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Method and system for detecting optical micro/nano newton force on spherical membrane

A detection system and detection method technology, applied in the direction of material analysis, measuring devices, scientific instruments, etc. through optical means, can solve the problems of insufficient measurement accuracy, and achieve the effects of low reliability, short life, and low yield

Inactive Publication Date: 2009-12-02
NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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Problems solved by technology

When the traditional micro force sensor can not reach the measurement accuracy and the traditional classification method can not completely classify, it is necessary to find a new classification method to solve the classification problem of cell molecules, and this problem has been plagued by biologists and medical research at home and abroad. workers

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  • Method and system for detecting optical micro/nano newton force on spherical membrane

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Embodiment Construction

[0019] The spherical membrane optical micro-nano force detection method and system of the present invention will be described below with reference to the accompanying drawings.

[0020] As shown in Figure 1, the spherical membrane optical micro-nano force detection method and system of the present invention include:

[0021] Microscope 101, loaded on the micro-operation platform, used for magnified observation when microparticles are loaded;

[0022] The micro-operation platform 102, the entire detection process is carried out on the micro-operation platform, the micro-operation platform in the figure mainly refers to the physical structure of the micro-operation platform, which is used to load the microscope, as a rigid physical platform for the micro-drive mechanism and the micro-particle clamping mechanism;

[0023] Disposable spherical membrane elimination mechanism 103, after the detection is completed, eliminates the disposable spherical membrane to prevent the disposabl...

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Abstract

The invention discloses a method and a system for detecting an optical micro / nano Newton force on a spherical membrane and relates to the technical field of micro / nano Newton force detection. The method realizes the detection a micro / nano Newton force applied on the spherical membrane through the detection of the variable quantity of an interference spectrum obtained by changing the diameter and thickness of the spherical membrane under the interference effect of the spherical membrane. The system comprises a micro operating platform, a micro particle loading mechanism, a point light source, an optical fiber sensor, a spectrum analyzer, a data processing system and other large parts. The system also comprises a disposable spherical membrane generating mechanism or a reusable spherical membrane support. The method and the system can bring huge economic benefits and technical support to the micro force detection fields such as biochemical fields, molecular chemistry fields and the like in China.

Description

technical field [0001] The invention relates to micro-nano force detection technology, more specifically, a method and system for detecting micro-nano force by utilizing the principle of spherical membrane optical interference. Background technique [0002] With the development of micro-nano technology and biomedical technology, nN-level micro-force measurement in the fields of microorganisms, cells, and molecular clusters has attracted more and more attention, and the research on micro-force sensors has become a new research hotspot. Most of the research on micro force sensors at home and abroad is based on silicon wafer cantilever beams, ZnO piezoelectric thin films, PZT piezoelectric twin crystal beams, etc. as sensitive elements, and the measurement accuracy can reach the μN level. Surface tension analysis has a certain effect, but it is not enough for the measurement of biological microtissue force, cell weight classification, and molecular cluster gravity measurement, ...

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Application Information

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IPC IPC(8): G01N21/00
Inventor 陆永华赵东标刘凯
Owner NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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