59 results about "Molecular chemistry" patented technology

This invention belongs to chemistry pharmaceutical field and relates to a medication transfer system, especially relates to an agglutinin masked medication-load transfer mechanism transferring from nose to brain. This invention comprises medication carrier nanograin, vesicle or lipid body surface finish agglutinin. By using the transfer system, resort time of medication-load system on nasal mucosa can be prolonged, dielectric mucosa absorb the medication-load system and selectively deliver small molecular chemistry medication, diagnosis medication, polypeptide proteins and gene medication into brain. This invention can deliver more medication into brain and relatively decrease medication in outer tissue, so it can depress toxic action at every pore while toning up prevention, cure and diagnosis effect of backbone diseases.

The invention provides a carbazole-based high-condensed ring dinitrogen-aza[7]helicene compound (I) and a synthetic method thereof, belonging to the technical field of chemical industry. A high-condensed ring dinitrogen-aza[7]helicene compound with high solubility is prepared successfully by taking a cheap carbazole derivative with a plurality of active spots as a raw material by a photocatalysis loop closing method. The method has the advantages of high yield, short time, easiness for operating and the like; and moreover, the use of an expensive reagent is avoided, so that the preparation cost is reduced, and popularization and application are easy. The carbazole-based high-condensed ring dinitrogen-aza[7]helicene compound (I) is recrystallized in different solvents, so that an inclusion compound crystal comprising different solvents is obtained. The high-condensed ring dinitrogen-aza[7]helicene compound can be widely applied in the fields of super molecular chemistry, asymmetric catalysis, chiral liquid crystals, organic two-order nonlinearity, organic electroluminescence, biological medicine and the like.

The present invention discloses a method for predicting the chemical absorption property of MgO nano-cluster surface vapor state deposition transition metal Au and Pt in absorbing CO molecules. The B3LYP method of the density functional theory (DFT) is effectively used to perform structural optimization on the following models of an absorption system: A: Mg909/Au/CO model, B: Mg909/Pt/CO model, C: Mg908/Au/CO model and D: Mg908/Pt/CO model. Output information comprising bond lengths, bond angles, dihedral angles, adsorption energy, front lines and the like can be simulated more conveniently and rapidly by using a computer, so that interference from other substances can be avoided, thereby acquiring calculated simulation data values more accurate than experimental data; absorption energy values in a series of absorption systems can be acquired to predict the absorption capability of the absorption system with respect to CO molecules; and structural optimization of future nano-MgO materials is performed, to enable the future nano-MgO materials to have advantages of a high adsorption rate, quick response, a large adsorption capacity and the like, and play important roles in environmental protection and resource conservation.

The invention belongs to the technical field of super-molecular chemistry and particularly relates to small molecule peptide-based cholesteric organic gel molecules and a preparation method thereof. The cholesteric organic gel molecules can form gel in an organic solvent and the formed gel has thermal stability and water stability and can respond to ultrasound for realizing transformation of ultrasonically-induced gel into gel. The organic gel molecule comprises 1) an anhydride naphthalene part serving as a luminophor, 2) a middle small peptide serving as a functional group for forming intermolecular hydrogen bonds and 3) a sterides part which has biocompatibility and serves as a gelation factor and a hydrophobic group. The molecule can form high-quality gel which has rich micro-nanoscale macro morphologies, such as nuclear shells, solid balls, defect balls, nanofiber, micro-fiber and the like, and has regular shape and high repeatability in nearly ten organic solvents including acetonitrile, ethanol, benzene, toluene, acetone and the like through a sol-gel process. The organic fluorescent gel has a certain application value in the aspects of nano material preparation, medicinal carrier transportation, biological marking and the like.

The present invention relates to the field of organic and high-molecular chemistry, and discloses a preparation method of substituted diaryl phosphate. It is characterized by that said invention uses substituted phenol or substituted diaryl bisphenol as raw material, in the presence of inorganic alkali and non-toxic solvent said invention makes three steps of phenol treatment, condensation reaction and direct alkali-adding aqueous solution salt formation be implemented in one reaction container.

The present disclosure provides an improved device that can be used to sense and characterize a variety of materials. The device may be used for a variety of applications, including genome sequencing, protein sequencing, biomolecular sequencing, and detection of ions, molecules, chemicals, biomolecules, metal atoms, polymers, nanoparticles and the like.

