208 results about "Methoxypropane" patented technology

The invention provides a spherical magnesium halide adduct and a preparation method thereof. The method comprises the following steps of: (1) mixing magnesium halide and alcohols except methanol with optional inert liquid media and heating the obtained mixture under stirring until a melt of the magnesium halide adduct is formed; (2) adding the melt of the magnesium halide adduct to cooling media after shearing and dispersing the melt to form spherical solid particles; and (3) carrying out contact reaction on the spherical solid particles and dimethoxy propane in the inert dispersion media. The invention also provides application of the magnesium halide adduct as a catalyst carrier. The magnesium halide adduct has the following beneficial effects: the morphology of particles of the magnesium halide adduct is more regular and is basically spherical; the particle size distribution is more concentrated; basically special-shaped particles do not exist; and the catalyst prepared by adopting the spherical magnesium halide adduct as the catalyst carrier has better hydrogen regulation sensitivity in propylene polymerization reaction.

The invention provides a spherical magnesium halide adduct and a preparation method and application thereof. The method comprises the following steps of: (1) mixing magnesium halide, alcohol except methanol, and an optional inert liquid medium, and heating the obtained mixture with stirring to form a magnesium halide adduct melt; (2) performing shear dispersion on the magnesium halide adduct melt, and adding into a cooling medium to form spherical solid particles; (3) performing contact reaction on the spherical solid particles and dimethoxy propane in an inert dispersion medium; and (4) performing contact reaction on a product obtained in the step (3) and a polyol ester compound in the inert dispersion medium. The magnesium halide adduct has a good particle shape, a smooth surface and high liquidity, and special-shaped particles do not exist; and a catalyst prepared by taking the magnesium halide adduct as a catalyst carrier has high hydrogen regulation sensitivity when used for olefin polymerization.

The olefin polymerization activator contains A,B,C trimaceral. A is the solid catalyst containing the element of the titanium, the magnesium, the chlorine and the inner power electron body, the inner power electron body is combined with the 1,4-fragrant bis ether [2,2, - two alkoxy-1, 1'-biphenyl, 2,2-two alkoxy-1, 1'-biphenyl, 10, 10'-two alkoxy-9, 9'joining humble] and the organic acid ester or the 1,3-bis ether [9, 9-two (the methoxy cymene) fluorine, 2, 2-dialkyl-1, 3-dimethoxypropane]; B is the organo aluminium; C is the outer power electron body-the organic silicon compound or 1,4-fragrant bis ether. The activator possess the high catalytic activity and is used for the propylene aggregation and can be adjusted between the 40,000-150,000gPP / gCat;The degree isotacticity (80%-90%) and the molecular weight distribution of the polymer can be adopted in the wide within range. The invention provides the new process of the 1, 4-fragrant bis ether.

The invention relates to a method for preparing ganciclovir. The method comprises the following steps of: a, adding paraformaldehyde into 1,3-dichloro-2-propanol [2], reacting under the action of a catalyst to obtain hemiformal [3], and reacting with an acetic anhydride to obtain 1,3-dichloro-2-acetoxylmethoxylpropane [4]; b, making 1,3-dichloro-2-acetoxylmethoxylpropane [4] react with absolute postassium acetate or anhydrous sodium acetate in an organic solvent medium in the presence of a tetraalkyl ammonium bromide catalyst with 1-20 carbon atoms and an acetic anhydride serving as a dehydrating agent to obtain 1,3-diacetoxy-2-acetoxymethoxyl propane [5]; c, performing a condensation reaction on 1,3-diacetoxy-2-acetoxymethoxyl propane [5] and 2,9-diacetyl guanine [6] in an organic solvent medium in the presence of a catalyst and an acetic anhydride serving as a dehydrating agent to obtain triacetyl ganciclovir [7]; and d, hydrolyzing the triacetyl ganciclovir [7] to obtain ganciclovir [1]. The method has the advantages of easy and controllable preparation process, high utilization ratios of raw materials, low cost and high yield of a prepared ganciclovir product.

