methylcellulose 12g, sorbitol 5g, magnesium stearate 1.5 g, prepare 1000 tablets according to the preparation method described in the technical scheme.

Embodiment 3

[0024] Example 3, atomoxetine 10g, β-cyclodextrin 22g, calcium sulfate 40g, fumed silica 12g, lactose 40g, low-substituted hydroxypropyl methylcellulose 9g, sorbitol 4g, magnesium stearate 1.0 g, prepare 1000 tablets according to the preparation method described in the technical scheme.

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PUM

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Abstract

The invention relates to an atomoxetine composition and belongs to the technical field of pharmaceutical preparations. The technical scheme of the present invention is: a kind of atomoxetine tablet composition, in the composition of unit dose, contain atomoxetine 5-30mg, beta cyclodextrin 18-26mg, calcium sulfate 30-46mg, Fumed silicon dioxide 8-16mg, lactose 30-50mg, low-substituted hydroxypropyl methylcellulose 6-12mg, sorbitol 2-5mg, magnesium stearate 0.8-1.5mg. The technical scheme of the invention provides a taste-masked stable atomoxetine tablet.

Description

technical field [0001] The invention relates to an atomoxetine composition and belongs to the technical field of pharmaceutical preparations. Background technique [0002] Attention deficit hyperactivity disorder (ADHD), known as ADHD in my country, is a common type of psychological disorder in childhood. Manifested by inattention and short attention span, hyperactivity, and impulsivity that are disproportionate to age and developmental level, often accompanied by learning difficulties, conduct disorders, and maladjustment. Domestic and foreign surveys found that the prevalence rate was 3% to 7%, and the male to female ratio was 4 to 9:1. Some children still have symptoms when they become adults, which obviously affects their studies, physical and mental health, family life and social skills in adulthood. [0003] Atomoxetine, chemical name: (R)-N-methyl-3-(2-methylphenoxy)amphetamine. It is a drug used to treat attention deficit hyperactivity disorder (ADHD), which belon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/69A61K47/38A61K47/26A61K47/04A61K47/02A61K31/138A61P25/14
CPCA61K9/2095A61K9/2009A61K9/2018A61K9/2054A61K31/138
Inventor 孙爱梅
Owner WEIHAI GUANBIAO INFORMATION TECH
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