31 results about "Bone function" patented technology

The present invention relates to a bone polypeptide, particularly bone polypeptide-1 and nucleic acid molecules encoding the same. The present invention provides the human primary sequence of bone polypeptide-1 as well as sequences of vertebrate homologs. The invention also provides cell lines engineered to express the cDNA, antibodies to detect its translation products, and recombinant adenoviruses to deliver an expressible cDNA into a host. Bone polypeptide-1 can be utilized to treat diseases affecting renal and bone functions.

A survivability and safety unit (also referred to as a safety unit) can be worn in high contact activities to minimize injuries and help prevent quadriplegic injuries and concussions. The safety unit of the present invention provides synthetic muscle and skeleton frame, strength and resistance enhancement. The safety unit of the present invention can replicate muscle and bone function as a kinematic device. It can withstand high velocity impacts, it dampens the impact load and extends the shock absorption distribution.

The invention mainly relates to a soft capsule helpful for increasing bone density and a preparation method thereof. The soft capsule helpful for increasing the bone density is characterized by consisting of the following raw materials in parts by weight: 400-550 parts of linseed oil, 10-30 parts of red deer bone superfine powder, 10-30 parts of an astragalus extract, 10-30 parts of bone collagen, 10-30 parts of an angelica extract, 1-3 parts of vitamin D and 10-30 parts of a drynaria rhizome extract. The soft capsule disclosed by the invention, guided by theories of traditional Chinese medicine and based on modern research achievements of the traditional Chinese medicine, is careful in material selection, strict in composition and rational in combination, and is added with natural components capable of improving osteoporosis, so that the composition can tonify Qi and benefit blood, enhance immunity, relieve fatigue, strengthen tendons and bones, remove pathological wind and promote diuresis, regenerate tissue to heal wound, and integrally improve physical function, and circulations of Qi and blood are smooth, and metabolism is normal. Red deer bone functions as strengthening tendons and bones, and regenerating tissue to heal wound; drynaria rhizome can relieve joint pain, and relieve osteoporosis; vitamin D has a function of resisting rachitis, and can promote calcium absorption; astragalus can promote regeneration of injured nerve; angelica functions as replenishing blood and promoting blood circulation, regulating menstruation and relieving pain, and relaxing bowl; and linseed oil has functions of preventing and treating cancers, coronary heart disease, diabetes, prostatic cancer and other diseases. The composition is remarkable in functions of replenishing blood and benefiting blood, and strengthening tendons and bones.

The invention discloses an artificial ligament having immunization bone formation function and a preparation method of the artificial ligament. The preparation method comprises the steps of (1) placing a PET artificial ligament in an ultrasonic machine, performing cleaning, and performing drying by airing; (2) cutting out the PET artificial ligament obtained in the step (1), placing the PET artificial ligament which is cut out in a beaker loaded with a Tris-HCL solution, adding 25mL of a dopamine hydrochloride solution to the beaker, and performing a reaction for 1-24h, to obtain a PET ligament modified by PDA; (3) placing the PET ligament modified by the PDA, obtained in the step (2) in a 50mL centrifugal tube, and then adding a CS-ADH solution to obtain a PET ligament modified by CS-PDA;and (4) slowly and uniformly dropwise adding 1-20ug of an rhBMP-2 solution to the surface of the PET ligament obtained in the step (3), performing freezing at minus 20 DEG C, performing staying overnight, and performing freeze drying in a bacteria-free freeze dryer so as to obtain the artificial ligament. The dopamine adopted for the artificial ligament is adsorbed to the PET through an autopolymerization reaction, and then through a reaction of the dopamine and chondroitin sulfate-ADH, chondroitin sulfate is connected to the surface of PET fibers, so that an immunoregulation function is provided for the PET artificial ligament.

