99 results about "Structural imaging" patented technology

For the high spatial resolution imaging of a structure of interest in a specimen, a substance is selected from a group of substances which have a fluorescent first state and a nonfluorescent second state; which can be converted fractionally from their first state into their second state by light which excites them into fluorescence, and which return from their second state into their first state; the specimen's structure of interest is imaged onto a sensor array, a spatial resolution limit of the imaging being greater (i.e. worse) than an average spacing between closest neighboring molecules of the substance in the specimen; the specimen is exposed to light in a region which has dimensions larger than the spatial resolution limit, fractions of the substance alternately being excited by the light to emit fluorescent light and converted into their second state, and at least 10% of the molecules of the substance that are respectively in the first state lying at a distance from their closest neighboring molecules in the first state which is greater than the spatial resolution limit; and the fluorescent light, which is spontaneously emitted by the substance from the region, is registered in a plurality of images recorded by the sensor array during continued exposure of the specimen to the light.

An apparatus for imaging a structure of interest comprises a plurality of imaging detectors mounted on a gantry. Each of the plurality of imaging detectors has a field of view (FOV), is independently movable with respect to each other, and is positioned to image a structure of interest within a patient. A data acquisition system receives image data detected within the FOV of each of the plurality of imaging detectors.

Systems, methods, and probes are provided for functional imaging by radioactive-emission-measurements, specific to body structures, such as the prostate, the esophagus, the cervix, the uterus, the ovaries, the heart, the breast, the brain, and the whole body, and other body structures. The nuclear imaging may be performed alone, or together with structural imaging, for example, by x-rays, ultrasound, or MRI. Preferably, the radioactive-emission-measuring probes include detectors, which are adapted for individual motions with respect to the probe housings, to generate views from different orientations and to change their view orientations. These motions are optimized with respect to functional information gained about the body structure, by identifying preferred sets of views for measurements, based on models of the body structures and information theoretic measures. A second iteration, for identifying preferred sets of views for measurements of a portion of a body structure, based on models of a location of a pathology that has been identified, makes it possible, in effect, to zoom in on a suspected pathology. The systems are preprogrammed to provide these motions automatically.

An optical measurement system and apparatus for carrying out cataract diagnostics in an eye of a patient includes a Corneal Topography Subsystem, a wavefront aberrometer subsystem, and an eye structure imaging subsystem, wherein the subsystems have a shared optical axis, and each subsystem is operatively coupled to the others via a controller. The eye structure imaging subsystem is preferably a fourierdomain optical coherence tomographer, and more preferably, a swept source OCT.

The invention discloses a structural imaging method for processing reflected wave seismic data in an undulating surface area. The method comprises the steps of: carrying out spline interpolation on root-mean-square velocity on a discrete point for three times; correcting initial timing lines of all seismic data waiting for deviation to a stacked imaging reference surface of common midpoints; carrying out prestack time migration by different migration apertures, selecting the migration aperture with the optimal effect; calculating an imaging range of a seismic channel to be deviated in a deviation result space, calculating imaging of common imaging points at the position of each imaging point in the imaging space range, calculating ray travelling time, and carrying out integral summation, and finishing kirchhoff prestack time migration of each seismic data in an original data space. According to the method, the effect of topografic relief on the kirchhoff prestack time migration is overcome, and the adaptability of the kirchhoff prestack time migration imaging method on the terrain is expanded to all earth surfaces.

Variation in position of test marks formed of overlapping exposed features imaged by an imaging structure such as that of a lithography tool are characterized at high speed and with extremely high accuracy by imaging test marks formed in resist or on a target or wafer by a lithographic process, collecting irradiance distribution data and fitting a mathematical function to respective portions or regions of output data corresponding to a test mark of a test mark pattern such as respective maxima or minima regions or other regions of the irradiance distribution data to determine actual location and shift of position of respective patterns of test marks. Metrology fields are formed of patterns of test marks on test wafers or production wafers preferably including a critical dimension exposed at different focus distances and / or illumination conditions to capture position / aberration data for the imaging structure. The imaging structure can then be adjusted or corrected to minimize or eliminate aberrations of performance of the imaging structure or the performance on a complete lithographic process and / or to achieve overlay positioning with high accuracy and minimal requirements for wafer space.

A method of imaging nervous tissue, comprising acquiring functional imaging modality data from a functional imaging modality which images an intrabody volume of a patient having a body part, the patient having been injected with an imaging agent having a nervous tissue uptake by an autonomic nervous system (ANS); and locating the nervous tissue in the intrabody volume based on the functional imaging modality data.

