The invention provides a liquid drop whispering gallery mode laser and a manufacturing method thereof. According to the liquid drop whispering gallery mode laser, a first single-mode optical fiber with the middle being provided with a cone area is connected with a pump light source and a spectrograph, a second single-mode optical fiber is connected to a trapping light source and an annular core optical fiber, the front end of the annular core optical fiber is processed into a cone frustum shaped optical fiber tip, a laser beam emitted by the trapping light source is injected into a fiber core of the annular core optical fiber through the second single-mode optical fiber, total reflection and refraction occur in light at an inclined plane of the cone frustum shaped optical fiber tip of the annular core optical fiber, an annular convergence optical field is formed near the cone frustum shaped optical fiber tip so as to realize an optical tweezers function, the optical tweezers stably capture a micro liquid drop, the captured liquid crystal micro liquid drop is enabled to be close to the cone area of the first single-mode optical fiber, the pump light source injects from the front end of the first single-mode optical fiber, and the spectrograph detects excited laser light at the rear end of the first single-mode optical fiber. According to the invention, a high Q-value liquid drop micro spherical cavity with a perfect surface is formed by surface tension, and the optical tweezers stably control the liquid drop micro-sphere. The liquid drop whispering gallery mode laser provided by the invention has an extremely low threshold.