The invention discloses a polyetheretherketone composite implant as well as a preparation method and application thereof. The composite implant comprises a polyetheretherketone substrate, a degradable polymer coating wrapping the surface of the polyetheretherketone substrate, and a functional substance loaded and / or grafted by the degradable polymer coating; the functional substance comprises a substance with an immune regulation function and / or a substance with an osteogenesis regulation function. The preparation method comprises the following steps: constructing the degradable polymer coating loaded with the functional substance on the surface of the polyetheretherketone substrate; modifying and activating the surface of the degradable polymer coating loaded with the functional substances, and introducing active groups to the surface of the degradable polymer coating loaded with the functional substances; and then the functional substances are grafted through active groups. The polyetheretherketone composite implant is applied to preparation of a medicine for treating bone defects. According to the polyetheretherketone composite implant prepared by the invention, the excellent mechanical property of the substrate polyetheretherketone is maintained, and the immunocompetence and the osteogenic activity of the surface are also increased.

The invention belongs to the medical field and discloses glucosamine bone glue peptide calcium granules. The glucosamine bone glue peptide calcium granules comprises bone collagen peptide, glucosamine, euphausia superb oil, isomaltooligosaccharide, D-ribose, oat essence, algal polysaccharides, dried small shrimp meal, vitamin D3, fish oil and pharmaceutical adjutants. The bone collagen peptide, the glucosamine, the dried small shrimp meal and the euphausia superb oil in the glucosamine bone glue peptide calcium granules can be absorbed by a human body easily, are jointly used for increasing bone density and recovering bone functions, have a synergistic effect and can enhance resistance, maintain beauty and care skin.

The invention discloses a defective mandibular fracture reconstruction titanium plate with an auxiliary bone grafting function. The defective mandibular fracture reconstruction titanium plate comprises a bridging part placed at the lower edge of the mandible and a support part placed at the lip and cheek side, wherein the bridging part comprises a main bridge body with the radian matched with that of the lower edge of the mandible and a main bone grafting bed; the support part comprises an auxiliary bridge body with the radian matched with that of the lip and cheek and an auxiliary bone grafting bed; the main bone grafting bed is arranged at the tongue side position of the main bridge body, the auxiliary bridge body is arranged in the middle of the auxiliary bone grafting bed, the auxiliary bone grafting bed is in moving connection with the main bridge body and the main bone grafting bed, and the main bone grafting bed and the auxiliary bone grafting bed are of titanium mesh structures. For the defective mandibular fracture reconstruction titanium plate with the auxiliary bone grafting function, the surgical operation is simplified, the surgical time is reduced, and the financial burden of patients is alleviated. Through the titanium-mesh bone grafting beds, the defect range is marked, meanwhile, the resetting of a fracture block is guided, the bending of the reconstruction plate during the surgery is avoided, the surgical time is reduced, the reconstruction plate and the mandible are in good lamination, and thus the fracture block displacement due to no laminating is avoided. The operation is simple, and the popularization is easy.

The invention discloses a traditional Chinese medicine composition of Niu Dali with the function of invigorating the kidney and strengthening the bones and a preparation method thereof. The traditional Chinese medicine composition of the present invention is mainly composed of Niu Dali, Eucommia, Epimedium, Cuscuta, Salvia Miltiorrhiza, Radix Puerariae, etc., the composition is rigorous, the medicine is less powerful, and the combination of all medicines can give full play to the overall adjustment advantages of the traditional Chinese medicine compound, and has the functions of nourishing the kidney and strengthening the muscles and bones It has a good curative effect on symptoms such as osteoporosis, waist and knee pain, weakness after illness, weakness and weakness.

Belonging to the technical field of medicine application, the invention discloses pharmaceutical application of caffeic acid 3, 4-dihydroxyl phenethylester. A prevention and / or treatment medicine prepared from the caffeic acid 3, 4-dihydroxyl phenethylester (CADPE) can be used for inhibiting osteoclast differentiation, inhibiting an osteoclast bone erosion function, promoting osteoblast differentiation, and promoting an osteoblast bone formation function. The medicine can be used for preventing and / or treating osteoclast activity abnormality caused diseases, which include osteoporosis, rheumatoid arthritis, periodontitis, tooth loss, Paget's disease, rickets, osteoclastoma, myeloma bone disease and cancer bone metastasis caused bone destruction, etc.

