207 results about "Methoxypropane" patented technology

The invention provides a spherical magnesium halide adduct and a preparation method thereof. The method comprises the following steps of: (1) mixing magnesium halide and alcohols except methanol with optional inert liquid media and heating the obtained mixture under stirring until a melt of the magnesium halide adduct is formed; (2) adding the melt of the magnesium halide adduct to cooling media after shearing and dispersing the melt to form spherical solid particles; and (3) carrying out contact reaction on the spherical solid particles and dimethoxy propane in the inert dispersion media. The invention also provides application of the magnesium halide adduct as a catalyst carrier. The magnesium halide adduct has the following beneficial effects: the morphology of particles of the magnesium halide adduct is more regular and is basically spherical; the particle size distribution is more concentrated; basically special-shaped particles do not exist; and the catalyst prepared by adopting the spherical magnesium halide adduct as the catalyst carrier has better hydrogen regulation sensitivity in propylene polymerization reaction.

The invention provides a spherical magnesium halide adduct and a preparation method and application thereof. The method comprises the following steps of: (1) mixing magnesium halide, alcohol except methanol, and an optional inert liquid medium, and heating the obtained mixture with stirring to form a magnesium halide adduct melt; (2) performing shear dispersion on the magnesium halide adduct melt, and adding into a cooling medium to form spherical solid particles; (3) performing contact reaction on the spherical solid particles and dimethoxy propane in an inert dispersion medium; and (4) performing contact reaction on a product obtained in the step (3) and a polyol ester compound in the inert dispersion medium. The magnesium halide adduct has a good particle shape, a smooth surface and high liquidity, and special-shaped particles do not exist; and a catalyst prepared by taking the magnesium halide adduct as a catalyst carrier has high hydrogen regulation sensitivity when used for olefin polymerization.

The invention discloses a nonionic hydrophilic monomer for synthesis of a waterborne polyurethane and a synthetic method thereof. The method provided by the invention comprises steps of: firstly utilizing 2, 2-dimethoxy propane to protect two hydroxy groups of 2, 2-dimethylolpropionic acid; reacting a product treated with hydroxy protection with polyethylene glycol monomethyl ether with a molecular weight of 1000-2000 for an esterification reaction; and further conducting dehydroxylation protection on an esterification product to generate a final product of the nonionic hydrophilic monomer with two hydroxyl groups on a chain segment and an ether bond on the other end. The monomer can be grafted to a main-chain structure of a waterborne polyurethane molecule; stability of a waterborne polyurethane emulsion prepared by modification by the monomer is greatly improved compared with that of a traditional block type nonionic waterborne polyurethane emulsion; besides, the waterborne polyurethane emulsion can avoid a problem of emulsion breaking in matching with other anionic or cationic auxiliaries. Raw materials for preparation of the functional monomer provided by the invention are easily available and low-cost; and the preparation process is simple, high-yield, and convenient for industrialized production.

The invention discloses a preparation method of N,N-bis(2-hydroxyethyl)methacrylamide. The N,N-bis(2-hydroxyethyl)methacrylamide is prepared mainly from diethanolamine, 2,2-dimethoxypropane and methyl methacrylate through a three-step reaction. The method has the advantages of simplicity and stability in process operation, easy separation and high yield of products in all steps, environmental protection, realization of the comprehensive yield of 85% or above, cheap and easily available raw materials, great reduction of the production cost, and facilitation of industrial scale production.

The invention discloses methanol gasoline for a vehicle and a preparation method thereof. The methanol gasoline is prepared from the following raw materials in parts by weight: 60-70 parts of methanol, 15-25 parts of 90# gasoline, 10-15 parts of dipropylene glycol methyl ether acetate, 5-10 parts of tert amyl methyl ether, 5-10 parts of dimethyl carbonate, 4-8 parts of diethylene glycol dimethyl ether, 3-6 parts of 2,2-dimethoxypropane, 1-2 parts of ferrocene, 0.5-1.5 parts of methyl cyclopentadiene tricarbonyl manganese, 0.8-1.4 parts of 2,5-di-tert-butyl hydroquinone, 0.4-0.8 part of glycerol monolaurate, 0.5-1 part of sodium petroleum sulfonate, 0.3-0.6 part of N-Polyoxyethylated-N-tallow-alkylamine, 5-10 parts of wood tar, 3-6 parts of isopropanol, 2.5-4.5 parts of fish meal, 2-3 parts of bone meal, 1-2 parts of stearic acid and 0.5-1 part of urotropine. The methanol gasoline disclosed by the invention is favorable in combustion characteristic, high in utilization ratio, favorable in anti-detonating quality, low in corrosivity, high in safety and reliability, energy-saving and environment-friendly, can be used instead of any of 90#, 93#, 97# and 98# gasoline for a vehicle, is novel environment-friendly alternative fuel, and can reduce pollutant emission and carbon emission; and the combustion emission of the methanol gasoline meets the standards in Europe and America. The methanol gasoline has excellent economic benefits and far-reaching social benefits.

