Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

220results about How to "Improve biological performance" patented technology

DNA origami-based construction method and application of precise recognition targeted nano-carrier

ActiveCN107469088AEnhance biological effectDelayed releaseOrganic active ingredientsNanomedicineDoxorubicinAnti-Tumor Drugs
The invention relates to a DNA origami-based construction method and an application of a precise recognition targeted nano-carrier, and belongs to the technical field of medicines. The carrier is composed of scaffold DNA, staple single-stranded DNA, special staple single-stranded DNA and a nucleic acid aptamer, wherein a molar ratio of the scaffold DNA to the staple single-stranded DNA to the special staple single-stranded DNA is 1:(5-10):(5-10); a molar ratio of the nucleic acid aptamer to origami is 1:(1-32); a molar ratio of the carrier to an antitumor medicine doxorubicin during drug loading is 1:(12500-50000); and the appropriate drug loading time is 2-6 h. The targeted nano-carrier has the advantages of realization of a target heat accurately-modified NDA carrier, improvement of the targeting effect of the carrier and the target heat induced biological effects, delaying of the drug release after drug loading, reduction of the toxic and side effects of anthracene ring antitumor drugs, and enhancement of the antitumor effect on tumor cells, and makes a drug-loaded system simultaneously perform chemotherapy effects and biotherapy effects.
Owner:ZHENGZHOU UNIV

Method for preparing porous bone scaffold by laser and increasing performance by adding zinc oxide

The invention relates to a method for preparing a porous bone scaffold by laser and increasing mechanical and biological performances of the porous bone scaffold by adding zinc oxide with little amount, which belongs to the bone tissue engineering field. Aiming at uncontrollable performances of aperture distribution, shape, space direction and connectivity in the preparation method of a traditional bone scaffold, and aiming at the disadvantages of poor mechanical property and fast resolving rate existed in tricalcium phosphate (beta-TCP), the invention provides the method for preparing the porous bone scaffold by using a selective laser sintering (SLS) technology, and provides the method for increasing performance by adding zinc oxide (ZnO). The method for preparing the porous bone scaffold has the advantages that the porous scaffold which enables three-dimensional interconnection is prepared by SLS, zinc oxide with little amount is added for introducing into a liquid phase, the particles densification can be promoted, crystal grain is refined, and the mechanical performance is improved, simultaneously, cell compatibility is increased, the degradation rate is reduced, and the biological performance is increased, so that the interconnected porous beta-TCP bone scaffold with enhanced mechanical performance and good biological performance can be finally prepared. The method has the advantages of simple preparation technology, convenient operation, low cost, easy control of technical parameter and the like.
Owner:CENT SOUTH UNIV

Chinese herb extract feed additive capable of effectively preventing and treating porcine epizootic diarrhea

The invention discloses a Chinese herb extract feed additive capable of effectively preventing and treating porcine epizootic diarrhea, and belongs to the field of feed additives. The feed additive is prepared from the main materials of snow grass meal, curcuma powder, semen cassiae powder, burdock powder, shallot white powder, Chinese herbal medicine preparation and curcuma extract, and toadstool and bacillus subtilis are scientifically compounded, so that the application amount of antibiotics medicine in cultivation of pigs is effectively reduced, the use amount of the antibiotic is reduced by above 60%, the drug property of the Chinese herbal medicine is improved, the porcine epizootic diarrhea caused by porcine epidemic diarrhea virus can be effectively prevented and treated, and the Chinese herb extract feed additive is safe and non-toxic. Besides, the amount of the additive in the feed is low, the quality is stable, an acting effect is improved by combining different Chinese herb extracts, the porcine epizootic diarrhea is reduced by 60-80%, and the taste and quality of animal products are obviously improved. A sense experimental evaluation proves that the evaluation score on the taste and quality of the animal products using the additive is improved by above 65%.
Owner:兴安双胞胎饲料有限公司

Hydroxyapatite/silk fibroin composite material and preparation method thereof

InactiveCN102058907AImprove mechanical propertiesGood practicability and application prospectProsthesisWollastoniteBiomimetic materials
The invention discloses a composite bionic bone material and a preparation method thereof, and in particular relates to a hydroxyapatite / silk fibroin composite bionic material and a preparation method thereof, belonging to the technical field of medical materials. The composite material comprises the following components in percent by mass: 40-60 percent of hydroxyapatite, 10-30 percent of wollastonite and 25-35 percent of silk fibroin. On the basis of tight matching and higher biological property of the hydroxyapatite / silk fibroin material, the wollastonite with better biological property and mechanical behavior is introduced, the mechanical behavior of the composite material is greatly improved without influencing the biological property, the three materials are compounded to obtain a bone tissue coloboma repairing material perfectly combining the mechanical behavior with the bioactivity and compatibility, and the bone tissue coloboma repairing material has better practicability andapplication prospect.
Owner:SUZHOU UNIV

Medical beta-titanium alloy composite material with osteogenesis inducing activity and preparation method thereof

