48results about How to "Broad medical application prospects" patented technology

The invention discloses a method for synthesizing a rare earth metal compound nano cluster and application of the rare earth metal compound nano cluster in the aspects of target imaging of diseased regions such as tumor and contrast medium preparation. The rare earth metal compound nano cluster prepared by the method has a small particle size, good permeability, high fluorescent stability, high sensibility and strong targeting, so that the tumor can be accurately positioned; the rare earth metal compound nano cluster is directly synthesized by biological tumor cells and has good biocompatibility; and the method is convenient to operate and intuitive in result, synchronous analysis and detection in multiple states and multiple modes can be carried out, and the method has a wide medical application prospect.

The invention discloses a Chinese-Western compound preparation for treating senile dementia and a preparation method thereof. The Chinese-Western compound preparation is formed by compounding traditional Chinese medicine components and Western medicine components. The traditional Chinese medicine components are prepared from the following raw materials in parts by weight: 10-20 parts of rhizoma gastrodiae, 10-15 parts of radix salviae miltiorrhizae, 10-15 parts of folium ginkgo, 5-10 parts of cortex albiziae, 5-10 parts of fructus alpiniae oxyphyllae, 2-5 parts of dark plum, and 5-10 parts oflumbricus; the western medicines are composed of the following components: 1-1.5 parts of piracetam, 1-1.5 parts of donepezil hydrochloride and 0.5-1 part of vitamin B1. The method of combining Chinese and Western medicines can effectively improve the circulation functions of brain nerves, brain blood vessels and brain blood circulation, improves and treats insomnia, amnesia, hypomnesia and cognitive decline caused by senile dementia, has the advantages of short course of treatment, quick effect and low side effects, and has broad medical application prospects.

The invention discloses a low-temperature plasma induced membrane-type artificial lung graft modification method. The modification method includes the following steps that poly 4-methyl-1-amylene membrane materials for a membrane-type artificial lung are placed into a cavity of a plasma processing instrument, working gas is any one or two of pure ammonia gas, pure oxygen, pure argon and pure carbon dioxide, the pressure of the working gas is kept to be 20 Pa, the materials are processed for 1-5 min at the discharge power of 30-300 W, the gas flow is 30 ml / min-120 ml / min, phosphoryl choline compound steam is led into the cavity to induce vapor phase grafting, the steam pressure is stabilized to be 20 Pa, and the materials are processed for 1-5 min at the discharge power of 30-300 W. According to the method, the artificial lung membrane materials are modified through the low-temperature plasma technology, the process is simple, consumed time is short, the efficiency is high, the energy consumption is low, the biocompatibility of a poly 4-methyl-1-amylene (PMP) membrane is obviously improved, and the transmission performance of O2 and CO2 is slightly reduced compared with that before modification, however, the method still has wide medical application prospects.

The invention belongs to the field of medicines, and in particular relates to a use of low-dose IL-2 for preparing a medicament for preventing and treating osteoporosis. The invention discloses a newmedical use of low-dose IL-2. The therapeutic medicine takes the low-dose IL-2 as a main active component, in a mouse disease model, after low-dose human recombinant IL-2 is administered, all indexesfor evaluating bone loss are significantly improved, the immunotherapy method obtains better practical therapeutic effects, and increases a safe and effective new medicine for clinically preventing and treating various types of osteoporosis, and further increases the new use to the clinical use of IL-2.

The invention relates to a pharmaceutical composition for treating Alzheimer's disease, and a preparation method of the pharmaceutical composition. The pharmaceutical composition is prepared by compounding a traditional Chinese medicine component and a western medicine component, wherein the traditional Chinese medicine component is prepared from the following raw material medicines in parts by weight: 10-30 parts of epimedium herb, 5-20 parts of radix rehmanniae preparata, 5-20 parts of rhizoma dioscoreae, 8-16 parts of folium ginkgo, 8-16 parts of safflower, 10-15 parts of lumbricus and 10-15 parts of rhizoma picrorhizae; the western medicine component is prepared from the following raw material medicines: 2-4 parts of nimodipine and 2-6 parts of donepezil hydrochloride. The pharmaceutical composition for treating the Alzheimer's disease is prepared by adopting a method of combining traditional Chinese medicines and western medicines; the multiple Chinese herbal medicines and westernmedicines are selected and combined, thus realizing a synergistic effect and further enhancing the treatment effect on the Alzheimer's disease; the pharmaceutical composition has the functions of resisting aging and improving memory, can be used for effectively treating the Alzheimer's disease, and is obvious in curative effect and low in side effects, thus having a wide medical application prospect.

