493 results about "Nicotinamide deficiency" patented technology

The invention discloses a skin whitening composition which comprises a white mulberry root-bark extract, a chamomile extract, a rhodiola rosea extract, a grape seed extract, a licorice extract, a morus australis extract, arbutin, kojic acid dipalmitate, nicotinamide, tetrahydrodiferuloylmethane, a moisturizer and a preservative. The effective skin whitening ingredients of the skin whitening composition can inhibit the activity of tyrosinase, can block the transportation of melanin and can inhibit the formation of melanin; the skin whitening composition can be applied to skin whitening cosmetics and is safe and effective.

A method of propagating mammalian endodermally derived progenitors such as hepatic progenitors, their progeny, or mixtures thereof is developed which includes culturing mammalian progenitors, their progeny, or mixtures thereof on a layer of embryonic mammalian feeder cells in a culture medium. The culture medium can be supplemented with one or more hormones and other growth agents. These hormones and other growth agents can include insulin, dexamethasone, transferrin, nicotinamide, serum albumin, beta-mercaptoethanol, free fatty acid, glutamine, CUSO4, and H2SeO3. The culture medium can also include antibiotics. Importantly, the culture medium does not include serum. The invention includes means of inducing the differentiation of the progenitors to their adult fates such as the differentiation of hepatic progenitor cells to hepatocytes or biliary cells by adding, or excluding epidermal growth factor, respectively. The method of producing mammalian progenitors is useful in that the progenitors can be used subsequently in one or more of the following processes: identification of growth and differentiation factors, toxicological studies, drug development, antimicrobial studies, or the preparation of an extracorporeal organ such as a bioartificial liver.

Methods and pharmaceutical compositions for use in the treatment of a benign and / or a malignant proliferative pathologies are disclosed. The methods comprise administration of nicotinamide or its analogs and / or cADPR or its analogs, optionally in combination with a vitamin D3 analog or a Vitamin A analog.

The invention discloses an oral care composition with fire clearing and pain eliminating functions. The oral care composition with fire clearing and pain eliminating functions is prepared from the following raw materials in percentage by mass: 0.01-1% of bezoar, 0.1-5% of scutellaria baicalensis extract, 0.1-5% of honeysuckle extract, 0.1-5% of rhizoma cimicifugae extract, 0.01-0.5% of borneol, 0.1-5% of sodium gualenate, 0.1-5% of nicotinamide and the balance of base material. The oral care composition with fire clearing and pain eliminating functions, disclosed by the invention, is targeted at people susceptible to oral inflammation and toothache and people suffering from gingivitis and periodontitis; and through a compounding technology, the oral care composition has the functions of cleaning the oral cavity and refreshing breath and also realizes the effects of clearing fire and eliminating pain, relieving toothache and gum bleeding and the like.

The invention discloses a pet dog food composition which comprises the raw materials based on parts by weight: 20-30 parts of corn, 10-20 parts of rice, 10-20 parts of soybean meal, 5-20 parts of chicken powder, 0.3-1 part of salt, 1-2 parts of chicken liver powder, 0.3-1 part of core material, 10-15 parts of milk powder, 1-10 parts of apple pulp and 5-15 parts of chicken grease; wherein the core material is formed by the raw materials based on parts by weight: 1 part of vitamin A, 0.1 part of vitamin D3, 2 parts of vitamin E, 2 parts of vitamin C fat, 0.1part of vitamin B1, 0.2 part of vitamin B2, 0.7 part of nicotinamide, 0.1 part of folic acid, 50 parts of choline, 10 parts of ferrum, 1 part of copper, 10 parts of zinc, 0.3 part of 1% iodine, 0.2 part of tea polyphenol, 100 parts of methionine, 215 parts of yeast powder, 500 parts of deep sea fish oil and 207.3 parts of carrier. The pet dog food has comprehensive and balanced nutrition as well as scientific and reasonable collocation, effectively improves the immunity of pet dogs, promotes growth and development of the dogs and protects the digestive tract to be healthy.

