The invention discloses dexlansoprazole-isonicotine eutectic and application of the eutectic. The eutectic is a crystalline complex combined by dexlansoprazole and isonicotine at a mole ratio of 1:1 in a non-covalent form; an X-ray powder diffraction spectrum of the eutectic comprises diffraction peaks expressed by the following 2 theta angles: 5.3-5.5 degrees, 10.7-10.9 degrees, 12.8-13.0 degrees, 14.9-15.1 degrees, 16.1-16.3 degrees, 18.4-18.6 degrees, 19.1-19.3 degrees, 19.9-20.1 degrees, 22.0-22.2 degrees, 22.6-22.8 degrees, 24.3-24.5 degrees, 25.8-26.0 degrees, 26.2-26.4 degrees, 27.0-27.2 degrees, 27.4-27.6 degrees, 31.4-31.6 degrees and 32.5-32.7 degrees. Compared with the prior art, the dexlansoprazole-isonicotine eutectic is excellent in crystal form stability and high in bioavailability, and has greater maximum apparent solubility in ultrapure water; a preparation method of the dexlansoprazole-isonicotine eutectic is simple, mild in condition and high in repeatability; a product can be conveniently, quickly and stably obtained; the crystal form purity of the product is high; obvious raw material impurities and residual solvents do not exist.