The invention discloses application of a gene FAM176A of a liver tissue and / or protein FAM176A coded by the gene FAM176A in serving as a target for resisting a hepatitis b virus or application of the gene or the protein in preparation of an anti-hepatitis b virus drug. Membrane-spanning protein FAM176A coded by the gene FAM176A of the liver tissue can inhibit duplication of HBV. An in vitro cell experiment and an in vivo animal experiment show that the FAM176A can inhibit the duplication of the HBV, and the structure of the protein FAM176A is forecast; moreover, a membrane-spanning region of the protein FAM176A is a key functional region for inhibiting the duplication of the HBV, which provides a new target for further development of a new anti-HBV drug; the target has a very wide medical application prospect.

　Disclosed in the present invention are a gold / silver fluorescent nanomaterial synthesized rapidly in-situ on the basis of biomolecules such as nucleosides, and a preparation method and a use for said material. In the invention, biomolecules such as nucleosides are used as a template for the rapid in-situ production of a gold / silver nanoalloy. The nanomaterial has excellent biocompatibility and stable fluorescence properties, is able to achieve highly-sensitive and rapid testing of the bodily fluid of both healthy people and patients having illnesses such as cancer, and facilitates diagnosis in respect of relevant physiological indicators. The method of the present invention allows for the detection of nucleosides and other related bio-substances in the bodily fluids of patients such as cancer patients. The invention thereby facilitates rapid, highly-sensitive, low-cost, and directly-observable testing for physiological indicators of patients such as cancer patients. The method is easy to apply, low in toxicity, highly sensitive, and high in specificity. Real-time, dynamic clinical testing can be implemented in multiple forms and modes, giving the invention great value and a wide range of prospects for medical / clinical application.

The invention discloses application of honey to preparation of a reagent for the long-term dynamic near-infrared targeting imaging of inflamed parts. The reagent is honey, propolis or royal jelly with excellent biocompatibility, or the reagent is the mixture of honey and propolis or royal jelly or the mixture of propolis and royal jelly. The reagent can be used for imaging and marking related inflamed parts specifically, accurately and rapidly under the in-situ biological positioning action and tracing and monitoring related inflamed parts dynamically, sensitively and rapidly for a long time in a non-invading manner. In addition, the reagent has no biological side and toxic effects and can be used for examining conveniently. The reagent can be used for realizing the real-time long-term dynamic near-infrared targeting imaging and related model imaging of the inflamed parts and has wide medical application prospect.

The invention discloses a method for synthesizing a rare earth metal compound nano cluster and application of the rare earth metal compound nano cluster in the aspects of target imaging of diseased regions such as tumor and contrast medium preparation. The rare earth metal compound nano cluster prepared by the method has a small particle size, good permeability, high fluorescent stability, high sensibility and strong targeting, so that the tumor can be accurately positioned; the rare earth metal compound nano cluster is directly synthesized by biological tumor cells and has good biocompatibility; and the method is convenient to operate and intuitive in result, synchronous analysis and detection in multiple states and multiple modes can be carried out, and the method has a wide medical application prospect.

A metallic ion reagent used for early rapid detection and multi-mode imaging of diseases related to malignant tumor and a cardiovascular disease, and an imaging preparation. The metallic ion reagent is a water solution containing metallic ions, and the metallic ions are prepared from at least one of ferric ions or ferrous ions, magnesium ions, transition metallic ions, rare earth metallic ions, and precious metallic ions; the transition metallic ions are one or a mixture of two of cerium ions and zinc ions; and a molar ratio of the ferric ions or the ferrous ions to other metallic ions is (5-1):1.

