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Soluble powder of crystalline valnemulin hydrochloride and application thereof

A vornimulin hydrochloride, soluble technology, which is applied in the directions of non-active ingredients medical preparations, powder delivery, respiratory diseases, etc., can solve the problem of limiting the clinical administration mode of vornimulin hydrochloride, transportation, storage, and inconvenience in use. , Amorphous powder has strong hygroscopicity and other problems, to achieve the effect of ensuring the dosage of poultry storage, stable physical and chemical properties, and significant curative effect.

Inactive Publication Date: 2019-08-30
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the premix is ​​only limited to mixing material administration, which limits the clinical administration of warnemulin hydrochloride, and the production cost of coating is relatively high and the process is complicated
Chinese patent CN 102416004 A discloses a self-emulsifying oral nanoemulsion preparation of venomulin hydrochloride for veterinary use and its preparation method. Although it overcomes the shortcomings of the premix, it is inconvenient to transport, store and use, and needs to be added to the components Various oils, preservatives, active agents, antioxidants, for farms, the industrial cost is high
Chinese patent CN 105534912 A discloses a highly stable soluble powder of warnemulin hydrochloride, although the stability has been improved by adding a stabilizer, but if it is to be industrialized, the production cost of adding additives is too high ; At the same time, the soluble powder is easy to fly and has a serious pungent odor during the production process, which is extremely inconvenient for production and administration, while the amorphous powder has strong hygroscopicity and is easy to agglomerate for long-term storage

Method used

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  • Soluble powder of crystalline valnemulin hydrochloride and application thereof
  • Soluble powder of crystalline valnemulin hydrochloride and application thereof
  • Soluble powder of crystalline valnemulin hydrochloride and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The percentage content of each component in Vonimulin Hydrochloride soluble powder is as follows:

[0028]

[0029] The preparation method is as follows:

[0030] Crush the formula amount of raw and auxiliary materials, pass through an 80-mesh sieve, dilute the sucralose with glucose in equal amounts to more than 2%, and mix it with the formula amount of Vonimulin hydrochloride hydrate crystals, oligofructose and remaining glucose , Mix well for 30 minutes, and pack it up.

Embodiment 2

[0032] The percentage content of each component in Vonimulin Hydrochloride soluble powder is as follows:

[0033]

[0034] The preparation method is as follows:

[0035] The raw and auxiliary materials of the formula are crushed and passed through an 80-mesh sieve. All the raw and auxiliary materials are mixed and mixed thoroughly for 30 minutes to make them uniform.

Embodiment 3

[0037] The percentage content of each component in Vonimulin Hydrochloride soluble powder is as follows:

[0038]

[0039]

[0040] The preparation method is as follows:

[0041] Crush the formula amount of the raw and auxiliary materials, pass through an 80-mesh sieve, dilute the vanilla flavor with lactose to over 2% by equal volume addition dilution method, mix with all the remaining raw and auxiliary materials, mix well for 30 minutes and mix well, and then pack it .

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PUM

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Abstract

The invention discloses soluble powder of crystalline valnemulin hydrochloride and application thereof. The soluble powder consists of valnemulin hydrochloride hydrate crystal, a flavoring agent and auxiliary materials. The soluble powder made of the crystalline valnemulin hydrochloride does not induce dampness, has good thermal stability and low production cost, has no pungent smell, does not need to be coated, has better water solubility, and is beneficial to take by drinking water for livestock and poultry groups. Meanwhile, the soluble powder medicine has good palatability, improves the compliance of livestock and poultry medicines, increases the water drinking amount and the feed intake of animals, ensures the medicine dosage of livestock and poultry, and further improves the curativeeffect of valnemulin hydrochloride in prevention and treatment of mycoplasma infection and sensitive bacterial infection diseases of livestock and poultry.

Description

Technical field [0001] The invention belongs to the technical field of veterinary medicine, and specifically relates to a soluble powder of crystalline vornemulin hydrochloride and its application. Background technique [0002] Valnemulin Hydrochloride (Valnemulin Hydrochloride), also known as Valnemulin Hydrochloride, is a new generation of pleuromutilin semi-synthetic antibiotic, which belongs to the same diterpene class with tiamulin. Vonemulin hydrochloride was first developed by Sandoz in 1984. It has the advantages of a wider antibacterial spectrum and lower toxicity. It is resistant to mycoplasma and a variety of Gram-positive bacteria, such as streptococcus, Staphylococcus aureus, Actinobacillus, etc. All have good antibacterial activity, the in vitro antibacterial effect is 10-100 times that of Tysecin, and the bioavailability is close to 100%. [0003] In 1999, Vonisiline hydrochloride was approved by the European Community for the prevention or treatment of swine dysent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/26A61K47/36A61K31/22A61P31/04A61P19/02A61P19/04A61P11/00
CPCA61K9/145A61K9/146A61K31/22A61P11/00A61P19/02A61P19/04A61P31/04
Inventor 王娟李亚玲吴燕子刘桂兰夏雪林栗栖凤刘爱玲李守军
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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