The invention discloses a cosmetic and a preparation method thereof. The cosmetic is prepared from five components of A, B, C, D and E. The cosmetic is composed of thirty raw materials including deionized water, hydroxyethyl cellulose, allantoin, carbopol U20, propanediol, 1,3-butanediol, sodium hyaluronate, an aloe vera extract, a natto extract, asiaticoside, vitamin C, bisabolol, an amino acid humectant, D-panthenol, VC ethyl ether, nicotinamide, glabridin, tranexamic acid, ceramide, algal polysaccharide, glucan, dipotassium glycyrrhizinate, an epidermal growth factor (EGF), triethanolamine, isothiazolinone, essence, squalane, jojoba oil, vitamin E oil and crystal sparkling pearl powder. The cosmetic has the functions of making skins fine and smooth, brightening the skins, repairing sensitive skins, controlling oil, toning skins and modifying skin blemishes, has no side effect or no dependence, and does not threaten health of a human body.

The invention relates to a skin-whitening chloasma-reducing skin-brightening composition comprising raw materials of, by weight: 0.5 to 20 parts of nicotinamide, 0.1 to 15 parts of L-ascorbic acid 2-glucoside, 0.1 to 10 parts of an yeast extract, 0.05 to 10 parts of sodium lactate / sodium gluconate, 0.01 to 3.5 parts of sodium hydroxide, and 10 to 60 parts of water. With the composition provided by the invention, appearing and transferring of skin melanin can be inhibited or prevented from various perspectives; skin collagen protein synthesizing can be promoted, skin nutrients can be supplemented, such that skin aging can be retarded; and whitening effects can be achieved rapidly. Whitening active components are likely to be decomposed, oxidized, and discolored. With the composition, the problems can be solved; influences of lights and heat on the effective components are reduced. The product produced by the invention is safer than other whitening agents. With the product produced by the invention, nutrients required by skins can be provided. With a sustained-releasing technology, the whitening effect is more durable.

The invention discloses a whitening composition and cream thereof. The whitening cream contains a whitening composition which is prepared from nicotinamide, arbutin, citrus peel extractives, tea extractives, scutellaria root extractives, cucumber extractives, apple extractives and the like, wherein the nicotinamide can enhance the skin barrier function, and has the effects of whitening the skin and resisting aging and acnes; the arbutin can inhibit activity of tyrosinase to achieve the whitening effect, and can protect the skin against free radical damage; the citrus peel extractives can enhance the skin brightness, lower percutaneous water loss and enhance the skin moisturizing and barrier functions; due to the synergistic effect of the tea extractives, the scutellaria root extractives, the cucumber extractives and the apple extractives, the effects of whitening, skin tendering and moisturizing are enhanced; the whitening composition is used in whitening skin care products such as a whitening cream product, dark skin and primary spots on the skin can be remarkably improved, the deposited stains and coloring matter accumulated over a long period can be faded and relieved, and the whitening effect is obvious.

The invention discloses a plant seed soaking and dressing agent, and relates to the technical field of crop seed soaking and dressing. The plant seed soaking and dressing agent is prepared from the raw materials of ferrous lactate, zinc lactate, thiamine, pyridoxine, nicotinamide, pine needle, light yellow sophora root and sweet wormwood by the following steps: A, mixing and smashing pine needle, light yellow sophora root and sweet wormwood, putting the mixture into 450-550ml of 70-90 percent ethanol for soaking for 10-20 days, pressing, filtering and removing residues to form a liquid medicament; B, putting ferrous lactate, zinc lactate, thiamine, pyridoxine and nicotinamide into the liquid medicament to form a seed soaking and dressing raw liquid; and C, adding water to blend into 5,000ml of diluted liquid medicament, and sealing the diluted liquid medicament for 20 hours to form the seed soaking and dressing agent. The plant seed soaking and dressing agent has the beneficial effects that through scientific matching of various insect-killing, sterilizing and body-strengthening elements, the resistance of seeds is enhanced, and an environment which is low in the quantity of insects and bacteria is created, so that healthy growth of seeds is ensured, plant diseases and insect pests are reduced, cold resistance and disease resistance are realized, robust growth of seedlings is ensured, and great social economical significance is achieved.