The invention discloses a synchronous detection method and application of polycyclic aromatic hydrocarbons and their derivatives in blood. The detection substance is extracted, detected, and analyzed synchronously, which includes the following steps: S1: Establish a mathematical model for analyzing the relationship between PAHs and SPAHs, screen SPAHs that have a strong correlation with PAHs, and use the screened SPAHs and PAHs as target detection substances ; S2: Extraction of the target detection substance; S3: Purification and separation of the sample; S4: Concentration and detection of the sample: analysis on the computer to obtain the content data of various components of the detection target PAHs and SPAHs. The application of this method is to apply the detected PAHs and SPAHs content data and relationship in the blood samples to assess the exposure characteristics of the two types of pollutants that are ubiquitous in the environment in the population or individuals, which improves the detection effect and specificity And expand the application range of detection data.

The invention relates to an external composition, and a preparation and an application thereof and belongs to the field of medicines. The external composition provided by the invention is a medicine composition which contains chlorhexidine or officinal salt thereof, or benzalkonium bromide or officinal salt thereof and a recombinant human epidermal growth factor or a recombinant cattle alkali fibroblast growth factor. According to the invention, the medicine composition is also further prepared into gel, liniment, ointment or paste, and the gel further comprises chitosan or officinal salt thereof and hyaluronic acid or officinal salt thereof. When being used for treating vagina inflammation, the external composition disclosed by the invention can improve a vagina microenvironment, promote growth of granulation tissue and repair vagina micro damage; and when being used for skin wound atraumatic restorative treatment, the external composition also can speed up restoration and regeneration of a wound tissue, promote healing and reduce scar formation, so that the external composition has a wide medical application prospect.

The invention discloses a method and application for synchronous detection of volatile pollutant exposure and effect markers in urine. The method selects OH-PAHs, mVOCs and 8-OHdG that may be correlated in the same urine sample as targets Detected substances are extracted, detected and analyzed synchronously, which includes the following steps: sample pretreatment; sample enrichment and separation; OHdG is detected on the machine, and the corresponding analysis is used to obtain the content data of various target detection substances in urine, and the correlation between the three is analyzed. The invention applies the analysis of the relationship between the content data of the target substance to evaluate the human body exposure characteristics of two types of pollutants. The invention enables synchronous detection and analysis of various target detection substances through an optimization scheme, simplifies the detection steps, reduces the detection cost, and expands the application range of the health exposure risk assessment results.

The present invention relates to the application of a chickpea extract in the preparation of medicines for treating androgen-dependent diseases. The preparation of the chickpea extract is to freeze-dry, pulverize, extract and concentrate the chickpea after germination to obtain Four components of chickpea germinated hypocotyl A, germinated chickpea cotyledon B, germinated chickpea whole bean C, and chickpea ungerminated whole bean D extract were carried out through the 5α-reductase in vitro screening model Through the screening of biological activity, the better active component is postgerminated hypocotyl A of chickpea, which has broad medical application prospects in the field of drugs for treating androgen-dependent diseases.

The invention discloses a preparation method of platinum nanoclusters and application of the platinum nanoclusters in tumor imaging agents and apoptosis agents. The preparation method comprises the following specific steps of: mixing a platinum salt solution and ascorbic acid (VC) and reduced glutathione (GSH), and heating in a water bath, wherein the synthesis speed and the particle size of the platinum nanoclusters are controlled by adjusting the pH and temperature of a solution and a ratio of components. The prepared platinum nanoclusters have a small particle size, good permeability, and excellent biocompatibility and stable fluorescence characteristics, can be used for high spatial and temporal resolution imaging on tumors and other lesion sites, and can effectively promote tumor cell apoptosis and tumor tissue ablation; the method and the application are simple and easy to implement, the toxicity is low, the sensitivity is high, the multi-mode real-time dynamic monitoring can be carried out, and the medical clinical application value and prospect are broad.