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306 results about "Intense fluorescence" patented technology

Compounds for fluorescence imaging

Methods and compositions involving enzyme-activatable fluorophore polymer imaging agents for photodetection of specific tissues and / or human diseases and disorders are provided. In certain embodiments, the imaging agent comprises a hydrophilic polymer backbone (e.g., poly(L)lysine), a hydrophobic fluorophore, and a hydrophilic solubilizing agent. The solubilizing agent may comprise a quarternary ammonium group (e.g., a 1-methylnicotinic group) to enhance self-quenching of the fluorophore. Various methods for the generation and purification of imaging agents are also provided, including methods involving solid phase probe extraction or ion exchange purification.
Owner:UNIVERSITY OF GENEVA

Strong-fluorescence boron dipyrromethene dye containing carbazole structure

The invention belongs to strong-fluorescence boron dipyrromethene dyes containing a carbazole structure in the technical field of organic chemical industry and fine chemical industry. Because a method for preparing the strong-fluorescence boron dipyrromethene dye containing the carbazole structure and derivatives thereof adopts boron dipyrromethene and carbazole aldehyde with substituent as raw materials, the molar ratio of the boron dipyrromethene to the carbazole aldehyde is 1:2-5, piperidine is a catalyst, a 4-angstrom molecular sieve is a dehydrating agent, and the molar ratio of the borondipyrromethene to the catalyst is 1:0.01-0.20; in an organic solvent, at the temperature of between 100 and 150 DEG C and under the protection of argon or nitrogen, the mixture reacts for 8 to 50 hours by stirring, the carbazole aldehyde and the active methylene of the boron dipyrromethene are dehydrated to generate the boron dipyrromethene derivatives; and after the carbazole structure with different substituents is introduced into the boron dipyrromethene, the optical property of the boron dipyrromethene compound is changed, the red shift of the absorption spectrum thereof is 80 nanometers, the red shift of the emission spectrum is 90 nanometers, higher fluorescence quantum yield is kept at 0.67, the laser efficiency reaches more than 30 percent, and the strong-fluorescence boron dipyrromethene derivatives containing the carbazole structure are obtained.
Owner:DALIAN UNIV OF TECH

Fluorescent probe used for detecting glutathione as well as preparation method and application thereof

InactiveCN104710979AEliminate the influence of background differences on the resultsHigh sensitivityOrganic chemistryBiological testingFluorescenceChemistry
The invention discloses a fluorescent probe used for detecting glutathione as well as a preparation method and application thereof. According to the invention, 1, 8-naphthalimide is used for building a classical ICT system, a phenyl sulfone part is introduced to the position of 4-, the ICT effect of a probe molecule is regulated and controlled, and due to the strong attracting electron effect of the phenyl sulfone in the position of the 4-, the probe molecule self is free from fluorescence emission. In case of the existence of glutathione, the phenyl sulfone part can be replaced by the glutathione, further the intramolecular electron transfer from sulphur atom in the position of the 4- (from glutathione) to the 1,8-naphthalimide can be generated, moreover, the ICT effect enables the probe molecule to send out strong fluorescence. The fluorescent probe provided by the invention can realize detection to the glutathione in cells, and has the advantages of being convenient and simple to operate, low in cost, sensitive in response, easy for popularization and application and the like.
Owner:ZHEJIANG SCI-TECH UNIV

Method for preparing water-soluble mercury ion fluorescence probe on basis of rhodamine and application of water-soluble mercury ion fluorescence probe

The invention discloses a method for preparing a water-soluble mercury ion fluorescence probe on the basis of rhodamine and application of the water-soluble mercury ion fluorescence probe. A structural formula of the Hg<2+> fluorescence probe are shown, and the water-soluble mercury ion fluorescence probe is synthesized from 1, 2, 4-trimellitic anhydride, 3-diethylamino phenol and hydrazine hydrate. The method and the application have the advantages that the water-soluble Hg<2+> fluorescence probe prepared by the aid of the method is simple in structure, is based on rhodamine derivatives and is the first fluorescence probe for detecting Hg<2+> in 100% aqueous solution by the aid of rhodamine lactam derivatives; ring opening of rhodamine lactam structures can be carried out under the induction effects of the Hg<2+> in systems, intense fluorescence can be generated, and the water-soluble mercury ion fluorescence probe is high in Hg<2+> detection sensitivity; the fluorescence probe is excellent in Hg<2+> selectivity and is almost free of interference of other positive ions; the Hg<2+> can be measured by the fluorescence probe without disturbance when pH (potential of hydrogen) values range from 5.0-8.0, the fluorescence probe and the Hg<2+> can act quickly, and the response time is shorter than 3 minutes; the probe further can be applied to measuring Hg<2+> in environmental water samples and carrying out fluorescence imaging on Hg<2+> in biological cells.
Owner:XIANGTAN UNIV