The invention provides an apple facial mask based on a traditional Chinese medicine formula.The apple mask comprises a silk matrix and a water-soluble substance.The water-soluble substance comprises apple extract, traditional Chinese medicine extract, seaweed extract, sodium hyaluronate, beta-glucan and assistant.The traditional Chinese medicine extract comprises tremella extract, centella asiatica extract, polygonum cuspidatum root extract, scutellaria root extract, tea extract, glycyrrhiza glabra root extract, chamomilla recutita flower extract, rosmarinus officinalis leaf extract and purslane herb extract.The seaweed extract contains chondrus crispus and bio-saccharide gum-1.The assistant comprises butanediol, propylene glycol, diglycerol, polyethylene glycol-400, Carbomer, hydroxyethyl cellulose, urea, allantoin, glycine betaine, nicotinamide, sodium glutamate, triethanolamine, 1,2-hexanediol, decoyl hydroximic acid, 1,3-propylene glycol, hexanediol and deionized water.The apple mask has the effects that stability is good, dispersibility is high, nutrients are proper in quantity and balanced, antibiosis and anticorrosion effects are achieved, and moisturizing, skin whitening and stain lightening are achieved.

The invention discloses a skin-whitening composition as well as a preparation method and applications of the skin-whitening composition. In the skin-whitening composition, various whitening agents and sun-screening agents with excellent properties are matched for use, so that the melanin formation can be inhibited, moreover, ultraviolet rays can be absorbed, and free radicals can be eliminated. The skin-whitening composition is prepared from radix puerariae extract, glutathione, kojic dipalmitate, ascorbyl glucoside, nicotinamide, beta-hydroxy acid, undecylenoyl phenylalanine, chamomile extract, green tea extract, licorice root extract, pomegranate bark extract, 1,3-butanediol, phenoxyethanol and water. The components are mixed to achieve the synergistic skin whitening effect, the skin whitening effect is obvious, safe and steady, and no toxic and side effects are caused.

The composite amino acid and vitamin capsule preparation includes coated amino acid granules and coated vitamin granules in the weight ratio of 1 to 0.68. The coated amino acid granules include isoleucine, leucine, lysine hydrochloride, phenylalanine, methionine, threonine, tryptophan, valine and arginine hydrochloride; and the coated vitamin granules include vitamin B1 nitrate, vitamin B2, vitamin B6, vitamin E acetate, and nicotinamide. The present invention also provides the preparation process of the composite amino acid and vitamin capsule preparation.

The invention discloses a preparation method of a polypeptide silk facial mask, which comprises the steps of fully mixing polypeptide powder and silk protein nutrient solution and cooling. Polypeptide powder is mainly composed of aloe vera, carnosine, oligopeptide, soluble collagen, 2‑o‑ethyl ascorbic acid, betaine, trehalose, niacinamide, allantoin; the protein nutrient solution of silk is mainly composed of water, glycerin, Propylene glycol, butylene glycol, malto-oligosaccharide glucoside, hydrogenated starch hydrolyzate, glycerol polymethacrylate, PVM / MA copolymer, carbomer, sodium hyaluronate triethanolamine, baobab pulp extract, tranexamic acid , Centella asiatica extract, dipotassium glycyrrhizate and other skin conditioners or moisturizers. Through the combination of polypeptide powder and silk protein liquid, it can effectively give fresh nutrition to the skin, promote the skin repair process, strengthen the nutrient absorption capacity, deeply nourish, smooth and rejuvenate the skin, and make the skin elastic.