The invention discloses a nonionic hydrophilic monomer for synthesis of a waterborne polyurethane and a synthetic method thereof. The method provided by the invention comprises steps of: firstly utilizing 2, 2-dimethoxy propane to protect two hydroxy groups of 2, 2-dimethylolpropionic acid; reacting a product treated with hydroxy protection with polyethylene glycol monomethyl ether with a molecular weight of 1000-2000 for an esterification reaction; and further conducting dehydroxylation protection on an esterification product to generate a final product of the nonionic hydrophilic monomer with two hydroxyl groups on a chain segment and an ether bond on the other end. The monomer can be grafted to a main-chain structure of a waterborne polyurethane molecule; stability of a waterborne polyurethane emulsion prepared by modification by the monomer is greatly improved compared with that of a traditional block type nonionic waterborne polyurethane emulsion; besides, the waterborne polyurethane emulsion can avoid a problem of emulsion breaking in matching with other anionic or cationic auxiliaries. Raw materials for preparation of the functional monomer provided by the invention are easily available and low-cost; and the preparation process is simple, high-yield, and convenient for industrialized production.

The invention discloses a method for preparing 2-chloropyrimidine, belonging to the technical field of methods for preparing chemical medicine intermediates. The method for preparing the 2-chloropyrimidine comprises the following steps of: (1) reacting dicyandiamide with ammonium chloride at high temperature, and obtaining guanidine hydrochloride; (2) reacting the guanidine hydrochloride with 1.1.3.3-tetramethoxypropane by refluxing under the condition of taking industrial hydrochloric acid as a solvent to obtain 2-amino pyrimidine; and (3) reacting the 2-amino pyrimidine with sodium nitrate at low temperature for producing the 2-chloropyrimidine by taking zinc chloride as a catalyst and taking the industrial hydrochloric acid as the solvent. The preparation method disclosed by the invention has the advantages of lower cost of raw materials, relatively simple technical process, mild reaction conditions, low operation difficulty, excellent maneuverability; convenience for post-treatment; and largely improved yield stable quality and applicability of large-scale industrial production of prepared products,.

The invention discloses a preparation method of N,N-bis(2-hydroxyethyl)methacrylamide. The N,N-bis(2-hydroxyethyl)methacrylamide is prepared mainly from diethanolamine, 2,2-dimethoxypropane and methyl methacrylate through a three-step reaction. The method has the advantages of simplicity and stability in process operation, easy separation and high yield of products in all steps, environmental protection, realization of the comprehensive yield of 85% or above, cheap and easily available raw materials, great reduction of the production cost, and facilitation of industrial scale production.

The invention discloses a preparation method of 4-oximide-5'-(2-methylpropionyl) uridine, which comprises the following steps: S1, in the presence of acid, reacting a compound 1 with 2, 2-dimethoxypropane in an organic solvent to obtain a compound 2; S2, in the presence of an alkali, enabling the compound 2 to react in an organic solvent to obtain a compound 3; S3, reacting the compound 3 in an organic solvent in the presence of a hydroxylamine aqueous solution to obtain a compound 4; S4, reacting the compound 4 in an organic solvent in the presence of an acid to obtain a compound I; the solidwith good crystallization performance prepared by the method is simple in preparation condition and good in conversion rate and atom economy.

The invention relates to a methacrylate polymer solid phase micro extraction fiber and a preparation method thereof, in particular to a solid phase micro extraction. A fiber is provided with a stainless steel substrate which is a stainless steel wire, and one end of the stainless steel wire is provided with a methacrylate polymer coating. The preparation steps of the invention are that: one end of the stainless steel wire is cleaned with water and dried after being ultrasonically cleaned by an acetone solvent and an ethanol solvent; trimethylolpropane trimethacrylate, toluol and azodiisobutyronitrile are added to the methacrylate in sequence, then ultrasonic blending process and nitrogen flushing and deoxygenizing process are conducted, and then a prepolymerization blended solution is obtained; the prepolymerization blended solution is injected to a glass point sampling capillary by a microliter syringe, then the stainless steel wire is vertically inserted into the central part of the point sampling tube, and the two ends of the point sampling tube are sealed by rubber, then the point sampling tube is placed into an oven for polymerizing and cross linked at a certain temperature. After a polymer solution is solidified at the surface of the fiber, the point sampling tube is soaked in a hydrofluoric acid solution for a certain period, then the glass tube wall is removed, and then the solid phase micro extraction fiber is obtained.

