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The present invention relates to methods of modulating mammalian stem cell and progenitor cell differentiation. The methods of the invention can be employed to regulate and control the differentiation and maturation of mammalian, particularly human stem cells along specific cell and tissue lineages. The methods of the invention relate to the use of certain small organic molecules to modulate the differentiation of stem or progenitor cell populations along specific cell and tissue lineages, and in particular, to the differentiation of embryonic-like stem cells originating from a postpartum placenta or for the differentiation of early progenitor cells to a granulocytic lineage. Finally, the invention relates to the use of such differentiated stem or progenitor cells in transplantation and other medical treatments.

The communication hardware of the system is controlled by software processes that are preferably grouped as engines that also retrieve process and store data using system hardware. The engines control the communication system hardware to send and receive signals to and from users of the system. The communication signals may include data and control signals for exchanging information and also control signals for remote hardware that, for example, generate displays on user hardware such as smart devices. The communications system allows coordination of segmented order deliveries in a segmented order distributed distribution system. The infrastructure described supports efficient communication to a network of couriers and smart device APPS. Systems, methods and applications for using electronic lists to facilitate commerce, excursion organization and political discourse are also described. Lists stored within the system may be used to facilitate a distributed distribution system using trusted drivers and authorized affiliates.

The present invention provides methods of modulating mammalian, particularly human, stem cell and progenitor cell differentiation to regulate and control the differentiation and maturation of these cells along specific cell and tissue lineages. The methods of the invention relate to the use of certain small organic molecules to modulate the differentiation of stem cell populations along specific cell and tissue lineages, particularly embryonic-like stem cells originating from a postpartum placenta or stem cells isolated form sources such as cord blood. The invention also relates to the treatment or prevention of myelodysplastic syndrome or myeloproliferative syndrome, or symptoms thereof, comprising administration of JNK or MKK inhibitors, alone or in combination, as well as with or without the use of unconditioned cells or cells conditioned in accordance with other aspects of the invention. Finally, the invention relates to the use of such differentiated stem cells in transplantation and other medical treatments.

The present invention relates to methods of modulating mammalian stem cell and progenitor cell differentiation. The methods of the invention can be employed to regulate and control the differentiation and maturation of mammalian, particularly human stem cells along specific cell and tissue lineages. The methods of the invention relate to the use of certain small organic molecules to modulate the differentiation of stem or progenitor cell populations along specific cell and tissue lineages, and in particular, to the differentiation of embryonic-like stem cells originating from a postpartum placenta or for the differentiation of early progenitor cells to a granulocytic lineage. Finally, the invention relates to the use of such differentiated stem or progenitor cells in transplantation and other medical treatments.

Structures and methods of manufacturing are disclosed of dislocation free stressed channels in bulk silicon and SOI (silicon on insulator) CMOS (complementary metal oxide semiconductor) devices by gate stress engineering with SiGe and / or Si:C. A CMOS device comprises a substrate of either bulk Si or SOI, a gate dielectric layer over the substrate, and a stacked gate structure of SiGe and / or Si:C having stresses produced at the interfaces of SSi(strained Si) / SiGe or SSi / Si:C in the stacked gate structure. The stacked gate structure has a first stressed film layer of large grain size Si or SiGe over the gate dielectric layer, a second stressed film layer of strained SiGe or strained Si:C over the first stressed film layer, and a semiconductor or conductor such as p(poly)-Si over the second stressed film layer.

The present invention relates to methods of modulating mammalian stem cell and progenitor cell differentiation. The methods of the invention can be employed to regulate and control the differentiation and maturation of mammalian, particularly human stem cells along specific cell and tissue lineages. The methods of the invention relate to the use of certain small organic molecules to modulate the differentiation of stem or progenitor cell populations along specific cell and tissue lineages, and in particular, to the differentiation of embryonic-like stem cells originating from a postpartum placenta or for the differentiation of early progenitor cells to a granulocytic lineage. Finally, the invention relates to the use of such differentiated stem or progenitor cells in transplantation and other medical treatments.

A neural paraphrase generator receives a sequence of tuples comprising a source sequence of words, each tuple comprising word data element and structured tag element representing a linguistic attribute about the word data element. An RNN encoder receives a sequence of vectors representing a source sequence of words, and RNN decoder predicts a probability of a target sequence of words representing a target output sentence based on a recurrent state in the decoder. An input composition component includes a word embedding matrix and a tag embedding matrix, and receives and transforms the input sequence of tuples into a sequence of vectors by 1) mapping word data elements to word embedding matrix to generate word vectors, 2) mapping structured tag elements to tag embedding matrix to generate tag vectors, and 3) concatenating word vectors and tag vectors. An output decomposition component outputs a target sequence of tuples representing predicted words and structured tag elements, the probability of each single tuple from the output is predicted based on a recurrent state of the decoder.