Systems, methods, and probes are provided for functional imaging by radioactive-emission-measurements, specific to body structures, such as the prostate, the esophagus, the cervix, the uterus, the ovaries, the heart, the breast, the brain, and the whole body, and other body structures. The nuclear imaging may be performed alone, or together with structural imaging, for example, by x-rays, ultrasound, or MRI. Preferably, the radioactive-emission-measuring probes include detectors, which are adapted for individual motions with respect to the probe housings, to generate views from different orientations and to change their view orientations. These motions are optimized with respect to functional information gained about the body structure, by identifying preferred sets of views for measurements, based on models of the body structures and information theoretic measures. A second iteration, for identifying preferred sets of views for measurements of a portion of a body structure, based on models of a location of a pathology that has been identified, makes it possible, in effect, to zoom in on a suspected pathology. The systems are preprogrammed to provide these motions automatically.

A tomography system based on Cerenkov tomography, comprising: a detector of Cerenkov fluorescence for acquiring optical plane images; a structural imaging system for acquiring three-dimensional structural images;a bed device for supporting an object to be imaged; a computer for forming an optical image, a structural image and a CLT image. The invention adopts the SP3 model and the semi threshold iterator to implement the global reconstruction of the CLT, and obtains the three-dimensional tomography to image of the distribution of the radiopharmaceutical and the molecular probe in vivo within a short time. Since ordinary CCD camera is used, the cost of the imaging system has been sharply reduced for the equipment's construct and maintenance compared with PET / SPECT or γ camera. Therefore the present invention expands the options of the molecular probe, and application of the is medicine Imaging.

The invention discloses a low-cost large-field functional-molecular-structural imaging system and method aiming at medical isotope. The system comprises a functional-molecular-structural imaging coaxial detector, a data processing device and a computer device, wherein the functional-molecular-structural imaging coaxial detector is used for scanning a physical imaging object to obtain the functional and molecular imaging image information and structural imaging image information of the physical imaging object and outputting the information to the data processing device; the data processing device is used for receiving and storing the functional and molecular image information and decomposing the structural information, carrying out fusion calculation on the functional-structural images, drawing a multi-modality fused section image, and transmitting the image to the computer device for displaying; and the computer device is used for realizing image reconstruction and displaying the functional-molecular-structural multi-modality fused section image. According to the invention, a charge-coupled device and spiral CT (computerized tomography) are adopted for detecting effective information at coaxial aperture position, thus as compared with PET (positron emission tomography) / CT, SPECT (single photon emission computed tomography) / CT and other bi-modality imaging devices, the imaging axial-direction field is enlarged, the whole body imaging time is shortened, and the isotope imaging cost is greatly lowered.

The invention discloses an optical bioluminescence tomography method and solves the problem that the three-dimensional reconstruction can be realized by integrating structure imaging technology, such as computer tomography or magnetic resonance imaging. In the method, the three-dimensional profile of the surface of an organism is obtained by a white light signal image and is used for the inversion of the bioluminescence source in vivo by combining quantitive reconstruction of the energy distribution of the surface of the organism so as to implement a low-cost optical bioluminescence tomography process. The method comprises the following specific steps of: acquiring data and preprocessing; reconstructing the three-dimensional profile of the surface of the organism; reconstructing the energy distribution of the surface of the organism; performing quantitive calibration on the surface energy; and inverting the source in vivo and performing three-dimensional display. The optical bioluminescence tomography method has the characteristics of high sensitivity and low cost, saves complex, time and power-consuming segmentation and rectification links and can be used in the field of bioluminescence tomography.

The invention relates to seismic imaging where complex geologies are likely to create data that is confusing or ambiguous for a conventional matrix of acquisition source points and receiver locations. With some understanding of the geological substructure, the acquisition source points and receiver locations that optimize the imaging may be found by using a reciprocal two-way wave equation propagation method coupled with a quality geologic model. With this, the acquisition source points and receiver locations that optimize the imaging may be selected and used to better resolve the substructure and avoid the inclusion of data that obscures understanding of the substructure.

The invention discloses a method for time migration of an inclined-shaft three-dimensional vertical seismic profile (VSP). The method includes: gridding an imaging area, and acquiring trajectories of an inclined shaft according to coordinates of demodulator points; extracting root-mean-square velocity from a root-mean-square velocity model obtained from ground data along the trajectories of the inclined shaft; moving the root-mean-square velocity to a time migration imaging datum plane of the VSP to acquire a root-mean-square velocity body; calculating aperture of time migration of VSP data by a formula that migration aperture equals to target layer depth is multiplied by the square of sine with the largest imaging angle and added with a half of the largest wellhead distance; acquiring total travel time of corresponding paths of seismic waves by the aid of a double-square-root equation; extending single-path VSP wave fields to the depth where a borehole geophone is located and completing pre-stack time migration of the VSP data. More reasonable structural imaging of the time migration of the three-dimensional VSP can be acquired through three-dimensional velocity space changing trend and distribution in the shaft trajectory direction and denoted by the inclined shaft, calculating efficiency is high, and simpleness in the process is achieved.