The invention discloses a composition with a skin whitening effect, and application thereof to cosmetics. The composition is prepared from the following ingredients in percentage by mass: 0.01 percent to 10 percent of 1-methylhydantoin-2-imide, 0.01 percent to 20 percent of nicotinamide, 0.01 percent to 20 percent of thyme extracts, 0.01 percent to 20 percent of orange peel extracts, 0.001 to 0.5 percent of fullerenes and the balance auxiliary materials and water. The composition has the advantages that the composition is safe and achieves the skin whitening effect; the irritability is low; free radicals can be effectively cleared away; efficient oxidation resistance is realized; the composition with the skin whitening effect is provided; the composition has different action mechanisms of inhibiting the tyrosinase activity, resisting oxidization, clearing away free radicals, brightening skin, holding moisture, accelerating the metabolism function of skin cells, and the like; the composition acts on the epidermal layer, the horny layer and the corium layer, so that the synergistic skin whitening effect is achieved; the irritation and the irritability are low.

The invention belongs to the technical field of cosmetics, and particularly relates to acne treatment essence cream and a preparing method thereof. The essence cream contains aluminum starch octenylsuccinate, salicylic acid, PCA zinc, zinc gluconate, nicotinamide, tangerine orange pericarp extract, amur corktree bark extract and retinyl palmitate. The acne treatment constituents in the essence cream are obtained through screening. The new acne treatment constituents in the essence cream can effectively restrain propionibacterium acnes. Experimental studies prove that a good acne treatment effect can be realized by adding the acne treatment constituents to the essence cream. Stability studies show that the essence cream has higher stability.

The invention discloses a Ictalurus punctatus compound feed, the contents of mass ratio of characteristic materials are as follows: vitamin A 0.005-0.007, vitamin D3 0.004-0.006, vitamin E 0.070-0.090, vitamin K3 0.002-0.004, vitamin B1 0.003-0.005, vitamin B2 0.005-0.007, vitamin B6 0.08-0.012, vitamin B12 0.001-0.003, nicotinamide 0.030-0.050, calcium pantothenate 0.10-0.30, folic acid 0.01-0.03, biotin 0.001-0.002, VC-phosphate 0.300-0.400, inositol 0.070-0.090, antioxidants 0.200-0.300, wheat-middlings 1.000-1.200, ferrous sulfate 0.400-0.600, copper sulfate 0.010-0.030, zinc sulfate 0.150-0.200, manganese sulfate 0.100-0.150, iodine 0.050-0.150, Se 0.050-0.070, cobalt chloride 0.010-0.030, magnesium sulfate 1.000-1.500, zeolite powder 5.0-6.0, xylo-oligosaccharide 0.008-0.012, bacillus licheniformis 0.01, weatings 90.-110., wheat-middlings 110-130, rice bran 75-85, soy bean powder 55-65, soybean meal 190-210, peanut meal 25-35, fish meal 95-105, cottonseed meal 75-85, rapeseed meal 110-130, gem meal 45-55, soybean oil 15-25, lysine 0.8-1.2, methionine 0.8-1.2, salt 2.0-2.5, betaine 3-5, allicin 0.1-0.3, choline chloride 1.0-2.0, calcium dihydrogen phosphate 15-25. Compared with other feeds, the usage rate of feed nutrient ingredients for Ictalurus punctatus is increased by 10-15%, feed coefficient is reduced by 5-10%, feed waste is reduced, nitrogen and phosphorus excretion of Ictalurus punctatus in the environment is reduced, at the same time the survival rate of Ictalurus punctatus is improved significantly.

The invention relates to drinkable food with eyesight protection effect. The drinkable food comprises eyesight protection ingredients including lutein and taurine; anti-fatigue ingredients including chemicals such as lysine, L-carnitine, nicotinamide, nucleic acid, oligosaccharide, inositol, octacosyl alcohol, 1,6-fructose diphosphate, vitamins, and / or Chinese medicinal materials or extracts thereof such as panax ginseng (Radix Ginseng), panax quinquefolium, phodiola sacra, cordyceps sinensis, gynostemma pentaphyllum, crataegus pinnatifida, ginkgo biloba leaf, polygonum multiflorum, hippophae rhamnoides, acanthopanax senticosus, astragalus membranaceus, angelica sinensis, and wolfberry polysaccharide. The formula of the inventive drinkable food conforms to the Chinese medicinal theory that the parts of the body and the whole of the body are an interdependent and interacted organic whole, and at the same time gives attention to the interrelationship of eyes and the whole of the body. The inventive drinkable food can be processed into a beverage, milk or a milk beverage, and an alcoholic beverage.