The invention discloses a magnetic putamen MOFs compound drug-loading system of pillararene nano-valve controlled-release, a preparation method and an application thereof, and belongs to the technicalfield of the compound drug-loading system. The preparation method comprises the following steps: using Fe3O4 as a nuclear matrix, enabling MOFs reaction mother solution to directly react with the nuclear matrix through an in-situ growth mode to form the magnetic putamen MOFs, and modifying 'connecting shaft' molecules on the magnetic putamen MOFs material loaded with the drug through a post-modification mode and performing the follow-up installation of the pillararene nano-valve mediated by a subjective and objective acting force, and realizing the controlled-release under the stimulation oflesion environment factors. Through changing the types of the pillararene nano-valve and the 'connecting shaft' molecules, the slow release of the drugs under the stimulation response can be realized.The whole compound material diagnosis and treatment system is capable of realizing the targeting drug release and the controllable drug release behavior by using the controllability of the nano-valveas the opportunity. The multi-functional point-fixing, timing and positioning treatment can be realized by organically combining the molecular chemistry and the material chemistry, so the disease treatment efficiency is improved.

The invention, which relates to the micro-nano Newton force detection technology field, discloses a system and a method for detection of a micro-nano Newton force on a spherical membrane vibratory quantum. According to the method, under an effect of spherical membrane vibration, on the basis of changes of a diameter and a thickness of a spherical membrane, detected vibratory quantum change information enables detection on a micro-nano Newton force exerted on a spherical membrane to be realized. The system comprises a micromanipulator platform, a corpuscule loading mechanism, a spot light source, a PSD sensor, a data processing system and the like. In addition, the system also comprises a one-time spherical membrane generation mechanism or a spherical membrane support that is used for a repeated spherical membrane. According to the invention, enormous economic benefits and technological supports are brought for micro-force detection fields like biomedicine and molecular chemistry and the like in China.

A method for preparing a supra-molecular graphene load manganese dioxide self-assembly relates to the technical field of supra-molecular chemistry. According to the invention, the electrochemical performance of a graphene-based super capacitor is improved by combining the properties of a manganese dioxide Faraday capacitor and high specific surface area and high conductivity of graphene. Graphene-manganese dioxide compound is simply and rapidly prepared through supra-molecular interaction; then, graphene is assembled through supra-molecular interaction; and finally, a three-dimensional self-assembly of graphene sandwich manganese dioxide nanoparticles is obtained. Experiments show that the self-assembly of graphene load manganese dioxide has higher specific capacitance than that of pure manganese dioxide, and the specific capacitance can be up to 867.8 Fg<-1>.

The invention discloses extraction equipment for detecting a high-molecular chemical reagent and an extraction process thereof.The extraction for detecting the high-molecular chemical reagent is carried out by adopting a multi-station design concept, and an arranged clamping mechanism can be used for clamping glass tubes loaded with reagents and having different sizes; an arranged extraction mechanism can realize synchronous extraction and automatic mixing of various reagents, so that the overall operation efficiency can be greatly improved; and meanwhile, single glass tubes and the mixed reagents can be subjected to centrifugal stirring treatment, so that the phenomena of chromatography and the like of the reagents are avoided, and the mixing speed and uniformity of the mixed reagents are improved.

The invention discloses a method for preparing a nanometer channel with molybdate nanowires, belonging to the nanometer technical field. The method comprises the following steps: a) preparing molybdate nanowires; b) dispersing the nanowires on a substrate; c) preparing the wall material of the nanometer channel on the substrate, wherein the wall material of the nanometer channel covers the nanowires; and d) dissolving the nanowires with the designated polar solvent to obtain the nanometer channel. The invention can be used to prepare the nanometer channel and has wide application prospect in local chemical analysis, local physical measurement, heat engineering, disease detection, cell screening, molecular chemistry test, mRNA extraction and passivation, protein crystallization and other aspects.

The invention belongs to the technical field of high-molecular chemistry synthesis, and particularly relates to a method for one-kettle preparation of a fluorosilicone block polymer-modified inorganic material. Activators regenerated by electron transfer for atom transfer radical polymerization are adopted to control a reaction, the concentration of a metal catalyst in a system is extremely low, side reactions between radicals and the catalyst and between the radicals can be effectively inhibited or reduced, and end group activity is better kept. Surface functionalized inorganic particles are used as an initiator, a first monomer and a reducing agent are added, and polymerization is initiated; and when the first monomer conversion rate is relatively high, a second monomer and the reducing agent are added and one-kettle preparation of the fluorosilicone block polymer-modified inorganic material can be achieved. The invention provides the technology of one-kettle preparation of the fluorosilicone block polymer-modified inorganic material, wherein the technology has the advantages of being low in catalyst concentration, mild in reaction conditions, simple in operation steps and suitable for industrialization. At the same time, the method has important significance in preparation of high-efficiency marine antifouling coatings, improvement of marine fishery industries, and even enhancement of naval power.