The invention provides a bioluminescent fault imaging reestablishment method for directly fusing structure imaging, belongs to the field of medical image processing, aims to solve problems existing in an existing bioluminescent fault imaging reestablishment algorithm and provides a method for conducting BLT reestablishment by fusing other imaging modes; according to the method, reestablishment images obtained through a structure imaging mode serve as apriori information to calculate and obtain a self-adapting regularization matrix, and thus BLT reestablishment is achieved; firstly, the transmission law of light in biological tissues is stimulated based on a diffusion equation, and numerical solution is conducted through a finite element method; BLT reestablishment is conducted to achieve fusing structure imaging, the sparse characteristic of a fluorescent light source is considered, and a method capable of achieving fusing without partitioning structure image tissues is provided; to achieve the solution of the method, an iterative method based on Split-Bregman is proposed.

The invention discloses a reverse time migration spatial amplitude compensation method which keeps seismic wave dynamics characteristics. A depth domain layer velocity model and forward modeling gun set data are adopted, seismic source waves are selected to conduct forward modeling of the single-gun wave equation in a depth domain, single-gun source wave fields of all times are stored, single-gun source wave field lighting is calculated, single-gun recording is used as reverse forward modeling of the initial boundary along a time shaft to obtain a receiving wave field, the uncompensated single-gun reverse time migration imaging and even gun source wave field lighting are calculated, the single-gun reverse time migration imaging formed after the compensation of the even gun source wave field lighting is obtained, and overlaying is carried out on all the single-gun reverse time migration imaging to obtain overlaid reverse time migrating imaging formed after the compensation of the even gun source wave field lighting. The reverse time migration spatial amplitude compensation method is superior to the single-gun source wave field lighting amplitude compensation method in the aspects of structural imaging in-phase axis relative maintaining, background noise compressing, and waveform and along-layer seismic attribute space-variant relative maintaining.

The invention discloses an integral fluorescence transmission imaging system used for small animals; the structure of the imaging system is as follows: a flat panel detector, an object stage, a flat mirror and an X-ray source are sequentially arranged from top to bottom, and the centers thereof are located on the same line; two LBDs, the centers of which are arranged on the same horizontal line, are respectively arranged above both sides of the X-ray source; a filter and a charge-coupled device are positioned on the side of the non-working surface of the flat mirror; the filter and the charge-coupled device share a common axis which goes through the center of the flat mirror; and the flat panel detector and the charge-coupled device are connected with a computer via a data acquisition board. The invention takes the advantage of digital X-ray transmission imaging technology in terms of structural imaging to solve the problem of inaccurate tumor locating of the current integral fluorescent optical imaging technology. The invention adopts computers to fuse the images acquired by the digital X-ray transmission imaging technology and the integral fluorescent optical imaging technology, thereby acquiring more detailed tumor information. Therefore, an effective research tool is provided for researching the invasion, growth and translocation of the tumor.

A system includes a structural imaging acquisition unit, a functional imaging acquisition unit, and one or more processors. The structural imaging acquisition unit is configured to perform a structural scan to acquire structural imaging information of a patient. The functional imaging acquisition unit is configured to perform a functional scan to acquire functional imaging information of a patient. The one or more processors are configured to generate a tissue-specific anatomical probability map using the structural imaging information; generate a tissue-non-specific anatomical probability map using the structural imaging information; generate local combined anatomical probability weights using the tissue-specific anatomical probability map, the tissue-non-specific anatomical probability map, and the functional image data; re-distribute the functional image data using the local combined anatomical probability weights to provide re-distributed functional volumetric data; and generate an image using the re-distributed functional volumetric data.

The invention relates generally to generation of biomimetic scaffolds for bone tissue engineering and, more particularly, to multi-level lamellar structures having rotated or alternated plywood designs to mimic natural bone tissue. The invention also includes methods of preparing and applying the scaffolds to treat bone tissue defects. The biomimetic scaffold includes a lamellar structure having multiple lamellae and each lamella has a plurality of layers stacked parallel to one another. The lamellae and / or the plurality of layers is rotated at varying angles based on the design parameters from specific tissue structural imaging data of natural bone tissue, to achieve an overall trend in orientation to mimic the rotated lamellar plywood structure of the naturally occurring bone tissue.