Preparation method and applications of hexatomic dinitrogen heterocyclic derivatives containing four identical substituent groups

InactiveCN106243091AHave electroluminescent propertiesOrganic chemistrySolid-state devicesPyridazinePyrazine
The invention discloses a preparation method and applications of hexatomic dinitrogen heterocyclic derivatives containing four identical substituent groups, and belongs to the field of application technology of luminescent materials in preparation of organic light-emitting devices. According to the preparation method, pyrazine and pyridazine are taken as electron acceptors of luminescent materials; the periphery of the electron acceptors is connected with electron donors such as carbazole, phenoxazine, and 9,9-dimethyl-9,10-dihydracridine; frontal orbital overlapping degree of HOMO and LUMO is adjusted, so that luminescent materials with thermally activated delayed fluorescence (TADF) characteristics are obtained. At room temperature, the hexatomic dinitrogen heterocyclic derivatives possess strong absorption at ultraviolet-visible region, a dilute solution of the hexatomic dinitrogen heterocyclic derivatives is capable of emitting strong fluorescence, the wavelength of emission peaks ranges from 450 to 615nm in the blue light-orange light range, the hexatomic dinitrogen heterocyclic derivatives can be applied to organic light-emitting devices as luminescent materials. According to devices based on compound M2, turn-on voltage is 3.9V, the maximum brightness 3846cdm<2> is achieved at a voltage of 12V; and the maximum luminous efficiency 17.4cdA<1> and the maximum power efficiency 12.21mW<1> are achieved when electric current density is 0.06mAcm<2>(4.5V).
Owner:DALIAN UNIV OF TECH

Pyrene derivative fluorescent probe molecule for recognizing and detecting formaldehyde as well as preparation method and application of fluorescent probe molecule

The invention provides a pyrene derivative fluorescent probe molecule for recognizing and detecting formaldehyde as well as a preparation method and application of the fluorescent probe molecule. Thepreparation method provided by the invention has simple synthetic steps only needs one step reaction and has a higher yield. The fluorescent probe provided by the invention does not have fluorescencein an HEPES buffer system, but can react specifically with the formaldehyde to generate a product with strong fluorescence, so as to achieve specific selection and quantitative analysis for the formaldehyde. The recognition characteristics of the probe B1 with aldehydes and amino acids in the HEPES buffer system are studied by a fluorescence spectrometer, results show that the probe B1 has high-efficiency specific selectivity for the formaldehyde, the lowest detection limit of the probe for the formaldehyde is 0.107[mu]M, and the probe has broad application prospects in the field of biomolecule detection.
Owner:河南省农业科学院农业质量标准与检测技术研究所

Preparation method and application of fluorescence-MRI (Magnetic Resonance Imaging) dual-mode image probe

The invention provides a preparation method and application of a fluorescence-MRI (Magnetic Resonance Imaging) dual-mode image probe, and particularly relates to a dual-mode image probe which combines a fluorescent nanoparticle and a paramagnetic contrast agent and a preparation method thereof, belonging to the field of functional materials. The main process of the method comprises the following step of: removing residues and moisture through dialysis and freeze-drying by taking an amino compound as a surface passivation agent and a gadolinium-based complex as a carbon source material and adopting a one-step forming method to obtain a fluorescence-MRI dual-mode gadolinium-doped carbon quantum dot. The method provided by the invention ahs the characteristics of simple process, low cost and easiness for large-scale production. The fluorescence-MRI dual-mode gadolinium-doped carbon quantum dot prepared through the method has the excellent characteristics of higher fluorescent property, higher relaxation efficiency, good biocompatibility and the like, is successfully applied to in-vitro live cell fluorescence imaging and in-vivo magnetic resonance imaging; the fluorescence-MRI dual-mode gadolinium-doped carbon quantum dot synthesized through the method is about to have wide application prospect in the field of biomedicine.
Owner:JIANGSU UNIV