The invention relates to a composition of novel nicotinamide insecticide nitenpyram. The preparation of the composition is a binary composition containing nitenpyram and the other insecticide. The other insecticide is buprofezin, pymetrozine, chlorpyrifos, thiamethoxam, fipronil, thiacloprid, dinotefuran, and the like. The preparation can be processed into new formulations of water dispersible granule, wettable powder, aqua, aqueous emulsion, soluble powder, colloidal suspension agent, and the like, wherein water is used as a solvent, an organic solvent is not used or used less so that the preparation has low toxicity and low residue and is environment-friendly. The nicotinamide insecticide is made of plant source farm chemical nicotinamide, and mainly acts on an acetylcholin esterase receptor of pests and the central nervous system of insects, thus the nicotinamide insecticide has high efficiency and selectivity and is safe to mammals. Compounded with other insecticides, the nicotinamide insecticide can improve the drug effect and enlarge the serviceable range. The novel nicotinamide insecticide is the optimal variety to replace highly-poisonous organophosphorus and organochlorine insecticides. The preparation of the novel nicotinamide insecticide is applied to controlling piercing mouth parts insects for rice, vegetables and other crops, and has the characteristics of low toxicity, low residue, less dosage, long lasting period, safety and no drug injuries to crops, and the like.

The invention provides a refreshing and moistening cream having refreshing texture and soft and smooth touch sense and making skin younger and brighter. The refreshing and moistening cream comprises the following components: cyclopentasiloxane; glycerol; isononyl isononanoate; propylene glycol; 1,2-pentanediol; ethanol; betaine; an ammonium acryloyldimethyltaurate / VP copolymer; a mixture of components of ceramide 3, ceramide 6 II, ceramide 1, phytosphingosine, cholesterol, sodium lauroyl lactylate, carbomer and xanthan gum; octyl polymethyl siloxane; hydroxyethyl urea; polydimethylsiloxane; sodium hyaluronate; hydrolytic sodium hyaluronate; glyceryl stearate citrate; nicotinamide; cyclopentasiloxane or dimethiconol; tocopherol acetate; methyl hydroxybenzoate; an acrylic acid (acrylate) / C10-30 alkanol acrylate cross-linked polymer; aminomethyl propanol; a mixture of glycerol stearate and PEG-100 stearate; a daily chemical fragrance compound and the like.

The invention relates to a composite for improving the conditions of hair and head skin, in particular to a hair or head skin cosmetic composition capable of preventing hair loss and promoting hair growth, which takes one of zinc pyrithione, panthenol, salicylic acid, nicotinamide and Chinese arborvitae kernel extract as an active ingredient.

The invention discloses acne clearing composition having acne clearing efficacy and a preparation method thereof. The acne clearing composition is prepared from rhizoma paridis yunnanensis extracts, spiraea ulmaria extracts, silanediol salicylate, papain, nicotinamide, beta glucan and 1,2-pentanediol. The acne clearing composition which is specially aimed at complex pathogenesis of acnes is safe, effective and easy to absorb and quite easy to add and apply to acne clearing cosmetics. The invention further discloses a facial mask with the acne clearing composition having acne clearing efficacy and a preparation method of the facial mask.

The invention discloses a chlorella silk mask for eliminating the turbid, beautifying skin and repairing radiation damage. The mask is manufactured by soaking non-woven fabric in mask essence. The mask essence comprises, by weight, 50-80 parts of water, 2-10 parts of 1,3-butanediol, 5-10 parts of chlorella extracts, 5-10 parts of rose extracts, 1-5 parts of betaine, 1-5 parts of 1,2-propylene glycol, 0.5-2 parts of acetyl hexapeptide-1, 0.25-0.5 part of xanthan gum, 0.2-1 part of acetyl tetrapeptide-2, 0.3-0.5 part of sodium hyaluronate, 0.8-1.5 parts of serine, 0.8-1.5 parts of citrulline, 0.5-1 part of nicotinamide, 0.5-1 part of methylisothiazolinone, 0.1-0.5 part of PEG-40 hydrogenated castor oil and 0.005-0.01 part of essence. The mask can deeply purify pores, clean away abundant grease, and promote water and grease balance of the skin, enables the skin cool, comfortable and vigorous and meanwhile has an anti-radiation function.

