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A low temperature plasma modified membrane artificial lung method

A low-temperature plasma and artificial lung technology, applied in suction devices, dialysis systems, etc., can solve problems such as insufficient biocompatibility, and achieve remarkable effects and simple processes

Inactive Publication Date: 2016-02-17
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the defect of insufficient biocompatibility of the existing poly-4-methyl-1-pentene (PMP) membrane type artificial lung, the invention provides a kind of poly-4-methyl-1-pentene modified by low temperature plasma Polyethylene (PMP) membrane, by grafting phosphorylcholine compounds, the method of making poly-4-methyl-1-pentene (PMP) membrane meet the standard of medical membrane artificial lung membrane, the prepared membrane artificial lung is expected to be used in Widely used in the medical field

Method used

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  • A low temperature plasma modified membrane artificial lung method
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  • A low temperature plasma modified membrane artificial lung method

Examples

Experimental program
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Effect test

Embodiment 1

[0021] Soak the poly-4-methyl-1-pentene membrane used in membrane-type artificial lung in deionized water for 24 hours, dry it in a vacuum drying oven, put the dried membrane into the chamber of the plasma processor, and the system Vacuumize to 20Pa, pass in argon gas, stabilize the working gas pressure at 20Pa, start the radio frequency power supply, adjust the discharge power to 300W, the processing time is 5min, and the gas flow rate is 60ml / min. Stop discharge and gas supply after processing, do not take out the sample, Reapply the vacuum to 20Pa. Introduce 2-methacryloyloxyethylphosphorylcholine steam into the cavity to initiate gas phase grafting, and stabilize the steam pressure at 20Pa, start the radio frequency power supply, adjust the discharge power to 300W, and the treatment time is 5min.

Embodiment 2

[0023] Soak the poly-4-methyl-1-pentene membrane used in membrane-type artificial lung in deionized water for 24 hours, dry it in a vacuum drying oven, put the dried membrane into the chamber of the plasma processor, and the system Vacuumize to 20Pa, inject oxygen, stabilize the working gas pressure at 20Pa, start the radio frequency power supply, adjust the discharge power to 30W, the processing time is 1min, and the gas flow rate is 120ml / min. Stop discharge and gas supply after processing, do not take out the sample, Re-extract the vacuum to 20Pa. Introduce 2-methacryloyloxyethylphosphorylcholine steam into the cavity to initiate gas phase grafting, and stabilize the steam pressure at 20Pa, start the radio frequency power supply, adjust the discharge power to 30W, and the treatment time is 1min.

Embodiment 3

[0025] Soak the poly-4-methyl-1-pentene membrane used in membrane-type artificial lung in deionized water for 24 hours, dry it in a vacuum drying oven, put the dried membrane into the chamber of the plasma processor, and the system Vacuumize to 20Pa, inject carbon dioxide, stabilize the working gas pressure at 20Pa, start the RF power supply, adjust the discharge power to 200W, the processing time is 2min, and the gas flow rate is 30ml / min. Stop discharge and gas supply after processing, do not take out the sample, Reapply the vacuum to 20Pa, Introduce 2-methacryloyloxyethylphosphorylcholine steam into the cavity to initiate gas phase grafting, and stabilize the steam pressure at 20Pa, start the radio frequency power supply, adjust the discharge power to 200W, and the treatment time is 2min.

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Abstract

The invention discloses a low-temperature plasma induced membrane-type artificial lung graft modification method. The modification method includes the following steps that poly 4-methyl-1-amylene membrane materials for a membrane-type artificial lung are placed into a cavity of a plasma processing instrument, working gas is any one or two of pure ammonia gas, pure oxygen, pure argon and pure carbon dioxide, the pressure of the working gas is kept to be 20 Pa, the materials are processed for 1-5 min at the discharge power of 30-300 W, the gas flow is 30 ml / min-120 ml / min, phosphoryl choline compound steam is led into the cavity to induce vapor phase grafting, the steam pressure is stabilized to be 20 Pa, and the materials are processed for 1-5 min at the discharge power of 30-300 W. According to the method, the artificial lung membrane materials are modified through the low-temperature plasma technology, the process is simple, consumed time is short, the efficiency is high, the energy consumption is low, the biocompatibility of a poly 4-methyl-1-amylene (PMP) membrane is obviously improved, and the transmission performance of O2 and CO2 is slightly reduced compared with that before modification, however, the method still has wide medical application prospects.

Description

Technical field [0001] The invention relates to a method for modifying a membrane-type artificial lung, in particular to a method for modifying a poly-4-methyl-1-pentene membrane-type artificial lung by using low-temperature plasma, especially for improving the biocompatibility of the surface of an artificial lung membrane sex. Background technique [0002] Membrane artificial lung, also known as membrane oxygenator or gas exchanger, its main function is to replace human lungs in the extracorporeal circulation of open thoracotomy when the lungs of the body become diseased or damaged carbon dioxide and at the same time absorb the oxygen necessary for the human body to maintain the life of lung disease patients. [0003] Poly-4-methyl-1-pentene (PMP) is a crystalline transparent polyolefin material with a stereoregular structure, which is obtained by directional polymerization of 4-methyl-1-pentene as a monomer. It has excellent performance and high temperature resistance, a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M1/16C08J7/18
CPCA61M1/1698C08J7/123C08J7/18C08J2323/20
Inventor 李磊刘耀东黄鑫王伟平
Owner NANJING UNIV
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