An apparatus for generating an overview image of a plurality of images comprises a storage unit and an image processor. The storage unit stores a plurality of processed images of the overview image and is able to provide the overview image containing the plurality of processed images at their assigned positions for displaying. The image processor determines feature points of a new image and compares the determined feature points of the new image with feature points of a stored processed image to identify common feature points and to obtain 3-dimensional positions of the common feature points. Further, the image processor determines common feature points located within a predefined maximum distance of relevance to a reference plane based on the 3-dimensional positions of the common feature points to identify relevant common feature points. Further, the image processor processes the new image by assigning the new image to a position in the overview image based on a comparison of an image information of each relevant common feature point of the new image with an image information of each corresponding relevant common feature point of the stored processed image without considering common feature points located beyond the predefined maximum distance of relevance to the reference plane.

An apparatus for generating an overview image of a plurality of images includes an image preprocessor which preprocesses a new image by assigning the new image to a position in the overview image based on position information contained by meta-data of the new image. A storage unit stores a plurality of images of the overview image and provides the overview image for display. Further, the image processor receives accuracy information of the position information. The image processor determines an overlap region of the preprocessed new image and a stored image within the overview image based on the assigned positions of the preprocessed new image and of the stored image. Further, a controllable processing engine processes the preprocessed new image by re-adjusting the assigned position of the preprocessed new image based on comparing features of the overlap region of the preprocessed new image and the stored image. The controllable processing engine is controlled by accuracy information of the position information.

An electricity-generating backpack that is substantially lighter in weight, has the multiple springs replaced with one large spring whose spring constant can be adjusted in the field in seconds, and replaces a DC generator with a brushless AC generator that permits approximately 70% generator efficiency and the generation of up to 20 W of electrical power by converting mechanical energy to electrical power. A device is provided that always removes some electricity, but not too much, as necessary to extract large levels of the electricity while controlling damping by providing electrical damping circuits including a DC-DC converter designed to emulate a desired load at its input terminals. Additional electricity generating E-MOD devices may be used for generating additional power by hooking an E-Mod device to a generator and to the backpack belt at the wearer's hip and includes a wand that fits against the wearer's femur so as to move through a range of motion as the patient walks. The system also provides multiple possibilities of electricity generation when not walking including a light-weight bicycle ergometer which can be mounted to the backpack frame and generate very high power levels (100 W). The electricity generated and stored by the backpack may be used to charge batteries and to power a number of devices that may be carried by the backpack, such as a Sterling Cooler System that is powered by the backpack's stored power to provide cooling power for cooling items carried by the backpack.

According to some embodiments, system and methods for image improvement comprise: receiving a plurality of frames of a given region of interest, the frames comprised of a plurality of pixels; determining, based on a quantum property of the frames, a normalized pixel intensity value for each pixel of each of the plurality of frames; and generating an improved image of the given region of interest based on the plurality of frames and the corresponding normalized pixel intensity values for the frames, the order of the image being two. Also embodiments for generating an image of a target illuminated by quantum entangled particles, such as, photons, are disclosed.

A wind turbine 36 has a back-to-back AC / DC / AC power electronic converter chain in which the grid side converter 48 is connected in series with DFIG stator windings 64. The machine side converter 56 is fed from the rotor windings 54 of the DFIG 44. Series connection of the grid side converter 48 enables voltage sag ride-through capability via control of the stator flux.In the event of a grid voltage sag, the series converter allows for a controlled response in the stator flux and electromagnetic shaft torque, protects the machine side converter and enables continued power delivery to the grid.

A process for removing hydrogen sulfide, other sulfur-containing compounds and / or sulfur and mercury from a gas stream contaminated with mercury, hydrogen sulfide or both. The method comprises the step of selective oxidation of hydrogen sulfide (H2S) in a gas stream containing one or more oxidizable components other than H2S to generate elemental sulfur (S) or a mixture of sulfur and sulfur dioxide (SO2). The sulfur generated in the gas stream reacts with mercury in the gas stream to generate mercuric sulfide and sulfur and mercuric sulfide are removed from the gas stream by co-condensation.

A stem-like bone implant includes longitudinal structural members and tension cables that provide curvature control and support, and rigidity against bending and buckling. The longitudinal structural members and tension cables may become an integral part of a composite regenerated bone having a substantially increased strength over natural bone. The flexibility of the implant is controlled by specifically varying the structural geometry of certain portions of the implant, and by adjusting the tension in the tension cables before, during and after the implantation operation to thereby adjust the stiffness of the implant. The tension cables may be adjusted to produce asymmetric or non-uniform levels of tension in the longitudinal structural members.