The invention relates to an application of CDC20 in an osteogenic differentiation process of mesenchymal stem cells. According to the invention, CDC20 has the effect of positively regulating and controlling an osteogenesis function of the mesenchymal stem cells, an application basis of CDC20 in the process of promoting osteogenic differentiation of the mesenchymal stem cells is provided, and the action mechanism of CDC20 on degradation of NF-kappa B active subunits p65 through a proteasome pathway is identified. The brand-new theoretical and experimental basis is provided for inhibiting activity of the target protein by using a small molecular compound in a targeted manner in the aspect of molecular treatment of bone regeneration.

A natural nutrient for repairing bone functions of people with osteoporosis and a preparing method thereof are disclosed. The method includes 1) cleaning moringa tree seeds and kudzu vine roots with clear water, crushing the materials separately with a crushing device, and mixing the crushed materials in a ratio to obtain a fermentation raw material; 2) inoculating the fermentation raw material with a strain stock solution obtained by mixing Bacillus subtilis, Saccharomyces cerevisiae, Lactobacillus plantarum and Lactobacillus fermentum according to a ratio, adding sugar and inorganic salt andthen performing fermentation; 3) directly drying a fermentation product, crushing the product and sieving the product to obtain a finished fermentation product A; or sterilizing a liquid obtained after a proper amount of water is added and centrifugal separation is performed to obtain a finished fermentation product B; or performing further concentration and drying to obtain a finished fermentation product C. The natural multi-element nutrient prepared by the method can effectively improve bone metabolism of middle-aged and aged people, increase bone density, improve bone strength, increase calcium deposits in bones, and effectively repair bone functions of people with osteoporosis.

The invention relates to a multifunctional 3D printing internal fixation plate used for pelvic bone repair, and relates to the field of medical instruments. The structure comprises a main body portion, a hollow filling block, fixing holes, an acetabular bone graft portion and an extension plate. The main body portion and the extension plate are respectively provided with a plurality of fixing holes, the left part of the main body portion is connected to the hollow filling block, the bottom of the main body portion is connected to the left side of the acetabular bone graft portion, and the right side of the acetabular bone graft portion is connected to the top of the extension plate. A preparation method of the invention is capable of scanning to obtain CT images, establishing an integratedinternal fixation plate model, 3D-printing internal fixation plates, and coating with a bio-coating. The multifunctional 3D printing internal fixation plate used for pelvic bone repair integrates aninternal fixation plate, a surgical guide plate and a bone grafting function, and can achieve the effects of positioning, bone setting and bone grafting simultaneously. The hollow part can realize bone grafting function and promote the healing of fracture, bone crack and bone tissue defect. The preparation method of the invention can create the internal fixation plate.

The invention provides an adjustable hard bed board with curved surfaces and stereoscopic curves. The adjustable hard bed board comprises a bed side, a hard bed board and 1-2 stereoscopic boards. The upper surface of the hard bed board is provided with the curved surfaces which are identical or similar to physiological curves of human bodies when the human bodies naturally lie on the backs, and the hard bed board is of an integrally formed structure; the stereoscopic boards comprise legs and boards, the boards are mounted on the legs, planes are arranged on the upper surfaces of the boards, the heights of the planes on the boards are flush with upper planes at two ends of the hard bed board, fast mounting structures are arranged on a side of each board, and fast mounting connectors which correspond to the fast mounting structures are arranged at the front end and the rear end of the hard bed board. The adjustable hard bed board with the curved surfaces and the stereoscopic curves has the advantages that the adjustable hard bed board is scientific in design and conforms to ergonomics, and bone functions can be supported and recovered by the aid of hard board beds.

