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Novel bionic 3D printing bioactive fusion cage and preparation method thereof

A 3D printing and bioactive technology, which is applied in the field of new bionic 3D printing bioactive fusion devices and the production field, can solve the problems such as the inability to continuously release low concentrations of rhBMP-2, achieve the optimization of three-dimensional structure and mechanical properties, and reduce the end plate Stress, the effect of optimizing the contact surface

Inactive Publication Date: 2019-10-15
SHENZHEN HOSPITAL OF SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The study directly immersed the stent in the rhBMP-2 solution. The in vitro test found that the release of rhBMP-2 reached the peak at 24 hours, and the release of rhBMP-2 decreased sharply after 24 hours, which could not achieve the purpose of sustained release of low concentration rhBMP-2.

Method used

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  • Novel bionic 3D printing bioactive fusion cage and preparation method thereof
  • Novel bionic 3D printing bioactive fusion cage and preparation method thereof
  • Novel bionic 3D printing bioactive fusion cage and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] A novel biomimetic 3D printing bioactive fuser is prepared by the following method:

[0055] (1) prepare 23% PLLA macromolecule 1,4-dioxane solution;

[0056] (2) Mix 18% n-HA with a particle size of 45nm into the PLLA polymer solution prepared in step (1), stir and vibrate vigorously for 6 hours to fully disperse n-HA to obtain PLLA / n-HA basic solution;

[0057] (3) Use low-temperature 3D printing technology to print porous anatomical fusion cages, and vacuum freeze-dry to remove organic solvents in the scaffolds to form porous anatomical fusion cages;

[0058] (4) First, dissolve 18 mg of PLGA in 6 mL of dichloromethane solvent, mix 5 mg of rhBMP-2 with 0.8 mL of distilled water, mix and stir the PLGA solution and rhBMP-2 solution, and add 8 mL of 1.5% polyvinyl alcohol As an emulsifier, carry out the first emulsification in the ultrasonic emulsification machine for 45 seconds, then pause for 10 minutes, perform the second emulsification in the ultrasonic emulsifica...

Embodiment 2

[0063] A novel biomimetic 3D printing bioactive fuser is prepared by the following method:

[0064] (1) prepare 25% PLLA macromolecule 1,4-dioxane solution;

[0065] (2) Mix 20% n-HA with a particle size of 50nm into the PLLA polymer solution prepared in step (1), stir and vibrate vigorously for 6 hours to fully disperse n-HA to obtain PLLA / n-HA basic solution;

[0066] (3) Use low-temperature 3D printing technology to print porous anatomical fusion cages, and vacuum freeze-dry to remove organic solvents in the scaffolds to form porous anatomical fusion cages;

[0067] (4) First, dissolve 19 mg of PLGA in 7 mL of dichloromethane solvent, mix 6 mg of rhBMP-2 with 0.9 mL of distilled water, mix and stir the PLGA solution and rhBMP-2 solution, and add 9 mL of 1.8% polyvinyl alcohol As an emulsifier, carry out the first emulsification in the ultrasonic emulsification machine for 45 seconds, then pause for 10 minutes, perform the second emulsification in the ultrasonic emulsifica...

Embodiment 3

[0072] (1) prepare 28% PLLA macromolecule 1,4-dioxane solution;

[0073] (2) Mix 23% of n-HA with a particle size of 55nm into the PLLA polymer solution prepared in step (1), stir and vibrate vigorously for 6 hours to fully disperse n-HA to obtain PLLA / n-HA basic solution;

[0074] (3) Use low-temperature 3D printing technology to print porous anatomical fusion cages, and vacuum freeze-dry to remove organic solvents in the scaffolds to form porous anatomical fusion cages;

[0075] (4) First, dissolve 20 mg of PLGA in 8 mL of dichloromethane solvent, mix 7 mg of rhBMP-2 with 1 mL of distilled water, mix and stir the PLGA solution and rhBMP-2 solution, add 10 mL of 2% polyvinyl alcohol The aqueous solution is used as an emulsifier to carry out the first emulsification in the ultrasonic emulsification machine for 45 seconds, then pause for 10 minutes, perform the second emulsification in the ultrasonic emulsification machine for 8 minutes, and then carry out centrifugal evaporatio...

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Abstract

The invention discloses a novel bionic 3D printing bioactive fusion cage and a preparation method thereof. The preparation method of the fusion cage comprises the following steps: (1) preparing a 1,4-dioxane solution of PLLA polymer; (2) mixing n-HA with the PLLA polymer solution to obtain a basic solution; (3) 3D-printing a porous anatomical fusion cage, and removing organic solvent to obtain a porous anatomical fusion cage; (4) preparing loading PLGA / rhBMP-2 nanoparticles; (5) dissolving the PLGA / rhBMP-2 nanoparticles in 10ml of distilled water; (6) soaking the porous anatomic fusion cagein the PLGA / rhBMP-2 nanoparticle solution, and coating meshes of the porous anatomic fusion cage with the PLGA / rhBMP-2 nanoparticles; and (7) freeze-drying and forming the porous anatomical fusion cage. The novel fusion cage prepared by the method with three-dimensional physiological anatomical space conformation, controllable degradation and controlled release realizes the optimization of mechanical property, has controllable degradation and bone function promotion, and solves the problems of fracture and collapse of OLIF operation endplate and displacement of a fusion cage.

Description

technical field [0001] The invention relates to the field of spinal fusion and internal fixation, in particular to a novel bionic 3D printed bioactive fusion device and a manufacturing method. Background technique [0002] Oblique lumbar inter-body fusion (OLIF) was first reported by Silvestre, France in 2012, and is a minimally invasive technique for the clinical treatment of lumbar degenerative diseases in recent years. This technology can significantly reduce surgical trauma, shorten operation time, reduce intraoperative bleeding, and promote rapid recovery of patients, which is in line with the concept of rapid recovery. However, the current OLIF fusion device has postoperative endplate fracture and fusion device displacement in patients, which often leads to aggravated low back pain, inability to stand or sit for a long time, and even stenosis of the intervertebral foramen, which compresses the nerve, resulting in pain and numbness in the lower limbs. Mild symptoms can...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/12A61L27/50A61L27/54A61L27/56B33Y70/00B33Y80/00
CPCA61L27/12A61L27/18A61L27/50A61L27/54A61L27/56A61L2300/414A61L2300/624A61L2430/38B33Y70/00B33Y80/00C08L67/04
Inventor 桑宏勋方国芳李修往吴家昌林云志谭亮张世浩陈敏
Owner SHENZHEN HOSPITAL OF SOUTHERN MEDICAL UNIV
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