The invention discloses a high-performance waterproof wallboard which comprises a base layer, a bonding layer, an thermal insulating layer, a plastering mortar layer, a fireproof layer, a waterproof layer, a latex layer, a decorative coating and a wear resistant layer sequentially arranged from inside to outside. The waterproof layer is prepared from an acrylic coating which comprises the raw materials: styrene, a styrene tar emulsion, methylacrylic acid, hydroxymethyl acrylamide, diacetone acrylamide, adipic dihydrazide, an organosilicon waterproofing agent, potassium persulfate, kaolin, gypsum powder, talcum powder, nano titanium dioxide, quartz powder, iron oxide red, 4-hydroxyl butyl acrylate, polyethylene glycol, a migration agent TX-10, a migration agent OP-10, aqueous stearic acid, hydroxyethyl cellulose sodium, sodium polyacrylate, a defoamer, ammonia water and water. The wallboard disclosed by the invention is good in waterproof effect, excellent in antibacterial effect, environmental-friendly and non-toxic and low in cost of raw materials.