The invention relates to a preparation method of 2, 2-dimethoxypropane. The method comprises the steps of adding a catalyst after mixing methanol and acetone, and reacting under a certain condition to obtain a crude product of 2, 2-dimethoxypropane; then, carrying out extractive distillation and redistillation to obtain a finished product of 2, 2-dimethoxypropane. The preparation method is simple in process, low in energy consumption and high in safety; experimental data proves that the yield can be up to over 90%, the purity of 2, 2-dimethoxypropane can be up to over 99%, and the quality of 2, 2-dimethoxypropane can be effectively improved.

The invention discloses methanol gasoline for a vehicle and a preparation method thereof. The methanol gasoline is prepared from the following raw materials in parts by weight: 60-70 parts of methanol, 15-25 parts of 90# gasoline, 10-15 parts of dipropylene glycol methyl ether acetate, 5-10 parts of tert amyl methyl ether, 5-10 parts of dimethyl carbonate, 4-8 parts of diethylene glycol dimethyl ether, 3-6 parts of 2,2-dimethoxypropane, 1-2 parts of ferrocene, 0.5-1.5 parts of methyl cyclopentadiene tricarbonyl manganese, 0.8-1.4 parts of 2,5-di-tert-butyl hydroquinone, 0.4-0.8 part of glycerol monolaurate, 0.5-1 part of sodium petroleum sulfonate, 0.3-0.6 part of N-Polyoxyethylated-N-tallow-alkylamine, 5-10 parts of wood tar, 3-6 parts of isopropanol, 2.5-4.5 parts of fish meal, 2-3 parts of bone meal, 1-2 parts of stearic acid and 0.5-1 part of urotropine. The methanol gasoline disclosed by the invention is favorable in combustion characteristic, high in utilization ratio, favorable in anti-detonating quality, low in corrosivity, high in safety and reliability, energy-saving and environment-friendly, can be used instead of any of 90#, 93#, 97# and 98# gasoline for a vehicle, is novel environment-friendly alternative fuel, and can reduce pollutant emission and carbon emission; and the combustion emission of the methanol gasoline meets the standards in Europe and America. The methanol gasoline has excellent economic benefits and far-reaching social benefits.

The invention discloses a method for preparing (2S)-2-[[(9H-fluorene-9-yl methoxy) carbonyl] amino]-3-(2,2-dimethyl-1,3-benzo dioxol-5-yl)propionate, which mainly aims to solve the technical problems of complicated steps and high operating difficulty in existing synthetic routes. The invention has the technical scheme that levodopa reacts with Fmoc N-hydroxysuccinimide este to obtain Fmoc acyl levodopa; and the Fmoc acyl levodopa reacts with 2,2-dimethoxypropane to obtain (2S)-2-[[(9H-fluoren-9-yl methoxy) carbonyl] amino]-3-(2,2-dimethyl-1,3- benzo dioxol-5-yl)propionate. The solvent used in the reaction of the Fmoc acyl levodopa and the 2,2-dimethoxypropane to obtain the (2S)-2-[[(9H-fluoren-9-yl methoxy) carbonyl] amino]-3-(2,2-dimethyl-1,3- benzo dioxol-5-yl)propionate is tetrahydrofuran; and the catalyst is pyridinium p-toluenesulfonate. The resultant obtained by the method is applied in the field of peptide synthesis as a non-natural amino acid protecting reagent.

The invention relates to the preparation of an absorption material and the application to medicament separation and enrichment, in particular to the preparation methods of a Lamivudine molecularly imprinted polymer and a Lamivudine molecularly imprinted solid phase extraction column and the applications thereof. The Lamivudine esterified ester is obtained through esterification synthesis. The molecularly imprinted polymer is synthesized by using the Lamivudine esterified ester as a template, methacrylic acid as a monomer, trimethoxy propane trimethyl acrylate as a crosslinker and chloroform as a porogen by adopting a body polymerization method; and molecularly imprinted polymer particles are uniformly filled in the solid-phase extraction column to obtain the Lamivudine molecular imprinting solid-phase extraction column. The invention realizes the efficient separation, enrichment and purification of Lamivudine in a biological sample and has high selectivity as compared with traditional related technologies, such as a common solvent extraction method, a C18 solid-phase extraction method, and the like. Moreover, the Lamivudine molecularly imprinted solid phase extraction column has low cost by being repeatedly used and can become a necessary method in the Lamivudine pretreatment in biological samples.