The invention discloses a method for preparing (2S)-2-[[(9H-fluorene-9-yl methoxy) carbonyl] amino]-3-(2,2-dimethyl-1,3-benzo dioxol-5-yl)propionate, which mainly aims to solve the technical problems of complicated steps and high operating difficulty in existing synthetic routes. The invention has the technical scheme that levodopa reacts with Fmoc N-hydroxysuccinimide este to obtain Fmoc acyl levodopa; and the Fmoc acyl levodopa reacts with 2,2-dimethoxypropane to obtain (2S)-2-[[(9H-fluoren-9-yl methoxy) carbonyl] amino]-3-(2,2-dimethyl-1,3- benzo dioxol-5-yl)propionate. The solvent used in the reaction of the Fmoc acyl levodopa and the 2,2-dimethoxypropane to obtain the (2S)-2-[[(9H-fluoren-9-yl methoxy) carbonyl] amino]-3-(2,2-dimethyl-1,3- benzo dioxol-5-yl)propionate is tetrahydrofuran; and the catalyst is pyridinium p-toluenesulfonate. The resultant obtained by the method is applied in the field of peptide synthesis as a non-natural amino acid protecting reagent.

The invention relates to the preparation of an absorption material and the application to medicament separation and enrichment, in particular to the preparation methods of a Lamivudine molecularly imprinted polymer and a Lamivudine molecularly imprinted solid phase extraction column and the applications thereof. The Lamivudine esterified ester is obtained through esterification synthesis. The molecularly imprinted polymer is synthesized by using the Lamivudine esterified ester as a template, methacrylic acid as a monomer, trimethoxy propane trimethyl acrylate as a crosslinker and chloroform as a porogen by adopting a body polymerization method; and molecularly imprinted polymer particles are uniformly filled in the solid-phase extraction column to obtain the Lamivudine molecular imprinting solid-phase extraction column. The invention realizes the efficient separation, enrichment and purification of Lamivudine in a biological sample and has high selectivity as compared with traditional related technologies, such as a common solvent extraction method, a C18 solid-phase extraction method, and the like. Moreover, the Lamivudine molecularly imprinted solid phase extraction column has low cost by being repeatedly used and can become a necessary method in the Lamivudine pretreatment in biological samples.

The invention discloses a preparation method of (4R-cis)-6-chloromethyl-2, 2-dimethyl-1, 3-dioxane-4-acetic acid isopropyl ester. The preparation method has the advantages that chloroacetaldehyde and acetaldehyde serve as reaction substrates to complete a condensation reaction under the action of aldolase, an open-loop esterification reaction between an oxidative obtained product and isopropanol is achieved in the presence of a catalyst, and ester exchange between the product and 2, 2-dimethoxy propane is completed to obtain a target product, so that synthetic route is short, highly toxic products are not used in the whole reaction process, and raw materials are low in cost.

The invention relates to a polyurethane material containing a polythioketal soft segment and capable of being degraded with active oxygen, and a preparation method thereof, wherein the polyurethane material comprises a polythioketal soft segment and a saturated aliphatic diisocyanate hard segment. The preparation steps comprise: carrying out a reaction on excess bis(2-mercaptoethyl)ether and 2,2-dimethoxypropane to prepare polythioketal; carrying out a reaction on the polythioketal and diisocyanate or on the polythioketal, polyethylene glycol and diisocyanate, and carrying out one-pot additionto obtain a prepolymer; and carrying out a diol or diamine chain extension reaction to obtain polyurethane. According to the present invention, by using the one-pot method, the polythioketal or the polythioketal and the polyethylene glycol as the soft segment are polymerized into the polyurethane; the polyurethane obtained by copolymerizing with the polyethylene glycol has amphiphilicity, and thehydrophilic/hydrophobic chain segment ratio can be adjusted through the feeding ratio; and the polyurethane can be used for producing nanoparticles, tissue engineering scaffolds or hydrogels, and issuitable for physiological environments with high active oxygen content, and has good application prospects in the biomedical field.

