120results about How to "Production is limited" patented technology

The present invention relates to trans-capsularly administering into a diseased joint a high specificity antagonist selected from the group consisting of: i) an inhibitor of a pro-inflammatory interleukin; ii) an inhibitor of TNF-α synthesis; iii) an inhibitor of membrane-bound TNF-α; iv) an inhibitor of a natural receptor of TNF-α; v) an inhibitor of NO synthase, vi) an inhibitor of PLA2 enzyme; vii) an anti-proliferative agent; viii) an anti-oxidant; ix) an apoptosis inhibitor selected from the group consisting of EPO mimetic peptides, EPO mimetibodies, IGF-I, IGF-II, and caspase inhibitors, and x) an inhibitor of MMPs; and xi) an inhibitor of p38 kinase.

Methods of improving protein production in animal cell cultures are provided. Cell culture methods are presented wherein glucose is fed in a restricted manner to cell culture; this restricted feeding of glucose to the cell culture results in lactate production being controlled to a low level. The restricted feeding of glucose in a fed-batch process is not accomplished through a constant-rate feeding of glucose, and the restricted feeding need not depend on sampling. Instead, restricted feeding of glucose to the culture is accomplished through feeding of glucose to the culture at a rate that is a function of an expected or a premodeled rate of glucose consumption by the animal cells when exposed to medium containing a high level of glucose. Because lactate production is controlled to low levels, recombinant protein production is increased.

A plating apparatus has an ashing unit (300) configured to perform an ashing process on a resist (502) applied on a surface of a seed layer (500) formed on a substrate (W), and a pre-wetting section (26) configured to provide hydrophilicity to a surface of the substrate after the ashing process. The plating apparatus includes a pre-soaking section (28) configured to bring the surface of the substrate into contact with a treatment solution to clean or activate a surface of the seed layer formed on the substrate. The plating apparatus also includes a plating unit (34) configured to bring the surface of the substrate into a plating solution in a plating tank while the resist is used as a mask so as to form a plated film (504) on the surface of the seed layer formed on the substrate.

A game machine for providing a game, the regularity of which cannot be easily recognized by the player, by making use of a chaotic random number produced by a random number generating means.

A substrate treating apparatus includes at least two types of treatment units, and a substrate carrying mechanism for carrying a substrate into / out of at least the two types of treatment units. At least the two types of treatment units are selected out of a chemical liquid treatment unit for supplying a chemical liquid to the substrate, a scrubbing unit for scrubbing a surface of the substrate, a polymer removal unit for supplying a polymer removal liquid to the substrate, a peripheral end surface treatment unit for supplying a treatment liquid to an area including the whole of one surface and a peripheral end surface of the substrate, and a gas phase treatment unit for supplying a vapor to the substrate.

A method of recovering hydrocarbons from hydrocarbonaceous materials can include forming a stationary permeability control infrastructure. This constructed infrastructure defines a substantially encapsulated volume. A comminuted hydrocarbonaceous material can be introduced into the control infrastructure to form a permeable body of hydrocarbonaceous material. The permeable body can be heated sufficient to remove hydrocarbons therefrom within a temperature range which is sufficient to substantially avoid formation of carbon dioxide or non-hydrocarbon leachates. During heating the hydrocarbonaceous material is substantially stationary as the constructed infrastructure is a fixed structure. Removed hydrocarbons can be collected for further processing, use in the process, and / or use as recovered.

An imaging device includes a light source layer having imaging light source units for radiating the imaging light containing a first wavelength on an object to be imaged, a detection layer having detection elements for detecting the light of the first wavelength radiated from the light source units, and a light-blocking unit interposed between the light source layer and the detection layer. The light source layer is held between the detection layer and the object to be imaged. The light-blocking unit is arranged in such a manner as to block the direct radiation of at least part of the light radiated from the light source units to the detection elements.

This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the invention relates to aromatic guanylhydrazone (more properly termed amidinohydrazone) compositions and their use to inhibit the uptake of arginine by macrophages and / or its conversion to urea. These compositions and methods are also useful in preventing the generation of nitric oxide (NO) by cells, and so to prevent NO-mediated inflammation and other responses in persons in need of same. In another embodiment, the compounds can be used to inhibit arginine uptake in arginine-dependent tumors and infections.

For achieving the protection of copyright, by suppressing illegal copy production thereof, in particular, when transmitting contents with using a wired or wireless LAN, as well as, for preventing the transmission of contents from deviating from a range of a personal use thereof, a contents transmitter apparatus and a contents receiver apparatus make an authentication, mutually, before transmitting contents therebetween. At the time when conducting this authentication, measurement is made upon a time-period up to arrival of a receipt confirmation responding to the transmission of an authentication request or a response to the authentication; then, only in the case when this value measured does not exceed a predetermined upper value, the transmission is conducted on the contents encrypted, and at the same time, address information and equipment information unique to the apparatus are registered, thereby conducting the transmission of encrypted contents, but without conducting the time-measurement thereon, when transmitting the contents, again. Also, while conducting the time-measurement periodically, dynamic management is made on the registration information, so that the contents thereof are suitable for the network structure at the present.

