The invention relates to
glucosamine sulfate compound salt and a preparation method thereof. The X-
ray diffraction of the compound salt shows that the compound salt has a strongest peak at the position of 27.080 degrees. The preparation method comprises the following steps: 1, enabling
chitin and a basic
carbonate solution to have a deacetylation reaction under the condition of
microwave heating, and
drying to obtain
glucosamine; 2, preparing the obtained
glucosamine into a glucosamine solution, adding an excessive acid
sulfate solution into the glucosamine solution for neutralizing the glucosamine solution, and enabling the glucosamine solution to be sulfated; removing the generated
ammonia by using
chlorine; adding
activated carbon for carrying out a decolorizing reaction, and filtering the
reaction product while the product is hot; 3, adding
chlorine-containing
metal salt into the solution obtained in the step 2, heating for carrying out an
ion exchange reaction, and then carrying out a
reflux reaction; 4, adding
alcohol as a precipitator into the solution obtained after the reactions of the step 3 are finished, filtering to obtain precipitate, and carrying out
freeze drying on the precipitate to obtain
glucosamine sulfate compound salt concentrate. The preparation method provided by the invention is simple in production technology, low in cost and high in product purity, enables the quality of the product to reach the pharmacopeia standards, and can be used for large-scale production.