The invention discloses a preparation method of an atorvastatin intermediate (3R, 5R)-7-amino-3,5-O-isopropylidene-3,5-dyhydroxyl heptylic acid tert-butyl acetate. The method comprises the following steps of: reacting (R)-epichlorohydrin and nitromethane to generate 1-chlorine-4-nitryl-(R)-2-butanol, and reacting with sodium cyanide to obtain (R)-3-hydroxyl-5-nitryl-valeronitrile; dropwise adding the product into a tert-butyl bromoacetate zinc reagent to generate 7-nitryl-5-hydroxyl-3-carbonyl-heptylic acid tert-butyl acetate; reacting with sodium borohydride to generate 7-nitryl-3,5-dyhydroxyl-heptylic acid tert-butyl acetate; reacting with 2,2-dimethoxypropane, acetone and methanesulfonic acid to obtain 7-nitryl-3,5-O-isopropylidene-3,5-dyhydroxyl-heptylic acid tert-butyl acetate; and obtaining (3R, 5R)-7-amino-3,5-O-isopropylidene-3,5-dyhydroxyl heptylic acid tert-butyl acetate by hydrogen reduction. The yield of the product is 80-86%, and the purity of the product is greater than or equal to 99.0%.

The invention relates to a method for synthesis of a material with dichlorvos selective separation function. Dichlorvos is taken as template molecule, room-temperature ion liquid (BMIM<+>PF6<->) is taken as an auxiliary template, methacrylic acid is taken as a functional monomer, TRIM is taken as a crosslinking agent and molecular engram technology is adopted to synthesize a novel material with selective adsorbing function. The invention has the advantages of low cost, simple laboratory operation and easy control of reaction conditions; the adsorbent adopting the synthesized material with dichlorvos selective separation function can be applied to solid-phase extraction and liquid chromatogram combination; the dichlorvos detection capacity is largely improved; the material is particularly applicable to adsorptive detection of trace dichlorvos in various fruits, vegetables and other complex hosts.

The invention relates to a solid catalyst component and a catalyst for olefinic polymerization. The solid catalyst component uses dialkoxy magnesium as a carrier and toluene as a dispersant to be contacted with at least one 2,3-di-non-linear chain alkyl-2-cyanosuccinic acid dibasic acid ester type compound and a 2-isopropyl-2-(3-methyl-butyl)-1,3-dimethoxypropane compound to react with titanium halide, and then the reaction product is processed by the titanium halide to obtain the solid catalyst component. The polymerization activity of the catalyst is high, the molecule weight distribution of the obtained polymer is wide, the bulk density is high, the hydrogen response and the stereospecificity expression are good, the grain shape is good, the fine powder content is less and the catalyst is suitable for developing the polyolefine grade.

The invention relates to a cleaning agent for organic sediments inside an oil tank and a preparation method of the cleaning agent. The cleaning agent comprises the following components in percentage by mass: 30%-60% of tetramethoxy-propane, 20%-40% of dimethoxy-ethane, 5%-15% of diethylene glycol octyl ether, 2%-10% of sodium polyphosphate, 1%-1.5% of sodium alkyl benzene sulfonate and 2%-3.5% of lauryl sodium sulfate. The cleaning agent disclosed by the invention can be cleaned on line and also be cleaned off line, generates no influence on production because of no need of shutdown when used for cleaning on line, so that cost and time are saved; the cleaning agent is harmless to an operator because an operator unnecessarily enters the oil tank, is pollution-free on the environment, can be used for recovering 90% hydrocarbon by recycling sludge and has the advantages of outstanding economic benefit, simple preparation method, short cleaning operation time, high cleaning quality, ecological and environmental friendliness, no three wastes discharge, no need of anti-rust treatment on a container after cleaning, good social benefit and economic benefit, harmlessness on human bodies, no corrosion on equipment and no secondary pollution.