The invention relates to a medical beta-titanium alloy composite material with osteogenesis inducting activity and a preparation method thereof. The material comprises a base material and a titanium oxide nano-tube array layer, which is generated in-situ and attached to the surface of the base material and contains BMP-2 cell growth factors. The base material is a medical beta-titanium alloy of the Ti-25Nb-6Zr-xMo family, wherein the x is between 2 and 5. The diameters of nano-tubes, which are generated in-situ on the alloy surface, are between 30 and 50 nm, the lengths of the nano-tubes are between 200 and 300 nm, and the nano-tubes are arranged in arrays and perpendicular to the surface of the titanium alloy. The medical beta-titanium alloy composite material has ultra-low elastic modulus and is capable of forming better interface mechanic matching with the bone tissue. So osteoblasts grow rapidly along the wall on the surface of medical beita-titanium alloy whose surface is loaded with titanium oxide nano-tube biological composite material containing BMP-2, and proliferate obviously. The composite material has a good effect on inducing osteoblasts to proliferate to form bone matrix and can be used to bone replacement or repairing.
Owner:HEBEI UNIV OF TECH

Stabilized chemical composition

Stabilized liquid agrochemical compositions are provided that comprise flowable, aqueous dispersion concentrates comprising a) a continuous aqueous liquid phase; b) at least one dispersed, solid phase comprising a dispersion of polymer particles having a mean particle size of at least one micron, wherein the outside surfaces of the particles comprise a colloidal solid material and wherein the particles have at least one agrochemically active ingredient distributed therein, optionally a non-porous particulate mineral that acts as a diffusion barrier to slow the release of the active ingredient, and optionally at least one non-cross-linkable mobile chemical such that the extraction of this chemical from the disperse phase renders it porous in a manner that allows the active ingredient to diffuse out. The colloidal solid is used to stabilize the polymenzable resin in an emulsion state during preparation.
Owner:SYNGENTA PARTICIPATIONS AG

Composite feed supplement capable of effectively improving feed utilization ratio and preparation thereof

The invention discloses a composite feed supplement capable of effectively improving the feed utilization ratio and preparation thereof and belongs to the field of feed supplements. The feed supplement comprises the following raw materials in parts by weight: 20-30 parts of radix asparagi powder, 20-35 parts of echinacea powder, 15-30 parts of cattail pollen powder, 20-30 parts of dogwood powder, 1-5 part (s) of cordyceps taishanensis powder, 1-5 part (s) of cordyceps sinensis fermentation liquor extractive, 2-8 parts of bacillus natto agent, 5-10 parts of radix asparagi composite extractive, 2-4 parts of Aspergillus awamori culture and 0.5-2 part (s) of licorice powder. The raw materials are respectively prepared by a certain methods and are uniformly mixed to obtain the composite feed supplement. The composite feed supplement can effectively improve the immunity and intestinal health of pigs, reduce diseases of pigs, ensure healthiness of pigs, promote growth and development, and simultaneously protect the feed against mildew and nutrient substances against oxidation loss, thereby improving the feed utilization ratio.
Owner:南宁鸿牌饲料科技有限公司

Bioactive porous poly-ether-ether-ketone as well as preparation method and application thereof

The invention relates to a bioactive porous poly-ether-ether-ketone material and a preparation method and application thereof. The active porous poly-ether-ether-ketone material has a pore diameter of450-800 [mu] m and a porosity of 30-95%, and hydroxyapatite microspheres are contained on the inner surfaces of pores. The preparation method comprises the following steps: uniformly adhering the hydroxyapatite microspheres to the surfaces of NaCl particles, performing sintering to obtain composite pore-forming particles, uniformly mixing the composite pore-forming particles with poly-ether-ether-ketone, performing compacting, performing sintering, and finally removing NaCl to obtain the porous poly-ether-ether-ketone material. Osteogenesis promoting medicines and antibacterial medicines canbe loaded into the material according to needs, and the hydroxyapatite microspheres on the inner surface are added, so that the bioinertness of the poly-ether-ether-ketone can be effectively improved,the poly-ether-ether-ketone has bioactivity, the medicines and growth factors can be loaded, a good slow release effect is achieved, and good osteogenesis promoting and antibacterial properties are achieved. The bioactive porous poly-ether-ether-ketone material disclosed by the invention has the advantages of simple process, low cost, controllable structure, convenient drug loading and the like.
Owner:BEIJING UNIV OF CHEM TECH

Bioactive porous hybrid carbon nanofiber material and preparation method thereof

The invention provides a bioactive porous hybrid carbon nanofiber material and a preparation method thereof, and belongs to the technical field of biological composite materials. The bioactive porous hybrid carbon nanofiber material is prepared by virtue of a process comprising the steps of evenly mixing a precursor sol-gel liquid of a bioactive substance, polyacrylonitrile, a pore-foaming agent and an organic solvent together under the conditions of heating in a water bath and ultrasonics, aging to obtain a spinning solution, forming a primary nanofiber film by virtue of an electrostatic spinning process, and then carrying out hot-stretching, pre-oxidating in heating stage by stage and carbonizing, and a preparation method of the bioactive porous hybrid carbon nanofiber material. Due to the bioactive nanoparticles existing on the surface of the material, the material has biocompatibility, bioactivity and biodegradability; due to existing regular-structure nano-scale pores, the material has the relatively high specific surface area, and therefore, the biological properties of the material are greatly improved. As a result, the bioactive porous hybrid carbon nanofiber material can be further used as a novel bone repair material or a bone tissue scaffold reinforcing material.
Owner:BEIJING UNIV OF CHEM TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products