The invention discloses a novel bionic 3D printing bioactive fusion cage and a preparation method thereof. The preparation method of the fusion cage comprises the following steps: (1) preparing a 1,4-dioxane solution of PLLA polymer; (2) mixing n-HA with the PLLA polymer solution to obtain a basic solution; (3) 3D-printing a porous anatomical fusion cage, and removing organic solvent to obtain a porous anatomical fusion cage; (4) preparing loading PLGA / rhBMP-2 nanoparticles; (5) dissolving the PLGA / rhBMP-2 nanoparticles in 10ml of distilled water; (6) soaking the porous anatomic fusion cagein the PLGA / rhBMP-2 nanoparticle solution, and coating meshes of the porous anatomic fusion cage with the PLGA / rhBMP-2 nanoparticles; and (7) freeze-drying and forming the porous anatomical fusion cage. The novel fusion cage prepared by the method with three-dimensional physiological anatomical space conformation, controllable degradation and controlled release realizes the optimization of mechanical property, has controllable degradation and bone function promotion, and solves the problems of fracture and collapse of OLIF operation endplate and displacement of a fusion cage.

The invention provides a pilose antler and fructus psoraleae composition with bone mineral density increase and osteoporosis prevention functions and a preparation method and application thereof, andbelongs to the technical fields of medicine and food. The composition comprises, by weight, 300-400 parts of sika deer pilose antler powder, 100-200 parts of fructus psoraleae alcohol extracts, 100-200 parts of kudzu vine root alcohol extracts and 50-150 parts of cucumber seed extracts. The composition has the promotion function of improving in-vivo calcium and phosphorus balance, can tonify the kidney, strengthen muscles and bones and condition blood vessels, and can improve the symptoms of waist and back aching pain and foot and knee weakness. The composition has the advantages of being purenatural, obvious in curative effect, free of toxic and side effects, convenient to take, small in toxic and side effect on other organ tissue, capable of being taken for a long time and the like, theformula is explicit, components are clear, the quality is easy to control, and the composition has the body building and bone strengthening functions and has remarkable curative effects on osteoporosis, fracture and other diseases.

The present disclosure provides ex vivo-derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture system. The bone constructs of the disclosure have utility in physiological studies of bone formation and bone function, in drug discovery, and in orthopedics.

The invention discloses a medicine for treating hyperosteogeny of the lumbar spine and a preparation method thereof. , red peony root, rehmannia glutinosa, cassia twig, black snake, frankincense, myrrh, salvia miltiorrhiza, sumac, Caulis Spatholobus, red peony root, amomum, lovage, and tribulus terrestris are prepared according to a certain weight ratio. The medicine of the present invention has Dispelling wind and dredging collaterals, dispelling phlegm and dispelling addiction, promoting blood circulation and promoting menstrual flow, removing blood stasis and relieving pain, tonifying liver and kidney, and strengthening bones and muscles. It is used for the treatment of lumbar hyperosteogeny with quick effect, good curative effect, and no recurrence.

The invention relates to the application of CDC20 in the osteogenic differentiation process of mesenchymal stem cells. It was found that CDC20 can positively regulate the osteogenic function of mesenchymal stem cells, which provided the basis for the application of CDC20 in promoting the osteogenic differentiation of mesenchymal stem cells, and identified its effect on NF‑κB active subunit p65 through proteasome Mechanism of action for pathway degradation. It provides a new theoretical and experimental basis for the targeted use of small molecular compounds to inhibit the activity of target proteins in the molecular therapy of bone regeneration.