The invention discloses a preparation method of (4R-cis)-6-chloromethyl-2, 2-dimethyl-1, 3-dioxane-4-acetic acid isopropyl ester. The preparation method has the advantages that chloroacetaldehyde and acetaldehyde serve as reaction substrates to complete a condensation reaction under the action of aldolase, an open-loop esterification reaction between an oxidative obtained product and isopropanol is achieved in the presence of a catalyst, and ester exchange between the product and 2, 2-dimethoxy propane is completed to obtain a target product, so that synthetic route is short, highly toxic products are not used in the whole reaction process, and raw materials are low in cost.

The invention relates to a polyurethane material containing a polythioketal soft segment and capable of being degraded with active oxygen, and a preparation method thereof, wherein the polyurethane material comprises a polythioketal soft segment and a saturated aliphatic diisocyanate hard segment. The preparation steps comprise: carrying out a reaction on excess bis(2-mercaptoethyl)ether and 2,2-dimethoxypropane to prepare polythioketal; carrying out a reaction on the polythioketal and diisocyanate or on the polythioketal, polyethylene glycol and diisocyanate, and carrying out one-pot additionto obtain a prepolymer; and carrying out a diol or diamine chain extension reaction to obtain polyurethane. According to the present invention, by using the one-pot method, the polythioketal or the polythioketal and the polyethylene glycol as the soft segment are polymerized into the polyurethane; the polyurethane obtained by copolymerizing with the polyethylene glycol has amphiphilicity, and thehydrophilic / hydrophobic chain segment ratio can be adjusted through the feeding ratio; and the polyurethane can be used for producing nanoparticles, tissue engineering scaffolds or hydrogels, and issuitable for physiological environments with high active oxygen content, and has good application prospects in the biomedical field.

The invention provides a preparation method of rosuvastatin calcium. The method comprises the following steps: carrying out condensation reaction on 4-(4-fluorophenyl)-6-isopropyl-2 chloropyrimidine-5-formaldehyde and (3R)-tertiary butyl dimethylsiloxo-5-oxo-6-triphenyl phosphaalkene hexanoate; and then removing a silylether protecting group of hydroxyl, carrying out stereoselectivity reduction, reacting with 2,2-dimethoxy propane, condensing with N-methyl methane sulfonamide, removing propylidene protection, hydrolyzing an ester group, salifying and carrying out other steps, so as to obtain the rosuvastatin calcium. According to the preparation method, the yield is stable, and the price of reagents is cheap; and the method is easy to operate and is beneficial to industrial production.

The invention discloses a preparation method of an atorvastatin intermediate (3R, 5R)-7-amino-3,5-O-isopropylidene-3,5-dyhydroxyl heptylic acid tert-butyl acetate. The method comprises the following steps of: reacting (R)-epichlorohydrin and nitromethane to generate 1-chlorine-4-nitryl-(R)-2-butanol, and reacting with sodium cyanide to obtain (R)-3-hydroxyl-5-nitryl-valeronitrile; dropwise adding the product into a tert-butyl bromoacetate zinc reagent to generate 7-nitryl-5-hydroxyl-3-carbonyl-heptylic acid tert-butyl acetate; reacting with sodium borohydride to generate 7-nitryl-3,5-dyhydroxyl-heptylic acid tert-butyl acetate; reacting with 2,2-dimethoxypropane, acetone and methanesulfonic acid to obtain 7-nitryl-3,5-O-isopropylidene-3,5-dyhydroxyl-heptylic acid tert-butyl acetate; and obtaining (3R, 5R)-7-amino-3,5-O-isopropylidene-3,5-dyhydroxyl heptylic acid tert-butyl acetate by hydrogen reduction. The yield of the product is 80-86%, and the purity of the product is greater than or equal to 99.0%.