Preparation method of self-assembled silver ball SERS (Surface Enhanced Raman Scattering) base with controllable silver nano sheet thickness

The invention belongs to the field of a nanometer material science and a laser Raman detection technology, and particularly relates to a preparation method of a self-assembled silver ball SERS (Surface Enhanced Raman Scattering) base with a controllable silver nano sheet thickness. The method takes silver nitrate as a silver source and L-ascorbic acid as a reducing agent, and comprises the following steps of: adding one organic acid with controlled amount to react in an ice bath (2-5 DEG C) for 2-15 minutes to obtain a silver micro-ball which is formed by self-assembling silver nano sheets with the controllable thickness in a range of 20-110nm. The silver micro-ball formed by self-assembling the silver nano sheets, which is prepared by the method, not only has the characteristic of high specific surface area of a common nano material, but also has the characteristics of controllable thickness of the surface silver nano sheets and serial and comparable surface roughness; and the silver micro-ball formed by self-assembling the silver nano sheets is a surface enhanced Raman base with the very good activity and is hopeful to be applied to aspects of surface enhanced fluorescence and photocatalysis.
Owner:UNIV OF SCI & TECH BEIJING

Method for quickly preparing silver nanocluster with strong fluorescence emission

The invention relates to a method for quickly preparing a silver nanocluster with strong fluorescence emission. The method is characterized in that by volume, 14.75 parts of redistilled water is put into a container, 2.0 parts of AgNO3 solution, 0.25 parts of NaBH4 solution and 3.0 parts of amino black 10B are added into a thermostat water bath in sequence in a mixing condition, so as to be mixed for 3 to 90 min at 30-80 DEG C, and then the silver nanocluster with strong fluorescence emission can be obtained. According to the method, a biological dye of amino black is used as a stabilizing agent, and the silver nanocluster with strong fluorescence emission can be prepared after 10 min. The method has the advantages of easiness in obtaining raw materials, simple system, short synthetic time, strong fluorescence and smaller size.
Owner:HUNAN UNIV OF SCI & TECH

Graphene quantum dot sensor and its application in detection of trinitrophenol

The invention relates to a graphene quantum dot sensor and its application in detection of trinitrophenol, and belongs to the field of analysis chemistry. A making method of the sensor comprises the following steps: mixing citric acid with ammonia water, and heating in a closed microwave digestion device to prepare nitrogen element doped graphene quantum dots; mixing the graphene quantum dots with a carboxymethyl chitosan solution, immersing a quartz thin plate in the obtained graphene quantum dot and carboxymethyl chitosan solution, and carrying out electrostatic force action to form a thin plate with a strong fluorescence signal. Creatinine molecules are adsorbed to the surface of the thin plate to identify trinitrophenol. When the thin plate is in contact with trinitrophenol, the fluorescence signal substantially weakens. The graphene quantum dot fluorescence thin plate chemical sensor made through the method has good photochemical stability, has obvious selection and identification capability on the explosive trinitrophenol, can realize detection of a tiny amount of trinitrophenol (the detection limit is 0.1[mu]g / L), and has wide application prospects in safety detection and environmental protection supervision.
Owner:JILIN UNIV

Polyester color silk production process

The invention relates to a polyester color silk production process. Polyester color silk is prepared by melting polyester chips and color master batch at high temperature, and drawing the components into silk. The polyester color silk production process comprises the following steps: precrystallizing glazed wet polyester chips in a crystallizer, putting the crystal into a solid-phase polycondensation reaction kettle for polycondensation reaction with nitrogen, feeding the tackified chips together with the color master batch which is subjected to drying and dehumidification treatment and cobalt acetate into a spinning screw rod extruder for melting, feeding the molten melt into a spinning component through a metering pump, filtering the melt inside the spinning component, spraying the melt into silk bundles through a spinneret plate at relatively high pressure, blowing cold air from a slow cooling area and a cooling accumulation chamber to cool the silk bundles, feeding the silk bundles into a drawing area, drying the silk bundles, heating to shape by using a heating roller, finally coiling to form, and packaging. Through the adoption of the process procedures, various types of colored industrial long polyester silk which is superhigh in wearing resistance, superhigh in fluorescence and superhigh in flexibility can be produced, and the colored industrial long polyester silk is widely used in multiple fields such as firefighting, braids, communication optical cables, fabrics and silk threads, and is accepted by users and the market.
Owner:YANGZHOU RUIHUI CHEM FIBER PROD
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