The invention discloses a liquid
chromatography-
mass spectrometry detection method capable of directly analyzing a salt-containing sample based on
electric arc thermal coupling, which comprises the following steps that 1) sample atomization is conducted, the spraying direction of a
liquid phase spraying generation module is adjusted, the direction pointed by a
nozzle is the tip of a
metal heat source with a tip, after being separated by liquid
chromatography, the sample enters a liquid path pipeline of the
liquid phase spray generation module and flows out from a liquid path spray head, atomized gas is sprayed out from a gas path spray head 112 through a gas path pipeline, and the sample in the liquid path spray head is atomized into small liquid drops under the action of the atomized gas; and 2)
ionization is conducted, the atomized droplets are sprayed on a
metal heat source which is coupled with the
electric arc and is provided with a tip, the
metal heat source with the tip ionizes the droplets to generate
gas phase ions, and then the
gas phase ions enter
mass spectrometry to realize efficient
ionization analysis of the charged ions. The liquid
chromatography combination is achieved, and the efficient separation characteristic of the liquid chromatography and the high salt tolerance characteristic of the AEAI are fused;.