Disclosed are an ion implantation method capable of dramatically increasing an implantation rate of hydrogen ions into a semiconductor substrate and a method for manufacturing an SOI wafer, in which manufacturing efficiency of the SOI wafer is sufficiently high. When the hydrogen ions are implanted to a predetermined depth of the semiconductor substrate, hydrogen gas is introduced into a chamber where an inner pressure is reduced and a predetermined magnetic field is formed, plasma is generated by introducing a microwave into the magnetic field, hydrogen ion beams containing hydrogen molecule ions is extracted from the plasma, and the hydrogen molecule ions are irradiated and implanted onto the semiconductor substrate. Thus, a throughput in the hydrogen ion implantation is improved, thus making it possible to enhance the manufacturing efficiency of the SOI wafer.

An electrical generator includes one or more magnets that move relative to one or more conductors to generate an electrical signal in each conductor. Each magnet has ferrofluid bearings in the vicinity of its opposite ends to provide a low friction interface between the magnet and a support structure. The ferrofluid bearings establish a field expansion medium that directs at least a portion of the magnetic field so that a greater portion of the field intersects the conductors than in the absence of the medium. The magnet aspect ratio is preferably on the order of unity.

The present invention discloses a computer-implemented online-offline workspace and method for creating, developing, storing, and managing digital content within a contextual and shared knowledge network. The invention includes a central service facility that provides an online platform for the users to work in a context-based and shared knowledge environment through a user interface on a wide range of user access devices. The online platform is embedded with a plurality of applications to allow the user to capture, create, develop, store, process, share, distribute, retrieve, reuse, and manage digital contents containing any one or a combination of the following: text, graphics, audio, video, whole or portions of web-pages and web-links. The invention further includes an end-user facility providing an offline platform that gets synchronized with the online platform upon detection of a secured communication network.

A vehicle motor-generator apparatus based on a field winding type of synchronous machine coupled to a power inverter and a battery, wherein the synchronous machine is controlled to operate as a motor to perform engine starting and thereafter be driven by the engine as an electrical generator, wherein during a short time interval at the commencement of engine starting, the armature winding of the synchronous machine is driven by a current such that magnetic flux is produced by the armature winding acting in the same direction as magnetic flux produced by the field winding, to thereby achieve increased torque during the time when maximum torque is required. In addition, the supplied field current is set at a maximum value during only an initial period when engine starting begins, until the first compression stroke of the engine has been completed, and thereafter set to a reduced value until the completion of engine starting, thereby reducing the amount temperature rise within the field winding during engine starting, while ensuring a sufficiently high value of initial torque.

The present invention is directed to a suppression system in which a carrier gas and suppression liquid are contained in a common containment vessel and separated by a separation member. The separation is one or more of movable, deformable, or shape changing in response to pressure exerted by the stored gas.

Methods and computer systems are provided for workflow management. A workflow engine may be provided that creates workflow items. Each workflow item may include a self descriptive part that specifies details for generating a device independent representations of a corresponding workflow item. Further, a workflow manager may be provided that generates the device independent representation based on the self descriptive part.

According to some embodiments, system and methods for image improvement comprise: receiving a plurality of frames of a given region of interest, the frames comprised of a plurality of pixels; determining, based on a quantum property of the frames, a normalized pixel intensity value for each pixel of each of the plurality of frames; and generating an improved image of the given region of interest based on the plurality of frames and the corresponding normalized pixel intensity values for the frames, the order of the image being two. Also embodiments for generating an image of a target illuminated by quantum entangled particles, such as, photons, are disclosed.

A combination of noise suppression using a Bark band modified Weiner filter and linear noise reduction improves elimination of noise in a telephone. A detector for detecting long, non-speech intervals is coupled to the output of the noise suppresser and controls selection of noise suppression or noise reduction. A gain smoothing filter has a long time constant when noise reduction is used and provides a gradual transition from one level of gain to another. Comfort noise is smoothly inserted by updating the data for generating comfort noise only during detected long, non-speech intervals.

