The invention relates to a preparation method of a hollow medical
metal micro-needle, which belongs to the technical field of
biomedical engineering. The preparation method comprises the steps of firstly opening a
silicon etching window on a double-throw
oxide silicon wafer by
lithography, wet-
etching silicon in the window for obtaining a
pyramid-shaped cavity, then throwing a negative
photoresist on the silicon
wafer for filling the
pyramid-shaped cavity, adjusting the height of the micro-needle through the thickness of the negative
photoresist, then selecting a specific
mask for exposing and removing the negative
photoresist in the
pyramid-shaped cavity, obtaining a micro-needle cavity with different shape,
sputtering a
metal thin film in the micro-needle cavity as a conducting layer,
electroplating a
metal layer on the conducting layer, finally opening a micro-needle through hole in the micro-needle, removing the silicon and the negative photoresist, and further obtaining the hollow metal micro-needle with the different shape. The preparation method adopts the silicon and non-silicon compounding method for preparing the hollow metal micro-needle, and the
processing cost is low. The shape of a needle tip of the micro-needle can be controlled by
exposure, thereby improving the effect of inserting the micro-needle into
skin, effectively controlling the height of the micro-needle and improving the strength of the micro-needle.