The invention belongs to the technical field of organic chemistry, and specifically relates to a preparation method of 2-[(4R, 6S)-6-substituted methyl-2, 2-dimethyl-1, 3-dioxan]-acetate. The preparation method specifically comprises: performing asymmetric epoxidation on (S)-1-substituted-4-ene-2-pentanol (II) to prepare (2S, 4R)-1-substituted-4-epoxy-2-pentanol (III); performing sodium cyanide ring-opening addition to prepare (3S, 5S)-6-substituted-3, 5-dihydroxyacetonitrile; performing a Pinner reaction to prepare (3S, 5S)-6-substituted-3, 5-dihydroxyhexanoate; and then performing a protection reaction with 2, 2-dimethoxypropane to prepare 2-[(4R, 6S)-6-substitued methyl-2, 2-dimethyl-1, 3-dioxan]-acetate (I). The preparation method of the invention is mild in reaction conditions, simple in operation, cheap and easily-available in raw materials, high in yield of the obtained product and high in stereoselectivity, and is applicable to industrialized production.

The present invention provides an atorvastatin calcium side chain intermediate preparation method comprising the following steps: (1) a compound II is added into 2,2-dimethoxypropane liquid, the molar ratio of compound II to 2,2-dimethoxypropane is 1: 2.2 to 13.2; (2) an acidic resin catalyst with the mass accounting for 2.6 to 9.5% of the mass of the compound II is added, and at 10-30DEG C, the mixture is stirred for reaction for 4-6 hours; and (3) the reaction system is filtered, filtrate is concentrated to obtain an oil matter, and the oil matter is recrystallized to obtain a solid atorvastatin calcium side chain intermediate I. By the method, the solid atorvastatin calcium side chain intermediate I with the purity of more than 99% is obtained, and the yield is greater than 95%. The reaction conditions are mild, decolorization treatment is not required, production cost is low, the reaction is stable and easy to control, safety is high, operation is easy, the catalyst and the reactant 2,2-dimethoxypropane are recyclable, waste liquids and waste residues are not produced, and the method is green and environmentally-friendly.

The invention relates to a method for synthesis of a material with dichlorvos selective separation function. Dichlorvos is taken as template molecule, room-temperature ion liquid (BMIM<+>PF6<->) is taken as an auxiliary template, methacrylic acid is taken as a functional monomer, TRIM is taken as a crosslinking agent and molecular engram technology is adopted to synthesize a novel material with selective adsorbing function. The invention has the advantages of low cost, simple laboratory operation and easy control of reaction conditions; the adsorbent adopting the synthesized material with dichlorvos selective separation function can be applied to solid-phase extraction and liquid chromatogram combination; the dichlorvos detection capacity is largely improved; the material is particularly applicable to adsorptive detection of trace dichlorvos in various fruits, vegetables and other complex hosts.

The invention relates to a solid catalyst component and a catalyst for olefinic polymerization. The solid catalyst component uses dialkoxy magnesium as a carrier and toluene as a dispersant to be contacted with at least one 2,3-di-non-linear chain alkyl-2-cyanosuccinic acid dibasic acid ester type compound and a 2-isopropyl-2-(3-methyl-butyl)-1,3-dimethoxypropane compound to react with titanium halide, and then the reaction product is processed by the titanium halide to obtain the solid catalyst component. The polymerization activity of the catalyst is high, the molecule weight distribution of the obtained polymer is wide, the bulk density is high, the hydrogen response and the stereospecificity expression are good, the grain shape is good, the fine powder content is less and the catalyst is suitable for developing the polyolefine grade.

The invention relates to a cleaning agent for organic sediments inside an oil tank and a preparation method of the cleaning agent. The cleaning agent comprises the following components in percentage by mass: 30%-60% of tetramethoxy-propane, 20%-40% of dimethoxy-ethane, 5%-15% of diethylene glycol octyl ether, 2%-10% of sodium polyphosphate, 1%-1.5% of sodium alkyl benzene sulfonate and 2%-3.5% of lauryl sodium sulfate. The cleaning agent disclosed by the invention can be cleaned on line and also be cleaned off line, generates no influence on production because of no need of shutdown when used for cleaning on line, so that cost and time are saved; the cleaning agent is harmless to an operator because an operator unnecessarily enters the oil tank, is pollution-free on the environment, can be used for recovering 90% hydrocarbon by recycling sludge and has the advantages of outstanding economic benefit, simple preparation method, short cleaning operation time, high cleaning quality, ecological and environmental friendliness, no three wastes discharge, no need of anti-rust treatment on a container after cleaning, good social benefit and economic benefit, harmlessness on human bodies, no corrosion on equipment and no secondary pollution.