An apparatus for determining a shape of a luminal sample including: a catheter including a lens, the catheter disposed within a strain-sensing sheath such that the lens rotates and translates; a structural imaging system optically coupled to the catheter; a strain-sensing system optically coupled to the catheter; and a controller coupled to the strain-sensing system and the structural imaging system. The controller determines: a first position of the catheter relative to the luminal sample at a first location within the strain-sensing sheath; a second position of the catheter relative to the luminal sample at a second location within the strain-sensing sheath; a first strain of the strain-sensing sheath at the first location; a second strain of the strain-sensing sheath at the second location; a local curvature of the luminal sample relative to the catheter; a local curvature of the catheter; and a local curvature of the luminal sample.

The present invention is directed to a method for real-time characterization of spatially-resolved tissue optical properties using OCT / LCI. Imaging data are acquired, processed, displayed and stored in real-time. The resultant tissue optical properties are then used to determine the diagnostic threshold and to determine the OCT / LCI detection sensitivity and specificity. Color-coded optical property maps are constructed to provide direct visual cues for surgeons to differentiate tumor versus non-tumor tissue. These optical property maps can be overlaid with the structural imaging data and / or Doppler results for efficient data display. Finally, the imaging system can also be integrated with existing systems such as tracking and surgical microscopes. An aiming beam is generally provided for interventional guidance. For intraoperative use, a cap / spacer may also be provided to maintain the working distance of the probe, and also to provide biopsy capabilities. The method is usable for research and clinical diagnosis and / or interventional guidance.

The invention relates to a system and a method for three-dimensional imaging based on terahertz chromatography of a planar array type detector. According to the method disclosed by the invention, a first gold-plated paraboloid mirror and a second gold-plated paraboloid mirror are arranged in a mutually corresponding manner to form a beam expanded unit, wherein the beam expanded unit is arranged between a CO2 pumping terahertz laser and a sample to be detected and can be used for enlarging a terahertz spot output by the CO2 pumping terahertz laser by twice and enabling the propagation directions of output light to be parallel. The sample to be tested is placed between the second gold-plated paraboloid mirror and a pyroelectric image detector; a numerical value of projection transmitting the sample to be detected is collected by the pyroelectric image detector and is called as a projection drawing I (x, y). According to the system and the method disclosed by the invention, a diffraction effect of terahertz waves is introduced to the planar array type detector, processed data is propagated to the back surface of the sample by using an angular spectrum diffraction and propagation theory, and then filtered and reestablished with a filter back-projection algorithm in order to restrain the diffraction effect of terahertz waves, and finally three dimensional structure imaging inside the sample is obtained.

A radiotherapy system including a radiotherapy component, a structural imaging component, a functional imaging component, and a workstation coupled to the radiotherapy component, the structural imaging component, and the functional imaging component. The workstation includes a processor which combines the structural imaging data and the functional imaging data to produce a fused model for a least a portion of the region of interest, to generate a plan for radiotherapy treatment of the region of interest based on the fused model, and apply, via the radiotherapy component, the radiotherapy treatment.

The invention discloses a diffusion MRI microstructure imaging-based minimum nuclear error analysis method. The method comprises the following steps of: (1) establishing a diffusion organization model, wherein a microstructure model comprises three features of a microstructure: linear structure anisotropy (LSA, D1), planar structure anisotropy (PSA, Dp) and spherical structure isotropy (SSI, Ds), and each feature model in each voxel is described as a mixed anisotropy / isotropy model; (2) calculating feature scalars, wherein the quantities of blocked and limited diffusions are captured through calculating differences between estimated microstructure scales; (3) generally presenting the minimum nuclear error analysis method; and (4) carrying out algorithm optimization, importing an auxiliary matrix variable Z, realizing a formula (as shown in the specification) and solving the minimum problem by utilizing an enhanced Lagrange multiplier. By combining a diffusion tensor imaging technology, the diffusion MRI microstructure imaging-based minimum nuclear error analysis method provided by the invention is capable of stably and efficiently estimating the fiber structures of relatively small intersection angles.

A method includes obtaining first 3D imaging data for a volume of interest. The first 3D imaging data includes structural imaging data and a target tissue of interest. The method further includes obtaining 2D imaging data. The 2D imaging data includes structural imaging data for a plane of the volume of interest. The plane includes at least three fiducial markers of a set of fiducial markers. The method further includes locating a plane, including location and orientation, in the first 3D imaging data that corresponds to the plane of the 2D imaging data by matching the at least three fiducial markers with corresponding fiducial markers identified in the first 3D imaging data and using the map. The method further includes visually displaying the first 3D imaging data with the 2D imaging data superimposed over at the corresponding plane located in the first 3D imaging data.