This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the invention relates to aromatic guanylhydrazone (more properly termed amidinohydrazone) compositions and their use to inhibit the uptake of arginine by macrophages and / or its conversion to urea. These compositions and methods are also useful in preventing the generation of nitric oxide (NO) by cells, and so to prevent NO-mediated inflammation and other responses in persons in need of same. In another embodiment, the compounds can be used to inhibit arginine uptake in arginine-dependent tumors and infections.

A method of recovering hydrocarbons from hydrocarbonaceous materials can include forming a constructed permeability control infrastructure. This constructed infrastructure defines a substantially encapsulated volume. A comminuted hydrocarbonaceous material can be introduced into the control infrastructure to form a permeable body of hydrocarbonaceous material. The permeable body can be heated sufficient to remove hydrocarbons therefrom. During heating the hydrocarbonaceous material is substantially stationary as the constructed infrastructure is a fixed structure. Removed hydrocarbons can be collected for further processing, use in the process, and / or use as recovered.

Although a product having such the IC chip has been diffused, information on the product may be capable of being perceived, abstracted, falsified, or the like by a third person with his external device during distribution of the product or after purchase of the product. Further, privacy may be seriously infringed. Paper money, various products, and the like are disclosed according to the present invention with an integrated circuit device having a switching memory for controlling reading and writing of information (lock / unlock of information) in order to protect the information recorded and stored in the integrated circuit such as an IC chip installed to the product or the like.

Method and devices for electrosurgery by means of oxy-hydro combustion. Deleterious effects to tissue are minimized by means of control of acid-base shift reactions, which reactions can further be employed to control oxy-hydro combustion reactions. In one embodiment, radiofrequency energy in electrical connection with electrodes is employed to induce electrolysis in an aqueous salt environment, thereby producing oxygen and hydrogen, with the same energy source employed to initiate a combustion reaction.

The present invention offers a method for forming an opening portion by a simple process without using a photomask or a resist. Further, the present invention proposes a method for manufacturing a semiconductor device at low cost. A plurality of light absorbing layers is formed over a substrate, an interlayer insulating layer is formed over the plurality of light absorbing layers, the plurality of light absorbing layers is irradiated with a linear or rectangular laser beam from the interlayer insulating layer side, and at least the interlayer insulating layer which is over the plurality of light absorbing layers is removed and an opening portion is formed; and accordingly, a plurality of opening portions can be formed by removing the plurality of light absorbing layers and an insulating film formed over the plurality of light absorbing layers.

The present invention offers a method for forming an opening portion by a simple process without using a photomask or a resist. Further, the present invention proposes a method for manufacturing a semiconductor device at low cost. A plurality of light absorbing layers is formed over a substrate, an interlayer insulating layer is formed over the plurality of light absorbing layers, the plurality of light absorbing layers is irradiated with a linear or rectangular laser beam from the interlayer insulating layer side, and at least the interlayer insulating layer which is over the plurality of light absorbing layers is removed and an opening portion is formed; and accordingly, a plurality of opening portions can be formed by removing the plurality of light absorbing layers and an insulating film formed over the plurality of light absorbing layers.

The present invention relates to trans-capsularly administering into a diseased joint an inhibitor of p38 MAP kinase or a different therapeutic agent.

Methods of treating or inhibiting ischemia and reperfusion injury are provided.

A process is provided for preparing a commercially acceptable pharmaceutical grade microcrystalline cellulose which comprises: a) repulping a pulp, the pulp having a composition, b) pressing the pulp obtained in a; c) decompacting of the pulp obtained in b; d) feeding the pulp obtained in c) into a pre-heated reactor; e) cooking the pulp in the reactor until the pulp obtains a desired degree of polymerization, said cooking being performed at a temperature, a time, and a pressure which is a function of the desired degree of polymerization and the composition of the pulp, the cooked pulp being hydrolyzed cellulose; f) partially depressurizing the reactor; g) injecting water into the reactor; h) discharging the hydrolyzed cellulose from the reactor, i) filtrating the hydrolyzed cellulose; j) deaggregating the hydrolyzed cellulose of step i; and k) drying the hydrolyzed cellulose to form microcrystalline cellulose.

