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Application of lung tonifying and blood circulation promoting capsule in treating or preventing PM2.5 induced pulmonary injury

A technology for nourishing the lung and activating blood circulation and lung injury, which is applied in the field of Bufei Huoxue Capsules, drugs for the treatment or prevention of lung injury, and drugs for lung injury. Problems, to achieve the effect of safety, low side effects, low cost, and suitable compatibility

Active Publication Date: 2017-03-08
GUANGDONG LEIYUNSHANG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In addition, we also found that the existing Bufei Huoxue Capsules are easy to cause moisture during storage, which makes the medicine not resistant to storage and affects the stability of the medicine

Method used

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  • Application of lung tonifying and blood circulation promoting capsule in treating or preventing PM2.5 induced pulmonary injury
  • Application of lung tonifying and blood circulation promoting capsule in treating or preventing PM2.5 induced pulmonary injury
  • Application of lung tonifying and blood circulation promoting capsule in treating or preventing PM2.5 induced pulmonary injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1 The raw material formula of Bufei Huoxue Capsules of the present invention

[0030] Composition 1: Astragalus 500g, Radix Paeoniae Rubra 1000g, Psoralen 360g.

[0031] Composition 2: Astragalus 1000g, Radix Paeoniae Rubra 1000g, Psoralen 500g.

[0032] Composition 3: Astragalus 500g, Radix Paeoniae Rubra 500g, Psoralen 250g.

[0033] Composition 4: Astragalus 720g, Radix Paeoniae Rubra 720g, Psoralen 360g.

Embodiment 2

[0034] Example 2 Preparation of Bufei Huoxue Capsule Extract of the present invention and content of active substances

[0035] The preparation of Bufei Huoxue capsule of the present invention:

[0036] Astragalus slices, Radix Paeoniae Rubra and Psoralen psoraleae of the raw material formula of composition 4 in Example 1 were crushed into coarse powder, 60%-70% ethanol alcohol was refluxed and extracted twice, and 5 amounts of 60%-70% ethanol were added for the first time, Extract for 2 hours, 4 times the amount of 60%-70% ethanol for the second time, extract for 1 hour, combine the two extracts, filter, recover the filtrate under reduced pressure until it has no alcohol smell, continue to concentrate under reduced pressure to a relative density of 1.30-1.40 Clear ointment, that is to say.

[0037] The extract of the Bufei Huoxue capsule contains the following active substances: astragaloside IV, paeoniflorin, psoralen and isopsoralen, the results are shown in Table 1, and...

Embodiment 3

[0044] Example 3 Preparation of Bufei Huoxue Capsule Extract of the present invention and content of active substances

[0045] In this experiment, supercritical CO 2 The process parameters of the extraction equipment were comprehensively studied to find the influence of various extraction conditions (extraction temperature, pressure, entrainer and time) on the extraction amount and effective substance content. After investigation, the ethanol concentration of the entrainer had little effect (the ethanol concentration was 70% ~90%, 80% is better), extraction pressure, extraction temperature, extraction time and entrainer are the main influencing factors, so the yield of astragaloside IV and extract is used as index to investigate the effect of four factors on The effect of the extraction effect. See Table 3 for the factors and levels of investigation.

[0046] Table 3 The level table of factors for the extraction process of Bufei Huoxue Capsules of the present invention

...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to application of a lung tonifying and blood circulation promoting capsule for treating or preventing pulmonary injury. The traditional Chinese medicine composition selects medicinal materials with appropriate compatibility, conforms to research theories of traditional Chinese medicine and modern medicine, and has good drug effects and low toxic side effects. The traditional Chinese medicine composition is mainly prepared from astragalus root, red peony root and fructus psoraleae.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to the use of Bufei Huoxue capsules as a drug for treating or preventing lung damage, in particular to the use of Bufei Huoxue capsules as a drug for treating and / or preventing PM2.5-induced lung damage. Background technique [0002] In recent years, air pollution has posed a serious threat to human health. Among the currently recognized air pollutants, particulate matter has the closest epidemiological relationship with the endpoints of human health effects, and particulate matter has become a quantitative health indicator for evaluating air pollution. Hazardous symbolic pollutants. More and more studies on epidemiological and toxicological data have confirmed that atmospheric particles, especially those with a diameter of <2.5um, are associated with increased mortality and morbidity among residents, and can cause asthma, decreased lung function, respiratory s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K36/65A61K9/48A61P11/00A61P7/00
CPCA61K9/485A61K36/481A61K36/487A61K36/65A61K36/71A61K2236/333A61K2236/37A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 关泽明钱坤谢扬辉
Owner GUANGDONG LEIYUNSHANG PHARM CO LTD
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