The invention discloses a tetrahydro carboline derivative modified with two amino acids and a preparation method and an application thereof. According to the invention, L-tryptophan methyl ester is allowed to react with 1,1,3,3-tetramethoxy propane by a microwave reaction; the obtained product is modified by amino acids to obtain a series of (1R, 3S)-1-[1-(1R, 3S)-tetrahydro beta-carboline-3-formyl amino acid-1-yl-methyl]-tetrahydro beta-carboline-3-formyl amino acid derivatives and intermediates thereof; and the derivatives are evaluated for in vitro antiplatelet aggregation activity and in vitro antithrombotic activity. The method of the invention is simple; the used raw materials are easily available, safe and cheap; the obtained product has antiplatelet aggregation activity and antithrombotic activity, which indicates the clinical application prospects of (1R, 3S)-1-[1-(1R, 3S)-tetrahydro beta-carboline-3-formyl amino acid-1-yl-methyl]-tetrahydro beta-carboline-3-formyl amino acidas an antithrombotic agent.

The invention discloses a method for preparing statins intermediates through biosynthesis, and specifically discloses an enzymatic method for preparing statins intermediates. The enzymatic method comprises the following steps: (a) carrying out catalytic reduction reactions on a compound (III) in the presence of alcohol dehydrogenase CmADH3, co-enzyme factors, and a regeneration system of an optional co-enzyme factor to produce a compound (II); (b) reacting the compound (II) with 2,2-dimethoxy propane to generate a compound (I). The provided method can reduce the production cost and environmental pollution, and thus has a great application value.

The invention relates to a preparation method of methylene bridged cucurbituril. The preparation method comprises the following steps: synthesizing 1,1,3,3-malonaldehyde tetramethyl acetal and urea into methylene bridged glycoluril at first; then feeding the methylene bridged glycoluril, paraformaldehyde and calcium salt or barium salt into a mixed solution of water and hydrochloric acid, reacting and refluxing, wherein the mass ratio of the methylene bridged glycoluril to formaldehyde is 1: (0.4-1), the volume ratio of the water to the hydrochloric acid is 1: (1-3), the ratio of the mass of the methylene bridged glycoluril to the volume of the hydrochloric acid is 1: 1-3, the mass ratio of the methylene bridged glycoluril to the calcium salt is 1: 0.05-0.4, and the mass ratio of the methylene bridged glycoluril to the barium salt is 1: 0.1-0.3; and carrying out cooling, suction filtration and washing to obtain the methylene bridged cucurbituril [4] or the methylene bridged cucurbituril [5]. The methylene bridged cucurbituril [4] and the methylene bridged cucurbituril [5] are synthesized in an oriented manner by using metal salt as a template, the method is simple and convenient, a purification process is simple, and the yield is obviously increased.

The disclosed six-membered carbocyclic nucleoside analogues comprise: adenosine analogue, guanosine analogue, carnine analogue, mercaptopurine riboside analogue, cytidine analogue, 5-fluorocytidine analogue, uridine analogue, 5-fluorouridine analogue, and thymidine analogue as well as their acceptable salts formed by equimolar acid in pharmacy. Wherein, the opposite five-step synthesis method using the pinitol, acetone, methane sulfonyl chloride, p-toluenesulfonyl chloride, benzene sulfochloride, and nucleoside base as materials; the pyridine, water, glacial acetic acid, absolute methanol, DMSO, N, N-DMF as the solvent; the p-toluenesulfonic acid, 2, 2-dimethoxylpropane, anhydrous NaSO4, NaHCO3, triethylamine, and anhydrous K2CO3 as the catalyst. This invention restrains specially the replication of HIV and herpesvirus.

