Preparation method of platinum nanoclusters and application of platinum nanoclusters in tumor imaging agents and apoptosis agents
A platinum nano-imaging agent technology, applied in echo/ultrasound imaging agents, MRI/MRI contrast agents, anti-tumor drugs, etc., to reduce cytotoxicity, broad medical application prospects, and enhance targeting effects
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Embodiment 1
[0027] Example 1 A rapid one-step method for the preparation of platinum fluorescent nanoclusters based on reduced glutathione:
[0028] 1) Prepare reduced glutathione (GSH) and platinum salt solution (chloroplatinic acid is used in this example).
[0029] 2) Mix an aqueous solution of reduced glutathione with a concentration of 0.05 mol / L and an aqueous solution of ascorbic acid (vitamin C) with a concentration of 0.05 mol / L, and then add an aqueous solution of platinum reagent with a concentration of 0.05 mol / L, the volume ratio of the three solutions It is 1:1:1, mix well, then heat in a water bath at 37°C, and the reaction is complete when the solution turns orange.
[0030] The platinum fluorescent nanoclusters prepared in this example have good stability and a uniform particle size of about 1.2-2.0 nm.
[0031] The fluorescence spectrum of the platinum fluorescent nanoclusters prepared in this example is as follows figure 1 As shown, curve 1 in the figure is the flu...
Embodiment 2
[0038] Example 2 A rapid one-step synthesis method for platinum fluorescent nanoclusters based on reduced glutathione:
[0039] 1) Prepare reduced glutathione (GSH) and platinum salt solution (potassium chloroplatinite is used in this example).
[0040] 2) Mix the reduced glutathione aqueous solution with a concentration of 0.1 mol / L and the ascorbic acid (vitamin C) aqueous solution with a concentration of 0.01 mol / L, and then add a platinum reagent aqueous solution with a concentration of 0.05 mol / L, the volume ratio of the three solutions It is 2:2:1, the three are fully mixed, and then heated in a water bath at 37°C, and the reaction is complete when the solution turns orange.
[0041] The platinum fluorescent nanoclusters prepared in this example have good stability and a uniform particle size of about 1.4-2.2 nm.
[0042] The emission wavelength of the platinum fluorescent nanoclusters prepared in this example is around 455nm, which is different from the Pt fluorescen...
Embodiment 3
[0043] Example 3 A rapid one-step synthesis method for platinum fluorescent nanoclusters based on reduced glutathione:
[0044] 1) Prepare reduced glutathione (GSH) and platinum salt solution (ammonium chloroplatinite is used in this example).
[0045] 2) Mix the reduced glutathione aqueous solution with a concentration of 0.01 mol / L and the ascorbic acid (vitamin C) aqueous solution with a concentration of 0.1 mol / L, and then add a platinum reagent aqueous solution with a concentration of 0.05 mol / L, the volume ratio of the three solutions It is 2:1:1, the three are fully mixed, and then heated in a water bath at 37°C, and the reaction is complete when the solution turns orange.
[0046] The platinum fluorescent nanoclusters prepared in this example have good stability and a uniform particle size of about 1.4-2.3 nm.
[0047] The emission wavelength of the platinum fluorescent nanoclusters prepared in this example is around 457nm, which is different from the Pt fluorescent...
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