40 results about "Biomimetic scaffold" patented technology

A novel method for building complex three-dimensional scaffolds for biomimetic applications such as in vitro organ growth, using a gelatin / sugar / water gel, ultraviolet radiation, and heat or enzyme is described. The method produces gelatin-sugar hydrogels demonstrating greater thermal stability, mechanical strength, and resistance to enzymatic degradation. The invention also provides a means to assemble the gelatin sugar hydrogel films into complex three-dimensional structures (scaffolds). To account for the native biochemical factors present in natural scaffolds, methods of conjugating such factors to the gelatin-sugar hydrogel are described. These scaffolds can then be applied for tissue culturing and organ growth. The present invention also describes a system and apparatus for constructing these complex three-dimensional scaffolds by taking advantage of the physical and chemical properties of the gelatin-sugar hydrogel.

The invention relates to a stereolithography-based process for manufacturing the porous structure of a bionic scaffold. The process comprises the following steps: scanning natural bones by Micro-CT to acquire the micro-structural model of the natural bones; further acquiring the negative-type model thereof through the Boolean operation; then, acquiring the negative-type model on a stereolithography basis; and finally pouring bioceramic slurry followed by high-temperature calcinations to obtain the controllable porous structure of the bionic scaffold. The porous structure of the bionic scaffold prepared by the method is the same as the real structure of bones; moreover, the method is even more favorable for the adhesion, creeping and osteogenesis substitution of cells.

The invention relates to a method for generating bionic brackets based on CT images. It converts it into a 3D model based on the patient’s CT image data provided by the hospital, and constructs a 3D model of the bone tissue defect. Finally, according to the requirements of tissue engineering, a heterogeneous porous structure geometric description model is established. Therefore, a three-dimensional bionic scaffold model with internal microstructure, suitable for the growth of bone seed cells, and used for repairing bone tissue defects is generated.

The invention discloses a myocardial bionic scaffold made from a composite conducting material and a preparation method thereof. According to the preparation method disclosed by the invention, a graphene oxide-gelatin hydrogel bionic scaffold with a reinforced conducting performance is formed by compounding a conducting material graphene oxide with gelatine, and then crosslinking genipin without biotoxicity. The elasticity modulus of the bionic scaffold can be regulated and controlled by changing a crosslinking degree, and the mechanical properties of internal myocardium can be better simulated; meanwhile, the surface micro-structure of the scaffold is controllable and the conducting material, that is, graphene oxide is compounded, thus realizing simulation for an internal myocardium micro-environment, promoting the growth of myocardial cells, and forming a highly-ordered space structure and conduction for intercellular electrophysiological signals and contraction signals; and therefore, the growth of the myocardial cells can be promoted and the functions of the myocardial cells can be improved.

The present invention relates to a method for manufacturing a three-dimensional (3D) biomimetic scaffold that exploits the use of electrical fields and electrical insulating materials to pattern previously polymerized hydro gels with different molecules and / or macromolecular entities. The invention also relates to the 3D-biomimetic scaffolds obtained and to the uses and applications thereof.

The invention provides a 3D biomimetic biological scaffold containing stem cell exosomes and its application. The biomimetic scaffold uses methacrylic anhydride gelatin, oxidized hyaluronic acid and dopamine-modified hyaluronic acid as the main material, and adds cartilage decellularization Matrix (DCM) or bone decellularized matrix (DBM) mimics the microenvironment of cartilage or osteochondral bone and adds mesenchymal stem cell exosomes (Exos) as a bioink, using 3D printing bioinks to construct containing Hydrogel‑DCM‑Exos and Hydrogel‑DBM‑Exos, a composite scaffold that mimics the bioactivity of cartilage and subchondral bone while promoting healing of articular cartilage and subarticular bone.

The invention discloses a bionic hydroxyapatite powder / gelatin / sodium alginate composite 3D printing support and a preparation method thereof. The preparation method of the biomimetic 3D scaffold includes: (1) preparation of hydroxyapatite powder with biomimetic hierarchical structure; (2) preparation of hydroxyapatite powder / gelatin / sodium alginate composite slurry; (3) biomimetic Preparation of 3D printed scaffolds. The invention uses 3D printing technology to prepare the machine / inorganic composite 3D printed scaffold with controllable external dimensions, good biocompatibility, and fully simulates the composition and multi-level structure of natural bone tissue, endowing the material with controllable mechanical strength ; The micro-nano multi-level structure of the composite scaffold has high osteogenic activity and osteoinductivity, and the multi-level porous structure can effectively induce the growth of tissues and blood vessels, and promote the regeneration and repair of bone tissue.

Described herein are novel methods of producing collagen-apatite (Col-Ap) scaffolds that exhibit a unique, anisotropic multi-level lamellar structure in which nano and submicron pores in each lamellae and macro pores are co-aligned.

The present invention provides a silver nanowire-mineralized collagen co-assembled biomimetic scaffold material, the silver nanowire-mineralized collagen co-assembled biomimetic scaffold material is a three-dimensional porous scaffold, and the three-dimensional porous scaffold is composed of silver nanowires, Collagen fibers wrapped on the surface of silver nanowires (AgNW) are interwoven, and nano-hydroxyapatite filled in the collagen fibers is also included. The present invention also provides a preparation method for the above-mentioned silver nanowire-mineralized collagen co-assembled biomimetic scaffold material. Collagen molecules wrapped on the surface of silver nanowires in the silver nanowire-mineralized collagen co-assembled biomimetic scaffold of the present invention can reduce the biotoxicity of the material and avoid affecting the compatibility and osteogenic performance; when the surface collagen molecules degrade in vivo, the partially exposed Silver nanowires can effectively inhibit the survival of bacteria at the implant site, and realize bone repair / antibacterial dual-mode treatment.

The present invention provides porous biomimetic scaffolds and methods for making the same. The scaffolds have graded pore sizes for enhanced cell penetration. The scaffolds are useful for wound regeneration by facilitating cell penetration into the scaffold interior and due to their inherent immunomodulatory effects. The scaffolds have tissue modeling specification by mimicking the inherent stratified structure of certain tissues.