This invention relates to a catalyst and a process for treating heavy hydrocarbons using the catalyst. The catalyst is useful for treating heavy hydrocarbons, de-metallize oil (DMO) and is particularly useful in VGO / DMO hydrocarbon blend. It is also useful for DAO. The catalyst acts to catalytically convert the VGO / DMO blend to shorter-chain valuable hydrocarbon products. The catalyst includes a catalytic support material, a catalytic metal impregnated upon the catalytic support material, and a promoter metal on the catalytic support material to enhance catalytic conversion. The combination of the catalytic support material with catalytic metal and promoter metal is operable to catalytically convert VGO / DMO into hydrocarbon products having shorter carbon chains.

A combustion chamber (10) of a turbomachine, comprising at least one bowl (95) with a substantially frustoconical wall that is formed with an annular row of air injection orifices, and a fuel injector (36) arranged upstream of the bowl, the annular row of air injection orifices comprising smaller-diameter orifices (140) and larger-diameter orifices (142) which are arranged in alternating fashion and with a uniform distribution around the axis of the bowl to produce two annular air / fuel mixture layers (144, 148).

A method for converting heavy olefins present in a product stream exiting a first reaction zone into light olefins and carbonaceous deposits on a catalyst without separation of the heavy olefins from the product stream exiting the first reaction zone. The method comprises creating the product stream exiting the first reaction zone, the product stream exiting the first reaction zone comprising the heavy olefins, moving the product stream exiting the first reaction zone to a second reaction zone without separation of the heavy olefins from the product stream exiting the first reaction zone, and contacting the product stream exiting the first reaction zone with the catalyst under conditions effective to form the light olefins, the contacting causing the carbonaceous deposits to form on at least a portion of the catalyst.

Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and / or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis

Methods of improving protein production in animal cell cultures are provided. Cell culture methods are presented wherein glucose is fed in a restricted manner to cell culture; this restricted feeding of glucose to the cell culture results in lactate production being controlled to a low level. The restricted feeding of glucose in a fed-batch process is not accomplished through a constant-rate feeding of glucose, and the restricted feeding need not depend on sampling. Instead, restricted feeding of glucose to the culture is accomplished through feeding of glucose to the culture at a rate that is a function of an expected or a premodeled rate of glucose consumption by the animal cells when exposed to medium containing a high level of glucose. Because lactate production is controlled to low levels, recombinant protein production is increased.

The present invention provides glass fiber fabric reinforcements, cement boards, and glass fiber coatings for such reinforcements. The glass fiber fabric reinforcement includes a glass fabric containing multiple yarns containing glass filaments and a polymeric coating disposed onto the multiple yarns to form a coated glass fabric. The polymeric coating comprises a polyolefin based copolymer composition whereby the glass fabric has a Gurley Stiffness measurement of about 100-3000 mg and an ASTM D 638 (2% Secant) modulus of compression of about 1-100 MPa. The reinforcement is sufficiently drapable and lacking in shape memory so as to be curved around the edge of a cement board during the manufacture of same.

A method of producing a range of diatomaceous earth filter aids having selectable permeabilities and less than about 1 percent by weight total crystalline silica. The method includes milling diatomaceous earth ore to a size range of between about 100 micrometers and about 1400 micrometers; calcining the milled diatomaceous earth in a calciner; and milling the calcined diatomaceous earth in an adjustable milling and classification system to produce diatomaceous earth filter aids. Systems to implement such methods and compositions produced by such methods are also described.

Methods are disclosed for producing C8 aromatic hydrocarbons. Representative methods comprise (a) fractionating an aromatic hydrocarbon containing feed stream (e.g., a feed stream comprising C9 and / or C10 aromatic hydrocarbons), to provide at least one methylated aromatic hydrocarbon-enriched fraction; and (b) reacting at least a portion of the at least one methylated aromatic hydrocarbon-enriched fraction in a transalkylation reaction zone to provide a transalkylation effluent comprising the C8 aromatic hydrocarbons. The presence of a methylated aromatic hydrocarbon-enriched fraction in the inlet stream to the transalkylation reaction zone provides a number of advantages as described herein.

A method for optimal production of synthetic diesel and naphtha from a hydrocracker includes hydrocracking a synthetic heavy hydrocarbon feed comprising an a value so as to form a diesel and a naphtha; selecting a desired diesel-to-naphtha ratio; calculating, based on the feed a and the desired diesel-to-naphtha ratio, a target molar ratio of hydrocarbons exiting to hydrocarbons entering the hydrocracker; and adjusting at least one hydrocracking conversion promoting condition so as to achieve said target molar ratio. The present invention further relates to a method for adjusting the overall production of a syngas-to-synthetic hydrocarbons plant in response to market conditions, comprising adjusting at least one hydrocracking conversion promoting condition and / or at least one conversion promoting condition within a Fischer-Tropsch reactor so as to maintain the overall diesel-to-naphtha ratio or to maintain a diesel production rate within a predetermined range of a desired value.