The invention mainly relates to soft capsules capable of promoting lactation and treating postpartum agalasisa, acute mastitis, woman breast hyperplasia and the like. The soft capsules are characterized by comprising the raw materials according to parts by weight: 300-520 parts of linseed oil, 10-30 parts of red deer meat, 10-30 parts of red deer bone, 10-30 parts of prepared rehmannia root extract, 10-30 parts of angelica sinensis extract, 10-30 parts of leonurus extract, 10-30 parts of poria cocos extract, 10-30 parts of sealwort extract, 10-30 parts of peach kernel extract and 10-30 parts of dandelion extract. The soft capsules are guided by the traditional Chinese medicine theory and based on the modern research result of the traditional Chinese medicine. In the formula, the red deer meat functions in treating consumptive disease and marked emaciation, and postpartum agalasisa; the red deer bone functions in tonifying thin and weak; the leonurus functions in promoting blood circulation for regulating menstruation; the sealwort functions in boosting qi and nourishing yin, and strengthening spleen and nourishing lung; the dandelion functions in clearing away heat and toxic materials; the angelica sinensis functions in regulating menstruation and relieving pain, replenishing blood and activating blood; and the linseed oil has prevention and treatment effects on cancer, coronary heart disease, diabetes mellitusm, prostatic cancer and the like. The formula improves the body condition on the whole, promotes lactation and treats the breast disease.

The present application relates to the technical field of medical instruments and provides an anti-loosening medical screw based on an organism osteogenesis function. The medical anti-loosening screw comprises a screw cap and a screw rod connected to the screw cap. The screw rod comprises a main rod and a thread spirally wound around the main rod. The cross section of the main rod is non-circular. The present medical anti-loosening screw based on an organism osteogenesis function can be applied to the medical fields such as orthopedics (spine, four limbs, pelvis, joints, etc.), maxillofacial surgery, odontology, and veterinarians and can be effectively prevented from loosening after operation after being implanted.

The invention discloses AB glue for intraoperative bleeding arresting of a bone surgery. Glue A is chitosan-starch paste containing a water-soluble calcium salt, and glue B is paste containing sodiumbeta-glycerophosphate, water-soluble phosphate and hydroxymethyl cellulose. After substances of the glue A and the glue B are mixed, an in-situ reaction can occur to form gel, which can be randomly filled in a bone defect and shape in 20 minutes after implanting, and thus, the AB glue has bleeding arresting and osteogenesis functions and can be applied to the intraoperative bleeding arresting of the bone surgery instead of bone wax. Compared with the traditional bone wax, the AB glue has the advantages that besides reserving the characteristics of random filling and bleeding arresting, the ABglue further has the advantages of good biocompatibility, degradability and osteogenesis promoting; and meanwhile, due to design of tubes A and B, the long-term stability of the material is guaranteed.

The invention discloses an application of bispecific phosphatase DUSP5 in preventing, relieving and / or treating osteoporosis. It is found that a DUSP5 gene has the effect of treating the osteoporosis. Based on the effect of DUSP5 in treating the osteoporosis diseases, DUSP5 can be used for preparing medicines for preventing, relieving and / or treating the osteoporosis and / or other osteogenic dysfunction diseases. The connection structural domain based on the DUSP5 is a key regulation and control part for promoting osteogenic differentiation of the bone marrow mesenchymal stem cells, and the osteogenic dysfunction diseases are expected to be treated more conveniently and effectively at lower cost by only synthesizing the connection structural domain polypeptide fragment or analogue of the DUSP5 subsequently.

The invention discloses a method for covalently grafting biomolecules on the surface of metal materials. First, a diamond-like carbon film is constructed on the surface of the metal implant material, and then the film is activated, and then the material is immersed in a solution containing biomolecules that promote osteogenesis, so that biomolecules can be covalently grafted on the surface of the metal implant material. On the other hand, the technology of the present invention is easy to operate, simple in process, mild in reaction conditions, can be carried out at room temperature, high in efficiency, low in cost, good in repeatability, simple in subsequent cleaning procedures, and does not use silane coupling agents and crosslinking agents , there is no risk of reagent residue, which is conducive to industrial production. Therefore, the product prepared according to the method of the present invention has a high application prospect in the field of medical implant materials.