The invention discloses a tetrahydro carboline derivative modified with two amino acids and a preparation method and an application thereof. According to the invention, L-tryptophan methyl ester is allowed to react with 1,1,3,3-tetramethoxy propane by a microwave reaction; the obtained product is modified by amino acids to obtain a series of (1R, 3S)-1-[1-(1R, 3S)-tetrahydro beta-carboline-3-formyl amino acid-1-yl-methyl]-tetrahydro beta-carboline-3-formyl amino acid derivatives and intermediates thereof; and the derivatives are evaluated for in vitro antiplatelet aggregation activity and in vitro antithrombotic activity. The method of the invention is simple; the used raw materials are easily available, safe and cheap; the obtained product has antiplatelet aggregation activity and antithrombotic activity, which indicates the clinical application prospects of (1R, 3S)-1-[1-(1R, 3S)-tetrahydro beta-carboline-3-formyl amino acid-1-yl-methyl]-tetrahydro beta-carboline-3-formyl amino acidas an antithrombotic agent.

The invention discloses a method for preparing statins intermediates through biosynthesis, and specifically discloses an enzymatic method for preparing statins intermediates. The enzymatic method comprises the following steps: (a) carrying out catalytic reduction reactions on a compound (III) in the presence of alcohol dehydrogenase CmADH3, co-enzyme factors, and a regeneration system of an optional co-enzyme factor to produce a compound (II); (b) reacting the compound (II) with 2,2-dimethoxy propane to generate a compound (I). The provided method can reduce the production cost and environmental pollution, and thus has a great application value.

The invention relates to a preparation method of methylene bridged cucurbituril. The preparation method comprises the following steps: synthesizing 1,1,3,3-malonaldehyde tetramethyl acetal and urea into methylene bridged glycoluril at first; then feeding the methylene bridged glycoluril, paraformaldehyde and calcium salt or barium salt into a mixed solution of water and hydrochloric acid, reacting and refluxing, wherein the mass ratio of the methylene bridged glycoluril to formaldehyde is 1: (0.4-1), the volume ratio of the water to the hydrochloric acid is 1: (1-3), the ratio of the mass of the methylene bridged glycoluril to the volume of the hydrochloric acid is 1: 1-3, the mass ratio of the methylene bridged glycoluril to the calcium salt is 1: 0.05-0.4, and the mass ratio of the methylene bridged glycoluril to the barium salt is 1: 0.1-0.3; and carrying out cooling, suction filtration and washing to obtain the methylene bridged cucurbituril [4] or the methylene bridged cucurbituril [5]. The methylene bridged cucurbituril [4] and the methylene bridged cucurbituril [5] are synthesized in an oriented manner by using metal salt as a template, the method is simple and convenient, a purification process is simple, and the yield is obviously increased.

The disclosed six-membered carbocyclic nucleoside analogues comprise: adenosine analogue, guanosine analogue, carnine analogue, mercaptopurine riboside analogue, cytidine analogue, 5-fluorocytidine analogue, uridine analogue, 5-fluorouridine analogue, and thymidine analogue as well as their acceptable salts formed by equimolar acid in pharmacy. Wherein, the opposite five-step synthesis method using the pinitol, acetone, methane sulfonyl chloride, p-toluenesulfonyl chloride, benzene sulfochloride, and nucleoside base as materials; the pyridine, water, glacial acetic acid, absolute methanol, DMSO, N, N-DMF as the solvent; the p-toluenesulfonic acid, 2, 2-dimethoxylpropane, anhydrous NaSO4, NaHCO3, triethylamine, and anhydrous K2CO3 as the catalyst. This invention restrains specially the replication of HIV and herpesvirus.

The invention discloses a preparation method of a diether type electron donor. The method comprises the following steps: 1, carrying out a condensation reaction on 3-methylbutyraldehyde under a preset reaction pressure with an aqueous solution of NaOH as a catalyst to obtain 2-isopropyl-5-methyl-2-hexenal; 2, carrying out a reduction reaction on 2-isopropyl-5-methyl-2-hexenal obtained in step 1 and H2 under the action of a Pd/C catalyst to obtain 2-isopropyl-5-methylhexanal; 3, reacting 2-isopropyl-5-methylhexanal obtained in step 2 with an aqueous solution of formaldehyde under the action of an inorganic alkali to obtain 2-isopropyl-2-isopentyl-1,3-propanediol; and 4, dissolving 2-isopropyl-2-isopentyl-1,3-propanediol in an organic solvent, and carrying out an etherification reaction on 2-isopropyl-2-isopentyl-1,3-propanediol and CH3Cl in the presence of the alkali to obtain 2-isopropyl-2-isopentyl-1,3-dimethoxypropane. By utilizing NaOH/H2O as the catalyst in the invention, technological conditions are optimized, the preparation cost is reduced, the total product yield is improved, and the efficiency is substantially improved.