A sterilization and decontamination system in which a non-thermal plasma discharge device is disposed upstream of a suspension media (e.g., a filter, electrostatic precipitator, carbon bed). The plasma discharge device generates a plasma that is emitted through apertures (e.g., capillaries or slits) in the primary dielectric. Plasma generated active sterilizing species when exposed to contaminants or undesirable particulate matter is able to deactivate or reduce such matter in contaminated fluid stream and / or on objects. Thus, the undesirable contaminants in the fluid to be treated are first reduced during their exposure to the plasma generated active sterilizing species in the plasma region of the discharge device. Furthermore, the plasma generated active sterilizing species are carried downstream to suspension media and upon contact therewith deactivate the contaminants collected on the suspension media itself. Advantageously, the suspension media may be cleansed in situ. To increase the sterilization efficiency an additive, free or carrier gas (e.g., alcohol, water, dry air) may be injected into the apertures defined in the primary dielectric. These additives increase the concentration of plasma generated active sterilizing agents while reducing the byproduct of generated undesirable ozone pollutants. Downstream of the filter the fluid stream may be further treated by being exposed to a catalyst media or additional suspension media to further reduce the amount of undesirable particulate matter.

The instant invention provides compositions comprising a prodrug, the prodrug comprising a therapeutically active drug; and a peptide selected from the group consisting of the sequences: Ser-Ser-Lys-Tyr-Gln (SEQ ID NO:1);Gly-Lys-Ser-Gln-Tyr-Gln (SEQ ID NO:2); and Gly-Ser-Ala-Lys-Tyr-Gln (SEQ ID NO:3) wherein the peptide is linked to the therapeutically active drug to inhibit the therapeutic activity of the drug, and wherein the therapeutically active drug is cleaved from the peptide upon proteolysis by an enzyme having a proteolytic activity of prostate specific antigen (PSA). The invention further provides methods of making and using the claimed compositions.

A sterilization and decontamination system in which a non-thermal plasma discharge device is disposed upstream of a suspension media (e.g., a filter, electrostatic precipitator, carbon bed). The plasma discharge device generates a plasma that is emitted through apertures (e.g., capillaries or slits) in the primary dielectric. Plasma generated active sterilizing species when exposed to contaminants or undesirable particulate matter is able to deactivate or reduce such matter in contaminated fluid stream and / or on objects. Thus, the undesirable contaminants in the fluid to be treated are first reduced during their exposure to the plasma generated active sterilizing species in the plasma region of the discharge device. Furthermore, the plasma generated active sterilizing species are carried downstream to suspension media and upon contact therewith deactivate the contaminants collected on the suspension media itself. Advantageously, the suspension media may be cleansed in situ. To increase the sterilization efficiency an additive, free or carrier gas (e.g., alcohol, water, dry air) may be injected into the apertures defined in the primary dielectric. These additives increase the concentration of plasma generated active sterilizing agents while reducing the byproduct of generated undesirable ozone pollutants. Downstream of the filter the fluid stream may be further treated by being exposed to a catalyst media or additional suspension media to further reduce the amount of undesirable particulate matter.

A pole mounted rotation platform and wind power generator that is secured to an existing structure, which may or may not be vertical, to augment an existing power grid. The pole mounted rotation platform and wind power generator includes a wind sail assembly and a platform capable of rotating about the existing structure. The pole mounted rotation platform and wind power generator may be assembled, secured, leveled and aligned to the existing structure as component parts and in such a manner that any existing equipment on the existing structure does not need to be repositioned or relocated. During usage, the wind sail assembly rotates about the existing structure via the rotation platform, the resulting rotational energy is converted to electrical power, and the electrical power is output to a suitable power-using, -storing or -converting system.

The subject invention pertains to a piezoelectric device structure for improved acoustic wave sensing and / or generation, and process for making same. The piezoelectric thin film field effect transducer can be a thin film transistor (TFT) with either a piezoelectric film gate or a composite gate having a dielectric film and a piezoelectric film. The TFT structure can be either a top gate device or a bottom gate device. In an embodiment, the piezoelectric device structure can be used to form an array of piezoelectric thin film field effect transducers. A TFT switch can drive each piezoelectric transducer in the array. The piezoelectric transducers can both generate and sense acoustic waves. In a sensing mode, a signal from an acoustic wave can be collected at a readout terminal of the piezoelectric transducer. In a generating mode, an excitation signal can be applied across the piezoelectric transducer while the switch is ‘on’.

Present invention suppresses undesirable effects of the bubbles trapped in a silica glass crucible on single crystallization during the pulling process under a high-temperature load. When raw material powder is melted in a mold 1, graphite components of electrodes and impurities contained in the raw material are removed by introducing hydrogen gas and / or oxygen gas immediately after the start of arc discharge. Graphite and impurities are prevented from entering the product crucible, thereby suppressing the volume increase rate of the bubbles and reducing the inner pressure of the bubbles. Gases remaining in voids of an accumulated layer of silica powder formed inside the mold 1 can be replaced with helium gas, by supplying helium gas to the accumulated layer from the mold 1.