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Magnetic putamen MOFs compound drug-loading system of pillararene nano-valve controlled-release, preparation method and application thereof

A columnarene and magnetic technology, applied in the field of composite drug-loading systems, to achieve the effects of strong designability, convenient preparation, and high drug loading efficiency

Pending Publication Date: 2018-02-02
JILIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of the fact that the current design of diagnosis and treatment systems based on MOFs materials has not been reported to use supramolecular nano-valves to modify MOFs with shell-core structure to prepare multifunctional composite drug-loading systems, this application actively researched and innovated, and finally prepared a " "Smart" MOFs composite drug-loading system, to expand the organic combination of supramolecular chemistry and material science, and develop a new direction for the development and utilization of intelligent composite diagnosis and treatment systems in the future

Method used

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  • Magnetic putamen MOFs compound drug-loading system of pillararene nano-valve controlled-release, preparation method and application thereof
  • Magnetic putamen MOFs compound drug-loading system of pillararene nano-valve controlled-release, preparation method and application thereof
  • Magnetic putamen MOFs compound drug-loading system of pillararene nano-valve controlled-release, preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0040] Based on Fe 3 o 4 Preparation of functional cores of nanoparticles

[0041] FeCl in a nitrogen atmosphere 3 ·6H 2 O (11.68g) and FeCl 2 4H 2 O (4.30g) was dissolved in 200mL of ultrapure water, stirred at 500rpm at 85°C for 2h, and then 40mL of NH with a volume fraction of 25% was added 3 ·H 2 O, stirred at 500 rpm for 1 h at 85°C. After the reaction is completed, cool to room temperature, magnetically separate, wash with water and ethanol once, and dry to obtain Fe 3 o 4 Nanoparticles. SEM characterization illustrates Fe in embodiment 1 3 o 4 Nanoparticle size is 10-15nm, such as figure 1 (A).

Embodiment 2

[0043] Preparation of magnetic MOFs materials

[0044] Get the Fe in embodiment 1 3 o 4 Nanoparticles (50mg) were dispersed in 5mL of polyvinylpyrrolidone (25mg) in DMF solution, ultrasonically reacted for 1h; zirconium tetrachloride (25.17mg) and 2-aminoterephthalic acid (19.47mg) were dissolved in DMF (10mL ), and then sequentially added to the above mixed solution, the resulting mixed solution was transferred to the reaction kettle for 12 hours at 80°C and 24 hours at 100°C, after the reaction was completed, the sample was cooled to room temperature, magnetically separated, and then washed with DMF and ethanol The magnetic MOFs material (Fe 3 o 4 @UiO-66) with a mass of 100mg.

Embodiment 3

[0046] Preparation of Linker Molecule 1-(6-Bromohexane)pyridine Bromide (Py)

[0047] Add 10 mL of 1,6-bromohexane to 100 mL of CH 2 Cl 2 1 mL of pyridine was slowly added dropwise to the above mixture, refluxed at 70°C for 36 h, cooled, distilled under reduced pressure, and dried to obtain Py molecules.

[0048] (Py): 1 H NMR (500MHz,D 2 O) δ8.86(d, J=6.1Hz, 2H), 8.56(t, J=7.9Hz, 1H), 8.09(t, J=7.0Hz, 2H), 4.64(t, J=7.3Hz, 2H ), 3.51(t, J=6.7Hz, 2H), 2.15–1.99(m, 2H), 1.95–1.78(m, 2H), 1.50(m, J=7.4Hz, 2H), 1.39(m, J= 7.9Hz, 2H). 1 H NMR spectrum as figure 2 .

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Abstract

The invention discloses a magnetic putamen MOFs compound drug-loading system of pillararene nano-valve controlled-release, a preparation method and an application thereof, and belongs to the technicalfield of the compound drug-loading system. The preparation method comprises the following steps: using Fe3O4 as a nuclear matrix, enabling MOFs reaction mother solution to directly react with the nuclear matrix through an in-situ growth mode to form the magnetic putamen MOFs, and modifying 'connecting shaft' molecules on the magnetic putamen MOFs material loaded with the drug through a post-modification mode and performing the follow-up installation of the pillararene nano-valve mediated by a subjective and objective acting force, and realizing the controlled-release under the stimulation oflesion environment factors. Through changing the types of the pillararene nano-valve and the 'connecting shaft' molecules, the slow release of the drugs under the stimulation response can be realized.The whole compound material diagnosis and treatment system is capable of realizing the targeting drug release and the controllable drug release behavior by using the controllability of the nano-valveas the opportunity. The multi-functional point-fixing, timing and positioning treatment can be realized by organically combining the molecular chemistry and the material chemistry, so the disease treatment efficiency is improved.

Description

technical field [0001] The technology of the present invention belongs to the technical field of composite drug-loading systems, and in particular relates to a magnetic-shell-core MOFs composite drug-loading system, a preparation method and an application thereof for controlled release of macrocyclic aromatic hydrocarbons-columnarene nano-valve. The present invention realizes the integration of controllable drug release in response to multiple stimuli under the synergistic effect of magnetic separation and magnetic resonance imaging, which is beneficial to realize timing, fixed-point, and localized treatment of the composite drug-loading system and improve disease treatment efficiency. Background technique [0002] Metal-organic frameworks (MOFs), as an emerging hybrid porous material composed of metal ions / ion clusters linked with organic ligands, have attracted extensive attention from researchers since their synthesis. Highly ordered porous structure, large specific surfa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18A61K49/12A61K49/10A61K9/51A61K31/513A61K47/32A61K47/12A61P35/00
CPCA61K49/1854A61K9/5123A61K9/5138A61K31/513A61K49/101A61K49/12A61K49/1833
Inventor 杨英威武明雪
Owner JILIN UNIV
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