The invention discloses an AB glue for hemostasis in orthopedic surgery, wherein glue A is chitosan-starch paste containing water-soluble calcium salt, and glue B is made of sodium β-glycerophosphate, water-soluble phosphate and hydroxymethyl cellulose Plain paste. When the substances of AB glue are mixed, they can react in situ to form a colloid that can fill bone defects arbitrarily and form within 20 minutes after implantation. It has the function of hemostasis and osteogenesis, and can replace bone wax for hemostasis in orthopedic surgery. Compared with traditional bone wax, in addition to retaining the characteristics of arbitrary filling and hemostasis, this material also has the advantages of good biocompatibility, degradability, and bone formation. At the same time, the design of the AB tube ensures the long-term stability of the material.

The invention discloses a bone structure prediction method suitable for periodical dynamic loads. The method comprises the following steps of: 1, determining a topological range of a to-be-predicted bone structure; 2, carrying out modeling; 3, carrying out finite element grid partition; 4, calculating a material performance parameter elastic modulus of the bone and defining a material attribute for each unit; 5, loading a mechanical boundary condition and a load for a bone structure finite element model; 6, carrying out finite element analysis and solution on the bone structure; 7, extractinga main stress and a Mises stress of each unit of the bone structure finite element model; 8, calculating a fatigue life circle index according to stress values of each unit; 9, calculating mechanicalexcitation of each unit; and 10, calculating a performance density by applying a bone reconstruction control equation. According to the method, bone structure prediction is capable of embodying the bone function adaptability principle of bones which serve as a vital organ, and embodying the characteristic such as a main bearing period dynamic load of the bones.

The invention belongs to the medical field and discloses glucosamine bone glue peptide calcium granules. The glucosamine bone glue peptide calcium granules comprises bone collagen peptide, glucosamine, euphausia superb oil, isomaltooligosaccharide, D-ribose, oat essence, algal polysaccharides, dried small shrimp meal, vitamin D3, fish oil and pharmaceutical adjutants. The bone collagen peptide, the glucosamine, the dried small shrimp meal and the euphausia superb oil in the glucosamine bone glue peptide calcium granules can be absorbed by a human body easily, are jointly used for increasing bone density and recovering bone functions, have a synergistic effect and can enhance resistance, maintain beauty and care skin.

The invention relates to a cooking stove, in particular to a special stove for making bone buns with the function of baking. A kind of bone steamed bun baking furnace, which is composed of a furnace body, a furnace bottom, a damper, a fire grate, a furnace door, a furnace top, a baking furnace groove and sand pellets. Compared with the existing technology, because the furnace does not directly heat the buns, but uses sand pellets as an indirect heating method, the outer shell of the buns is slowly baked with hot air, and the inside of the buns is cooked by hot sand pellets, so it is slowly baked and hardened. Afterwards, the shape of the bun is like a big white bone, not black, not burnt, not yellow, and it tastes: the outer shell is hard and crisp, the inner gluten is glutinous, and the taste of wheat is strong.

The invention discloses a 3D printed bone tissue engineering scaffold with functions of sustained release and osteogenesis promotion and a preparation method thereof, belonging to the technical field of biomedical materials. The scaffold is formed by in-situ cross-linking of porous calcium phosphate material and sodium alginate, and simultaneously loads drug icariin. The bone tissue engineering scaffold prepared by the present invention has good biocompatibility and bioactivity. At the same time, by adding icariin drug to the printing ink, the osteogenic performance of the scaffold is further enhanced, and finally regulated by 3D printing and post-processing The pore structure of the scaffold, the cross-linking degree of the scaffold can be adjusted by changing the concentration of the calcium chloride cross-linking agent and the cross-linking time, and then the degradation rate of the material in vivo can be adjusted. The sustained drug release effect of the stent is realized by changing the drug concentration to regulate the drug loading of the stent. The stent material of the present invention can be used as artificial bone and bone tissue engineering reconstruction and repair, and has broad clinical application prospects.