The invention discloses a plant source composition. The plant source composition comprises the following ingredients: saccharomycopsis ferment filtrate, nicotinamide, panthenol, sodium ascorbyl phosphate, arbutin and a compound extract, wherein the compound extract comprises radix cynanchi atrati extract, chlorella extract, rice germ extract, barley malt extract, vaccinii myrtilli folium extract,punica granatum fruit extract, fructus hippophae extract, sesame sprout extract, wild soybean sprout extract, wheat malt extract, tomato fruit extract and aloe barbadensis leaf extract. The plant source composition further comprises the following ingredients: a conditioner, a humectant, a pH regulator, an emollient, a solubilizer, a solvent and a chelating agent. The plant source composition has the cooperative efficacies of whitening the skin, preserving moisture and resisting oxidation, the essence has fine and smooth texture, and the active ingredients can be easily absorbed by the skin.

The invention discloses a cosmetic capable of eliminating striae gravidarum and scars, which is prepared by the following components: 1.8-2.3 parts of 1,3-butanediol, 1.6-2.4 parts of nicotinamide, 0.08-0.13 part of allantoin, 0.05-0.6 part of preservative, 0.8-1.3 parts of cell growth factor, 0.6-1.5 parts of VB2, 0.85-1.35 parts of asiaticoside, 2.0-3.0 parts of cocoa oil, 2.5-3.5 parts of collagen, etc. The cosmetic can ensure skin to be moist and soft, promote cell growth, quicken wound healing, promote wound surfaces of skin and mucosa to heal, shrink scar, quicken the repair of injured epidermic cells, and strengthen regeneration ability of epidermic cells, thus enabling skin to be full, keeping skin elasticity and strengthening skin physiological function. The cosmetic is safe and reliable without any toxic or side effect, can narrow, shallow, lighten and fade away striae gravidarum and scars with effective repair rate of 100%, harmlessly repair scar cells, prevent pigmentation, promote normal growth of skin cells, update scar tissue, recovery original memory of skin and restore beautiful skin.

A method of propagating mammalian endodermally derived progenitors such as hepatic progenitors, their progeny, or mixtures thereof is developed which includes culturing mammalian progenitors, their progeny, or mixtures thereof on a layer of embryonic mammalian feeder cells in a culture medium. The culture medium can be supplemented with one or more hormones and other growth agents. These hormones and other growth agents can include insulin, dexamethasone, transferrin, nicotinamide, serum albumin, β-mercaptoethanol, free fatty acid, glutamine, CuSO4, and H2SeO3. The culture medium can also include antibiotics. Importantly, the culture medium does not include serum.The invention includes means of inducing the differentiation of the progenitors to their adult fates such as the differentiation of hepatic progenitor cells to hepatocytes or biliary cells by adding, or excluding epidermal growth factor, respectively.The method of producing mammalian progenitors is useful in that the progenitors can be used subsequently in one or more of the following processes: identification of growth and differentiation factors, toxicological studies, drug development, antimicrobial studies, or the preparation of an extracorporeal organ such as a bioartificial liver.

The invention belongs to the technical field of daily cosmetics and relates to a pearl amino acid stayup brightening and moistening mask and a preparation method thereof. The pearl amino acid stayup brightening and moistening mask is prepared from hydrolyzed pearl powder, PEG / PPG-17 / 6 copolymer, hydroxyethyl urea, nicotinamide, PEG-50 shea butter, witchhazel extract, Aloe vera extract, lactobacillus / soybean fermented product extract, lalang grass rhizome extract, viscum album leaf extract, xylitol-based glucoside, alcohols, esters, acrylic acid (ester) / C10-30 alkanol acrylic ester cross-linked polymer, triethanolamine and phenylcarbinol. Pearl essence is fused with an amino acid compound, in coordination with plant active factors, fatigue and darkness of skin generated after stayup can be relieved and repaired, moisturizing, hydrating, lubricating and brightening are synchronously conducted, and fresh, tender and exuberant bright skin is represented. The pearl amino acid stayup brightening and moistening mask has the advantages of being simple in process, comprehensive in nutrition, obvious in effect and the like, and is a good brightening and skin-beautifying skin care product.