The invention provides a spherical magnesium halide adduct and a preparation method thereof. The method comprises the following steps of: (1) mixing magnesium halide and alcohols except methanol with optional inert liquid media and heating the obtained mixture under stirring until a melt of the magnesium halide adduct is formed; (2) adding the melt of the magnesium halide adduct to cooling media after shearing and dispersing the melt to form spherical solid particles; and (3) carrying out contact reaction on the spherical solid particles and dimethoxy propane in the inert dispersion media. The invention also provides application of the magnesium halide adduct as a catalyst carrier. The magnesium halide adduct has the following beneficial effects: the morphology of particles of the magnesium halide adduct is more regular and is basically spherical; the particle size distribution is more concentrated; basically special-shaped particles do not exist; and the catalyst prepared by adopting the spherical magnesium halide adduct as the catalyst carrier has better hydrogen regulation sensitivity in propylene polymerization reaction.

A high efficient diesel oil additive is composed of the following raw materials in parts by weight: 6 to 14 parts of tween, 7 to 9 parts of magnesium nitrate, 6 to 13 parts of N,N-dimethyl myristyl tert-alcohol, 8 to 12 parts of dimethoxy propane, 4 to 7 parts of ethyl nitrate, 3 to 6 parts of petroleum ether, 4 to 9 parts of dimethyl carbonate, 2 to 4 parts of isoamyl alcohol, 1.5 to 6 parts of triethanolamine, 7 to 8 parts of ferrocene, 3 to 7 parts of DMC, 11 to 13.5 parts of glycerol, 8 to 11 parts of 4-trifluoromethoxy benzyl alcohol, 7 to 9 parts of polyisobutylene amine, 1.2 to 4 parts of O,O-dibutyl zinc dithiophosphate, and 8 to 12 parts of tert-butyl alcohol. The provided diesel oil additive can save the energy, is efficient, is capable of improving the diesel oil performances and promoting the burning efficiency of diesel oil, and can reduce the accumulated carbon at the same time.

The invention discloses a preparation method of a diether type electron donor. The method comprises the following steps: 1, carrying out a condensation reaction on 3-methylbutyraldehyde under a preset reaction pressure with an aqueous solution of NaOH as a catalyst to obtain 2-isopropyl-5-methyl-2-hexenal; 2, carrying out a reduction reaction on 2-isopropyl-5-methyl-2-hexenal obtained in step 1 and H2 under the action of a Pd / C catalyst to obtain 2-isopropyl-5-methylhexanal; 3, reacting 2-isopropyl-5-methylhexanal obtained in step 2 with an aqueous solution of formaldehyde under the action of an inorganic alkali to obtain 2-isopropyl-2-isopentyl-1,3-propanediol; and 4, dissolving 2-isopropyl-2-isopentyl-1,3-propanediol in an organic solvent, and carrying out an etherification reaction on 2-isopropyl-2-isopentyl-1,3-propanediol and CH3Cl in the presence of the alkali to obtain 2-isopropyl-2-isopentyl-1,3-dimethoxypropane. By utilizing NaOH / H2O as the catalyst in the invention, technological conditions are optimized, the preparation cost is reduced, the total product yield is improved, and the efficiency is substantially improved.

The invention relates to a synthetic method of 3-deoxidized-D-sweet dew-2-octulosonic ammonium salt. The synthetic method comprises the following steps: using D-sweet dew as a raw material and performing the reaction on D-sweet dew and 2,2-dimethoxy propane; protecting hydroxy at 2 and 3 positions and 5 and 6 positions by isopropylidene to obtain an intermediate in a formula I; performing the reaction on a product in the formula I and 2-dimethoxy phosphoroso-2-dimethyl tertiary butyl silica ethyl acetate in a formula II to obtain an intermediate in a formula III; removing a silicyl oxide protecting group in a product in the formula III to form intramolecular hemiketal so as to obtain an intermediate in a formula IV; performing the deprotection, saponification and ammonium salt formation reaction on a product in the formula IV to obtain the final product 3-deoxidized-D-sweet dew-2-octulosonic ammonium salt. The method has the advantages of low price of the raw material, easiness for obtaining the raw material, mild reaction condition, simplicity and convenience for operation, high safety, high route total yield, simplicity for purification treatment on the final product and stable quality of the final product, and thus, the synthetic method disclosed by the invention enables the total cost to be greatly reduced and is suitable for the requirements on large-scale industrial production.