The invention discloses a single-light-source and double-waveband OCT imaging system, which is characterized by comprising a signal source, a neutral attenuator, a circulator, a first coupler, an indicator light source, a reference arm, a sample arm, a second coupler, a first receiving device, a second receiving device, a multi-channel acquisition card and a computer. The OCT imaging system provided by the invention is based a double-waveband SOCT technology, and by analyzing optical characteristic differences of different tissue ingredients on two wavebands, the double-waveband SOCT technology, in comparison with a single-waveband SOCT technology, can achieve more accurate plaque ingredient automatic analysis with a lower computation complexity. The structure provided by the invention, based on a conventional OCT structure, can conduct OCT structural imaging on a sample, and in addition, the structure can implement automatic analysis on plaque ingredients, so that more reference information can be provided to medical personnel and an assisting effect can be achieved on disease diagnosis and treatment.

A method for the non-invasive imaging of an anatomic tissue structure in isolation from surrounding tissues, including: receiving from an input device magnetic imaging data from a patient of the anatomic tissue structure and surrounding tissues; segmenting the imaging data to isolate the anatomic tissue structure imaging data from the imaging data for the surrounding tissues; separating the anatomic tissue structure imaging data into data populations corresponding to tissue microstructures; constructing an image from the imaging data for at least one of the tissue microstructures; and storing or displaying the image. An apparatus embodying the disclosed method is also described, as well as a method for the quantitative measurement of a nerve tissue suspected of demyelination.

A system includes a structural imaging acquisition unit, a functional imaging acquisition unit, and one or more processors. The structural imaging acquisition unit is configured to perform a structural scan to acquire structural imaging information of a patient. The functional imaging acquisition unit is configured to perform a functional scan to acquire functional imaging information of a patient. The one or more processors are configured to obtain, using the structural imaging information, a structural image of the patient including anatomical volumetric data; determine an anatomical probability map corresponding to a probability that a determined anatomical object correlates to potential functional data; obtain, using the functional imaging information, a functional image of the patient including functional volumetric data; re-distribute the functional volumetric data using the anatomical probability map to provide re-distributed functional volumetric data; and generate an image using the re-distributed functional volumetric data.

The invention discloses a magnetic compatible optical brain function imaging method and device. The method is characterized in that an output scanning light beam of an optical coherence tomography system is transmitted to a magnetic resonance imaging device through a relay light path; brain tissue three-dimensional space optical scattered signal detection is conducted on the basis of an optical coherence technology, and meanwhile, magnetic resonance imaging detection is conducted through a magnetic resonance imaging device to obtain brain tissue magnetic resonance signals; event stimulation isconducted, and blood flow signals are extracted on the basis of rapid dynamic characteristics; and then, nerve tissue response signals of a non-blood-flow area are extracted on the basis of the dynamic characteristics of the event stimulation. According to the method, optical coherence imaging can be synchronously conducted under a nuclear magnetic resonance imaging condition, high-resolution nerve tissue and haemodynamics response signals are obtained, an OCT scanning light beam is transmitted to a sample position of an MRI machine area, an imaging harassing phenomenon does not exist, and label-free and high-resolution three-dimensional structure imaging and blood flow imaging can be realized.

The invention discloses a photoacoustic ultrasonic bimodal imaging system and method for transplanted kidney. The system comprises a pulse laser which is used for the transplanted kidney to generate an photoacoustic signal; the ultrasonic transducer is used for receiving the photoacoustic signal and converting the photoacoustic signal into an electric signal; the ultrasonic transceiving module isused for transmitting and receiving electric signals; a photoacoustic signal processing unit; a data collection unit; and the computer is used for controlling the pulse laser and the ultrasonic transceiving module, performing image reconstruction on the digitized photoacoustic signal to obtain a photoacoustic image, and performing color coding on the photoacoustic image to realize development of functional information such as transplanted kidney microvascular distribution, intravascular blood oxygen content, oxygenated / deoxygenated hemoglobin content and the like. Structural imaging of the transplanted kidney can be achieved, functional information such as castruty distribution, intravascular blood oxygen content and oxygenated / deoxygenated hemoglobin content of the transplanted kidney canbe provided, and namely simultaneous real-time imaging of the structure and the function of the transplanted kidney is achieved.