The invention relates to an anti-allergic moisturizing composition with a function of repairing skin barrier and an external preparation thereof. The main component of the anti-allergic moisturizing composition with the function of repairing skin barrier comprises the following components of repairing skin barrier in parts by weight: 3-10 parts of a grape seed extract and 1-5 parts of nicotinamide, the following components of natural extracts anti-allergic itch-relieving components: 0.5-1 part of dipotassium glycyrrhizinate, 1-2 parts of a chamomile extract and 0.25-1 part of a radix sophorae flavescentis extract, and the following moisturizing nutritional components: 1-3 parts of polydimethylsiloxane, 3-5 parts of glycerinum, 4-8 parts of propylene glycol, 4-8 parts of butanediol, 2-5 parts of sodium hyaluronate and 0.5-2 parts of allantoin. The components are combined to prepare an external emulsion preparation which has the function of repairing skin barrier and anti-allergic, moisturizing and nutritional performances.

The present invention relates to the effect of naturally occurring compounds on tumor development. As an example of proof, we used low; non-toxic doses of three compound e.g. Calcium D-glucarate, a naturally occurring Ca++ salt of D-glucaric acid; Nicotinamide (NA), a naturally occurring vitamin and butyric acid (BA), a naturally occurring saturated short chain fatty acid. 7,12 dimethylbenzanthracene (DMBA), which is a very potent skin carcinogen and is an environmental pollutant, was used for skin tumor development. Experiment was performed upto 30 weeks. All the above-mentioned compounds were used either alone or concomitantly any two or all the three. In the positive control group 100% tumorigenesis was attained in 28 weeks, use of single compound led to the inhibition of DMBA induced tumorigenesis between 33 to 47%, use of two compounds resulted in the 73 to 80% reduction in tumorigenesis but the concomitant use of three compounds resulted into 100% inhibition of tumor development at the end of 30 weeks. This led us to conclude that the concomitant use of Cag, NA and BA in combination of two is useful for preventing skin tumor develoment for a sort or long period of time. But the concomitant use of all the three compounds, as described, exhibited the perfect synergistic effect in preventing the tumor development completely. This strategy should be equally effective in the management of benign and possibly malignant tumor in any organ caused by any mean.

The invention discloses premixed feed for improving the growth speed and the nutrient substance digestion rate of minks at a breeding period. The premixed feed per one kilogram comprises the following raw material components: 265g-300g of corn protein powder, 15g-20g of compound vitamin B, 25g-35g of a complex enzyme preparation, 250000-300000 IU of vitamin A, 12g-15g of vitamin C, 2000-2500 IU of vitamin E, 50000-80000 IU of vitamin D, 0.6g-1g of vitamin K, 25g-28g of methionine, 15g-18g of lysine, 0.5g-1g of biotin, 55g-70g of choline chloride, 7g-9g of ferrous sulfate monohydrate, 9g-12g of copper sulfate pentahydrate, 10g-12.5g of manganese sulfate, 16g-20g of zinc sulphate monohydrate, 5g-6g of sodium selenite, 6g-8g of cobalt chloride, 5g-6g of potassium iodate, 10g-15g of yeast, 0.5g-0.6g of pantothenic acid, 3g-5g of nicotinamide, 0.5g-0.6g of folic acid, 140g-150g of calcium hydrogen phosphate, 30g-40g of table salt and 260g-300g of puffed corn powder. The premixed feed can be used for effectively improving the daily gain and the digestion rate of proteins, fat and carbohydrates of the minks at a breeding period, reducing the diarrhea rate of the minks and improving the culture benefits of the minks.