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A biomimetic hydroxyapatite powder/gelatin/sodium alginate composite 3D printing scaffold and preparation method thereof

A technology of hydroxyapatite and sodium alginate, applied in prosthesis, tissue regeneration, additive processing, etc., can solve problems such as unfavorable stem cell growth, enhance osteogenic activity and osteoinductivity, and promote bone tissue regeneration and repair , rheology and stability improvement effect

Active Publication Date: 2021-09-21
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] D.Mao,Q.Li,D.Li,Y.Tan,Q.Che,3D porous poly(epsilon-caprolactone) / 58S bioactive glass-sodium alginate / gelatin hybrid scaffold prepared by a modified melt molding method for bone tissue engineering ,Materials&Design 160 (2018) 1-8. This study used sodium alginate and gelatin as printing ink to promote the repair of bone tissue by loading bioglass, but the alkaline environment generated by the degradation process of bioglass is not conducive to the growth of stem cells

Method used

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  • A biomimetic hydroxyapatite powder/gelatin/sodium alginate composite 3D printing scaffold and preparation method thereof
  • A biomimetic hydroxyapatite powder/gelatin/sodium alginate composite 3D printing scaffold and preparation method thereof
  • A biomimetic hydroxyapatite powder/gelatin/sodium alginate composite 3D printing scaffold and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Preparation of hydroxyapatite powder with hierarchical structure:

[0067] Configured with 24mM (NH4) 2 PO 4 solution, adjust the pH to 6.0 to obtain solution a. 40mmol of Ca(NO 3 ) 2 4H 2 O was added to solution a, fully dissolved, and stirred evenly to obtain solution b. Then add 6mmol of sodium citrate into solution b and stir vigorously to obtain a mixed solution. The mixture was transferred to a polytetrafluoroethylene-lined autoclave, and reacted at 180° C. for 3 h. After centrifugal washing and freeze-drying, the hydroxyapatite powder (ie HA particles) with hierarchical structure was obtained. Under the observation of scanning electron microscope, its appearance was as follows: figure 1 shown. The HA particles have a surface micro-nano hierarchical structure and a hollow structure, and the specific surface area is as high as 106.7m 2 / g.

Embodiment 2

[0069] The preparation of hydroxyapatite powder / gelatin / sodium alginate composite 3D printing scaffold includes the following steps:

[0070] (1) Preparation of hydroxyapatite powder / gelatin / sodium alginate composite slurry: take 5g of gelatin particles, add to 50mL of deionized water, fully magnetically stir, stir evenly, and obtain a concentration of 0.1g / mL gelatin solution; then add 5 g of the HA particles obtained in Example 1, and stir until the HA particles are evenly dispersed in the gelatin solution; add 2.2 g of sodium alginate to the above solution, stir well, and ultrasonically remove air bubbles to obtain printing paste;

[0071] (2) Preparation of biomimetic 3D printing scaffold: put the composite slurry of hydroxyapatite particles / gelatin / sodium alginate (that is, the printing slurry) into the barrel, the diameter of the needle is 0.4mm, and the external dimensions of the scaffold material are designed It is a circle with a diameter of 10mm and a height of 2mm....

Embodiment 3

[0073] The preparation of hydroxyapatite powder / gelatin / sodium alginate composite 3D printing scaffold includes the following steps:

[0074] (1) Preparation of hydroxyapatite powder / gelatin / sodium alginate composite slurry: take 5g of gelatin particles, add them to 50mL of deionized water, and fully magnetically stir to obtain a gelatin solution with a concentration of 0.1g / mL Then add 7.5g of the HA particles obtained in Example 1, and stir until the HA particles are evenly dispersed in the gelatin solution; add 1.8g of sodium alginate to the above solution, stir well, and ultrasonically remove air bubbles, and the printing paste is prepared material;

[0075] (2) Preparation of biomimetic 3D printing scaffold: put the composite slurry of hydroxyapatite particles / gelatin / sodium alginate (that is, the printing slurry) into the barrel, the diameter of the needle is 0.4mm, and the external dimensions of the scaffold material are designed It is a circle with a diameter of 10mm ...

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Abstract

The invention discloses a bionic hydroxyapatite powder / gelatin / sodium alginate composite 3D printing support and a preparation method thereof. The preparation method of the biomimetic 3D scaffold includes: (1) preparation of hydroxyapatite powder with biomimetic hierarchical structure; (2) preparation of hydroxyapatite powder / gelatin / sodium alginate composite slurry; (3) biomimetic Preparation of 3D printed scaffolds. The invention uses 3D printing technology to prepare the machine / inorganic composite 3D printed scaffold with controllable external dimensions, good biocompatibility, and fully simulates the composition and multi-level structure of natural bone tissue, endowing the material with controllable mechanical strength ; The micro-nano multi-level structure of the composite scaffold has high osteogenic activity and osteoinductivity, and the multi-level porous structure can effectively induce the growth of tissues and blood vessels, and promote the regeneration and repair of bone tissue.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a bionic apatite powder / gelatin / sodium alginate composite 3D printing bracket and a preparation method thereof. Background technique [0002] With the improvement of living standards and the aggravation of population aging, people's demand for repairing bone defects caused by trauma, bone tumor resection and bone tissue lesions has increased dramatically. Autologous bone grafting is considered to be the gold standard for the treatment of bone defects, but its source is limited, the graft body is difficult to shape, and the implantation site is prone to lesions. Allograft bone is easy to obtain, but its clinical use is greatly limited due to the spread of disease, inactivation during material processing, and ethical disputes. The development of new bone tissue repair materials has brought new hope for the repair of bone defects. [0003] Natural bone is ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/22A61L27/20A61L27/50A61L27/56B33Y70/10B33Y80/00B33Y10/00
CPCA61L27/12A61L27/20A61L27/222A61L27/50A61L27/56A61L2430/02B33Y10/00B33Y70/00B33Y80/00C08L5/04
Inventor 王迎军徐东杜昶
Owner SOUTH CHINA UNIV OF TECH
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